GREMLIN Database
PF13858 - Uncharacterized protein
UniProt: W0RMX1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 170 (166)
Sequences: 2657 (2181)
Seq/√Len: 169.3
META: 0.95

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_P122_A3.8291.00
51_G76_I3.6031.00
70_L154_L2.7581.00
90_F94_L2.7541.00
46_L50_F2.6451.00
77_S153_A2.5591.00
15_S87_T2.4721.00
69_A161_A2.3171.00
64_I69_A2.1991.00
117_T120_Q2.1621.00
123_A127_E2.1131.00
120_Q123_A2.0701.00
91_V96_M2.0121.00
54_A58_T2.0081.00
1_R5_T1.9981.00
56_R166_R1.9811.00
3_V75_L1.9601.00
52_V164_L1.9431.00
53_R57_D1.9421.00
19_V24_F1.9421.00
77_S157_T1.9191.00
73_G157_T1.7451.00
109_E112_R1.7321.00
8_L12_G1.7151.00
7_G11_G1.6911.00
55_Y72_V1.6851.00
108_L125_S1.6661.00
101_E105_A1.6491.00
109_E113_A1.6161.00
52_V160_S1.5791.00
89_Q93_R1.5341.00
10_A80_A1.5331.00
98_D101_E1.5311.00
34_L38_Y1.5241.00
87_T91_V1.5201.00
124_Q127_E1.5161.00
118_P121_L1.5101.00
60_G64_I1.5091.00
63_S169_P1.5061.00
45_F49_F1.4881.00
68_R71_G1.4761.00
126_Q130_R1.4411.00
78_L150_L1.4001.00
82_V146_F1.3841.00
111_A121_L1.3761.00
73_G153_A1.3641.00
38_Y42_V1.3611.00
102_R105_A1.3361.00
49_F53_R1.3291.00
127_E130_R1.3091.00
66_F162_G1.3061.00
116_A124_Q1.3061.00
105_A109_E1.2941.00
30_F106_Y1.2931.00
105_A108_L1.2741.00
66_F70_L1.2601.00
71_G74_L1.2461.00
70_L74_L1.2411.00
10_A47_L1.2331.00
5_T54_A1.2301.00
140_V144_M1.2261.00
53_R58_T1.2041.00
146_F150_L1.1891.00
85_V142_A1.1871.00
122_A125_S1.1831.00
74_L150_L1.1821.00
19_V87_T1.1781.00
116_A120_Q1.1761.00
160_S164_L1.1711.00
133_E136_R1.1651.00
55_Y60_G1.1621.00
11_G83_C1.1591.00
18_M87_T1.1331.00
107_V111_A1.1311.00
89_Q94_L1.1201.00
156_M160_S1.1171.00
108_L112_R1.1171.00
49_F160_S1.1151.00
63_S168_G1.1111.00
3_V72_V1.1021.00
66_F163_I1.1011.00
111_A124_Q1.0891.00
98_D102_R1.0881.00
91_V99_Y1.0811.00
41_M44_S1.0741.00
52_V73_G1.0731.00
66_F161_A1.0651.00
104_A108_L1.0480.99
65_S68_R1.0480.99
148_E151_P1.0220.99
17_M21_S1.0110.99
106_Y110_K1.0060.99
111_A114_S1.0060.99
110_K113_A1.0040.99
66_F158_L0.9880.99
74_L154_L0.9550.99
64_I164_L0.9540.99
126_Q129_A0.9530.99
159_V162_G0.9520.99
67_G70_L0.9410.99
21_S36_V0.9380.99
48_V73_G0.9070.98
125_S129_A0.8980.98
130_R133_E0.8950.98
107_V110_K0.8750.98
77_S81_C0.8750.98
8_L83_C0.8700.98
11_G15_S0.8690.98
124_Q128_M0.8670.98
110_K114_S0.8500.98
53_R56_R0.8470.98
53_R164_L0.8430.97
2_I6_F0.8420.97
116_A121_L0.8410.97
122_A126_Q0.8390.97
48_V77_S0.8360.97
14_L44_S0.8330.97
139_L142_A0.8320.97
85_V145_T0.8320.97
52_V69_A0.8230.97
15_S83_C0.8210.97
14_L80_A0.8190.97
144_M147_V0.8190.97
13_L47_L0.8080.97
52_V72_V0.8070.97
155_L159_V0.8040.97
128_M131_F0.8040.97
104_A107_V0.8000.97
91_V95_M0.7990.96
93_R141_N0.7870.96
144_M148_E0.7870.96
85_V146_F0.7860.96
50_F54_A0.7850.96
89_Q142_A0.7740.96
15_S91_V0.7740.96
54_A59_V0.7710.96
14_L40_T0.7600.95
153_A157_T0.7590.95
70_L157_T0.7550.95
14_L84_Y0.7530.95
99_Y103_Y0.7470.95
31_D110_K0.7460.95
139_L143_A0.7440.95
57_D60_G0.7440.95
162_G165_R0.7370.95
101_E104_A0.7320.94
148_E152_V0.7310.94
120_Q124_Q0.7300.94
44_S149_P0.7300.94
103_Y107_V0.7260.94
15_S19_V0.7190.94
11_G80_A0.7180.94
100_M104_A0.7170.94
115_G121_L0.7170.94
94_L97_P0.7170.94
92_Y99_Y0.7120.93
119_E123_A0.7120.93
50_F53_R0.7070.93
37_G41_M0.7060.93
55_Y64_I0.7020.93
123_A126_Q0.7000.93
154_L157_T0.6970.93
52_V161_A0.6860.92
81_C146_F0.6830.92
106_Y109_E0.6730.91
85_V88_W0.6710.91
32_R35_V0.6710.91
72_V76_I0.6700.91
84_Y88_W0.6670.91
91_V94_L0.6670.91
60_G68_R0.6660.91
17_M43_L0.6580.90
129_A136_R0.6510.90
12_G83_C0.6480.90
22_M91_V0.6460.90
140_V143_A0.6430.89
14_L41_M0.6420.89
51_G72_V0.6390.89
138_P142_A0.6380.89
88_W92_Y0.6310.89
67_G71_G0.6280.88
9_I47_L0.6260.88
36_V40_T0.6210.88
71_G154_L0.6210.88
21_S35_V0.6170.87
6_F51_G0.6130.87
124_Q129_A0.6110.87
86_V89_Q0.6100.87
57_D64_I0.6100.87
130_R134_M0.6090.87
49_F57_D0.6050.86
10_A14_L0.6000.86
30_F102_R0.5950.86
12_G15_S0.5930.85
47_L50_F0.5920.85
4_L8_L0.5900.85
114_S117_T0.5900.85
111_A116_A0.5890.85
33_G36_V0.5880.85
56_R62_G0.5880.85
10_A44_S0.5880.85
151_P155_L0.5870.85
52_V64_I0.5850.85
121_L125_S0.5830.84
15_S18_M0.5820.84
49_F164_L0.5780.84
35_V39_T0.5780.84
81_C149_P0.5770.84
96_M102_R0.5750.84
66_F154_L0.5740.83
11_G14_L0.5740.83
75_L79_V0.5730.83
12_G46_L0.5710.83
108_L111_A0.5700.83
68_R168_G0.5690.83
112_R118_P0.5640.82
25_H28_I0.5600.82
143_A147_V0.5580.82
82_V86_V0.5560.81
69_A162_G0.5550.81
75_L78_L0.5550.81
103_Y106_Y0.5530.81
121_L124_Q0.5490.81
88_W145_T0.5490.81
60_G72_V0.5480.81
73_G77_S0.5400.80
128_M134_M0.5390.79
6_F50_F0.5380.79
64_I68_R0.5370.79
86_V90_F0.5350.79
52_V157_T0.5350.79
69_A164_L0.5340.79
6_F10_A0.5280.78
97_P113_A0.5270.78
9_I13_L0.5250.78
61_G168_G0.5240.78
48_V157_T0.5220.77
6_F72_V0.5220.77
34_L37_G0.5140.76
56_R164_L0.5110.76
22_M26_E0.5110.76
92_Y100_M0.5100.76
47_L80_A0.5080.75
116_A123_A0.5080.75
4_L86_V0.5070.75
131_F135_Y0.5060.75
14_L20_V0.5040.75
81_C150_L0.5010.74
100_M136_R0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kncA 1 0.2529 26.4 0.922 Contact Map
2l9uA 2 0.2118 19.8 0.927 Contact Map
2nwlA 3 0.8529 15.7 0.93 Contact Map
2l8sA 1 0.2353 15.5 0.93 Contact Map
2w84A 1 0.3353 14.2 0.931 Contact Map
2m3eA 1 0.2529 10.6 0.935 Contact Map
1iijA 1 0.2059 10.3 0.935 Contact Map
2k1aA 1 0.2353 10.2 0.935 Contact Map
3rvyA 3 0.5353 9.8 0.936 Contact Map
4tkrA 2 0.7765 9.5 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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