GREMLIN Database
PF07593 - (441-556) ASPIC/UnbV
UniProt: Q1ITH1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 116 (102)
Sequences: 34898 (25463)
Seq/√Len: 2521.2
META: 0.945

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_S99_Y2.8831.00
42_T78_S2.5031.00
78_S90_T2.3821.00
19_H97_D2.3311.00
40_K82_R2.2491.00
40_K80_E2.1821.00
40_K47_T2.0031.00
26_A101_A1.9821.00
42_T47_T1.9711.00
80_E88_V1.9671.00
26_A103_L1.9071.00
82_R88_V1.8681.00
85_S104_E1.7751.00
39_V66_V1.7691.00
24_E101_A1.7611.00
80_E90_T1.7391.00
103_L106_K1.7201.00
22_S67_H1.6751.00
42_T80_E1.6371.00
50_D68_F1.6091.00
40_K49_T1.5851.00
22_S65_R1.5531.00
38_K49_T1.5181.00
31_N34_A1.4591.00
91_V102_I1.4511.00
78_S92_K1.4491.00
43_A48_Q1.4371.00
24_E99_Y1.4151.00
38_K51_E1.4111.00
94_I100_Y1.3661.00
24_E65_R1.3571.00
23_F79_V1.3551.00
41_I68_F1.3451.00
75_K93_D1.3421.00
33_L64_L1.3331.00
89_D105_G1.3091.00
52_I66_V1.3011.00
50_D66_V1.2621.00
83_W89_D1.2431.00
28_T104_E1.2101.00
65_R99_Y1.1891.00
38_K82_R1.1581.00
37_A81_V1.1201.00
27_G104_E1.1151.00
23_F100_Y1.1091.00
43_A46_V1.0941.00
44_G73_A1.0921.00
95_Q98_H1.0901.00
28_T103_L1.0701.00
44_G77_D1.0571.00
43_A73_A1.0541.00
42_T77_D1.0531.00
87_K104_E1.0321.00
79_V94_I1.0211.00
46_V73_A1.0161.00
5_G8_T1.0031.00
19_H96_A1.0031.00
25_L37_A0.9991.00
23_F39_V0.9991.00
31_N35_L0.9941.00
25_L52_I0.9901.00
18_N72_T0.9761.00
70_L96_A0.9671.00
45_G73_A0.9661.00
91_V94_I0.9441.00
22_S63_D0.9421.00
25_L34_A0.9371.00
61_Q64_L0.9251.00
18_N71_G0.9201.00
21_V100_Y0.9001.00
56_G62_N0.8931.00
27_G31_N0.8831.00
55_G61_Q0.8791.00
70_L76_I0.8761.00
73_A77_D0.8761.00
29_K87_K0.8721.00
81_V102_I0.8641.00
26_A32_R0.8501.00
48_Q68_F0.8481.00
21_V76_I0.8311.00
95_Q100_Y0.8241.00
30_S85_S0.8241.00
25_L39_V0.8211.00
20_W97_D0.8201.00
76_I96_A0.8171.00
53_H56_G0.8121.00
63_D67_H0.8091.00
75_K95_Q0.8091.00
19_H74_T0.8001.00
41_I76_I0.7851.00
52_I64_L0.7781.00
35_L54_S0.7661.00
41_I70_L0.7431.00
37_A84_P0.7401.00
54_S61_Q0.7241.00
30_S104_E0.7221.00
41_I79_V0.7221.00
56_G59_L0.7201.00
27_G34_A0.7131.00
8_T11_R0.7121.00
34_A37_A0.7121.00
28_T105_G0.7021.00
39_V79_V0.6961.00
13_K16_P0.6921.00
39_V68_F0.6811.00
50_D53_H0.6711.00
15_V18_N0.6681.00
52_I63_D0.6651.00
55_G62_N0.6541.00
89_D102_I0.6491.00
35_L55_G0.6431.00
96_A100_Y0.6411.00
89_D106_K0.6191.00
57_S62_N0.6001.00
63_D66_V0.5941.00
56_G60_S0.5931.00
54_S62_N0.5891.00
20_W67_H0.5881.00
52_I55_G0.5801.00
67_H99_Y0.5761.00
17_G72_T0.5721.00
56_G63_D0.5711.00
87_K105_G0.5691.00
53_H62_N0.5671.00
54_S64_L0.5661.00
20_W99_Y0.5661.00
52_I65_R0.5641.00
43_A77_D0.5631.00
30_S84_P0.5601.00
25_L83_W0.5571.00
91_V105_G0.5501.00
35_L64_L0.5501.00
23_F66_V0.5501.00
37_A52_I0.5501.00
81_V91_V0.5501.00
25_L89_D0.5491.00
27_G33_L0.5291.00
34_A52_I0.5291.00
58_Y61_Q0.5291.00
93_D96_A0.5281.00
56_G61_Q0.5271.00
14_G17_G0.5251.00
19_H72_T0.5211.00
23_F68_F0.5161.00
18_N69_G0.5161.00
7_P59_L0.5141.00
28_T87_K0.5101.00
51_E55_G0.5051.00
74_T95_Q0.5031.00
35_L52_I0.5031.00
51_E82_R0.5021.00
14_G18_N0.5011.00
50_D55_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a7kA 2 0.7759 54.3 0.879 Contact Map
2qqrA 1 0.8534 31.1 0.896 Contact Map
2mamA 1 0.8362 21.4 0.904 Contact Map
2mcaA 1 0.5259 16.4 0.909 Contact Map
2xdpA 2 0.8276 14 0.911 Contact Map
3dmqA 1 0.5517 11.7 0.914 Contact Map
2xetA 1 0.7241 9.6 0.918 Contact Map
2e5pA 1 0.4569 7.9 0.921 Contact Map
2m0oA 1 0.6034 6.7 0.923 Contact Map
3v6cB 1 0.4052 6.2 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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