GREMLIN Database
PF02325 - Uncharacterized protein YggT
UniProt: P64564 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 188 (169)
Sequences: 2974 (2086)
Seq/√Len: 160.5
META: 0.727

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_I158_L4.4931.00
45_Q49_G3.1361.00
103_G162_L2.8591.00
156_M163_Y2.7001.00
57_A63_S2.6501.00
113_M134_A2.6451.00
135_D142_R2.6011.00
109_V134_A2.5961.00
57_A60_P2.5351.00
145_L148_M2.3551.00
110_L158_L2.3161.00
25_M30_C2.2801.00
24_W133_L2.2431.00
141_I157_I2.2281.00
3_T164_V2.0931.00
73_S76_K2.0881.00
48_I65_S2.0581.00
52_R62_D2.0401.00
135_D139_R2.0391.00
58_M63_S1.8811.00
12_I76_K1.8441.00
148_M153_F1.8241.00
20_L69_A1.8181.00
141_I154_S1.8001.00
47_I50_P1.7991.00
9_S13_E1.6731.00
104_L108_W1.6551.00
16_T72_L1.6181.00
110_L155_P1.6041.00
156_M159_V1.5781.00
131_I135_D1.5761.00
141_I161_L1.5601.00
47_I68_V1.5581.00
145_L157_I1.5501.00
108_W112_V1.5411.00
61_I66_L1.5361.00
161_L165_I1.5101.00
104_L166_N1.5051.00
3_T168_G1.5001.00
39_F43_V1.4781.00
15_Y19_L1.4751.00
116_M127_E1.4581.00
19_L68_V1.4541.00
105_L109_V1.4351.00
107_F111_L1.4161.00
74_F94_G1.3861.00
18_V43_V1.3601.00
100_K166_N1.3331.00
39_F148_M1.3281.00
159_V163_Y1.3141.00
115_I119_V1.3131.00
20_L102_I1.3131.00
6_F160_L1.2961.00
10_T160_L1.2851.00
111_L115_I1.2761.00
69_A98_L1.2631.00
102_I106_I1.2551.00
55_I67_L1.2421.00
113_M135_D1.2391.00
50_P54_V1.2281.00
32_F41_V1.2181.00
6_F10_T1.2101.00
107_F162_L1.2031.00
14_L18_V1.1961.00
24_W102_I1.1761.00
137_L158_L1.1721.00
153_F156_M1.1711.00
22_R44_T1.1581.00
16_T73_S1.1581.00
103_G166_N1.1491.00
76_K97_I1.1461.00
107_F166_N1.1211.00
6_F167_M1.1141.00
31_D128_Y1.1121.00
70_Y74_F1.1101.00
141_I144_L1.1061.00
74_F90_I1.1031.00
106_I137_L1.0850.99
164_V170_A1.0700.99
145_L153_F1.0670.99
92_I96_L1.0660.99
62_D65_S1.0600.99
113_M131_I1.0400.99
141_I145_L1.0120.99
114_A119_V1.0080.99
17_M101_T1.0080.99
25_M37_S0.9690.99
23_I65_S0.9680.99
27_W61_I0.9680.99
109_V130_L0.9660.99
28_A106_I0.9640.99
19_L47_I0.9570.99
52_R57_A0.9500.99
139_R143_R0.9460.99
82_K86_F0.9460.99
123_R128_Y0.9450.99
152_D155_P0.9420.99
18_V40_V0.9340.98
116_M119_V0.9210.98
5_T80_L0.9170.98
3_T167_M0.9110.98
128_Y132_Q0.9070.98
73_S97_I0.9010.98
55_I60_P0.8990.98
111_L159_V0.8990.98
8_L83_V0.8910.98
11_V160_L0.8900.98
26_Q62_D0.8890.98
17_M105_L0.8820.98
38_Q42_K0.8760.98
48_I68_V0.8740.98
103_G165_I0.8720.98
145_L154_S0.8720.98
163_Y167_M0.8700.98
160_L164_V0.8700.98
139_R142_R0.8680.97
43_V148_M0.8680.97
114_A138_L0.8580.97
23_I66_L0.8580.97
90_I94_G0.8570.97
79_V82_K0.8410.97
60_P63_S0.8360.97
114_A159_V0.8360.97
110_L138_L0.8360.97
138_L155_P0.8260.97
33_Y41_V0.8230.97
110_L159_V0.8180.96
12_I72_L0.8180.96
12_I16_T0.8160.96
59_G63_S0.8110.96
16_T101_T0.8070.96
107_F163_Y0.7950.96
6_F163_Y0.7930.96
69_A105_L0.7890.96
24_W106_I0.7890.96
10_T14_L0.7830.95
19_L48_I0.7750.95
111_L162_L0.7600.95
74_F78_I0.7560.94
77_A90_I0.7550.94
3_T170_A0.7490.94
138_L156_M0.7440.94
160_L167_M0.7430.94
164_V167_M0.7410.94
18_V44_T0.7360.94
32_F38_Q0.7350.94
57_A62_D0.7320.93
163_Y166_N0.7250.93
15_Y72_L0.7240.93
22_R136_P0.7210.93
131_I134_A0.7210.93
162_L166_N0.7110.92
114_A156_M0.7040.92
114_A118_W0.7030.92
16_T19_L0.7010.92
157_I161_L0.7000.92
53_R56_P0.6930.91
31_D132_Q0.6900.91
36_F126_I0.6880.91
23_I27_W0.6770.91
71_I75_I0.6760.90
150_G163_Y0.6750.90
82_K88_P0.6700.90
3_T6_F0.6700.90
13_E164_V0.6670.90
5_T9_S0.6660.90
75_I78_I0.6620.90
106_I134_A0.6590.89
13_E16_T0.6570.89
80_L84_V0.6560.89
140_P144_L0.6560.89
7_L164_V0.6470.88
77_A81_F0.6390.88
41_V45_Q0.6370.88
51_L68_V0.6340.87
89_I92_I0.6340.87
103_G169_V0.6330.87
135_D151_I0.6330.87
116_M140_P0.6310.87
144_L154_S0.6300.87
120_S127_E0.6300.87
77_A97_I0.6250.87
106_I110_L0.6250.87
21_L133_L0.6250.87
21_L25_M0.6230.87
8_L79_V0.6220.86
69_A94_G0.6160.86
142_R147_A0.6160.86
111_L114_A0.6150.86
16_T98_L0.6080.85
87_L94_G0.6080.85
22_R26_Q0.6060.85
114_A155_P0.6000.84
70_Y94_G0.5960.84
14_L160_L0.5960.84
157_I160_L0.5950.84
90_I96_L0.5950.84
76_K80_L0.5940.84
43_V46_P0.5920.84
19_L72_L0.5900.83
112_V130_L0.5890.83
51_L64_A0.5870.83
30_C34_N0.5860.83
150_G156_M0.5840.83
2_N5_T0.5810.82
8_L76_K0.5800.82
7_L160_L0.5790.82
137_L141_I0.5790.82
82_K85_T0.5780.82
114_A130_L0.5770.82
4_L164_V0.5750.82
52_R65_S0.5680.81
81_F84_V0.5670.81
135_D154_S0.5670.81
13_E76_K0.5660.81
34_N37_S0.5610.80
72_L75_I0.5600.80
78_I90_I0.5600.80
32_F37_S0.5590.80
127_E130_L0.5590.80
103_G107_F0.5530.79
93_A97_I0.5510.79
51_L122_G0.5460.78
141_I148_M0.5440.78
118_W153_F0.5440.78
37_S40_V0.5430.78
41_V59_G0.5430.78
12_I130_L0.5410.78
30_C33_Y0.5380.77
6_F164_V0.5370.77
44_T62_D0.5370.77
107_F123_R0.5350.77
28_A31_D0.5350.77
15_Y39_F0.5340.77
127_E131_I0.5330.77
33_Y132_Q0.5310.77
153_F157_I0.5300.76
19_L32_F0.5280.76
37_S132_Q0.5280.76
104_L107_F0.5240.76
134_A137_L0.5240.76
30_C106_I0.5240.76
70_Y91_W0.5240.76
97_I101_T0.5230.75
15_Y47_I0.5230.75
110_L137_L0.5160.74
42_K148_M0.5160.74
114_A147_A0.5120.74
46_P124_S0.5090.74
88_P92_I0.5080.73
108_W156_M0.5060.73
89_I93_A0.5050.73
88_P91_W0.5020.72
110_L162_L0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nwlA 3 0.766 2.3 0.96 Contact Map
1ymmC 1 0.0745 1.7 0.963 Contact Map
4p6vD 1 0.4574 1.4 0.965 Contact Map
3j1rA 5 0.1383 1.3 0.966 Contact Map
4b19A 1 0.1596 1.2 0.966 Contact Map
3j9pD 4 0.8457 1 0.968 Contact Map
2lq1A 1 0.0691 1 0.968 Contact Map
4o2hA 2 0.2553 0.8 0.97 Contact Map
1b9uA 1 0.1809 0.7 0.971 Contact Map
3g7pA 2 0.4309 0.7 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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