GREMLIN Database
PF09551 - Stage II sporulation protein R
UniProt: P39151 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 190 (173)
Sequences: 1286 (1099)
Seq/√Len: 83.6
META:

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_T113_G5.6841.00
52_R104_E4.1231.00
34_V108_I3.3341.00
29_H73_E3.2381.00
179_K184_E3.1611.00
26_L70_M2.8231.00
33_A69_T2.7021.00
58_K61_E2.6961.00
19_D116_A2.6871.00
70_M75_A2.5631.00
48_I52_R2.5101.00
66_A79_I2.4591.00
48_I104_E2.3771.00
67_K79_I2.2661.00
69_T72_K2.2231.00
63_K81_V2.1501.00
26_L110_L2.0681.00
10_I55_I2.0261.00
10_I83_F2.0251.00
59_L81_V2.0241.00
63_K67_K1.9581.00
33_A36_K1.9361.00
88_F105_A1.8791.00
85_K102_E1.8241.00
68_E72_K1.7911.00
17_N23_D1.7721.00
70_M77_Q1.7711.00
69_T73_E1.7431.00
10_I52_R1.7291.00
70_M79_I1.7101.00
92_L97_V1.7061.00
9_A98_Y1.7031.00
82_D109_T1.6861.00
67_K71_E1.6591.00
70_M110_L1.6431.00
45_I51_A1.5911.00
15_L109_T1.5891.00
87_S102_E1.5671.00
26_L75_A1.5431.00
2_P6_P1.5331.00
79_I110_L1.5160.99
63_K80_S1.5080.99
18_S23_D1.4730.99
9_A13_R1.4290.99
86_I107_L1.4280.99
59_L106_I1.4250.99
28_R32_D1.4070.99
62_I81_V1.3950.99
67_K70_M1.3930.99
53_R57_S1.3770.99
161_A165_K1.3750.99
45_I54_V1.3690.99
85_K104_E1.3570.99
90_T100_A1.3490.99
183_V186_I1.3470.99
60_P63_K1.3190.99
31_R35_N1.2920.98
183_V187_S1.2530.98
137_V140_Q1.2370.98
26_L79_I1.2160.98
15_L107_L1.2150.98
17_N77_Q1.2110.97
137_V141_E1.2060.97
141_E144_E1.1820.97
47_S50_E1.1780.97
77_Q110_L1.1670.97
12_L51_A1.1240.96
75_A110_L1.1170.96
163_K166_K1.1130.96
83_F106_I1.1060.96
21_D25_Q1.0980.95
38_I42_V1.0970.95
30_I69_T1.0960.95
23_D77_Q1.0640.95
28_R31_R1.0600.95
30_I70_M1.0510.94
37_E65_I1.0480.94
35_N131_F1.0280.94
13_R98_Y1.0270.94
14_I108_I1.0250.93
161_A166_K1.0230.93
5_I9_A1.0230.93
78_S110_L1.0200.93
41_W58_K1.0110.93
162_E166_K1.0020.93
70_M73_E0.9950.92
162_E165_K0.9930.92
34_V62_I0.9740.92
65_I69_T0.9700.91
91_K105_A0.9570.91
28_R116_A0.9560.91
15_L84_D0.9540.91
67_K78_S0.9520.91
161_A164_A0.9490.91
165_K169_N0.9270.89
92_L98_Y0.9260.89
184_E187_S0.9190.89
17_N112_N0.9030.88
120_C127_C0.8950.88
35_N38_I0.8850.87
81_V84_D0.8660.86
95_N141_E0.8640.86
37_E106_I0.8610.86
12_L93_Y0.8580.86
33_A37_E0.8550.85
80_S109_T0.8480.85
162_E167_E0.8480.85
83_F86_I0.8430.85
12_L98_Y0.8410.84
30_I33_A0.8310.84
81_V106_I0.8210.83
130_D133_N0.8190.83
41_W54_V0.8180.83
49_E64_A0.8160.83
55_I83_F0.8110.82
30_I75_A0.7960.81
25_Q29_H0.7940.81
12_L35_N0.7930.81
163_K167_E0.7920.81
60_P64_A0.7800.80
89_P130_D0.7780.79
33_A68_E0.7760.79
66_A70_M0.7700.79
13_R181_F0.7700.79
161_A168_E0.7690.79
81_V108_I0.7670.78
148_K161_A0.7640.78
26_L73_E0.7640.78
165_K168_E0.7600.78
5_I86_I0.7590.78
38_I116_A0.7490.77
33_A65_I0.7490.77
34_V65_I0.7430.76
38_I62_I0.7390.76
5_I96_M0.7320.75
26_L77_Q0.7230.74
42_V55_I0.7190.74
38_I122_L0.7190.74
87_S100_A0.7150.73
116_A129_L0.7140.73
64_A68_E0.7140.73
143_K147_K0.7120.73
86_I98_Y0.7040.72
64_A67_K0.7000.72
12_L96_M0.6980.72
37_E61_E0.6970.72
59_L63_K0.6970.72
138_K141_E0.6850.70
86_I105_A0.6820.70
56_R83_F0.6800.70
94_G130_D0.6800.70
163_K168_E0.6730.69
54_V58_K0.6670.68
33_A72_K0.6640.68
182_L185_W0.6540.67
35_N129_L0.6540.67
89_P129_L0.6470.66
74_G77_Q0.6460.66
6_P88_F0.6450.66
55_I108_I0.6430.65
17_N20_S0.6400.65
65_I134_G0.6390.65
28_R122_L0.6380.65
6_P9_A0.6370.65
95_N138_K0.6360.65
32_D121_V0.6360.65
38_I41_W0.6330.64
15_L86_I0.6330.64
84_D87_S0.6290.64
22_Q75_A0.6280.64
21_D116_A0.6280.64
9_A14_I0.6260.63
38_I55_I0.6240.63
14_I30_I0.6240.63
29_H69_T0.6170.62
46_T123_F0.6140.62
133_N136_A0.6130.62
62_I82_D0.6130.62
94_G128_F0.6110.61
46_T50_E0.6100.61
90_T98_Y0.6070.61
6_P13_R0.6060.61
168_E172_K0.6030.60
54_V60_P0.6020.60
137_V144_E0.5980.60
137_V142_D0.5950.59
35_N96_M0.5950.59
14_I92_L0.5940.59
35_N91_K0.5920.59
96_M176_T0.5920.59
9_A86_I0.5910.59
53_R56_R0.5910.59
13_R91_K0.5890.59
60_P78_S0.5880.59
144_E169_N0.5850.58
50_E112_N0.5780.57
36_K143_K0.5760.57
98_Y180_F0.5760.57
25_Q135_E0.5760.57
40_T54_V0.5760.57
180_F183_V0.5740.57
61_E64_A0.5700.56
56_R60_P0.5670.56
67_K81_V0.5650.56
83_F184_E0.5650.56
6_P122_L0.5650.56
9_A91_K0.5640.55
13_R35_N0.5640.55
22_Q25_Q0.5640.55
90_T136_A0.5630.55
8_Q48_I0.5610.55
2_P89_P0.5600.55
131_F134_G0.5590.55
59_L83_F0.5590.55
10_I38_I0.5590.55
23_D121_V0.5580.55
136_A140_Q0.5570.54
9_A35_N0.5500.54
182_L186_I0.5490.53
116_A123_F0.5480.53
100_A106_I0.5470.53
10_I48_I0.5470.53
139_E144_E0.5460.53
7_D123_F0.5460.53
82_D86_I0.5430.53
66_A81_V0.5430.53
58_K62_I0.5430.53
2_P81_V0.5420.53
166_K169_N0.5420.53
89_P128_F0.5420.53
161_A169_N0.5410.52
46_T139_E0.5390.52
122_L128_F0.5330.51
12_L86_I0.5310.51
13_R107_L0.5290.51
65_I108_I0.5280.51
90_T130_D0.5280.51
44_D148_K0.5270.51
70_M76_N0.5220.50
31_R55_I0.5210.50
144_E147_K0.5210.50
14_I42_V0.5210.50
26_L53_R0.5210.50
164_A168_E0.5200.50
12_L122_L0.5190.49
12_L40_T0.5180.49
13_R28_R0.5180.49
89_P98_Y0.5160.49
98_Y107_L0.5150.49
35_N107_L0.5130.49
135_E139_E0.5120.49
35_N93_Y0.5110.48
14_I98_Y0.5100.48
44_D47_S0.5060.48
55_I122_L0.5040.47
6_P105_A0.5030.47
88_F128_F0.5020.47
82_D107_L0.5020.47
6_P89_P0.5010.47
140_Q144_E0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1usuB 1 0.2947 15 0.958 Contact Map
2ak5A 3 0.3 9.6 0.961 Contact Map
3pe0A 1 0.7842 7.9 0.963 Contact Map
4ujrH 1 0.1421 7.2 0.963 Contact Map
4f14A 1 0.2474 6.9 0.964 Contact Map
2nwmA 1 0.2737 6.1 0.965 Contact Map
2ew3A 1 0.2789 5.6 0.965 Contact Map
2kw6A 2 0.3 5.3 0.966 Contact Map
1utiA 1 0.2632 4.8 0.966 Contact Map
3w0lB 1 0.3105 4.8 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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