GREMLIN Database
PF07483 - (416-522) Bll6027 protein
UniProt: Q89HG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 107 (106)
Sequences: 1530 (1123)
Seq/√Len: 109.1
META: 0.878

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_P17_G3.1141.00
46_V49_G2.8911.00
67_S78_L2.8381.00
52_D95_S2.6091.00
44_E97_H2.5591.00
22_T29_A2.4631.00
65_V92_L2.3901.00
25_N35_Y2.3891.00
9_Y22_T2.3441.00
57_N61_G2.3221.00
92_L95_S2.2581.00
74_F77_T2.1061.00
52_D78_L2.0811.00
24_K73_N2.0721.00
42_A98_Q1.8541.00
52_D67_S1.8221.00
30_V35_Y1.7781.00
11_D22_T1.7581.00
31_I34_N1.7511.00
40_P55_W1.7511.00
62_Y81_E1.7061.00
69_D73_N1.7061.00
55_W74_F1.7041.00
13_N18_G1.5191.00
23_L53_V1.5141.00
14_P18_G1.4941.00
37_A57_N1.4641.00
53_V68_T1.4301.00
51_Y72_G1.4291.00
24_K29_A1.3601.00
103_D107_G1.3571.00
87_S91_A1.3401.00
57_N60_T1.2940.99
38_W57_N1.2920.99
64_S79_T1.2880.99
45_Q70_S1.2730.99
6_D13_N1.2410.99
4_V13_N1.2340.99
64_S77_T1.2110.99
99_D103_D1.1200.98
67_S76_S1.1090.98
44_E98_Q1.1080.98
79_T82_V1.1040.98
9_Y14_P1.0780.98
9_Y29_A1.0650.98
4_V15_T1.0490.97
50_G72_G1.0440.97
93_E99_D1.0150.97
45_Q50_G1.0120.97
23_L68_T1.0070.97
63_F89_L1.0020.97
56_K60_T0.9910.96
38_W66_W0.9720.96
10_Y32_A0.9610.96
77_T80_P0.9600.96
5_L9_Y0.9590.96
78_L81_E0.9580.95
41_V63_F0.9510.95
53_V65_V0.9390.95
5_L10_Y0.9370.95
44_E95_S0.9340.95
56_K63_F0.9300.95
44_E52_D0.9270.95
2_A9_Y0.9250.95
2_A5_L0.9110.94
67_S75_V0.9060.94
93_E96_F0.8960.94
78_L95_S0.8920.93
46_V50_G0.8890.93
2_A15_T0.8650.92
4_V9_Y0.8530.92
13_N19_A0.8510.92
2_A13_N0.8490.92
46_V95_S0.8470.92
32_A55_W0.8320.91
85_S90_I0.8300.91
38_W81_E0.8260.90
91_A94_T0.8070.89
33_G40_P0.8000.89
12_L43_A0.7980.89
89_L100_L0.7670.87
39_S58_A0.7640.87
10_Y40_P0.7490.86
74_F78_L0.7420.85
67_S95_S0.7300.84
41_V100_L0.7180.83
37_A59_S0.7140.83
45_Q49_G0.7140.83
90_I105_S0.7110.83
58_A61_G0.7100.82
72_G89_L0.7000.82
82_V89_L0.6970.81
44_E56_K0.6930.81
103_D106_I0.6860.80
25_N34_N0.6770.79
10_Y72_G0.6740.79
86_D90_I0.6720.79
64_S67_S0.6720.79
54_A68_T0.6710.79
65_V89_L0.6650.78
65_V77_T0.6630.78
52_D90_I0.6620.78
45_Q97_H0.6620.78
41_V103_D0.6590.78
60_T63_F0.6580.77
40_P43_A0.6510.77
61_G83_P0.6480.76
37_A58_A0.6470.76
35_Y68_T0.6460.76
36_G57_N0.6410.76
25_N62_Y0.6400.76
52_D96_F0.6390.75
55_W78_L0.6380.75
34_N44_E0.6380.75
38_W64_S0.6340.75
4_V11_D0.6330.75
5_L32_A0.6310.74
49_G70_S0.6290.74
54_A65_V0.6210.73
23_L74_F0.6080.72
48_G67_S0.6070.72
5_L8_S0.6060.71
54_A96_F0.6030.71
83_P89_L0.5980.70
13_N21_P0.5970.70
73_N77_T0.5950.70
54_A98_Q0.5900.69
46_V52_D0.5890.69
13_N16_A0.5880.69
80_P83_P0.5880.69
65_V96_F0.5810.68
87_S90_I0.5800.68
2_A8_S0.5790.68
4_V16_A0.5700.67
8_S19_A0.5650.66
30_V66_W0.5500.64
2_A16_A0.5460.64
14_P44_E0.5410.63
4_V14_P0.5380.62
12_L40_P0.5380.62
94_T105_S0.5300.61
56_K102_G0.5300.61
13_N17_G0.5290.61
40_P54_A0.5280.61
59_S84_G0.5230.60
16_A32_A0.5210.60
53_V96_F0.5200.60
31_I35_Y0.5170.59
40_P74_F0.5150.59
45_Q51_Y0.5140.59
52_D92_L0.5130.59
99_D107_G0.5060.58
13_N20_G0.5040.57
75_V78_L0.5040.57
93_E103_D0.5030.57
35_Y76_S0.5020.57
86_D105_S0.5000.57
64_S80_P0.5000.57
40_P100_L0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ijeA 1 0.9626 19.7 0.899 Contact Map
4o9xA 1 0.972 17.8 0.901 Contact Map
4iglA 1 0.972 16.7 0.902 Contact Map
4wk0A 1 0.9626 10.9 0.91 Contact Map
4um9A 1 0.972 9.5 0.913 Contact Map
2yugA 1 0.8131 7.2 0.917 Contact Map
4irzA 1 0.9626 6.9 0.918 Contact Map
3vi3A 1 0.972 6.2 0.92 Contact Map
3fcsA 2 0.9252 5.8 0.921 Contact Map
1j7qA 1 0.5794 4.8 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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