GREMLIN Database
PF03706 - UPF0104 membrane protein MJ1595
UniProt: Q58990 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 336 (299)
Sequences: 31617 (26409)
Seq/√Len: 1527.3
META: 0.772

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
283_D308_R3.2511.00
21_L25_A2.9951.00
74_N77_N2.9271.00
63_K67_K2.8921.00
33_I37_I2.8421.00
77_N110_L2.8251.00
40_N43_Y2.7621.00
28_G31_K2.7591.00
296_P299_V2.7071.00
284_T288_L2.6661.00
61_R232_S2.6511.00
60_A63_K2.6351.00
255_S258_C2.5321.00
59_S79_F2.4981.00
50_L245_L2.4861.00
43_Y245_L2.4391.00
244_W248_L2.4181.00
64_F227_V2.3191.00
247_F303_V2.3151.00
88_I102_F2.2841.00
114_P117_L2.2691.00
223_W227_V2.2431.00
57_I231_L2.2361.00
56_V75_F2.2311.00
79_F83_L2.2171.00
60_A231_L2.2031.00
76_K80_L2.1191.00
73_A78_I2.0501.00
171_Y175_N2.0001.00
57_I238_F1.9431.00
108_S115_K1.9411.00
63_K78_I1.9341.00
100_E126_R1.9341.00
47_A246_L1.9141.00
62_W121_T1.9121.00
22_A26_Y1.8991.00
247_F259_V1.8181.00
81_L106_Y1.8171.00
18_L22_A1.8151.00
85_G103_R1.7951.00
42_E46_L1.7881.00
288_L291_S1.7801.00
282_A308_R1.7641.00
57_I234_M1.7611.00
103_R125_E1.7401.00
50_L238_F1.7211.00
275_T281_T1.7081.00
185_K188_K1.7081.00
148_G151_Y1.7071.00
31_K34_K1.7061.00
64_F231_L1.6991.00
77_N80_L1.6771.00
89_N99_G1.6661.00
65_I228_A1.6491.00
321_I325_I1.6271.00
286_M304_T1.5741.00
17_F21_L1.5741.00
75_F79_F1.5601.00
283_D304_T1.5511.00
288_L292_A1.5491.00
300_A304_T1.5321.00
22_A25_A1.5181.00
67_K72_S1.5131.00
262_V289_S1.5021.00
113_I118_A1.4801.00
287_I291_S1.4571.00
247_F252_Y1.4541.00
46_L245_L1.4521.00
90_N316_T1.4511.00
185_K189_F1.4491.00
20_I24_M1.4461.00
150_K153_E1.4341.00
63_K75_F1.4291.00
266_T270_G1.4231.00
269_S285_V1.4221.00
80_L322_A1.4201.00
59_S75_F1.4121.00
220_K224_E1.3831.00
224_E227_V1.3641.00
59_S78_I1.3631.00
61_R125_E1.3621.00
115_K119_F1.3551.00
60_A75_F1.3481.00
170_I174_A1.3391.00
61_R129_D1.3351.00
104_A119_F1.3201.00
34_K37_I1.3151.00
140_V144_F1.3111.00
71_Y113_I1.3091.00
43_Y46_L1.3021.00
29_L33_I1.3001.00
244_W259_V1.2961.00
87_F319_G1.2961.00
295_I300_A1.2871.00
206_S209_E1.2841.00
62_W103_R1.2741.00
304_T308_R1.2711.00
43_Y249_S1.2611.00
41_P45_I1.2501.00
297_P301_A1.2491.00
43_Y248_L1.2471.00
242_K307_D1.2271.00
149_F152_L1.2231.00
140_V264_L1.1991.00
287_I301_A1.1931.00
175_N178_L1.1901.00
181_K185_K1.1871.00
129_D236_Y1.1821.00
205_Q209_E1.1811.00
320_Y324_L1.1781.00
230_F234_M1.1651.00
104_A108_S1.1651.00
77_N81_L1.1581.00
53_L238_F1.1581.00
80_L325_I1.1521.00
47_A249_S1.1441.00
92_T98_G1.1291.00
49_I53_L1.1291.00
101_A105_Y1.1261.00
243_L286_M1.1241.00
254_V258_C1.1241.00
43_Y47_A1.1121.00
128_L228_A1.1101.00
64_F224_E1.1101.00
156_I159_W1.1091.00
201_T205_Q1.1081.00
29_L32_I1.1021.00
175_N179_L1.0971.00
202_K206_S1.0971.00
19_F23_I1.0921.00
16_S20_I1.0901.00
42_E45_I1.0901.00
248_L253_V1.0891.00
66_I78_I1.0871.00
178_L181_K1.0851.00
211_Y215_K1.0811.00
105_Y109_K1.0771.00
31_K35_V1.0751.00
176_K179_L1.0741.00
104_A122_V1.0691.00
198_Y202_K1.0671.00
100_E103_R1.0601.00
51_Q242_K1.0541.00
243_L303_V1.0471.00
102_F106_Y1.0421.00
240_I260_S1.0401.00
246_L249_S1.0351.00
71_Y117_L1.0311.00
83_L322_A1.0291.00
287_I300_A1.0241.00
55_S83_L1.0231.00
104_A118_A1.0221.00
263_Y266_T1.0131.00
105_Y108_S1.0061.00
115_K118_A1.0041.00
247_F254_V1.0011.00
39_T44_V1.0011.00
250_L306_L1.0001.00
142_G145_V1.0001.00
278_G282_A0.9981.00
33_I36_L0.9981.00
56_V79_F0.9871.00
177_G181_K0.9831.00
151_Y154_Y0.9801.00
30_D33_I0.9791.00
138_L142_G0.9771.00
158_S161_F0.9761.00
208_E212_N0.9701.00
35_V38_N0.9671.00
30_D34_K0.9521.00
39_T249_S0.9471.00
132_I136_F0.9451.00
282_A304_T0.9441.00
266_T286_M0.9421.00
95_M98_G0.9401.00
258_C293_F0.9401.00
47_A310_V0.9391.00
65_I121_T0.9391.00
94_S98_G0.9371.00
262_V266_T0.9361.00
176_K180_I0.9351.00
204_L208_E0.9291.00
274_I278_G0.9271.00
34_K38_N0.9221.00
291_S297_P0.9211.00
99_G103_R0.9201.00
61_R235_R0.9191.00
305_L308_R0.9181.00
84_M88_I0.9161.00
21_L24_M0.9151.00
215_K218_K0.9141.00
281_T284_T0.9051.00
322_A325_I0.9031.00
83_L318_L0.9021.00
299_V302_A0.8951.00
260_S264_L0.8951.00
215_K219_N0.8941.00
48_F310_V0.8921.00
64_F67_K0.8921.00
71_Y114_P0.8871.00
162_L166_T0.8861.00
45_I49_I0.8831.00
258_C262_V0.8791.00
116_G209_E0.8781.00
81_L107_L0.8771.00
212_N215_K0.8731.00
209_E212_N0.8701.00
202_K205_Q0.8671.00
18_L21_L0.8641.00
178_L182_T0.8581.00
287_I297_P0.8521.00
200_E204_L0.8511.00
84_M106_Y0.8511.00
66_I71_Y0.8461.00
180_I184_T0.8441.00
101_A104_A0.8431.00
273_S281_T0.8381.00
274_I281_T0.8351.00
57_I235_R0.8341.00
63_K72_S0.8341.00
139_F143_Y0.8311.00
243_L307_D0.8291.00
126_R129_D0.8281.00
66_I121_T0.8271.00
58_L235_R0.8261.00
220_K223_W0.8251.00
132_I233_V0.8241.00
244_W256_V0.8231.00
301_A304_T0.8231.00
165_L168_I0.8211.00
27_I32_I0.8211.00
39_T43_Y0.8131.00
174_A177_G0.8091.00
294_N300_A0.8091.00
156_I160_I0.8081.00
246_L306_L0.8081.00
35_V299_V0.8061.00
102_F105_Y0.8011.00
266_T278_G0.7921.00
125_E129_D0.7811.00
68_I224_E0.7811.00
51_Q55_S0.7801.00
174_A178_L0.7801.00
105_Y115_K0.7761.00
276_P308_R0.7751.00
80_L84_M0.7751.00
128_L132_I0.7741.00
177_G180_I0.7741.00
47_A242_K0.7721.00
150_K154_Y0.7711.00
173_I176_K0.7691.00
285_V288_L0.7681.00
166_T170_I0.7651.00
31_K298_S0.7591.00
159_W163_F0.7561.00
284_T287_I0.7501.00
279_F308_R0.7471.00
240_I259_V0.7441.00
74_N78_I0.7441.00
218_K222_G0.7321.00
266_T269_S0.7311.00
23_I26_Y0.7301.00
184_T187_S0.7301.00
237_I240_I0.7291.00
135_F229_I0.7251.00
122_V126_R0.7251.00
222_G226_V0.7211.00
298_S302_A0.7201.00
159_W162_L0.7171.00
282_A307_D0.7161.00
237_I241_L0.7151.00
224_E228_A0.7151.00
181_K184_T0.7121.00
87_F320_Y0.7091.00
246_L303_V0.7081.00
80_L83_L0.7071.00
201_T204_L0.7071.00
263_Y267_L0.7041.00
108_S118_A0.7031.00
321_I324_L0.7031.00
239_D243_L0.7011.00
118_A122_V0.7011.00
162_L165_L0.7001.00
132_I135_F0.7001.00
157_L160_I0.7001.00
48_F314_L0.6971.00
227_V231_L0.6951.00
16_S276_P0.6941.00
140_V143_Y0.6941.00
225_V228_A0.6911.00
318_L322_A0.6891.00
52_I314_L0.6881.00
226_V230_F0.6881.00
239_D267_L0.6861.00
81_L85_G0.6831.00
314_L317_I0.6821.00
282_A286_M0.6801.00
88_I92_T0.6801.00
267_L270_G0.6801.00
227_V230_F0.6781.00
290_F295_I0.6771.00
199_D203_I0.6761.00
58_L125_E0.6751.00
133_F236_Y0.6701.00
286_M290_F0.6641.00
26_Y30_D0.6621.00
216_F219_N0.6611.00
180_I208_E0.6601.00
62_W125_E0.6591.00
66_I107_L0.6581.00
163_F167_A0.6571.00
25_A29_L0.6551.00
24_M29_L0.6531.00
207_I211_Y0.6531.00
35_V302_A0.6531.00
241_L245_L0.6521.00
241_L244_W0.6491.00
28_G32_I0.6481.00
233_V237_I0.6471.00
317_I321_I0.6461.00
238_F241_L0.6461.00
39_T250_L0.6421.00
66_I113_I0.6411.00
119_F122_V0.6401.00
90_N312_Y0.6351.00
286_M303_V0.6351.00
252_Y299_V0.6341.00
55_S86_L0.6341.00
213_S216_F0.6301.00
53_L56_V0.6281.00
262_V290_F0.6271.00
285_V289_S0.6271.00
51_Q239_D0.6271.00
299_V303_V0.6271.00
56_V60_A0.6251.00
69_L117_L0.6231.00
318_L321_I0.6221.00
177_G182_T0.6221.00
163_F166_T0.6211.00
61_R128_L0.6201.00
133_F137_T0.6191.00
54_V238_F0.6191.00
158_S162_L0.6171.00
39_T306_L0.6161.00
40_N249_S0.6151.00
278_G283_D0.6141.00
40_N251_S0.6121.00
179_L183_V0.6071.00
129_D232_S0.6061.00
182_T185_K0.6061.00
107_L118_A0.6051.00
59_S82_V0.6041.00
51_Q310_V0.6041.00
242_K310_V0.5991.00
106_Y110_L0.5981.00
308_R311_S0.5971.00
58_L129_D0.5971.00
309_L313_I0.5951.00
240_I256_V0.5951.00
275_T278_G0.5941.00
164_S168_I0.5941.00
65_I125_E0.5921.00
287_I304_T0.5911.00
103_R107_L0.5881.00
236_Y240_I0.5871.00
116_G120_S0.5871.00
246_L307_D0.5851.00
61_R126_R0.5851.00
78_I82_V0.5851.00
172_L176_K0.5851.00
145_V148_G0.5831.00
50_L242_K0.5831.00
199_D202_K0.5831.00
149_F154_Y0.5831.00
141_I145_V0.5811.00
176_K182_T0.5811.00
46_L50_L0.5801.00
59_S63_K0.5781.00
135_F139_F0.5751.00
104_A115_K0.5751.00
242_K311_S0.5751.00
50_L241_L0.5721.00
231_L234_M0.5721.00
81_L110_L0.5691.00
252_Y295_I0.5681.00
36_L39_T0.5681.00
200_E203_I0.5671.00
241_L256_V0.5611.00
170_I175_N0.5571.00
26_Y29_L0.5571.00
82_V86_L0.5561.00
273_S276_P0.5521.00
92_T101_A0.5521.00
165_L169_I0.5521.00
84_M322_A0.5521.00
16_S23_I0.5501.00
41_P46_L0.5501.00
157_L161_F0.5491.00
303_V307_D0.5481.00
203_I206_S0.5471.00
245_L248_L0.5461.00
259_V290_F0.5461.00
117_L121_T0.5451.00
283_D305_L0.5451.00
235_R239_D0.5451.00
45_I48_F0.5441.00
186_I189_F0.5421.00
57_I60_A0.5411.00
173_I177_G0.5401.00
230_F233_V0.5401.00
240_I244_W0.5381.00
125_E232_S0.5371.00
291_S300_A0.5361.00
168_I175_N0.5351.00
184_T188_K0.5351.00
96_R99_G0.5341.00
64_F68_I0.5341.00
95_M129_D0.5341.00
145_V149_F0.5301.00
129_D133_F0.5291.00
99_G102_F0.5291.00
280_G283_D0.5271.00
204_L207_I0.5261.00
276_P282_A0.5261.00
27_I301_A0.5251.00
187_S190_I0.5231.00
216_F220_K0.5231.00
104_A107_L0.5211.00
41_P44_V0.5181.00
36_L306_L0.5181.00
37_I40_N0.5161.00
269_S273_S0.5161.00
54_V235_R0.5151.00
130_T133_F0.5151.00
60_A64_F0.5141.00
58_L82_V0.5131.00
21_L26_Y0.5131.00
128_L232_S0.5121.00
39_T47_A0.5121.00
132_I232_S0.5091.00
226_V229_I0.5081.00
315_P318_L0.5071.00
305_L309_L0.5061.00
205_Q208_E0.5031.00
264_L268_L0.5031.00
38_N41_P0.5011.00
49_I52_I0.5001.00
257_I260_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jwaA 2 0.1161 12.6 0.953 Contact Map
2m20A 2 0.1101 9.8 0.955 Contact Map
2kv5A 1 0.0893 8.8 0.956 Contact Map
4gx0A 3 0.3006 8.8 0.956 Contact Map
2kluA 1 0.125 8.8 0.956 Contact Map
1lnqA 6 0.2262 8.7 0.956 Contact Map
4gxbB 1 0.003 6.3 0.958 Contact Map
2l2tA 2 0.128 6.3 0.959 Contact Map
2mfrA 1 0.1488 5.8 0.959 Contact Map
2ks1B 1 0.131 4.8 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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