GREMLIN Database
PF01610 - Transposase for insertion sequence element IS1001
UniProt: Q06126 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 406 (379)
Sequences: 8448 (5849)
Seq/√Len: 300.4
META: 0.859

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
242_A247_E4.2221.00
155_E210_K3.7051.00
156_Y178_I3.2451.00
191_R222_L3.1651.00
214_I233_I3.0101.00
61_R75_H2.8561.00
32_S75_H2.8051.00
320_R323_W2.7301.00
243_K349_R2.6831.00
321_P362_R2.6551.00
64_D106_R2.5581.00
336_E351_K2.5291.00
329_N354_L2.4411.00
244_Y346_F2.4011.00
154_I183_L2.3641.00
212_V224_I2.3391.00
173_V377_I2.3291.00
209_I228_S2.3161.00
195_R223_E2.3051.00
255_D342_A2.3041.00
19_E36_K2.3031.00
155_E178_I2.2631.00
279_R288_Q2.2261.00
214_I224_I2.2261.00
34_Y75_H2.2231.00
244_Y312_L2.1721.00
199_E227_H2.1491.00
159_M194_A2.1101.00
195_R226_A2.0841.00
216_M235_Y2.0801.00
384_A387_Y2.0401.00
202_P205_A2.0341.00
111_C127_F2.0331.00
311_E334_Q2.0271.00
78_R94_L2.0241.00
188_G193_T2.0131.00
202_P206_A2.0121.00
252_V305_V2.0091.00
79_R92_E1.9591.00
191_R226_A1.9131.00
195_R227_H1.9121.00
121_Q125_R1.8711.00
158_A177_P1.8671.00
59_V75_H1.8451.00
280_N313_K1.8241.00
175_V370_V1.8221.00
114_L126_F1.7801.00
182_V397_I1.7661.00
325_R354_L1.7661.00
235_Y356_G1.7641.00
376_T385_Y1.7601.00
108_A140_A1.7561.00
221_E235_Y1.7161.00
318_Y323_W1.7041.00
315_L327_A1.6981.00
333_E337_Q1.6971.00
44_C47_C1.6931.00
117_S122_A1.6911.00
389_D392_Y1.6861.00
238_F242_A1.6831.00
372_G375_N1.6781.00
61_R73_V1.6511.00
274_R278_L1.6491.00
20_R34_Y1.6451.00
280_N283_N1.6351.00
378_K381_K1.6341.00
129_L134_V1.6331.00
282_D313_K1.6311.00
237_L241_V1.6261.00
17_G36_K1.6191.00
46_Q90_R1.6181.00
244_Y343_L1.6091.00
185_I397_I1.6011.00
331_W335_A1.6001.00
110_A127_F1.5911.00
176_D179_G1.5791.00
139_K391_E1.5761.00
251_R254_V1.5741.00
22_E34_Y1.5741.00
111_C137_L1.5601.00
198_F224_I1.5571.00
390_Q394_F1.5521.00
60_R78_R1.5491.00
375_N385_Y1.5411.00
203_P207_Q1.5411.00
223_E227_H1.5351.00
211_A365_L1.5301.00
162_F378_K1.5291.00
62_V97_L1.5281.00
47_C83_C1.5141.00
156_Y211_A1.5131.00
158_A370_V1.4921.00
379_V385_Y1.4861.00
341_A344_N1.4831.00
335_A343_L1.4511.00
318_Y327_A1.4451.00
119_N122_A1.4431.00
252_V342_A1.4351.00
130_G133_T1.4341.00
83_C86_C1.4251.00
308_L343_L1.4191.00
356_G359_A1.4131.00
59_V77_P1.4121.00
273_S277_L1.4061.00
372_G376_T1.3961.00
321_P325_R1.3881.00
336_E344_N1.3821.00
394_F398_R1.3731.00
256_Q301_P1.3681.00
174_V197_F1.3671.00
285_D288_Q1.3611.00
49_A85_Q1.3501.00
303_L307_V1.3501.00
44_C83_C1.3471.00
377_I397_I1.3441.00
213_A367_T1.3181.00
247_E251_R1.3031.00
375_N382_R1.3001.00
111_C134_V1.2961.00
250_D254_V1.2841.00
256_Q259_Q1.2801.00
332_Y351_K1.2641.00
157_L174_V1.2611.00
255_D301_P1.2591.00
315_L357_I1.2571.00
53_Q56_E1.2451.00
213_A365_L1.2421.00
190_S193_T1.2401.00
189_R217_T1.2361.00
336_E348_Q1.2331.00
221_E225_Q1.2311.00
176_D181_Q1.2281.00
175_V373_I1.2231.00
221_E233_I1.2231.00
354_L358_L1.2231.00
163_A167_G1.2201.00
30_T71_R1.2191.00
322_A326_Q1.1931.00
222_L226_A1.1911.00
332_Y336_E1.1871.00
254_V274_R1.1851.00
367_T370_V1.1841.00
122_A125_R1.1831.00
379_V382_R1.1811.00
115_L138_D1.1771.00
163_A170_Y1.1551.00
34_Y59_V1.1531.00
54_V57_T1.1471.00
240_V357_I1.1431.00
185_I394_F1.1391.00
284_L292_L1.1351.00
98_G105_D1.1321.00
198_F228_S1.1301.00
221_E356_G1.1281.00
251_R345_T1.1221.00
325_R355_H1.1211.00
107_L129_L1.1201.00
284_L306_Y1.0941.00
35_L74_L1.0941.00
139_K392_Y1.0931.00
232_E362_R1.0911.00
143_R391_E1.0911.00
163_A168_H1.0891.00
333_E336_E1.0891.00
162_F377_I1.0841.00
232_E359_A1.0781.00
251_R255_D1.0701.00
55_H89_P1.0701.00
17_G38_T1.0701.00
186_G193_T1.0691.00
187_P394_F1.0651.00
375_N379_V1.0581.00
211_A234_V1.0571.00
62_V76_V1.0481.00
391_E394_F1.0441.00
120_V135_K1.0431.00
289_A293_D1.0421.00
348_Q352_G1.0381.00
218_T222_L1.0381.00
195_R199_E1.0361.00
381_K393_F1.0331.00
71_R128_E1.0311.00
221_E353_Y1.0241.00
353_Y356_G1.0171.00
308_L335_A1.0141.00
206_A227_H1.0121.00
180_R369_I1.0051.00
209_I231_A1.0011.00
191_R195_R1.0011.00
279_R283_N1.0001.00
156_Y210_K0.9981.00
350_L357_I0.9961.00
63_R73_V0.9961.00
360_R364_P0.9881.00
206_A228_S0.9801.00
237_L360_R0.9771.00
57_T77_P0.9721.00
78_R91_L0.9721.00
279_R285_D0.9701.00
156_Y365_L0.9701.00
187_P390_Q0.9621.00
360_R366_N0.9611.00
324_A361_C0.9601.00
115_L123_V0.9601.00
123_V134_V0.9571.00
171_A390_Q0.9571.00
237_L317_F0.9571.00
138_D396_K0.9561.00
372_G385_Y0.9531.00
101_Q108_A0.9521.00
243_K247_E0.9511.00
63_R66_P0.9501.00
281_R310_D0.9491.00
67_I72_V0.9411.00
103_V108_A0.9341.00
114_L127_F0.9331.00
30_T73_V0.9311.00
157_L209_I0.9261.00
162_F171_A0.9251.00
358_L361_C0.9251.00
184_W394_F0.9241.00
189_R220_Y0.9241.00
43_L50_R0.9191.00
255_D258_N0.9141.00
82_W89_P0.9131.00
201_L205_A0.9111.00
211_A363_H0.9111.00
323_W326_Q0.9101.00
98_G140_A0.9081.00
240_V316_W0.9071.00
261_R264_R0.9061.00
304_T337_Q0.9051.00
248_V346_F0.9031.00
132_H136_T0.9011.00
103_V107_L0.9011.00
111_C123_V0.8971.00
66_P128_E0.8961.00
109_Q141_R0.8951.00
332_Y347_A0.8931.00
177_P213_A0.8921.00
311_E314_R0.8921.00
212_V228_S0.8901.00
245_G309_R0.8891.00
119_N383_R0.8891.00
232_E363_H0.8861.00
36_K77_P0.8861.00
165_H169_R0.8861.00
216_M243_K0.8831.00
101_Q140_A0.8821.00
250_D274_R0.8821.00
24_P32_S0.8811.00
108_A137_L0.8801.00
343_L346_F0.8801.00
225_Q233_I0.8801.00
250_D278_L0.8791.00
111_C129_L0.8781.00
22_E32_S0.8781.00
159_M214_I0.8771.00
157_L212_V0.8771.00
241_V245_G0.8771.00
184_W398_R0.8741.00
189_R219_A0.8711.00
319_Q323_W0.8711.00
158_A175_V0.8691.00
382_R385_Y0.8691.00
54_V79_R0.8671.00
60_R91_L0.8651.00
175_V369_I0.8631.00
32_S61_R0.8601.00
177_P365_L0.8581.00
243_K346_F0.8561.00
261_R271_K0.8561.00
184_W193_T0.8541.00
47_C86_C0.8521.00
53_Q84_E0.8511.00
207_Q230_Q0.8461.00
237_L366_N0.8441.00
234_V363_H0.8411.00
314_R317_F0.8411.00
281_R306_Y0.8391.00
325_R329_N0.8351.00
174_V184_W0.8351.00
334_Q337_Q0.8321.00
214_I221_E0.8321.00
219_A222_L0.8301.00
76_V94_L0.8291.00
311_E327_A0.8201.00
379_V383_R0.8191.00
103_V137_L0.8171.00
203_P206_A0.8161.00
241_V313_K0.8131.00
194_A224_I0.8101.00
80_R89_P0.8091.00
52_R56_E0.8081.00
346_F349_R0.8081.00
257_A271_K0.8081.00
281_R289_A0.8071.00
346_F350_L0.8071.00
243_K352_G0.8071.00
98_G101_Q0.8031.00
375_N378_K0.8031.00
135_K392_Y0.8001.00
344_N348_Q0.8001.00
46_Q88_G0.7991.00
64_D104_T0.7981.00
168_H189_R0.7951.00
82_W87_G0.7951.00
388_R392_Y0.7921.00
19_E34_Y0.7900.99
114_L118_S0.7890.99
308_L334_Q0.7890.99
164_L171_A0.7880.99
58_T91_L0.7880.99
212_V231_A0.7870.99
118_S122_A0.7850.99
366_N369_I0.7770.99
45_E90_R0.7770.99
184_W196_A0.7760.99
41_V50_R0.7710.99
121_Q124_A0.7710.99
249_I277_L0.7710.99
52_R55_H0.7700.99
294_E297_Q0.7660.99
325_R358_L0.7650.99
117_S126_F0.7640.99
154_I201_L0.7630.99
273_S276_L0.7620.99
187_P391_E0.7610.99
310_D313_K0.7600.99
299_N303_L0.7590.99
254_V258_N0.7590.99
338_S344_N0.7560.99
174_V186_G0.7550.99
291_R294_E0.7500.99
46_Q86_C0.7480.99
284_L288_Q0.7480.99
256_Q302_L0.7460.99
276_L291_R0.7460.99
250_D253_R0.7450.99
328_W350_L0.7450.99
44_C86_C0.7420.99
107_L111_C0.7420.99
225_Q356_G0.7390.99
273_S295_L0.7390.99
341_A345_T0.7370.99
296_L306_Y0.7370.99
216_M240_V0.7360.99
138_D399_A0.7340.99
138_D395_L0.7340.99
48_G93_R0.7330.99
224_I233_I0.7280.99
243_K345_T0.7280.99
156_Y363_H0.7220.99
345_T352_G0.7220.99
21_V33_I0.7200.99
186_G196_A0.7200.99
51_C84_E0.7180.99
139_K395_L0.7170.99
259_Q263_D0.7100.99
332_Y354_L0.7090.99
387_Y393_F0.7070.99
51_C55_H0.7060.99
173_V182_V0.7050.99
37_P92_E0.7020.99
304_T339_G0.7010.99
273_S291_R0.7010.99
323_W327_A0.7000.99
109_Q113_Q0.6990.99
33_I72_V0.6980.99
279_R284_L0.6950.99
171_A397_I0.6940.99
62_V104_T0.6920.99
55_H58_T0.6910.99
118_S126_F0.6900.99
378_K382_R0.6890.99
63_R107_L0.6890.99
198_F227_H0.6880.99
344_N347_A0.6880.99
252_V340_I0.6870.99
305_V343_L0.6850.99
240_V350_L0.6840.99
218_T353_Y0.6830.99
64_D74_L0.6830.99
192_E196_A0.6820.99
192_E195_R0.6810.98
312_L331_W0.6780.98
286_R289_A0.6780.98
205_A208_R0.6780.98
277_L302_L0.6760.98
213_A368_S0.6740.98
214_I235_Y0.6730.98
66_P69_E0.6720.98
113_Q117_S0.6720.98
359_A362_R0.6720.98
51_C56_E0.6700.98
18_V33_I0.6680.98
35_L76_V0.6680.98
107_L127_F0.6660.98
339_G344_N0.6660.98
369_I373_I0.6640.98
51_C85_Q0.6630.98
103_V133_T0.6620.98
378_K385_Y0.6610.98
296_L303_L0.6610.98
318_Y322_A0.6600.98
164_L169_R0.6580.98
261_R267_R0.6580.98
150_D153_K0.6570.98
135_K139_K0.6560.98
316_W361_C0.6550.98
376_T382_R0.6550.98
234_V359_A0.6550.98
199_E206_A0.6530.98
308_L331_W0.6530.98
110_A126_F0.6520.98
120_V138_D0.6520.98
251_R342_A0.6510.98
315_L318_Y0.6500.98
257_A261_R0.6500.98
193_T196_A0.6480.98
304_T307_V0.6450.98
329_N333_E0.6420.98
155_E208_R0.6390.98
299_N311_E0.6370.98
345_T348_Q0.6370.98
198_F223_E0.6360.98
112_S141_R0.6340.98
242_A245_G0.6320.98
152_S205_A0.6310.98
112_S138_D0.6310.98
269_I298_A0.6270.97
335_A338_S0.6260.97
349_R352_G0.6250.97
45_E81_L0.6240.97
69_E106_R0.6240.97
110_A114_L0.6240.97
117_S125_R0.6220.97
328_W354_L0.6210.97
24_P30_T0.6190.97
245_G278_L0.6180.97
248_V343_L0.6160.97
68_F72_V0.6160.97
56_E80_R0.6150.97
55_H82_W0.6130.97
218_T221_E0.6130.97
81_L90_R0.6120.97
16_Y35_L0.6110.97
163_A169_R0.6110.97
306_Y310_D0.6110.97
248_V345_T0.6100.97
94_L97_L0.6090.97
334_Q339_G0.6070.97
275_W279_R0.6070.97
112_S137_L0.6040.97
31_L67_I0.6030.97
45_E83_C0.6030.97
42_M81_L0.6010.97
39_A42_M0.6010.97
258_N261_R0.6000.97
247_E250_D0.6000.97
156_Y213_A0.6000.97
306_Y309_R0.5990.97
154_I205_A0.5970.97
18_V21_V0.5940.96
120_V131_W0.5920.96
53_Q82_W0.5920.96
395_L399_A0.5910.96
93_R99_R0.5910.96
173_V185_I0.5880.96
218_T352_G0.5870.96
392_Y396_K0.5870.96
184_W197_F0.5850.96
174_V194_A0.5840.96
255_D259_Q0.5830.96
309_R313_K0.5810.96
30_T61_R0.5810.96
392_Y395_L0.5790.96
138_D392_Y0.5790.96
113_Q116_Q0.5770.96
196_A199_E0.5750.96
321_P358_L0.5750.96
191_R223_E0.5740.96
32_S73_V0.5740.96
65_L68_F0.5730.96
305_V340_I0.5720.96
251_R258_N0.5710.96
124_A131_W0.5700.96
318_Y326_Q0.5690.95
355_H359_A0.5690.95
314_R318_Y0.5690.95
336_E339_G0.5680.95
63_R71_R0.5680.95
381_K385_Y0.5680.95
23_W70_Y0.5650.95
327_A330_H0.5640.95
42_M45_E0.5630.95
234_V360_R0.5620.95
163_A166_K0.5610.95
195_R222_L0.5570.95
81_L92_E0.5570.95
153_K209_I0.5550.95
351_K354_L0.5540.95
213_A234_V0.5540.95
165_H168_H0.5520.95
249_I309_R0.5520.95
316_W324_A0.5510.95
139_K143_R0.5490.95
149_P181_Q0.5490.95
237_L313_K0.5480.94
163_A381_K0.5480.94
280_N317_F0.5470.94
330_H334_Q0.5460.94
206_A230_Q0.5450.94
247_E254_V0.5410.94
206_A209_I0.5380.94
165_H381_K0.5380.94
314_R327_A0.5370.94
332_Y350_L0.5360.94
194_A198_F0.5350.94
167_G170_Y0.5340.94
316_W327_A0.5330.94
138_D142_L0.5330.94
211_A359_A0.5330.94
41_V53_Q0.5320.94
241_V312_L0.5320.94
275_W303_L0.5300.93
171_A394_F0.5300.93
131_W135_K0.5280.93
248_V305_V0.5280.93
330_H333_E0.5280.93
260_L267_R0.5280.93
260_L264_R0.5280.93
369_I372_G0.5260.93
69_E110_A0.5260.93
37_P40_K0.5240.93
114_L123_V0.5230.93
194_A197_F0.5220.93
302_L306_Y0.5210.93
161_E220_Y0.5200.93
120_V392_Y0.5200.93
98_G108_A0.5170.93
86_C90_R0.5170.93
105_D109_Q0.5160.93
335_A347_A0.5160.93
102_R133_T0.5130.92
345_T349_R0.5130.92
43_L49_A0.5120.92
276_L285_D0.5120.92
54_V89_P0.5110.92
287_Q290_V0.5100.92
331_W347_A0.5090.92
377_I393_F0.5090.92
51_C54_V0.5080.92
387_Y392_Y0.5070.92
64_D68_F0.5070.92
188_G217_T0.5060.92
348_Q351_K0.5040.92
217_T222_L0.5040.92
304_T338_S0.5040.92
202_P208_R0.5040.92
201_L204_G0.5030.92
292_L296_L0.5030.92
177_P369_I0.5020.92
31_L72_V0.5010.91
257_A274_R0.5010.91
340_I343_L0.5010.91
249_I252_V0.5000.91
380_I396_K0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o9xA 2 0.2931 97.6 0.93 Contact Map
2gloA 1 0.133 91.2 0.954 Contact Map
3ga8A 1 0.1601 90.1 0.955 Contact Map
1jkoC 1 0.1108 88.4 0.957 Contact Map
1tc3C 1 0.1232 87.7 0.957 Contact Map
2elhA 1 0.1897 86 0.958 Contact Map
1vd4A 1 0.1527 85.9 0.958 Contact Map
1pdnC 1 0.2906 85.9 0.958 Contact Map
1zs4A 4 0.2044 84.9 0.959 Contact Map
2jn6A 1 0.2315 84.7 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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