GREMLIN Database
PF14155 - (70-160) Uncharacterized protein
UniProt: W5TPN4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (82)
Sequences: 2641 (1735)
Seq/√Len: 191.5
META: 0.706

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_D18_T2.9921.00
16_N74_R2.7901.00
40_G75_P2.6431.00
42_D73_S2.4791.00
47_E50_R2.1881.00
18_T68_T2.0781.00
20_T68_T2.0641.00
22_H64_E1.8891.00
41_M45_G1.8711.00
21_V78_G1.8611.00
35_V52_E1.7881.00
9_L24_K1.7851.00
37_V52_E1.7721.00
43_T76_A1.7251.00
51_R67_T1.7031.00
22_H66_N1.6771.00
38_V67_T1.6621.00
23_F53_V1.6121.00
24_K64_E1.5621.00
42_D46_S1.5011.00
39_R79_N1.3901.00
29_H32_Q1.3851.00
27_R34_V1.3831.00
23_F67_T1.3301.00
39_R47_E1.3281.00
33_P56_P1.3231.00
14_V18_T1.3061.00
51_R69_V1.2981.00
37_V50_R1.2731.00
13_L19_V1.2701.00
41_M79_N1.2401.00
19_V40_G1.2331.00
7_D24_K1.1911.00
14_V20_T1.1551.00
13_L74_R1.1481.00
49_G69_V1.1351.00
41_M77_N1.1331.00
12_D20_T1.1331.00
55_V65_L1.1301.00
26_T62_T1.1141.00
33_P54_L1.0751.00
19_V78_G1.0681.00
9_L22_H1.0681.00
10_G22_H1.0461.00
20_T66_N1.0461.00
35_V54_L1.0191.00
11_Y76_A1.0091.00
19_V75_P0.9991.00
69_V78_G0.9971.00
71_T75_P0.9760.99
23_F80_I0.9690.99
44_E73_S0.9580.99
40_G71_T0.9020.99
28_K31_E0.8810.99
27_R30_P0.8710.99
33_P57_G0.8410.98
39_R81_Y0.8240.98
27_R32_Q0.8200.98
37_V84_S0.8170.98
25_V34_V0.8090.98
8_Q77_N0.7900.97
23_F65_L0.7850.97
8_Q11_Y0.7830.97
30_P61_G0.7630.97
11_Y77_N0.7540.97
23_F55_V0.7500.96
6_P23_F0.7480.96
53_V67_T0.7430.96
55_V67_T0.7390.96
6_P80_I0.7340.96
38_V81_Y0.7340.96
13_L75_P0.7290.96
7_D26_T0.7260.96
39_R50_R0.7220.96
26_T30_P0.7000.95
39_R45_G0.6980.95
34_V55_V0.6890.94
27_R63_V0.6870.94
47_E81_Y0.6760.94
28_K32_Q0.6760.94
24_K62_T0.6750.94
9_L64_E0.6740.94
42_D72_T0.6600.93
27_R55_V0.6560.93
8_Q72_T0.6530.93
46_S73_S0.6400.92
48_V73_S0.6350.92
15_D71_T0.6260.91
37_V81_Y0.6250.91
42_D48_V0.6230.91
14_V68_T0.6210.91
12_D22_H0.6200.91
13_L71_T0.6200.91
27_R33_P0.6130.90
48_V71_T0.6070.90
43_T70_K0.5990.89
8_Q19_V0.5970.89
3_D28_K0.5960.89
5_Q53_V0.5960.89
27_R56_P0.5950.89
7_D62_T0.5880.88
42_D70_K0.5880.88
50_R81_Y0.5740.87
10_G66_N0.5730.87
32_Q56_P0.5610.86
72_T76_A0.5570.85
23_F38_V0.5550.85
53_V65_L0.5500.85
40_G77_N0.5480.84
59_D63_V0.5420.84
25_V53_V0.5370.83
21_V41_M0.5350.83
62_T66_N0.5230.82
50_R54_L0.5210.81
8_Q23_F0.5180.81
31_E61_G0.5140.81
30_P55_V0.5090.80
55_V58_S0.5050.79
17_S73_S0.5040.79
81_Y84_S0.5040.79
41_M81_Y0.5030.79
21_V80_I0.5000.79
11_Y78_G0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l76A 2 0.5824 8.4 0.904 Contact Map
4v12A 2 0.6154 4.2 0.917 Contact Map
4i3gA 1 0.967 3.3 0.921 Contact Map
2knqA 1 0.3407 2.9 0.923 Contact Map
1gk8I 3 0.2967 2.6 0.925 Contact Map
3butA 2 0.956 2.3 0.927 Contact Map
3zyzA 1 0.967 1.8 0.931 Contact Map
3iduA 1 0.9231 1.8 0.931 Contact Map
1x9lA 1 0.3516 1.8 0.932 Contact Map
1v5rA 1 0.7253 1.7 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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