GREMLIN Database
PF10944 - Uncharacterized protein MT0921.1
UniProt: P9WKP4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 79 (78)
Sequences: 2456 (1524)
Seq/√Len: 172.6
META: 0.94

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_E36_Q3.3311.00
42_I72_A2.6931.00
71_P74_Q2.4921.00
57_L62_G2.4851.00
73_D77_G2.3841.00
47_C69_V2.2911.00
38_R41_E2.2111.00
53_Q67_A2.0551.00
20_R41_E2.0271.00
6_L55_R1.9201.00
10_R14_A1.9081.00
18_A22_Q1.7961.00
57_L66_E1.7421.00
8_H11_D1.5841.00
39_R43_E1.5461.00
2_D58_R1.5411.00
63_D66_E1.5391.00
29_S33_E1.4151.00
53_Q70_R1.4141.00
22_Q33_E1.3671.00
14_A18_A1.3651.00
32_E35_Q1.3591.00
57_L60_T1.3491.00
35_Q39_R1.3291.00
4_E43_E1.3291.00
57_L67_A1.3261.00
38_R42_I1.2871.00
53_Q57_L1.2811.00
23_L34_Q1.2601.00
74_Q77_G1.2541.00
28_I33_E1.2321.00
8_H43_E1.2211.00
23_L29_S1.2111.00
6_L10_R1.1311.00
62_G66_E1.0941.00
7_A11_D1.0681.00
8_H47_C1.0490.99
3_S8_H1.0470.99
17_K21_A1.0250.99
69_V72_A1.0240.99
23_L28_I1.0080.99
43_E46_Q0.9780.99
46_Q72_A0.9630.99
3_S7_A0.9590.99
18_A21_A0.9490.99
31_S35_Q0.9390.99
4_E7_A0.9370.99
29_S32_E0.9290.99
6_L13_V0.9210.99
39_R42_I0.9180.99
6_L43_E0.9150.99
34_Q38_R0.9110.99
1_T4_E0.8790.98
74_Q79_T0.8730.98
20_R37_L0.8570.98
12_L15_E0.8280.97
36_Q40_I0.8120.97
10_R52_R0.7970.97
12_L40_I0.7850.96
37_L40_I0.7750.96
17_K20_R0.7710.96
36_Q39_R0.7710.96
15_E18_A0.7580.96
11_D18_A0.7540.95
35_Q38_R0.7450.95
2_D15_E0.7420.95
20_R23_L0.7370.95
1_T65_R0.7190.94
55_R59_Q0.7160.94
13_V52_R0.7050.93
13_V20_R0.7040.93
25_H28_I0.6970.93
31_S34_Q0.6850.92
20_R34_Q0.6850.92
23_L27_G0.6790.92
10_R13_V0.6680.92
23_L33_E0.6640.91
56_A59_Q0.6640.91
17_K58_R0.6580.91
13_V40_I0.6580.91
26_G29_S0.6550.91
17_K48_W0.6500.90
21_A24_R0.6470.90
7_A14_A0.6440.90
69_V79_T0.6370.89
53_Q62_G0.6250.89
46_Q69_V0.6200.88
11_D15_E0.6190.88
7_A10_R0.6120.88
38_R46_Q0.6100.87
70_R74_Q0.6040.87
42_I76_E0.6020.87
58_R74_Q0.5880.85
14_A17_K0.5840.85
73_D79_T0.5820.85
20_R24_R0.5700.84
56_A60_T0.5630.83
21_A25_H0.5540.82
5_T20_R0.5460.81
62_G68_V0.5450.81
24_R27_G0.5440.81
8_H12_L0.5400.80
44_L47_C0.5330.79
48_W65_R0.5290.79
65_R68_V0.5280.79
22_Q27_G0.5280.79
33_E36_Q0.5200.78
13_V48_W0.5200.78
11_D14_A0.5190.78
62_G65_R0.5180.77
20_R52_R0.5180.77
44_L51_L0.5130.77
20_R62_G0.5110.77
23_L26_G0.5100.76
47_C51_L0.5100.76
20_R74_Q0.5060.76
56_A67_A0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wo8A 2 0.7342 12 0.916 Contact Map
1t3wA 4 0.5823 10.4 0.918 Contact Map
3abzA 3 0.8101 10.1 0.919 Contact Map
3rrxA 1 0.8101 8.9 0.92 Contact Map
4i3gA 1 0.8101 8.9 0.92 Contact Map
2x41A 1 0.8101 8.6 0.921 Contact Map
4yyfA 1 0.7722 7.9 0.922 Contact Map
3zyzA 1 0.8228 6.8 0.924 Contact Map
2r9iA 1 0.7089 6.8 0.925 Contact Map
3tevA 1 0.7722 6.7 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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