GREMLIN Database
PF16170 - (250-346) Uncharacterized protein MT0969
UniProt: P9WKN6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 97 (87)
Sequences: 928 (637)
Seq/√Len: 68.3
META: 0.411

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_G34_Y4.0121.00
31_D35_H3.4291.00
11_T58_T3.0721.00
21_V40_V3.0621.00
5_D22_R3.0531.00
8_A21_V3.0471.00
55_A66_A2.6351.00
58_T63_S2.5591.00
56_T63_S2.4541.00
59_I62_R2.3911.00
39_T72_T2.3691.00
9_T16_R2.0451.00
72_T76_T1.9691.00
20_R41_F1.6520.99
30_I73_P1.6510.99
56_T65_P1.5440.99
8_A19_V1.2740.97
57_L66_A1.2670.96
25_G31_D1.2670.96
23_L79_V1.2300.96
47_T75_G1.1970.95
5_D20_R1.1730.94
22_R33_N1.1670.94
70_E76_T1.1590.94
50_T53_R1.1550.94
77_H87_Y1.1150.93
25_G37_Q1.1090.93
80_A85_P1.1060.92
72_T78_S1.1040.92
40_V79_V1.0930.92
57_L79_V1.0680.91
28_D31_D1.0510.90
35_H80_A1.0430.90
4_Y7_A1.0150.89
49_L79_V1.0100.89
77_H85_P1.0060.88
46_E71_Q0.9910.88
24_T76_T0.9600.86
59_I70_E0.9550.86
35_H82_V0.9530.86
12_L15_A0.9400.85
30_I34_Y0.9340.84
15_A45_P0.9170.83
83_G86_P0.9130.83
31_D67_R0.8990.82
63_S68_I0.8980.82
11_T16_R0.8930.82
67_R83_G0.8890.81
82_V85_P0.8880.81
25_G30_I0.8860.81
34_Y51_H0.8860.81
42_D76_T0.8860.81
81_G87_Y0.8750.80
21_V29_P0.8720.80
49_L58_T0.8640.79
59_I76_T0.8630.79
39_T78_S0.8620.79
27_L69_T0.8390.77
8_A30_I0.8200.76
24_T30_I0.8160.75
10_L17_F0.8070.75
31_D77_H0.8020.74
70_E85_P0.7940.73
14_G61_G0.7930.73
32_G85_P0.7930.73
28_D33_N0.7880.73
61_G88_A0.7850.73
26_H37_Q0.7750.72
12_L55_A0.7600.70
78_S81_G0.7500.69
35_H69_T0.7490.69
18_R47_T0.7440.68
7_A18_R0.7430.68
54_A65_P0.7360.68
37_Q70_E0.7360.68
37_Q76_T0.7360.68
11_T14_G0.7330.67
20_R23_L0.7160.66
9_T60_G0.7100.65
26_H30_I0.6990.64
75_G83_G0.6980.64
66_A79_V0.6970.63
45_P48_S0.6880.62
3_T39_T0.6780.61
3_T56_T0.6740.61
3_T72_T0.6720.61
12_L16_R0.6670.60
29_P68_I0.6640.60
39_T46_E0.6640.60
13_A16_R0.6610.59
8_A40_V0.6550.59
31_D85_P0.6510.58
26_H34_Y0.6500.58
53_R80_A0.6460.58
48_S56_T0.6450.57
15_A65_P0.6400.57
13_A27_L0.6380.57
33_N82_V0.6260.55
11_T65_P0.6250.55
24_T34_Y0.6140.54
81_G86_P0.6130.54
5_D35_H0.6100.53
9_T58_T0.6060.53
23_L42_D0.6040.53
35_H73_P0.5960.52
52_A67_R0.5860.50
31_D66_A0.5850.50
71_Q77_H0.5850.50
9_T18_R0.5820.50
70_E74_W0.5780.50
34_Y47_T0.5700.49
37_Q78_S0.5690.48
71_Q74_W0.5660.48
9_T15_A0.5660.48
4_Y87_Y0.5600.47
48_S88_A0.5580.47
52_A79_V0.5550.47
43_S46_E0.5360.45
42_D47_T0.5300.44
14_G63_S0.5260.43
12_L63_S0.5240.43
7_A30_I0.5240.43
2_Q12_L0.5230.43
69_T72_T0.5230.43
5_D65_P0.5220.43
69_T78_S0.5190.43
37_Q81_G0.5150.42
64_A82_V0.5100.41
24_T80_A0.5030.41
3_T11_T0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aw7A 1 0.7732 29 0.915 Contact Map
3r7fA 3 0.3299 5.5 0.939 Contact Map
4pdxA 2 0.9175 4.1 0.942 Contact Map
4pj0O 1 0.3505 3.4 0.945 Contact Map
3boeA 1 0.5876 3.3 0.945 Contact Map
3wu2O 1 0.3505 3.2 0.945 Contact Map
2f0cA 3 0.4433 3.1 0.946 Contact Map
2cfuA 2 0.9485 2.9 0.946 Contact Map
4r8xA 4 0.9175 2.9 0.946 Contact Map
4egvA 1 0.732 2.5 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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