GREMLIN Database
PF09831 - Uncharacterized protein YaiL
UniProt: P51024 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 176 (170)
Sequences: 1475 (904)
Seq/√Len: 69.3
META: 0.877

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_Q55_E3.5441.00
92_D118_R3.3511.00
92_D129_Y3.3361.00
78_R130_A2.8381.00
55_E59_Q2.7821.00
41_E45_A2.6641.00
58_K62_L2.3991.00
79_I114_L2.2331.00
102_D105_T2.2251.00
87_G98_K2.1811.00
46_Q50_D2.0961.00
87_G100_F2.0791.00
61_A65_E2.0701.00
48_E52_Q2.0541.00
40_E43_K2.0411.00
107_A111_N2.0251.00
117_A132_I2.0161.00
1_L5_E1.9951.00
81_I130_A1.9611.00
105_T131_I1.9151.00
14_T17_K1.8811.00
15_S19_A1.8711.00
88_F150_L1.8681.00
52_Q56_Q1.8501.00
117_A148_I1.8411.00
86_I106_Q1.8291.00
23_R26_K1.8131.00
138_D142_Q1.8031.00
166_A169_K1.6921.00
33_R36_R1.6841.00
62_L65_E1.6771.00
42_N46_Q1.6751.00
56_Q59_Q1.6741.00
69_Q143_R1.6540.99
115_A137_A1.6460.99
70_V144_D1.6290.99
71_K126_E1.6220.99
138_D141_A1.6200.99
16_K23_R1.6100.99
48_E51_K1.5980.99
54_S58_K1.5720.99
43_K46_Q1.5230.99
40_E44_K1.5070.99
49_R53_L1.4720.99
70_V140_I1.4390.98
57_Q60_A1.4290.98
106_Q110_I1.4240.98
1_L9_K1.4180.98
90_F129_Y1.4060.98
37_A40_E1.3960.98
17_K21_V1.3950.98
103_K107_A1.3420.98
35_A39_V1.3340.97
65_E69_Q1.3230.97
70_V147_S1.3030.97
55_E58_K1.2890.97
132_I136_V1.2870.97
134_A138_D1.2770.97
157_E162_D1.2740.97
39_V42_N1.2650.97
73_L136_V1.2440.96
44_K48_E1.2390.96
114_L131_I1.2390.96
85_D103_K1.2330.96
34_E37_A1.2120.96
101_V109_L1.1690.95
4_Q8_L1.1680.95
58_K61_A1.1650.94
159_Q164_P1.1640.94
132_I148_I1.1640.94
4_Q22_E1.1590.94
68_A143_R1.1440.94
38_A41_E1.1380.94
34_E38_A1.1360.94
59_Q62_L1.1210.93
164_P167_D1.1160.93
33_R37_A1.1120.93
53_L57_Q1.1090.93
59_Q63_A1.0880.92
164_P169_K1.0760.92
73_L76_M1.0720.92
13_V17_K1.0690.91
2_T5_E1.0480.91
37_A41_E1.0410.90
89_N98_K1.0380.90
54_S65_E1.0340.90
160_D164_P1.0220.90
62_L66_Y1.0160.89
39_V74_I1.0160.89
43_K47_L1.0070.89
44_K47_L0.9980.88
18_A21_V0.9920.88
171_P176_W0.9750.87
105_T114_L0.9720.87
153_A156_A0.9630.87
12_L23_R0.9570.86
118_R149_V0.9520.86
140_I143_R0.9490.86
51_K55_E0.9490.86
173_D176_W0.9490.86
71_K75_E0.9470.86
165_Y168_F0.9200.84
161_E164_P0.9130.83
164_P168_F0.9100.83
108_Q113_R0.9100.83
14_T23_R0.9040.83
75_E78_R0.9030.83
56_Q60_A0.9030.83
158_E161_E0.9010.83
138_D151_H0.8990.83
84_G102_D0.8800.81
74_I119_L0.8790.81
72_Q75_E0.8720.81
70_V146_S0.8680.80
17_K20_K0.8640.80
103_K106_Q0.8600.80
3_L7_L0.8480.79
159_Q169_K0.8430.78
116_I149_V0.8430.78
171_P174_L0.8370.78
115_A150_L0.8290.77
172_D176_W0.8280.77
104_L108_Q0.8250.77
20_K25_A0.8010.75
14_T105_T0.7980.74
77_N136_V0.7960.74
22_E26_K0.7940.74
43_K111_N0.7940.74
24_T30_V0.7890.74
62_L69_Q0.7880.73
68_A139_K0.7840.73
66_Y139_K0.7750.72
82_A102_D0.7550.70
1_L4_Q0.7540.70
115_A134_A0.7520.70
4_Q17_K0.7490.70
107_A110_I0.7460.69
119_L126_E0.7410.69
15_S22_E0.7340.68
36_R70_V0.7300.68
69_Q139_K0.7250.67
77_N103_K0.7250.67
49_R52_Q0.7200.67
26_K31_Q0.7160.66
20_K30_V0.7130.66
86_I103_K0.7130.66
159_Q163_D0.7090.65
15_S18_A0.7090.65
36_R40_E0.7050.65
141_A147_S0.7000.64
132_I140_I0.6980.64
159_Q162_D0.6950.64
117_A130_A0.6950.64
41_E44_K0.6880.63
74_I133_P0.6870.63
75_E119_L0.6800.62
63_A168_F0.6770.62
2_T7_L0.6760.62
54_S57_Q0.6740.61
158_E164_P0.6720.61
80_T84_G0.6670.61
134_A151_H0.6650.60
91_T94_N0.6650.60
95_L153_A0.6640.60
23_R30_V0.6580.60
119_L128_E0.6570.59
5_E64_K0.6530.59
85_D127_G0.6520.59
42_N45_A0.6510.59
2_T18_A0.6500.59
40_E47_L0.6490.59
47_L51_K0.6490.59
153_A168_F0.6470.58
47_L143_R0.6470.58
155_S160_D0.6440.58
118_R129_Y0.6410.58
79_I133_P0.6380.57
7_L28_S0.6360.57
38_A87_G0.6330.57
10_A85_D0.6330.57
27_K31_Q0.6320.57
82_A131_I0.6310.56
25_A30_V0.6290.56
67_K144_D0.6260.56
73_L142_Q0.6210.55
60_A63_A0.6170.55
141_A151_H0.6170.55
64_K161_E0.6170.55
38_A42_N0.6160.55
26_K30_V0.6160.55
33_R83_N0.6120.54
3_L6_Q0.6110.54
62_L135_S0.6060.53
75_E126_E0.6050.53
47_L50_D0.6030.53
50_D53_L0.5920.52
88_F116_I0.5910.52
24_T27_K0.5900.52
63_A67_K0.5860.51
70_V136_V0.5850.51
80_T102_D0.5820.51
81_I105_T0.5770.50
98_K170_V0.5730.49
102_D108_Q0.5730.49
88_F152_S0.5650.49
136_V143_R0.5640.48
7_L62_L0.5640.48
15_S30_V0.5570.48
114_L154_L0.5530.47
104_L107_A0.5530.47
81_I98_K0.5520.47
74_I147_S0.5510.47
41_E48_E0.5480.46
108_Q145_A0.5470.46
64_K116_I0.5450.46
15_S23_R0.5450.46
96_I99_I0.5440.46
39_V128_E0.5430.46
79_I89_N0.5430.46
22_E30_V0.5420.46
79_I105_T0.5420.46
12_L15_S0.5410.46
139_K143_R0.5400.45
165_Y172_D0.5400.45
88_F110_I0.5380.45
66_Y69_Q0.5370.45
69_Q73_L0.5370.45
100_F128_E0.5350.45
31_Q159_Q0.5340.45
1_L18_A0.5330.45
4_Q66_Y0.5330.45
73_L133_P0.5290.44
4_Q25_A0.5290.44
49_R170_V0.5250.44
119_L162_D0.5240.44
16_K27_K0.5240.44
93_G99_I0.5230.43
27_K51_K0.5160.43
66_Y162_D0.5150.43
84_G109_L0.5140.42
52_Q96_I0.5140.42
88_F151_H0.5130.42
27_K30_V0.5120.42
111_N152_S0.5120.42
170_V176_W0.5110.42
37_A67_K0.5050.41
98_K106_Q0.5040.41
39_V57_Q0.5040.41
45_A111_N0.5040.41
24_T28_S0.5040.41
5_E8_L0.5030.41
141_A145_A0.5010.41
66_Y143_R0.5000.41
33_R149_V0.5000.41
115_A151_H0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xk8G 1 0.3807 8.6 0.958 Contact Map
4phrA 1 0.4773 4.5 0.963 Contact Map
4relA 1 0.358 4.1 0.964 Contact Map
1pkhA 5 0.3693 3.5 0.965 Contact Map
2kccA 1 0.4659 3.5 0.965 Contact Map
3ojaB 1 0.4432 2.8 0.967 Contact Map
3cm1A 3 0.2784 2.5 0.967 Contact Map
3ky8A 2 0.3466 2.4 0.968 Contact Map
2id0A 1 0.5852 2.3 0.968 Contact Map
1tj7A 4 0.517 2.2 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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