GREMLIN Database
PF09912 - Uncharacterized protein
UniProt: Q8KCS8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 125 (122)
Sequences: 4050 (3411)
Seq/√Len: 308.8
META:

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_N79_D4.0301.00
73_N79_D3.5421.00
63_T109_S3.3331.00
20_N74_A3.0131.00
14_L21_L2.9291.00
23_V54_V2.7971.00
72_E89_G2.6001.00
63_T111_V2.3461.00
69_Q78_L2.3021.00
15_R89_G2.1001.00
22_S69_Q2.0321.00
12_T120_T1.9501.00
5_G61_Y1.7471.00
16_S72_E1.7351.00
81_N84_G1.7221.00
70_H89_G1.7041.00
22_S44_K1.6261.00
10_R118_E1.6041.00
33_P67_A1.5751.00
6_A57_G1.5241.00
113_D116_T1.5181.00
11_I68_V1.5171.00
10_R51_E1.5041.00
91_G121_I1.5031.00
14_L47_A1.4791.00
10_R120_T1.4681.00
65_A108_A1.4571.00
110_F119_L1.4321.00
8_T55_V1.4011.00
68_V121_I1.3921.00
47_A52_P1.3791.00
78_L90_V1.3611.00
17_T50_S1.3581.00
20_N44_K1.3541.00
12_T122_N1.3291.00
101_G107_D1.3251.00
104_S107_D1.3041.00
105_F109_S1.2921.00
81_N85_M1.2831.00
112_L117_M1.2631.00
45_I54_V1.2411.00
28_A31_G1.2121.00
25_L56_F1.2101.00
10_R53_L1.1981.00
14_L52_P1.1911.00
20_N46_P1.1751.00
8_T53_L1.1741.00
81_N87_K1.1721.00
8_T118_E1.1621.00
95_N122_N1.1411.00
90_V98_S1.1371.00
16_S70_H1.1131.00
21_L52_P1.1061.00
7_I112_L1.0951.00
93_S110_F1.0781.00
7_I59_I1.0781.00
73_N88_E1.0701.00
43_A54_V1.0661.00
5_G112_L1.0451.00
24_A67_A1.0451.00
92_S108_A1.0411.00
114_K117_M1.0311.00
40_V60_P1.0221.00
9_V66_V1.0031.00
98_S101_G0.9901.00
12_T51_E0.9901.00
6_A55_V0.9791.00
106_D109_S0.9771.00
24_A42_R0.9651.00
26_F67_A0.9621.00
9_V56_F0.9621.00
91_G123_L0.9531.00
45_I52_P0.9531.00
29_K106_D0.9321.00
32_F108_A0.9121.00
61_Y115_K0.9081.00
5_G115_K0.9011.00
75_N88_E0.8961.00
15_R72_E0.8921.00
17_T47_A0.8841.00
61_Y114_K0.8711.00
96_P108_A0.8511.00
93_S119_L0.8471.00
25_L59_I0.8401.00
27_N40_V0.8391.00
82_F87_K0.8391.00
23_V56_F0.8301.00
18_N72_E0.8061.00
80_A84_G0.8041.00
78_L87_K0.8031.00
23_V43_A0.7891.00
9_V23_V0.7790.99
4_S58_D0.7670.99
66_V91_G0.7600.99
20_N76_G0.7600.99
32_F103_P0.7560.99
113_D117_M0.7490.99
73_N77_K0.7400.99
11_I14_L0.7400.99
92_S98_S0.7400.99
16_S47_A0.7390.99
79_D88_E0.7350.99
90_V95_N0.7340.99
39_A42_R0.7330.99
21_L68_V0.7280.99
101_G104_S0.7260.99
44_K76_G0.7260.99
43_A56_F0.7250.99
13_G123_L0.7230.99
66_V121_I0.7200.99
11_I23_V0.7200.99
27_N31_G0.7170.99
63_T105_F0.7170.99
26_F38_R0.7140.99
7_I117_M0.7120.99
43_A57_G0.7110.99
32_F67_A0.7060.99
9_V119_L0.7020.99
32_F65_A0.7010.99
92_S96_P0.6980.99
98_S108_A0.6960.99
102_P108_A0.6950.99
21_L47_A0.6910.99
4_S61_Y0.6720.98
14_L70_H0.6710.98
26_F33_P0.6620.98
27_N60_P0.6470.98
48_A52_P0.6440.98
56_F59_I0.6430.98
31_G37_E0.6390.98
96_P101_G0.6330.98
69_Q89_G0.6300.98
23_V68_V0.6280.98
47_A50_S0.6260.98
98_S102_P0.6240.98
47_A70_H0.6240.98
7_I110_F0.6220.98
14_L123_L0.6150.97
17_T49_G0.6140.97
17_T52_P0.6060.97
3_G6_A0.6010.97
19_G70_H0.6010.97
7_I25_L0.5960.97
72_E88_E0.5910.97
52_P70_H0.5870.96
59_I112_L0.5820.96
37_E41_R0.5810.96
14_L89_G0.5790.96
2_A5_G0.5780.96
5_G114_K0.5760.96
9_V54_V0.5750.96
22_S76_G0.5730.96
96_P104_S0.5710.96
80_A83_L0.5710.96
61_Y113_D0.5710.96
103_P108_A0.5680.96
28_A105_F0.5680.96
68_V91_G0.5670.96
35_K38_R0.5640.96
66_V119_L0.5640.96
65_A105_F0.5620.96
80_A85_M0.5620.96
92_S107_D0.5560.95
25_L64_Y0.5550.95
31_G39_A0.5540.95
87_K99_K0.5540.95
53_L57_G0.5500.95
83_L87_K0.5500.95
33_P65_A0.5480.95
26_F39_A0.5430.95
35_K67_A0.5360.94
33_P108_A0.5360.94
27_N30_K0.5310.94
36_Y39_A0.5280.94
24_A35_K0.5270.94
46_P74_A0.5190.93
61_Y112_L0.5170.93
89_G123_L0.5170.93
16_S89_G0.5100.93
26_F31_G0.5090.93
92_S105_F0.5060.92
64_Y110_F0.5020.92
25_L66_V0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fxkA 1 0.832 33.4 0.917 Contact Map
1nqjA 1 0.584 25 0.922 Contact Map
2xwxA 2 0.632 22.6 0.924 Contact Map
1vw1A 5 0.976 21.8 0.924 Contact Map
3jqwA 1 0.608 20.8 0.925 Contact Map
2b39A 1 0.84 18 0.927 Contact Map
4q1zA 1 0.688 12.4 0.933 Contact Map
4d0jA 4 0.8 12.2 0.933 Contact Map
4iibA 2 0.792 12.1 0.933 Contact Map
3abzA 3 0.864 12 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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