GREMLIN Database
PF14198 - TnpV protein
UniProt: R6MUZ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 110 (109)
Sequences: 2057 (1341)
Seq/√Len: 128.5
META: 0.936

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_L7_Y3.9001.00
88_E92_R3.7491.00
75_E99_R3.2781.00
28_H52_H2.8811.00
43_L48_K2.6841.00
23_V27_R2.5481.00
38_V42_N2.4581.00
88_E91_G2.1261.00
85_N88_E2.1231.00
80_K84_E2.0281.00
2_L5_D1.9541.00
22_G57_D1.9031.00
86_Q90_V1.8051.00
30_R34_Q1.7541.00
24_W27_R1.7411.00
66_R70_Q1.7261.00
3_Q8_L1.6571.00
19_T58_K1.6461.00
97_R101_T1.6461.00
57_D61_E1.6351.00
95_N99_R1.4981.00
69_K72_A1.4031.00
42_N45_T1.3941.00
75_E96_I1.3891.00
72_A93_M1.3841.00
40_Y44_L1.3601.00
41_T45_T1.3531.00
21_I54_A1.3311.00
58_K62_D1.3301.00
63_M107_E1.3091.00
32_L39_L1.2581.00
21_I25_G1.2391.00
77_V96_I1.2331.00
25_G57_D1.2271.00
105_N109_I1.2040.99
26_Q29_L1.1890.99
3_Q10_D1.1890.99
101_T105_N1.1810.99
55_E59_Q1.1750.99
77_V81_L1.1690.99
64_F68_V1.1530.99
36_R39_L1.1500.99
64_F101_T1.1400.99
75_E92_R1.1390.99
77_V92_R1.1230.99
38_V45_T1.1120.99
27_R105_N1.0960.99
29_L40_Y1.0670.99
39_L42_N1.0670.99
24_W105_N1.0460.98
87_M90_V1.0420.98
4_G8_L1.0390.98
23_V101_T1.0210.98
63_M67_L1.0160.98
50_N54_A1.0160.98
14_P47_G0.9930.98
69_K73_E0.9920.98
32_L52_H0.9850.98
78_T81_L0.9770.98
92_R96_I0.9730.97
63_M66_R0.9620.97
71_K99_R0.9400.97
52_H56_I0.9280.97
31_Y39_L0.9270.97
72_A76_G0.9260.97
24_W64_F0.9220.97
96_I99_R0.9060.96
70_Q74_R0.8890.96
61_E64_F0.8890.96
19_T54_A0.8860.96
54_A58_K0.8690.95
29_L32_L0.8660.95
59_Q108_L0.8630.95
68_V72_A0.8550.95
105_N110_F0.8520.95
37_K41_T0.8520.95
63_M108_L0.8490.95
17_K51_E0.8370.94
76_G81_L0.8360.94
65_L68_V0.8330.94
95_N98_S0.8290.94
37_K45_T0.8290.94
42_N46_A0.8180.93
29_L33_K0.8160.93
62_D66_R0.8090.93
48_K51_E0.8090.93
79_E82_K0.8050.93
7_Y10_D0.8030.93
100_A104_V0.8020.93
68_V100_A0.7900.92
21_I53_L0.7850.92
71_K96_I0.7720.91
3_Q14_P0.7670.91
64_F104_V0.7600.91
4_G7_Y0.7570.90
81_L88_E0.7520.90
10_D13_L0.7430.90
28_H31_Y0.7430.90
3_Q7_Y0.7420.89
30_R33_K0.7420.89
17_K50_N0.7410.89
23_V26_Q0.7400.89
5_D8_L0.7320.89
53_L57_D0.7250.88
98_S107_E0.7210.88
43_L46_A0.7120.87
31_Y36_R0.7100.87
64_F97_R0.7070.87
47_G51_E0.7040.87
71_K103_I0.6920.86
9_P13_L0.6900.86
67_L103_I0.6870.86
29_L41_T0.6790.85
56_I59_Q0.6770.85
21_I57_D0.6730.84
23_V105_N0.6670.84
15_P18_E0.6640.84
70_Q73_E0.6580.83
17_K20_E0.6580.83
66_R73_E0.6540.83
19_T57_D0.6450.82
76_G92_R0.6440.82
2_L10_D0.6250.80
24_W61_E0.6200.79
39_L43_L0.6100.78
33_K44_L0.6070.78
91_G95_N0.6050.78
71_K75_E0.6010.77
71_K74_R0.5980.77
72_A78_T0.5970.77
24_W60_A0.5940.76
89_W93_M0.5850.75
68_V93_M0.5820.75
28_H59_Q0.5800.75
9_P12_Q0.5780.74
33_K41_T0.5760.74
84_E88_E0.5740.74
26_Q30_R0.5680.73
75_E95_N0.5660.73
39_L52_H0.5630.72
21_I27_R0.5610.72
24_W109_I0.5530.71
54_A57_D0.5530.71
65_L69_K0.5470.70
16_E47_G0.5460.70
68_V96_I0.5450.70
90_V94_N0.5400.69
31_Y35_N0.5380.69
59_Q66_R0.5330.68
68_V97_R0.5310.68
72_A77_V0.5270.67
60_A108_L0.5270.67
24_W30_R0.5240.67
51_E55_E0.5230.67
33_K40_Y0.5230.67
19_T50_N0.5210.67
33_K36_R0.5190.66
43_L51_E0.5070.64
67_L71_K0.5050.64
18_E87_M0.5030.64
78_T92_R0.5020.64
24_W101_T0.5010.64
17_K54_A0.5010.64
36_R41_T0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2di0A 1 0.4909 13.5 0.934 Contact Map
2aplA 1 0.6455 5.1 0.946 Contact Map
1z6nA 1 0.5455 4 0.949 Contact Map
2ddhA 2 0.4545 3.9 0.949 Contact Map
4nfaA 1 0.4182 3.6 0.95 Contact Map
2qfaB 1 0.4545 3.3 0.951 Contact Map
1kd8B 1 0.1727 3 0.952 Contact Map
3c3fA 3 0.1273 2.9 0.952 Contact Map
2rawB 1 0.3909 2.8 0.952 Contact Map
4hjbC 3 0.1727 2.7 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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