GREMLIN Database
PF09369 - (390-749) Uncharacterized ATP-dependent helicase YprA
UniProt: P50830 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 360 (343)
Sequences: 3275 (2117)
Seq/√Len: 114.3
META: 0.611

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_E163_R6.2221.00
150_V162_V5.8821.00
200_V236_A4.8391.00
111_I162_V4.3721.00
198_G238_W3.7901.00
9_A19_V3.7751.00
184_I187_T3.3651.00
195_L315_F3.2861.00
51_A80_L3.0671.00
126_M135_L3.0191.00
323_K327_T2.9171.00
183_E199_D2.8841.00
197_Y235_S2.8801.00
290_T294_T2.6651.00
179_L282_V2.6481.00
140_I165_V2.5481.00
263_V326_I2.4471.00
314_R317_D2.4371.00
324_Q328_H2.4051.00
344_E348_A2.3831.00
206_P225_I2.3241.00
140_I149_Q2.2451.00
188_K316_S2.2201.00
135_L160_A2.2191.00
111_I124_G2.2091.00
146_V164_K2.2011.00
58_A82_R2.1611.00
57_R60_E2.1591.00
82_R85_E2.1011.00
137_D152_K2.0591.00
180_K201_T2.0481.00
187_T194_S2.0401.00
153_L160_A2.0231.00
109_V132_M1.9841.00
310_E314_R1.9841.00
201_T233_H1.9751.00
201_T231_E1.9611.00
72_E75_Q1.9101.00
182_L201_T1.8971.00
240_E294_T1.8901.00
213_K218_E1.8711.00
169_Y211_K1.8521.00
246_E253_L1.8441.00
268_V311_V1.8371.00
186_K313_K1.8361.00
131_A160_A1.8171.00
152_K161_Y1.8171.00
109_V128_R1.7971.00
267_I325_L1.7961.00
203_N231_E1.7931.00
189_E194_S1.7531.00
111_I135_L1.7461.00
185_D199_D1.7421.00
203_N229_E1.7371.00
56_F71_L1.7231.00
287_A290_T1.7131.00
263_V322_A1.7111.00
114_Q151_E1.7021.00
49_C99_I1.7001.00
109_V160_A1.6781.00
75_Q82_R1.6391.00
149_Q165_V1.6371.00
209_F223_G1.6351.00
108_N125_E1.6111.00
44_V73_Y1.5991.00
154_D157_H1.5991.00
287_A296_F1.5951.00
44_V70_I1.5661.00
109_V131_A1.5531.00
237_A297_L1.5291.00
210_K219_N1.5281.00
36_N310_E1.5261.00
258_L262_N1.5191.00
109_V155_W1.5111.00
111_I126_M1.5001.00
175_L204_A1.4991.00
181_V296_F1.4801.00
140_I167_V1.4721.00
187_T196_H1.4641.00
113_D116_D1.4461.00
258_L344_E1.4451.00
268_V279_V1.4441.00
21_H328_H1.4341.00
240_E292_L1.4331.00
181_V289_H1.4281.00
235_S309_E1.4251.00
205_L229_E1.3761.00
212_I219_N1.3701.00
249_G252_T1.3501.00
257_L293_P1.3421.00
124_G141_Y1.3351.00
128_R230_E1.3341.00
316_S320_E1.3321.00
28_R337_S1.3301.00
109_V158_K1.3241.00
237_A315_F1.3231.00
132_M230_E1.3201.00
102_R141_Y1.3201.00
68_S72_E1.3191.00
185_D235_S1.3141.00
310_E313_K1.3111.00
315_F319_N1.3081.00
116_D120_V1.3061.00
147_Q167_V1.3011.00
170_Y217_F1.3001.00
199_D233_H1.2920.99
271_Y321_A1.2920.99
131_A135_L1.2880.99
102_R124_G1.2870.99
41_I309_E1.2850.99
186_K309_E1.2840.99
284_Q287_A1.2790.99
48_K79_V1.2750.99
210_K222_S1.2710.99
18_I24_Y1.2570.99
311_V318_I1.2560.99
190_K193_T1.2480.99
264_L322_A1.2470.99
172_D212_I1.2410.99
267_I322_A1.2260.99
71_L87_Y1.2210.99
109_V135_L1.2130.99
264_L297_L1.2100.99
23_E27_N1.2040.99
265_Q281_V1.2030.99
75_Q87_Y1.1960.99
184_I196_H1.1900.99
127_D130_S1.1800.99
47_L70_I1.1780.99
7_M19_V1.1770.99
94_F97_S1.1710.99
208_I222_S1.1690.99
32_S310_E1.1640.99
62_F67_V1.1620.99
114_Q163_R1.1590.99
69_D72_E1.1580.99
33_A273_M1.1500.99
58_A68_S1.1480.99
132_M155_W1.1400.99
258_L261_S1.1390.99
56_F60_E1.1290.99
343_I348_A1.1250.99
260_I323_K1.1190.99
16_Q19_V1.1170.98
62_F65_M1.1100.98
263_V325_L1.1080.98
114_Q152_K1.1060.98
341_T344_E1.1050.98
75_Q80_L1.1040.98
261_S281_V1.1030.98
188_K195_L1.1010.98
262_N344_E1.1000.98
335_C338_C1.0990.98
133_T175_L1.0800.98
168_E213_K1.0710.98
71_L80_L1.0710.98
107_E128_R1.0570.98
297_L318_I1.0520.98
110_V122_I1.0440.98
21_H324_Q1.0380.98
334_G338_C1.0330.97
126_M130_S1.0330.97
177_V204_A1.0240.97
24_Y337_S1.0140.97
44_V77_E1.0130.97
276_R343_I1.0100.97
211_K221_G1.0090.97
128_R132_M1.0070.97
243_T292_L0.9970.97
95_P98_N0.9950.97
50_A55_P0.9840.97
189_E192_R0.9840.97
188_K312_F0.9790.97
107_E158_K0.9770.96
331_C335_C0.9680.96
24_Y28_R0.9640.96
182_L233_H0.9620.96
280_H300_H0.9550.96
18_I270_V0.9520.96
261_S265_Q0.9450.96
261_S283_S0.9410.96
345_G348_A0.9350.95
83_N88_H0.9340.95
243_T247_D0.9290.95
242_K256_L0.9180.95
178_Q288_A0.9110.95
320_E324_Q0.9090.95
279_V300_H0.9070.95
331_C334_G0.9010.94
329_C334_G0.9000.94
52_Y96_A0.8930.94
343_I346_I0.8910.94
213_K216_T0.8910.94
197_Y309_E0.8890.94
20_R330_P0.8880.94
174_N222_S0.8860.94
130_S134_L0.8810.94
342_E346_I0.8760.94
271_Y314_R0.8750.94
72_E82_R0.8740.94
329_C335_C0.8740.94
324_Q327_T0.8710.93
82_R87_Y0.8710.93
155_W227_L0.8710.93
113_D164_K0.8700.93
262_N265_Q0.8690.93
262_N348_A0.8680.93
149_Q167_V0.8680.93
331_C338_C0.8600.93
168_E214_M0.8590.93
60_E67_V0.8580.93
149_Q169_Y0.8560.93
49_C95_P0.8540.93
47_L67_V0.8510.93
342_E345_G0.8490.93
341_T348_A0.8450.92
19_V26_F0.8450.92
265_Q283_S0.8420.92
189_E193_T0.8390.92
137_D173_A0.8380.92
277_N280_H0.8350.92
130_S135_L0.8330.92
259_G300_H0.8330.92
266_H325_L0.8310.92
59_D68_S0.8300.92
124_G143_H0.8300.92
258_L348_A0.8300.92
133_T204_A0.8290.92
73_Y77_E0.8240.91
253_L285_I0.8170.91
13_P289_H0.8170.91
341_T345_G0.8170.91
242_K292_L0.8160.91
321_A324_Q0.8090.91
130_S160_A0.8060.90
100_S106_Q0.8050.90
329_C338_C0.8050.90
52_Y94_F0.7990.90
259_G265_Q0.7980.90
274_C279_V0.7960.90
42_I305_I0.7960.90
20_R328_H0.7950.90
258_L283_S0.7920.90
172_D210_K0.7920.90
240_E290_T0.7910.90
176_A207_T0.7890.90
256_L259_G0.7850.89
244_A247_D0.7850.89
123_I162_V0.7840.89
100_S105_S0.7830.89
258_L265_Q0.7830.89
132_M227_L0.7790.89
58_A85_E0.7760.89
265_Q300_H0.7720.88
186_K197_Y0.7700.88
149_Q157_H0.7700.88
265_Q282_V0.7680.88
38_E65_M0.7640.88
46_H99_I0.7640.88
102_R206_P0.7630.88
114_Q161_Y0.7570.88
265_Q346_I0.7540.87
239_L264_L0.7540.87
277_N343_I0.7540.87
211_K223_G0.7540.87
69_D73_Y0.7500.87
276_R280_H0.7440.87
280_H311_V0.7410.86
179_L296_F0.7400.86
175_L207_T0.7390.86
71_L74_L0.7370.86
9_A15_D0.7340.86
241_I253_L0.7330.86
243_T250_E0.7310.86
121_R146_V0.7270.85
239_L319_N0.7260.85
299_D303_G0.7250.85
52_Y95_P0.7240.85
47_L56_F0.7230.85
337_S340_G0.7210.85
46_H54_L0.7160.84
203_N255_Q0.7150.84
339_I343_I0.7130.84
3_S216_T0.7130.84
9_A16_Q0.7100.84
115_S164_K0.7080.84
268_V272_I0.7080.84
112_V122_I0.7060.84
163_R166_D0.7050.84
113_D121_R0.7040.83
38_E66_E0.7010.83
272_I349_K0.7000.83
272_I307_L0.7000.83
126_M134_L0.6970.83
155_W160_A0.6950.83
342_E348_A0.6930.82
168_E215_T0.6920.82
67_V71_L0.6920.82
236_A308_A0.6880.82
243_T246_E0.6870.82
140_I169_Y0.6860.82
149_Q163_R0.6820.81
208_I224_P0.6820.81
264_L295_I0.6820.81
187_T312_F0.6810.81
10_N101_L0.6790.81
184_I194_S0.6750.81
62_F66_E0.6750.81
8_V27_N0.6740.81
180_K289_H0.6730.81
49_C91_S0.6720.81
73_Y76_E0.6710.80
297_L322_A0.6710.80
265_Q322_A0.6710.80
110_V220_I0.6710.80
103_S170_Y0.6700.80
256_L310_E0.6680.80
63_G67_V0.6680.80
185_D197_Y0.6680.80
194_S240_E0.6660.80
281_V300_H0.6630.80
265_Q345_G0.6590.79
202_V326_I0.6570.79
20_R325_L0.6560.79
74_L80_L0.6520.79
313_K316_S0.6490.78
45_D48_K0.6490.78
258_L281_V0.6490.78
5_I34_R0.6490.78
128_R158_K0.6450.78
101_L214_M0.6440.78
51_A56_F0.6430.78
5_I17_Y0.6430.78
232_L307_L0.6410.77
272_I311_V0.6410.77
237_A308_A0.6400.77
175_L206_P0.6370.77
341_T346_I0.6360.77
49_C96_A0.6350.77
48_K89_W0.6350.77
109_V153_L0.6330.76
151_E157_H0.6330.76
325_L328_H0.6330.76
266_H276_R0.6300.76
154_D159_K0.6280.76
160_A228_P0.6280.76
182_L199_D0.6280.76
131_A153_L0.6270.76
148_Y324_Q0.6270.76
174_N208_I0.6260.76
32_S314_R0.6260.76
283_S346_I0.6250.76
211_K220_I0.6240.75
248_I251_K0.6230.75
179_L236_A0.6230.75
236_A241_I0.6220.75
42_I52_Y0.6210.75
18_I25_F0.6180.75
322_A325_L0.6170.75
121_R152_K0.6170.75
265_Q297_L0.6160.75
214_M217_F0.6140.74
14_I262_N0.6140.74
136_H150_V0.6140.74
22_P136_H0.6130.74
261_S344_E0.6130.74
43_L144_E0.6120.74
281_V346_I0.6110.74
151_E159_K0.6100.74
139_A209_F0.6100.74
301_Y305_I0.6080.74
216_T219_N0.6080.74
39_N42_I0.6060.73
281_V345_G0.6040.73
12_T15_D0.6040.73
234_T299_D0.6040.73
212_I217_F0.6030.73
259_G345_G0.6020.73
239_L315_F0.6020.73
180_K203_N0.5990.72
196_H240_E0.5980.72
93_S98_N0.5960.72
46_H238_W0.5950.72
95_P99_I0.5950.72
176_A222_S0.5950.72
138_E209_F0.5940.72
237_A311_V0.5930.72
88_H91_S0.5930.72
192_R244_A0.5910.71
72_E76_E0.5910.71
192_R242_K0.5910.71
19_V25_F0.5880.71
71_L82_R0.5880.71
10_N15_D0.5870.71
271_Y317_D0.5870.71
266_H269_P0.5840.71
284_Q288_A0.5820.70
261_S342_E0.5810.70
283_S345_G0.5800.70
213_K220_I0.5790.70
281_V287_A0.5760.70
75_Q88_H0.5760.70
170_Y212_I0.5750.69
18_I28_R0.5750.69
188_K313_K0.5740.69
282_V287_A0.5730.69
20_R25_F0.5730.69
49_C221_G0.5720.69
210_K221_G0.5710.69
237_A318_I0.5710.69
179_L201_T0.5710.69
110_V218_E0.5700.69
178_Q271_Y0.5690.69
265_Q280_H0.5690.69
182_L231_E0.5680.68
320_E327_T0.5680.68
90_A136_H0.5680.68
255_Q345_G0.5670.68
68_S71_L0.5630.68
261_S266_H0.5620.68
269_P279_V0.5620.68
9_A123_I0.5620.68
93_S181_V0.5610.68
135_L273_M0.5610.68
255_Q258_L0.5600.67
259_G262_N0.5580.67
176_A205_L0.5580.67
45_D70_I0.5570.67
261_S280_H0.5570.67
339_I347_K0.5560.67
136_H225_I0.5540.67
115_S167_V0.5530.66
21_H24_Y0.5520.66
71_L75_Q0.5520.66
143_H255_Q0.5510.66
177_V282_V0.5500.66
282_V294_T0.5500.66
116_D121_R0.5490.66
202_V343_I0.5490.66
220_I223_G0.5480.66
199_D235_S0.5480.66
107_E280_H0.5470.66
343_I347_K0.5470.66
327_T330_P0.5460.65
265_Q344_E0.5450.65
194_S292_L0.5450.65
317_D332_H0.5430.65
109_V137_D0.5420.65
204_A302_P0.5410.65
242_K245_D0.5400.65
144_E175_L0.5390.64
11_S14_I0.5390.64
66_E70_I0.5390.64
262_N266_H0.5390.64
66_E216_T0.5380.64
177_V200_V0.5380.64
299_D308_A0.5370.64
17_Y24_Y0.5370.64
7_M26_F0.5360.64
331_C336_P0.5360.64
264_L319_N0.5350.64
255_Q341_T0.5330.64
41_I44_V0.5330.64
96_A273_M0.5330.64
300_H345_G0.5320.63
279_V299_D0.5320.63
66_E69_D0.5310.63
75_Q78_A0.5290.63
122_I168_E0.5290.63
184_I289_H0.5280.63
281_V295_I0.5270.63
3_S35_I0.5260.63
138_E258_L0.5260.63
190_K312_F0.5250.62
46_H101_L0.5240.62
265_Q279_V0.5240.62
52_Y103_S0.5240.62
143_H276_R0.5230.62
70_I73_Y0.5230.62
20_R27_N0.5230.62
319_N323_K0.5220.62
121_R168_E0.5210.62
101_L178_Q0.5210.62
204_A300_H0.5210.62
123_I310_E0.5210.62
147_Q165_V0.5200.62
248_I252_T0.5200.62
174_N207_T0.5200.62
43_L70_I0.5190.62
183_E186_K0.5190.62
109_V126_M0.5190.62
123_I257_L0.5190.62
176_A208_I0.5180.61
101_L219_N0.5170.61
32_S36_N0.5160.61
64_A67_V0.5150.61
262_N281_V0.5140.61
20_R263_V0.5140.61
124_G214_M0.5130.61
264_L271_Y0.5120.61
50_A53_E0.5110.60
18_I232_L0.5080.60
79_V98_N0.5070.60
108_N218_E0.5070.60
105_S129_F0.5060.60
20_R28_R0.5060.60
142_L147_Q0.5060.60
55_P220_I0.5050.59
24_Y27_N0.5040.59
295_I299_D0.5040.59
12_T262_N0.5040.59
327_T332_H0.5030.59
265_Q343_I0.5010.59
4_L12_T0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o8bA 1 0.4139 98.5 0.908 Contact Map
1sqsA 2 0.1889 26.1 0.971 Contact Map
1gteA 4 0.2528 18.3 0.973 Contact Map
1y1bA 1 0.0889 14 0.975 Contact Map
1j7nA 2 0.1778 10.7 0.976 Contact Map
3ipzA 3 0.1167 10.1 0.976 Contact Map
3zywA 1 0.1472 8.2 0.977 Contact Map
3gx8A 1 0.1083 8.2 0.977 Contact Map
4dv8A 1 0.1778 7.7 0.977 Contact Map
2mjgA 2 0.0778 6.9 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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