GREMLIN Database
PF05284 - Uncharacterized protein y4eB
UniProt: P55425 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 101 (100)
Sequences: 1301 (677)
Seq/√Len: 67.7
META:

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_A66_L6.4911.00
42_F56_Q2.8981.00
29_I68_V2.6971.00
34_N41_H2.5641.00
71_D78_P2.4551.00
19_R24_N2.2501.00
71_D98_R2.1451.00
45_Y49_V2.0281.00
41_H56_Q2.0231.00
17_S26_K1.9581.00
29_I44_I1.8341.00
22_A74_S1.8291.00
59_S62_D1.7611.00
44_I70_L1.7071.00
21_L25_V1.6910.99
56_Q64_D1.6840.99
50_E53_A1.6320.99
92_Y95_I1.6010.99
69_K78_P1.5910.99
57_K80_Y1.5750.99
82_T95_I1.5630.99
86_V91_G1.5170.99
54_A68_V1.4620.99
57_K65_Y1.4520.98
86_V93_Q1.4520.98
27_A51_L1.4360.98
58_R64_D1.4120.98
30_G45_Y1.3810.98
45_Y48_A1.3750.98
3_T9_S1.3590.98
36_S39_G1.3480.97
27_A31_R1.3400.97
43_R50_E1.3340.97
82_T97_S1.2590.96
97_S100_N1.2390.96
29_I42_F1.2090.95
60_E64_D1.2000.95
8_T13_G1.2000.95
10_T13_G1.1910.95
57_K82_T1.1840.95
20_T72_D1.1810.95
46_A51_L1.1500.94
68_V88_G1.1450.94
78_P98_R1.1120.93
23_L49_V1.0860.92
1_M4_I1.0850.92
14_F23_L1.0820.91
18_I51_L1.0490.90
7_F94_L1.0470.90
34_N39_G1.0130.89
39_G69_K1.0130.89
85_E90_D1.0100.88
17_S24_N0.9760.87
25_V51_L0.9740.86
35_P68_V0.9400.84
2_A6_T0.9230.83
70_L79_I0.9000.82
69_K80_Y0.8960.82
83_L94_L0.8830.81
67_S97_S0.8650.79
82_T92_Y0.8630.79
25_V46_A0.8590.79
88_G91_G0.8540.78
59_S63_R0.8430.77
19_R49_V0.8380.77
18_I100_N0.8380.77
23_L58_R0.8370.77
35_P51_L0.8360.77
8_T67_S0.8200.75
44_I68_V0.8180.75
85_E92_Y0.8150.75
29_I32_I0.7970.73
19_R51_L0.7970.73
66_L82_T0.7860.72
57_K67_S0.7840.72
45_Y50_E0.7830.72
67_S80_Y0.7830.72
18_I27_A0.7820.72
8_T90_D0.7710.71
56_Q91_G0.7670.70
37_D60_E0.7650.70
36_S89_E0.7650.70
44_I99_P0.7490.69
9_S31_R0.7430.68
72_D98_R0.7340.67
60_E63_R0.7230.66
14_F92_Y0.7190.65
14_F58_R0.7110.65
86_V89_E0.7060.64
35_P62_D0.7040.64
36_S60_E0.7030.64
43_R53_A0.6940.63
9_S92_Y0.6850.62
42_F66_L0.6760.61
19_R48_A0.6710.60
87_E93_Q0.6570.59
39_G71_D0.6530.58
44_I58_R0.6490.58
68_V94_L0.6450.57
21_L86_V0.6420.57
80_Y95_I0.6340.56
6_T10_T0.6320.56
1_M5_G0.6320.56
59_S65_Y0.6270.55
8_T76_P0.6240.55
18_I78_P0.6220.54
30_G81_A0.6220.54
3_T100_N0.6210.54
46_A49_V0.6150.54
51_L82_T0.6080.53
29_I41_H0.6050.52
48_A60_E0.6050.52
10_T15_T0.5980.52
57_K100_N0.5970.51
37_D59_S0.5970.51
22_A76_P0.5970.51
54_A67_S0.5950.51
39_G43_R0.5940.51
20_T42_F0.5770.49
63_R80_Y0.5580.47
80_Y85_E0.5570.47
7_F98_R0.5560.47
39_G84_T0.5510.46
79_I93_Q0.5500.46
38_K62_D0.5500.46
53_A57_K0.5490.46
14_F66_L0.5490.46
80_Y92_Y0.5430.45
53_A67_S0.5400.45
78_P94_L0.5390.45
30_G42_F0.5380.44
19_R25_V0.5340.44
13_G42_F0.5330.44
84_T92_Y0.5330.44
38_K61_Q0.5320.44
12_N18_I0.5320.44
36_S61_Q0.5320.44
13_G32_I0.5310.44
35_P39_G0.5280.43
29_I54_A0.5270.43
72_D78_P0.5270.43
57_K60_E0.5260.43
13_G19_R0.5220.43
23_L72_D0.5130.42
58_R62_D0.5100.41
49_V99_P0.5060.41
70_L74_S0.5040.40
84_T95_I0.5010.40
28_R47_G0.5000.40
41_H58_R0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nqaA 3 0.5347 16.7 0.931 Contact Map
2dlgA 1 0.6139 12.9 0.935 Contact Map
2j7nA 2 0.9109 10 0.938 Contact Map
1qxpA 1 0.7426 8.2 0.94 Contact Map
3zfdA 1 0.4059 6.6 0.943 Contact Map
1v8kA 3 0.3069 6.1 0.944 Contact Map
2r9fA 1 0.5347 5.9 0.944 Contact Map
2vrqA 1 0.901 5.9 0.944 Contact Map
3bowA 1 0.5347 5.6 0.945 Contact Map
2zfiA 1 0.2772 5.4 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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