GREMLIN Database
PF06793 - UPF0262 protein Nwi_0248
UniProt: Q3SW25 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 153 (152)
Sequences: 1521 (829)
Seq/√Len: 67.2
META: 0.916

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_A112_G5.9391.00
118_D122_R3.8641.00
5_A48_T3.2621.00
48_T67_G3.0051.00
64_R68_A2.9381.00
38_A133_H2.8181.00
3_I49_L2.6811.00
50_H63_R2.5141.00
122_R136_F2.4671.00
29_Y33_E2.4131.00
122_R125_Q2.3101.00
64_R70_V2.2521.00
7_T50_H2.2501.00
51_I60_F2.2151.00
101_A105_K2.0991.00
54_T72_T2.0341.00
34_K137_E2.0101.00
1_H38_A1.9711.00
111_M115_G1.9301.00
63_R67_G1.8881.00
61_D72_T1.8751.00
13_I16_S1.8701.00
44_G47_F1.7591.00
122_R126_E1.7391.00
95_Y99_R1.7271.00
39_P42_A1.6960.99
3_I6_V1.6550.99
86_D119_E1.6510.99
42_A64_R1.6440.99
48_T65_E1.6350.99
90_I116_I1.6060.99
147_S150_H1.5910.99
90_I112_G1.5810.99
69_P72_T1.5740.99
4_V48_T1.5590.99
44_G64_R1.4950.99
80_F123_T1.4800.99
109_I115_G1.4660.98
92_D96_Q1.4550.98
88_F147_S1.4210.98
42_A70_V1.4140.98
9_D12_S1.4090.98
73_H132_V1.3540.97
12_S16_S1.3340.97
22_H26_I1.2900.97
147_S152_K1.2790.96
23_E47_F1.2650.96
84_V147_S1.2520.96
15_R25_A1.2470.96
26_I29_Y1.2420.96
96_Q99_R1.2220.95
83_I120_G1.1970.95
9_D13_I1.1880.95
100_T105_K1.1790.94
49_L127_R1.1770.94
21_E24_R1.1710.94
90_I93_S1.1660.94
63_R69_P1.1530.94
76_S79_P1.1500.94
108_A116_I1.1450.93
59_M74_L1.1280.93
42_A47_F1.1250.93
28_I32_V1.1160.93
98_I106_I1.1050.92
41_G44_G1.0990.92
94_Y99_R1.0990.92
121_S136_F1.0760.91
29_Y98_I1.0650.91
20_I148_V1.0580.90
39_P70_V1.0530.90
75_L127_R1.0420.90
6_V32_V1.0290.89
6_V49_L1.0170.89
94_Y98_I1.0020.88
60_F73_H0.9790.87
16_S21_E0.9780.87
118_D137_E0.9530.85
13_I20_I0.9350.84
19_D33_E0.9340.84
78_T81_R0.9170.83
96_Q101_A0.9140.83
59_M76_S0.9100.82
32_V95_Y0.9020.82
39_P62_I0.8980.81
75_L80_F0.8980.81
10_E16_S0.8940.81
79_P127_R0.8830.80
82_R85_K0.8790.80
97_A106_I0.8720.80
32_V46_P0.8650.79
33_E98_I0.8640.79
9_D28_I0.8490.78
97_A109_I0.8340.76
105_K118_D0.8330.76
3_I60_F0.8300.76
46_P85_K0.8270.76
57_R74_L0.8260.76
142_L145_L0.8060.74
16_S20_I0.8050.74
91_C95_Y0.8020.74
26_I33_E0.8000.73
51_I128_L0.7970.73
127_R131_K0.7940.73
22_H29_Y0.7900.72
7_T48_T0.7890.72
36_L133_H0.7870.72
83_I121_S0.7860.72
53_I77_L0.7830.72
88_F119_E0.7790.71
84_V107_E0.7760.71
22_H33_E0.7740.71
76_S82_R0.7730.71
99_R115_G0.7730.71
88_F120_G0.7610.70
32_V35_N0.7590.69
73_H151_W0.7590.69
90_I115_G0.7570.69
51_I148_V0.7560.69
25_A53_I0.7530.69
41_G71_V0.7520.69
1_H36_L0.7480.68
61_D69_P0.7420.68
83_I123_T0.7360.67
129_N133_H0.7320.67
18_P25_A0.7290.66
85_K102_T0.7260.66
125_Q136_F0.7080.64
135_D138_T0.7050.64
34_K121_S0.7040.64
6_V10_E0.7030.63
82_R96_Q0.7020.63
58_L149_L0.7010.63
83_I89_M0.7000.63
104_D112_G0.7000.63
53_I150_H0.6990.63
31_L51_I0.6970.63
55_G80_F0.6860.62
91_C107_E0.6840.61
79_P83_I0.6760.60
38_A50_H0.6730.60
33_E101_A0.6730.60
148_V151_W0.6700.60
80_F146_I0.6690.60
140_R144_T0.6680.60
72_T77_L0.6630.59
15_R21_E0.6620.59
40_E121_S0.6610.59
42_A71_V0.6600.59
48_T63_R0.6580.58
55_G150_H0.6560.58
31_L84_V0.6510.58
118_D136_F0.6460.57
104_D116_I0.6390.56
64_R69_P0.6370.56
3_I151_W0.6330.55
85_K89_M0.6320.55
121_S132_V0.6280.55
59_M72_T0.6280.55
11_D16_S0.6260.55
34_K68_A0.6240.54
90_I108_A0.6180.54
53_I89_M0.6120.53
19_D107_E0.6070.52
67_G70_V0.6050.52
16_S151_W0.6040.52
19_D25_A0.6040.52
73_H120_G0.6000.52
120_G147_S0.5980.51
126_E129_N0.5960.51
43_E70_V0.5910.50
14_G151_W0.5880.50
16_S73_H0.5870.50
123_T126_E0.5850.50
23_E91_C0.5840.50
85_K98_I0.5840.50
92_D126_E0.5790.49
4_V64_R0.5750.49
59_M86_D0.5690.48
95_Y98_I0.5670.48
29_Y94_Y0.5650.47
76_S151_W0.5650.47
91_C99_R0.5630.47
131_K139_A0.5620.47
22_H53_I0.5620.47
8_L26_I0.5600.47
17_G104_D0.5590.47
19_D99_R0.5580.47
12_S15_R0.5550.46
125_Q133_H0.5550.46
71_V148_V0.5530.46
142_L148_V0.5520.46
89_M119_E0.5520.46
42_A109_I0.5510.46
49_L60_F0.5490.46
40_E148_V0.5470.45
111_M114_R0.5460.45
17_G31_L0.5420.45
72_T82_R0.5390.44
89_M100_T0.5360.44
41_G73_H0.5350.44
56_N74_L0.5330.44
26_I51_I0.5320.44
18_P109_I0.5320.44
50_H62_I0.5310.43
140_R145_L0.5300.43
74_L132_V0.5270.43
1_H44_G0.5230.42
7_T36_L0.5230.42
26_I101_A0.5230.42
56_N107_E0.5200.42
10_E14_G0.5180.42
29_Y55_G0.5160.42
95_Y101_A0.5160.42
36_L134_V0.5150.42
4_V60_F0.5140.41
140_R143_F0.5110.41
137_E146_I0.5100.41
65_E78_T0.5100.41
145_L149_L0.5090.41
46_P81_R0.5090.41
29_Y74_L0.5050.40
53_I84_V0.5050.40
139_A146_I0.5050.40
135_D140_R0.5050.40
121_S147_S0.5030.40
23_E88_F0.5030.40
47_F70_V0.5010.40
4_V7_T0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1njhA 2 0.4379 39.3 0.948 Contact Map
1nv8A 1 0.6209 25.2 0.953 Contact Map
4kwyA 1 0.817 13.2 0.959 Contact Map
3dgpB 1 0.2418 8.4 0.962 Contact Map
1ydlA 1 0.268 6.7 0.964 Contact Map
2jpuA 1 0.5163 4.4 0.967 Contact Map
3mkrB 1 0.732 4.1 0.968 Contact Map
4mcxB 2 0.4771 4 0.968 Contact Map
2wpvA 1 0.4967 3.5 0.968 Contact Map
3vpzA 2 0.6536 3.4 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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