GREMLIN Database
PF08897 - Uncharacterized protein
UniProt: Q0KCJ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 140 (139)
Sequences: 1544 (1011)
Seq/√Len: 85.7
META:

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_K30_E3.9821.00
102_S105_E3.5071.00
113_C136_C3.4131.00
9_V13_F2.6911.00
21_L48_R2.6411.00
116_E120_Q2.3671.00
110_V137_V2.2951.00
78_S107_Q2.2821.00
16_A34_V2.2411.00
92_A137_V2.2321.00
120_Q124_T2.2271.00
18_Q22_T2.1931.00
20_Q38_G2.1111.00
12_F33_A2.0381.00
77_I110_V1.9401.00
8_E11_R1.9291.00
36_W71_L1.8521.00
46_L58_Y1.8151.00
73_M111_M1.7911.00
84_D90_R1.7871.00
103_P107_Q1.7851.00
28_P31_A1.7461.00
135_D138_K1.7401.00
34_V38_G1.7011.00
32_I75_L1.7001.00
11_R15_D1.6961.00
100_L109_Q1.6961.00
73_M115_G1.6661.00
18_Q24_G1.6611.00
31_A35_D1.6251.00
93_Y103_P1.5781.00
91_Q95_A1.5651.00
15_D18_Q1.5471.00
90_R94_E1.5441.00
36_W78_S1.4870.99
5_S8_E1.4820.99
92_A138_K1.4100.99
120_Q136_C1.3870.99
13_F72_S1.3830.99
11_R54_L1.3560.99
46_L64_Q1.3480.99
60_P63_G1.3300.99
81_V103_P1.3180.99
93_Y110_V1.3180.99
117_M136_C1.3060.99
14_C53_A1.2940.98
37_I47_L1.2910.98
84_D91_Q1.2870.98
85_Q130_G1.2790.98
84_D87_R1.2550.98
135_D139_R1.2530.98
97_A106_A1.2480.98
56_Q64_Q1.1870.97
91_Q94_E1.1810.97
32_I83_V1.1760.97
20_Q34_V1.1570.97
59_T62_Q1.1460.97
58_Y64_Q1.1120.96
50_T54_L1.1000.96
3_N7_E1.0920.96
120_Q126_Q1.0850.96
93_Y97_A1.0820.95
26_L34_V1.0680.95
121_A128_P1.0680.95
78_S93_Y1.0450.94
93_Y107_Q1.0390.94
9_V72_S1.0360.94
27_T30_E1.0330.94
4_P9_V0.9960.93
60_P65_T0.9910.93
49_D52_G0.9900.93
9_V33_A0.9850.93
81_V93_Y0.9820.92
5_S9_V0.9810.92
32_I78_S0.9760.92
92_A95_A0.9730.92
26_L31_A0.9650.92
39_E103_P0.9640.92
33_A72_S0.9630.92
87_R131_D0.9480.91
6_R57_D0.9470.91
45_G48_R0.9370.91
29_L75_L0.9300.90
119_W123_R0.9270.90
97_A102_S0.9020.89
35_D39_E0.8930.88
117_M130_G0.8870.88
9_V85_Q0.8850.88
36_W107_Q0.8780.87
105_E109_Q0.8610.86
94_E98_R0.8420.85
73_M117_M0.8340.85
13_F71_L0.8330.85
6_R17_W0.8320.85
15_D27_T0.8210.84
71_L75_L0.8160.83
107_Q111_M0.8140.83
58_Y63_G0.8090.83
4_P13_F0.8020.82
76_S81_V0.7940.82
28_P32_I0.7920.81
17_W44_H0.7910.81
73_M77_I0.7830.81
97_A100_L0.7810.81
121_A125_G0.7700.80
80_Q133_Y0.7680.79
95_A98_R0.7680.79
32_I79_E0.7660.79
117_M128_P0.7660.79
9_V76_S0.7590.79
111_M117_M0.7560.78
17_W20_Q0.7520.78
97_A103_P0.7470.78
73_M107_Q0.7470.78
130_G134_V0.7360.77
23_G48_R0.7340.76
2_F12_F0.7250.75
81_V107_Q0.7200.75
7_E55_S0.7080.74
12_F71_L0.6950.72
72_S78_S0.6860.71
76_S107_Q0.6770.70
35_D78_S0.6770.70
95_A138_K0.6750.70
63_G116_E0.6690.69
14_C50_T0.6670.69
9_V12_F0.6650.69
89_I117_M0.6650.69
72_S118_L0.6640.69
59_T64_Q0.6630.69
58_Y116_E0.6630.69
15_D24_G0.6610.69
32_I82_S0.6600.68
3_N8_E0.6600.68
60_P64_Q0.6580.68
13_F85_Q0.6530.68
35_D103_P0.6530.68
49_D98_R0.6500.67
23_G30_E0.6470.67
60_P118_L0.6470.67
33_A75_L0.6440.67
51_E95_A0.6370.66
117_M121_A0.6360.66
88_G134_V0.6320.65
37_I44_H0.6310.65
65_T119_W0.6300.65
32_I73_M0.6240.64
25_V28_P0.6210.64
84_D88_G0.6200.64
28_P72_S0.6190.63
44_H48_R0.6160.63
59_T115_G0.6150.63
46_L53_A0.6150.63
89_I137_V0.6110.62
33_A85_Q0.6110.62
52_G55_S0.6090.62
78_S103_P0.6060.62
20_Q31_A0.6020.61
11_R14_C0.5990.61
58_Y65_T0.5960.61
11_R50_T0.5940.60
32_I35_D0.5940.60
65_T111_M0.5910.60
36_W72_S0.5880.60
97_A135_D0.5870.59
18_Q109_Q0.5860.59
17_W48_R0.5840.59
103_P110_V0.5830.59
117_M132_H0.5760.58
85_Q117_M0.5730.58
92_A110_V0.5690.57
95_A137_V0.5670.57
118_L128_P0.5650.57
81_V90_R0.5580.56
119_W122_Q0.5580.56
47_L71_L0.5570.55
112_E122_Q0.5570.55
82_S112_E0.5560.55
35_D38_G0.5530.55
71_L115_G0.5500.55
83_V117_M0.5460.54
127_P131_D0.5460.54
12_F16_A0.5420.53
73_M97_A0.5400.53
73_M95_A0.5400.53
65_T112_E0.5390.53
96_L99_R0.5380.53
87_R98_R0.5380.53
19_K23_G0.5350.53
2_F51_E0.5320.52
93_Y113_C0.5320.52
33_A83_V0.5270.51
52_G56_Q0.5240.51
9_V14_C0.5240.51
92_A136_C0.5240.51
4_P104_H0.5240.51
98_R105_E0.5230.51
7_E27_T0.5180.50
97_A138_K0.5170.50
20_Q23_G0.5160.50
39_E78_S0.5160.50
121_A127_P0.5140.50
112_E115_G0.5080.49
85_Q118_L0.5060.49
34_V62_Q0.5050.49
16_A102_S0.5030.48
127_P130_G0.5020.48
81_V104_H0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mbaA 1 0.9071 16.8 0.955 Contact Map
1ashA 1 0.8857 12.7 0.957 Contact Map
1ewqA 2 0.7857 11.7 0.958 Contact Map
3wctC 1 0.8429 9.8 0.96 Contact Map
2p18A 1 0.65 9.5 0.96 Contact Map
4hrrB 2 0.9 9.3 0.96 Contact Map
4g1vA 3 0.8857 8.7 0.96 Contact Map
2wtgA 2 0.8929 8.2 0.961 Contact Map
1x9fC 1 0.8429 8 0.961 Contact Map
1yhuA 2 0.8857 7.7 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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