GREMLIN Database
PF14345 - Uncharacterized membrane-anchored protein
UniProt: Q2SNL6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 157 (155)
Sequences: 1604 (1384)
Seq/√Len: 111.2
META: 0.864

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_E56_S4.0851.00
43_R49_D3.1301.00
44_S47_Q3.0981.00
32_T140_E3.0731.00
142_K152_V3.0361.00
125_F130_G2.6921.00
81_T91_Q2.6401.00
140_E155_R2.6311.00
131_E134_E2.4981.00
139_G151_L2.4791.00
49_D128_G2.3991.00
35_L57_L2.3921.00
144_S148_D2.3431.00
49_D130_G2.3151.00
83_D89_R2.2811.00
55_Y120_S2.2431.00
94_A106_A2.2381.00
92_R104_E2.2011.00
25_R29_S2.0881.00
79_I92_R2.0771.00
51_M125_F2.0191.00
18_G22_A2.0151.00
34_L155_R1.8871.00
76_G109_Y1.8721.00
35_L141_V1.8581.00
33_L105_V1.8211.00
100_A104_E1.8061.00
130_G134_E1.7891.00
140_E153_G1.7731.00
82_L88_A1.7341.00
126_Q129_L1.7061.00
75_D108_L1.6001.00
129_L132_F1.5991.00
51_M134_E1.5911.00
78_V90_F1.5911.00
143_V147_G1.5771.00
54_R59_R1.5691.00
77_Y94_A1.5431.00
32_T142_K1.5121.00
31_E82_L1.5071.00
35_L80_A1.4871.00
47_Q124_F1.4641.00
21_I25_R1.4511.00
13_L17_N1.4181.00
78_V93_L1.4171.00
120_S141_V1.4061.00
26_L150_L1.3941.00
31_E105_V1.3921.00
79_I100_A1.3821.00
16_C19_L1.3421.00
79_I104_E1.3050.99
58_M121_D1.2620.99
101_G104_E1.2620.99
49_D125_F1.2220.99
80_A88_A1.1910.99
125_F128_G1.1520.99
55_Y121_D1.1430.99
20_I24_E1.1310.98
81_T104_E1.1040.98
99_E106_A1.1030.98
58_M118_I1.0950.98
79_I94_A1.0820.98
105_V143_V1.0630.98
77_Y97_A1.0620.98
43_R128_G1.0350.97
126_Q133_Y1.0340.97
77_Y106_A1.0330.97
77_Y96_S1.0270.97
94_A97_A1.0240.97
70_D73_T1.0140.97
51_M130_G1.0120.97
80_A105_V1.0120.97
125_F133_Y0.9990.97
94_A99_E0.9900.96
141_V149_V0.9860.96
44_S124_F0.9790.96
70_D95_Q0.9740.96
137_R142_K0.9640.96
54_R115_R0.9630.96
24_E28_A0.9590.96
87_V138_Y0.9430.95
23_K150_L0.9420.95
55_Y122_A0.9200.95
23_K26_L0.9050.94
104_E107_M0.9010.94
44_S122_A0.8900.94
14_L18_G0.8900.94
80_A106_A0.8870.94
19_L23_K0.8850.93
140_E152_V0.8840.93
38_A59_R0.8830.93
133_Y136_A0.8830.93
122_A127_E0.8820.93
122_A125_F0.8670.93
37_L53_L0.8650.93
37_L57_L0.8630.93
55_Y119_A0.8600.92
149_V153_G0.8470.92
35_L88_A0.8400.92
64_A70_D0.8280.91
97_A106_A0.8210.91
60_E118_I0.8100.90
24_E27_L0.8020.90
17_N20_I0.7890.89
82_L86_S0.7870.89
109_Y118_I0.7860.89
121_D141_V0.7850.89
2_R5_L0.7810.88
22_A26_L0.7780.88
76_G93_L0.7660.87
81_T103_S0.7650.87
49_D127_E0.7580.87
124_F150_L0.7580.87
37_L151_L0.7420.86
14_L21_I0.7410.86
141_V147_G0.7390.85
34_L85_D0.7350.85
76_G111_I0.7340.85
23_K128_G0.7210.84
143_V149_V0.7210.84
35_L58_M0.7200.84
49_D126_Q0.7190.84
11_L14_L0.7180.84
10_A14_L0.7070.83
39_P127_E0.7000.82
117_K121_D0.6980.82
15_V19_L0.6960.82
110_R117_K0.6920.81
49_D131_E0.6910.81
29_S145_P0.6880.81
91_Q104_E0.6810.80
20_I27_L0.6810.80
8_G11_L0.6800.80
7_G11_L0.6790.80
78_V118_I0.6790.80
13_L124_F0.6770.80
40_R57_L0.6730.80
45_I49_D0.6720.80
78_V109_Y0.6680.79
44_S51_M0.6640.79
2_R86_S0.6630.79
43_R125_F0.6570.78
138_Y151_L0.6570.78
118_I121_D0.6530.78
152_V155_R0.6520.78
33_L88_A0.6520.78
129_L133_Y0.6500.77
75_D110_R0.6500.77
71_V74_A0.6490.77
12_V16_C0.6490.77
120_S149_V0.6430.77
60_E90_F0.6430.77
133_Y154_L0.6420.76
76_G116_V0.6370.76
36_E137_R0.6360.76
8_G12_V0.6340.76
109_Y121_D0.6340.76
14_L24_E0.6340.76
2_R11_L0.6330.75
33_L124_F0.6320.75
52_R121_D0.6310.75
27_L152_V0.6260.75
77_Y108_L0.6260.75
7_G113_G0.6210.74
71_V135_A0.6170.74
41_D50_Y0.6140.73
37_L47_Q0.6130.73
34_L87_V0.6130.73
84_E112_R0.6110.73
8_G16_C0.6110.73
46_M130_G0.6060.72
132_F136_A0.6040.72
11_L15_V0.6010.72
119_A149_V0.5990.71
43_R126_Q0.5960.71
13_L20_I0.5950.71
79_I99_E0.5880.70
34_L86_S0.5800.69
53_L134_E0.5750.68
51_M120_S0.5740.68
38_A56_S0.5730.68
79_I91_Q0.5690.67
6_W15_V0.5660.67
119_A122_A0.5650.67
92_R97_A0.5640.67
61_I64_A0.5600.66
8_G64_A0.5570.66
12_V51_M0.5560.66
52_R55_Y0.5550.66
27_L47_Q0.5530.65
34_L140_E0.5510.65
123_F154_L0.5500.65
100_A103_S0.5490.65
79_I106_A0.5460.64
30_G143_V0.5460.64
3_R7_G0.5450.64
112_R115_R0.5440.64
74_A111_I0.5420.64
100_A106_A0.5420.64
19_L22_A0.5380.63
70_D74_A0.5380.63
17_N21_I0.5370.63
54_R118_I0.5360.63
6_W102_A0.5340.63
61_I78_V0.5320.62
57_L116_V0.5270.62
9_L12_V0.5230.61
64_A67_D0.5230.61
5_L149_V0.5220.61
43_R53_L0.5220.61
31_E85_D0.5200.61
62_D112_R0.5180.60
58_M116_V0.5180.60
58_M120_S0.5170.60
12_V125_F0.5170.60
24_E150_L0.5160.60
37_L54_R0.5160.60
12_V23_K0.5160.60
17_N22_A0.5150.60
109_Y116_V0.5150.60
12_V15_V0.5140.60
24_E47_Q0.5100.59
26_L37_L0.5090.59
55_Y78_V0.5060.59
51_M131_E0.5050.58
148_D152_V0.5050.58
37_L139_G0.5050.58
58_M119_A0.5050.58
4_I24_E0.5040.58
123_F149_V0.5010.58
20_I26_L0.5000.58
43_R130_G0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aq5B 1 0.6752 5.7 0.948 Contact Map
3fe4A 1 0.6497 5.4 0.948 Contact Map
2jnaA 2 0.6115 5.1 0.949 Contact Map
2x5pA 1 0.5605 3.1 0.954 Contact Map
3hmcA 1 0.6115 2.8 0.955 Contact Map
4xtrG 1 0.1401 2.8 0.955 Contact Map
4lgvA 4 0.8535 2.7 0.955 Contact Map
1nroR 1 0.0637 2.2 0.957 Contact Map
3ry3A 1 0.7134 2 0.958 Contact Map
4wjvI 1 0.0637 1.9 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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