GREMLIN Database
PF11749 - Molybdopterin-guanine dinucleotide biosynthesis protein A
UniProt: Q1QIT9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 152 (150)
Sequences: 1426 (1020)
Seq/√Len: 83.3
META: 0.945

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_T133_H5.3951.00
38_T46_T4.9341.00
76_I96_A3.9171.00
38_T41_A3.5521.00
81_S110_N3.3901.00
75_I114_A3.2841.00
41_A46_T3.1891.00
42_D45_G2.8391.00
40_R47_L2.7911.00
126_E130_A2.6891.00
53_A91_I2.6261.00
96_A117_M2.4131.00
10_R20_I2.3251.00
141_K144_R2.3041.00
96_A125_I2.1911.00
127_R131_E2.1511.00
107_A110_N2.0231.00
79_V104_F1.9661.00
3_V55_I1.9521.00
122_R126_E1.7271.00
64_R99_A1.7171.00
142_R145_G1.6741.00
103_S106_D1.6011.00
76_I117_M1.6001.00
64_R97_D1.5501.00
128_F132_H1.5491.00
144_R147_A1.5291.00
26_V115_V1.5080.99
8_E45_G1.5030.99
14_S17_T1.4510.99
57_L125_I1.4120.99
76_I94_V1.3910.99
67_E99_A1.3830.99
77_W114_A1.3570.99
53_A94_V1.3400.99
49_Y52_S1.3400.99
119_D122_R1.3360.99
17_T20_I1.3320.99
6_V39_L1.3170.99
78_V115_V1.2690.98
38_T48_Y1.2650.98
147_A151_A1.2460.98
55_I94_V1.2290.98
93_A104_F1.2050.97
61_E99_A1.1980.97
12_A20_I1.1960.97
79_V93_A1.1620.97
5_V26_V1.1590.97
11_A14_S1.1240.96
1_I124_A1.1230.96
63_G67_E1.1200.96
25_G47_L1.0780.95
11_A15_A1.0710.95
55_I76_I1.0610.94
66_R70_A1.0550.94
68_N71_S1.0550.94
147_A150_E1.0550.94
80_M89_Y1.0450.94
9_R19_F1.0440.94
27_L49_Y1.0320.94
1_I28_P1.0280.94
4_G49_Y1.0190.93
36_W50_A1.0170.93
64_R109_A1.0140.93
102_E105_T1.0080.93
69_L125_I1.0050.93
123_G130_A1.0040.93
41_A44_D1.0000.93
12_A18_D0.9910.92
38_T96_A0.9900.92
106_D109_A0.9860.92
12_A17_T0.9830.92
59_R132_H0.9770.92
140_V143_K0.9730.92
125_I129_I0.9680.91
83_S87_W0.9600.91
145_G148_D0.9490.90
146_R150_E0.9470.90
28_P124_A0.9370.90
123_G127_R0.9310.90
25_G115_V0.9210.89
62_T129_I0.9140.89
8_E24_V0.9140.89
2_P54_A0.9120.89
148_D151_A0.9020.88
8_E47_L0.8990.88
98_S102_E0.8660.86
66_R135_E0.8620.86
99_A102_E0.8520.85
12_A19_F0.8480.85
9_R46_T0.8380.84
23_A111_L0.8370.84
66_R129_I0.8360.84
69_L142_R0.8290.83
67_E101_G0.8280.83
30_A34_E0.8280.83
102_E106_D0.8230.83
61_E97_D0.8210.83
105_T112_V0.8170.83
8_E22_R0.8140.82
139_F142_R0.8110.82
46_T50_A0.8110.82
135_E139_F0.7960.81
77_W101_G0.7860.80
60_S108_S0.7820.80
58_Y61_E0.7790.79
80_M98_S0.7790.79
15_A19_F0.7750.79
69_L129_I0.7720.79
97_D107_A0.7680.78
74_A129_I0.7670.78
61_E100_E0.7640.78
117_M121_I0.7640.78
109_A114_A0.7580.78
81_S92_T0.7540.77
99_A103_S0.7530.77
14_S18_D0.7520.77
117_M125_I0.7500.77
91_I143_K0.7470.77
11_A101_G0.7460.76
67_E70_A0.7410.76
2_P6_V0.7320.75
99_A107_A0.7310.75
23_A113_E0.7290.75
98_S139_F0.7270.75
3_V94_V0.7260.74
10_R25_G0.7260.74
29_G95_T0.7250.74
70_A138_E0.7240.74
97_D136_R0.7110.73
52_S91_I0.7080.73
89_Y92_T0.7050.72
120_V123_G0.7000.72
11_A19_F0.6930.71
39_L49_Y0.6910.71
36_W48_Y0.6860.70
111_L128_F0.6810.70
51_G131_E0.6810.70
19_F61_E0.6760.69
13_A17_T0.6760.69
109_A124_A0.6750.69
11_A44_D0.6710.69
125_I130_A0.6690.68
15_A143_K0.6670.68
48_Y107_A0.6630.68
93_A121_I0.6570.67
72_G101_G0.6550.67
104_F124_A0.6490.66
129_I133_H0.6490.66
5_V94_V0.6490.66
12_A25_G0.6440.65
80_M113_E0.6430.65
96_A142_R0.6420.65
61_E77_W0.6410.65
35_P54_A0.6390.65
38_T45_G0.6350.64
17_T39_L0.6330.64
13_A43_A0.6320.64
27_L39_L0.6310.64
77_W98_S0.6280.63
60_S128_F0.6260.63
101_G112_V0.6210.63
68_N98_S0.6200.62
62_T98_S0.6200.62
23_A78_V0.6200.62
5_V82_P0.6190.62
7_I50_A0.6180.62
141_K150_E0.6170.62
23_A89_Y0.6160.62
126_E129_I0.6060.61
10_R43_A0.6000.60
33_I134_V0.5980.60
52_S110_N0.5950.59
66_R97_D0.5950.59
64_R103_S0.5940.59
106_D124_A0.5890.59
2_P32_D0.5890.59
63_G106_D0.5860.58
134_V138_E0.5850.58
14_S44_D0.5840.58
85_G106_D0.5820.58
103_S140_V0.5760.57
4_G36_W0.5750.57
60_S132_H0.5720.56
38_T111_L0.5710.56
53_A93_A0.5690.56
79_V138_E0.5680.56
77_W112_V0.5660.56
6_V47_L0.5600.55
95_T133_H0.5590.55
145_G149_L0.5580.54
117_M122_R0.5550.54
84_E123_G0.5530.54
127_R134_V0.5520.54
101_G110_N0.5500.53
38_T43_A0.5480.53
106_D113_E0.5470.53
75_I113_E0.5450.53
67_E105_T0.5440.53
10_R22_R0.5410.52
32_D119_D0.5390.52
49_Y54_A0.5380.52
54_A128_F0.5360.52
118_P121_I0.5340.51
142_R148_D0.5290.51
69_L141_K0.5280.51
69_L117_M0.5270.50
36_W51_G0.5260.50
81_S90_A0.5250.50
79_V112_V0.5240.50
103_S109_A0.5240.50
2_P29_G0.5190.49
67_E102_E0.5190.49
120_V129_I0.5180.49
63_G99_A0.5160.49
3_V124_A0.5150.49
99_A108_S0.5120.48
20_I30_A0.5110.48
77_W97_D0.5080.48
51_G91_I0.5080.48
30_A107_A0.5060.48
59_R73_A0.5050.47
146_R149_L0.5030.47
21_W106_D0.5000.47
7_I26_V0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xfiA 1 0.7434 5.6 0.955 Contact Map
4me7E 2 0.2895 4.9 0.957 Contact Map
2kkeA 2 0.3487 4.3 0.958 Contact Map
3bcwA 2 0.4803 4.1 0.958 Contact Map
4eo1A 1 0.1908 4 0.958 Contact Map
3v4yB 1 0.1908 3.8 0.959 Contact Map
3exqA 2 0.8618 3.4 0.96 Contact Map
2r7dA 1 0.8421 3.1 0.961 Contact Map
4o5vA 2 0.4276 2.8 0.961 Contact Map
4j19A 1 0.0724 2.6 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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