GREMLIN Database
PF14127 - Uncharacterized protein
UniProt: Q8A2Y9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 166 (162)
Sequences: 2200 (1479)
Seq/√Len: 116.2
META:

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_N72_A4.1141.00
42_N99_Q3.7271.00
120_K125_P3.3801.00
136_A141_S3.3611.00
146_Y156_E2.6951.00
89_T93_K2.6831.00
43_V102_L2.6651.00
42_N98_T2.5351.00
85_K89_T2.3271.00
104_I140_A2.1361.00
63_Y76_H2.1361.00
30_E33_R2.0901.00
40_V44_K1.9961.00
97_F140_A1.9791.00
126_F130_F1.9221.00
39_L155_T1.8621.00
5_I10_T1.8141.00
67_L76_H1.8121.00
90_A93_K1.8051.00
43_V158_V1.7821.00
79_R83_G1.7731.00
29_N32_E1.7231.00
51_K54_N1.7051.00
56_A59_E1.6521.00
147_D150_G1.6141.00
60_T80_V1.6051.00
41_R99_Q1.5901.00
119_V122_F1.5781.00
70_E73_R1.5401.00
105_K152_D1.5401.00
5_I9_D1.5391.00
63_Y66_T1.5301.00
130_F134_F1.5041.00
91_R95_L1.4961.00
78_K123_M1.4931.00
39_L102_L1.4871.00
59_E63_Y1.4791.00
89_T131_Y1.4161.00
64_L67_L1.4041.00
107_I115_S1.3971.00
135_A140_A1.3921.00
61_Y65_Q1.3731.00
160_L164_N1.3651.00
47_Y51_K1.3341.00
33_R37_Y1.3281.00
72_A75_K1.3201.00
67_L72_A1.2971.00
31_K35_E1.2810.99
56_A87_Q1.2740.99
104_I118_L1.2640.99
77_L123_M1.2590.99
70_E74_Q1.2230.99
60_T77_L1.2230.99
49_I52_E1.2070.99
52_E56_A1.1940.99
54_N110_Q1.1880.99
133_T137_L1.1870.99
158_V162_V1.1710.99
25_L157_R1.1700.99
64_L77_L1.1320.99
132_Q136_A1.1230.99
36_Y40_V1.1200.99
109_R156_E1.1180.99
61_Y113_S1.1150.99
60_T76_H1.1090.99
27_F32_E1.1080.98
6_Y11_I1.0970.98
149_L153_K1.0940.98
127_K131_Y1.0900.98
58_I62_E1.0810.98
76_H80_V1.0760.98
129_G133_T1.0700.98
71_K75_K1.0690.98
38_R41_R1.0680.98
38_R42_N1.0650.98
92_M95_L1.0520.98
102_L155_T1.0490.98
155_T162_V1.0400.98
108_D145_E1.0250.97
123_M127_K1.0250.97
46_V102_L1.0230.97
49_I88_Y1.0160.97
54_N58_I1.0100.97
52_E55_Q1.0030.97
101_K140_A0.9990.97
56_A60_T0.9970.97
96_S99_Q0.9960.97
30_E34_L0.9850.97
49_I91_R0.9830.97
157_R161_L0.9770.97
32_E35_E0.9730.97
82_K86_E0.9710.97
47_Y162_V0.9650.96
42_N96_S0.9620.96
97_F139_G0.9610.96
119_V142_L0.9600.96
101_K104_I0.9570.96
80_V122_F0.9480.96
56_A80_V0.9430.96
104_I142_L0.9410.96
53_I107_I0.9380.96
27_F36_Y0.9150.95
132_Q141_S0.9050.95
28_K32_E0.9050.95
135_A142_L0.8980.95
51_K163_E0.8940.95
67_L70_E0.8920.94
61_Y118_L0.8910.94
81_E132_Q0.8910.94
88_Y91_R0.8830.94
154_L157_R0.8820.94
108_D115_S0.8800.94
6_Y12_P0.8730.94
51_K110_Q0.8690.94
127_K134_F0.8690.94
46_V50_S0.8650.93
110_Q153_K0.8430.93
87_Q91_R0.8360.92
60_T63_Y0.8350.92
3_M12_P0.8300.92
52_E87_Q0.8260.92
16_L19_V0.8210.92
133_T136_A0.8200.92
52_E91_R0.8100.91
58_I61_Y0.8080.91
125_P129_G0.8070.91
15_Q18_T0.8070.91
108_D114_T0.8050.91
62_E66_T0.7810.89
77_L81_E0.7810.89
44_K162_V0.7780.89
113_S117_E0.7740.89
56_A84_L0.7730.89
97_F132_Q0.7680.89
50_S54_N0.7680.89
110_Q130_F0.7640.88
63_Y67_L0.7510.88
59_E76_H0.7510.88
68_P72_A0.7490.87
7_N10_T0.7470.87
6_Y15_Q0.7470.87
136_A139_G0.7400.87
45_K99_Q0.7390.87
95_L100_G0.7310.86
132_Q143_K0.7310.86
50_S103_L0.7300.86
27_F33_R0.7240.86
39_L154_L0.7230.86
47_Y102_L0.7220.85
122_F129_G0.7200.85
141_S144_K0.7180.85
75_K79_R0.7070.84
57_I111_S0.7040.84
60_T123_M0.7040.84
80_V88_Y0.7030.84
37_Y40_V0.7030.84
154_L158_V0.6970.83
80_V83_G0.6880.83
50_S53_I0.6870.82
24_P27_F0.6860.82
19_V23_R0.6840.82
84_L131_Y0.6830.82
4_C11_I0.6790.82
106_L111_S0.6750.81
43_V162_V0.6730.81
57_I118_L0.6720.81
40_V88_Y0.6720.81
52_E88_Y0.6710.81
35_E39_L0.6680.81
22_F110_Q0.6670.81
17_R20_Y0.6620.80
102_L158_V0.6610.80
38_R99_Q0.6580.80
85_K123_M0.6560.80
77_L131_Y0.6510.79
85_K88_Y0.6480.79
56_A124_G0.6480.79
46_V96_S0.6440.78
45_K96_S0.6410.78
105_K151_E0.6410.78
64_L122_F0.6370.78
43_V159_V0.6290.77
31_K37_Y0.6280.77
61_Y122_F0.6260.76
35_E38_R0.6260.76
118_L122_F0.6210.76
146_Y155_T0.6190.75
53_I88_Y0.6170.75
4_C12_P0.6160.75
115_S118_L0.6150.75
103_L134_F0.6140.75
108_D147_D0.6140.75
56_A88_Y0.6090.74
113_S122_F0.6060.74
20_Y23_R0.6060.74
54_N111_S0.6050.74
101_K144_K0.6040.74
67_L73_R0.6030.74
83_G87_Q0.6000.73
9_D16_L0.6000.73
74_Q111_S0.5990.73
57_I89_T0.5890.72
119_V127_K0.5850.71
104_I115_S0.5840.71
86_E90_A0.5820.71
96_S102_L0.5810.71
25_L29_N0.5810.71
53_I84_L0.5810.71
37_Y154_L0.5800.71
46_V98_T0.5760.70
23_R36_Y0.5760.70
64_L73_R0.5710.70
159_V163_E0.5690.69
26_K146_Y0.5680.69
153_K157_R0.5660.69
43_V155_T0.5640.69
62_E65_Q0.5630.68
5_I11_I0.5580.68
32_E37_Y0.5570.68
150_G154_L0.5570.68
17_R24_P0.5520.67
105_K108_D0.5510.67
57_I61_Y0.5490.67
81_E85_K0.5470.66
151_E154_L0.5460.66
158_V161_L0.5460.66
23_R110_Q0.5440.66
8_G11_I0.5370.65
112_N135_A0.5300.64
123_M140_A0.5300.64
134_F139_G0.5290.64
63_Y79_R0.5290.64
79_R102_L0.5270.63
60_T121_A0.5230.63
150_G153_K0.5170.62
54_N61_Y0.5150.62
156_E159_V0.5150.62
31_K34_L0.5140.61
61_Y141_S0.5130.61
26_K29_N0.5100.61
99_Q102_L0.5090.61
47_Y159_V0.5040.60
41_R96_S0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4x86A 1 0.2108 16.2 0.954 Contact Map
1rt8A 1 0.5542 14.6 0.955 Contact Map
2q5xA 1 0.6566 13 0.956 Contact Map
2hh7A 3 0.4759 7 0.961 Contact Map
2wujA 2 0.2289 6.9 0.961 Contact Map
1sz9A 1 0.6446 6.4 0.962 Contact Map
1dxxA 2 0.5904 6.3 0.962 Contact Map
2kl5A 1 0.3434 6.1 0.962 Contact Map
1pxyA 1 0.5783 5.9 0.962 Contact Map
3d9jA 2 0.6084 5.7 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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