GREMLIN Database
PF03899 - ATP synthase protein I
UniProt: Q9HT13 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 126 (114)
Sequences: 3470 (2563)
Seq/√Len: 240.1
META: 0.752

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_V41_G5.3681.00
37_G104_V3.0991.00
43_I85_L2.8591.00
39_L89_A2.5551.00
86_F101_L2.4551.00
86_F105_Y2.3921.00
50_Y77_G2.3161.00
43_I89_A2.2211.00
90_F98_A2.1591.00
50_Y54_K2.1551.00
97_M100_A2.1511.00
22_A38_L1.9951.00
18_V45_W1.9211.00
18_V108_T1.7341.00
15_L45_W1.7261.00
75_E79_L1.6781.00
112_S116_P1.6431.00
51_F74_G1.5811.00
8_F11_L1.5581.00
44_A105_Y1.5211.00
25_L29_W1.5091.00
47_P82_T1.5061.00
12_L16_V1.4971.00
31_P35_Y1.4941.00
21_A37_G1.4831.00
91_A94_K1.4561.00
30_G33_A1.4511.00
43_I47_P1.3981.00
11_L45_W1.3901.00
36_S96_L1.3431.00
32_V35_Y1.3261.00
104_V108_T1.3211.00
25_L28_S1.3161.00
48_N112_S1.3041.00
50_Y81_L1.3041.00
29_W33_A1.3041.00
88_L92_G1.3021.00
26_W34_G1.2881.00
25_L37_G1.2851.00
43_I101_L1.2731.00
44_A108_T1.2661.00
68_V72_Y1.2621.00
93_V96_L1.2531.00
43_I86_F1.2281.00
44_A109_L1.2001.00
47_P81_L1.1921.00
89_A101_L1.1701.00
33_A37_G1.1651.00
114_C117_L1.1521.00
82_T105_Y1.1521.00
105_Y109_L1.1511.00
21_A107_L1.1461.00
72_Y109_L1.1361.00
54_K77_G1.0941.00
89_A96_L1.0901.00
9_R13_V1.0871.00
17_V111_V1.0501.00
22_A34_G1.0491.00
35_Y42_M1.0441.00
72_Y76_A1.0261.00
10_L14_Q1.0181.00
38_L42_M0.9921.00
22_A41_G0.9911.00
49_C53_Y0.9881.00
44_A47_P0.9841.00
87_A91_A0.9731.00
44_A82_T0.9711.00
87_A92_G0.9661.00
79_L83_A0.9571.00
98_A110_M0.9551.00
25_L33_A0.9521.00
111_V115_A0.9521.00
82_T85_L0.9461.00
60_G63_A0.9421.00
47_P78_K0.9411.00
36_S97_M0.9411.00
75_E78_K0.9331.00
42_M47_P0.9221.00
56_F61_A0.9111.00
102_F110_M0.8931.00
39_L101_L0.8690.99
57_R60_G0.8500.99
54_K73_A0.8470.99
25_L103_G0.8360.99
98_A102_F0.8340.99
90_F102_F0.8210.99
67_I71_F0.8170.99
21_A104_V0.8130.99
42_M46_L0.8070.99
108_T112_S0.8040.99
40_G104_V0.8000.99
110_M114_C0.7950.99
86_F90_F0.7910.99
109_L112_S0.7860.99
99_P103_G0.7720.99
11_L48_N0.7480.98
67_I72_Y0.7440.98
88_L91_A0.7250.98
51_F78_K0.7070.98
51_F71_F0.7010.97
24_S28_S0.7000.97
58_F63_A0.6950.97
26_W31_P0.6890.97
63_A66_E0.6650.96
104_V107_L0.6630.96
19_L23_I0.6520.96
103_G106_L0.6480.96
12_L42_M0.6390.96
79_L98_A0.6330.95
113_W117_L0.6310.95
106_L110_M0.6240.95
92_G95_P0.6190.95
66_E69_R0.6140.94
57_R66_E0.6120.94
100_A104_V0.6100.94
67_I70_S0.6080.94
33_A97_M0.6060.94
64_A67_I0.6040.94
99_P104_V0.6010.94
16_V31_P0.6010.94
15_L19_L0.6010.94
39_L42_M0.5990.94
7_A11_L0.5980.94
69_R73_A0.5970.94
80_I91_A0.5970.94
8_F49_C0.5930.93
55_A67_I0.5840.93
76_A80_I0.5800.93
13_V88_L0.5790.93
70_S74_G0.5740.92
47_P51_F0.5740.92
51_F55_A0.5720.92
5_L8_F0.5700.92
52_A55_A0.5690.92
56_F67_I0.5680.92
37_G100_A0.5660.92
54_K57_R0.5640.92
44_A48_N0.5570.91
44_A96_L0.5530.91
55_A74_G0.5520.91
22_A30_G0.5520.91
72_Y75_E0.5510.91
73_A76_A0.5510.91
51_F112_S0.5420.90
49_C52_A0.5410.90
43_I108_T0.5400.90
13_V111_V0.5400.90
8_F22_A0.5390.90
87_A90_F0.5370.89
6_P10_L0.5370.89
48_N51_F0.5310.89
9_R12_L0.5260.88
32_V93_V0.5200.88
44_A112_S0.5200.88
60_G64_A0.5190.88
77_G81_L0.5170.88
15_L18_V0.5160.88
65_R69_R0.5160.88
71_F82_T0.5130.87
112_S117_L0.5130.87
11_L49_C0.5120.87
10_L79_L0.5120.87
37_G41_G0.5110.87
8_F15_L0.5110.87
55_A79_L0.5090.87
108_T111_V0.5090.87
54_K74_G0.5070.87
5_L24_S0.5050.86
48_N71_F0.5010.86
81_L85_L0.5010.86
85_L89_A0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8968 19.8 0.89 Contact Map
2xq2A 2 0.9365 9 0.906 Contact Map
4cz8A 2 0.9683 5.9 0.913 Contact Map
4czbA 2 0.9683 5.7 0.914 Contact Map
4av3A 2 0.9603 5.4 0.915 Contact Map
4bwzA 2 0.9683 5.1 0.916 Contact Map
3k3fA 3 0.8651 4.1 0.92 Contact Map
4djkA 2 0.8968 3.8 0.921 Contact Map
4j05A 3 0.9683 3.4 0.922 Contact Map
4humA 1 0.9762 3.3 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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