GREMLIN Database
PF05231 - (1-311) Probable diguanylate cyclase YegE
UniProt: P38097 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 311 (286)
Sequences: 6654 (5458)
Seq/√Len: 322.7
META: 0.719

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_E229_R4.9291.00
141_V156_F3.9081.00
104_G135_P3.2681.00
29_F52_I3.0551.00
173_L240_L2.9701.00
30_T75_G2.9241.00
55_V174_G2.8991.00
301_E304_F2.8881.00
120_N123_D2.8341.00
54_M104_G2.7961.00
143_V159_W2.7191.00
60_H64_M2.6031.00
122_A126_R2.5871.00
300_S304_F2.5671.00
218_F221_V2.5391.00
176_L236_F2.5021.00
177_F233_M2.4531.00
19_L67_G2.3791.00
226_S238_I2.3781.00
231_P234_E2.3621.00
290_F294_R2.3391.00
201_T238_I2.2631.00
177_F237_L2.2321.00
223_L280_A2.0931.00
51_S166_G2.0911.00
215_P218_F2.0801.00
290_F293_E2.0701.00
124_W285_M2.0561.00
235_A280_A2.0461.00
96_I142_L2.0181.00
57_F105_A2.0151.00
92_T146_L2.0091.00
254_P257_L2.0001.00
219_I222_L1.9681.00
205_S245_M1.9481.00
57_F65_W1.9381.00
50_T167_A1.9121.00
22_L56_A1.8861.00
225_W229_R1.8651.00
248_L252_A1.8641.00
136_P164_S1.8391.00
197_T226_S1.8321.00
67_G71_S1.8321.00
300_S303_H1.8231.00
218_F222_L1.8151.00
108_L114_W1.8031.00
107_L130_G1.7881.00
62_G106_V1.7861.00
246_V269_P1.7461.00
54_M167_A1.7361.00
23_G67_G1.7171.00
145_L152_P1.7091.00
165_I274_L1.7041.00
205_S242_T1.6761.00
103_V138_L1.6641.00
65_W102_V1.6481.00
55_V171_V1.5941.00
118_L127_L1.5781.00
59_R178_K1.5481.00
106_V110_K1.5361.00
194_S230_L1.5261.00
73_S94_T1.5181.00
54_M171_V1.5001.00
43_L155_A1.4921.00
193_E197_T1.4891.00
61_A65_W1.4491.00
121_L289_A1.4311.00
144_V152_P1.4231.00
169_A243_V1.4151.00
127_L171_V1.4071.00
239_F277_L1.3921.00
23_G27_F1.3791.00
275_L279_P1.3781.00
190_L193_E1.3701.00
57_F101_A1.3641.00
53_M72_C1.3611.00
226_S230_L1.3471.00
62_G109_R1.3421.00
298_S301_E1.3271.00
97_N100_E1.3261.00
33_S48_F1.3181.00
51_S171_V1.3091.00
71_S75_G1.3001.00
230_L234_E1.2841.00
50_T53_M1.2751.00
294_R298_S1.2601.00
114_W123_D1.2591.00
197_T230_L1.2581.00
255_S258_A1.2561.00
234_E238_I1.2551.00
131_S167_A1.2491.00
94_T98_I1.2371.00
250_M253_D1.2311.00
124_W281_N1.2021.00
235_A284_T1.1971.00
111_L126_R1.1721.00
25_V52_I1.1681.00
221_V279_P1.1621.00
103_V106_V1.1591.00
68_I71_S1.1511.00
57_F64_M1.1441.00
52_I56_A1.1421.00
100_E139_G1.1411.00
100_E163_E1.1391.00
50_T97_N1.1231.00
177_F236_F1.1181.00
55_V59_R1.1181.00
193_E230_L1.1081.00
23_G71_S1.1021.00
64_M67_G1.1021.00
47_W97_N1.1001.00
292_A296_H1.0981.00
51_S55_V1.0901.00
137_L140_G1.0801.00
76_N163_E1.0791.00
171_V175_L1.0761.00
27_F82_L1.0681.00
61_A64_M1.0661.00
140_G160_V1.0631.00
167_A171_V1.0631.00
261_R264_L1.0621.00
200_I222_L1.0611.00
59_R174_G1.0541.00
299_E303_H1.0481.00
76_N162_S1.0371.00
243_V273_F1.0341.00
111_L130_G1.0321.00
202_L241_T1.0241.00
50_T101_A1.0231.00
173_L236_F1.0151.00
148_P152_P1.0151.00
48_F170_L1.0141.00
293_E297_I1.0131.00
115_Y119_Q1.0071.00
90_N94_T1.0071.00
132_A164_S1.0031.00
31_L35_E0.9921.00
53_M101_A0.9821.00
130_G134_V0.9771.00
69_A95_T0.9741.00
130_G135_P0.9731.00
269_P273_F0.9731.00
78_A81_I0.9721.00
193_E225_W0.9691.00
228_V287_M0.9661.00
27_F31_L0.9641.00
198_L202_L0.9621.00
97_N159_W0.9611.00
54_M105_A0.9571.00
47_W50_T0.9571.00
192_F196_L0.9511.00
297_I301_E0.9491.00
159_W163_E0.9471.00
235_A239_F0.9431.00
231_P291_R0.9401.00
193_E209_M0.9271.00
101_A105_A0.9181.00
151_D154_R0.9161.00
56_A60_H0.9161.00
29_F49_P0.9131.00
130_G133_I0.9131.00
116_N123_D0.9091.00
74_L77_I0.9071.00
76_N97_N0.9051.00
160_V164_S0.9031.00
118_L124_W0.8991.00
27_F74_L0.8991.00
136_P167_A0.8971.00
231_P238_I0.8901.00
133_I136_P0.8891.00
87_S90_N0.8891.00
100_E167_A0.8881.00
239_F280_A0.8821.00
287_M291_R0.8781.00
26_S76_N0.8761.00
69_A98_I0.8751.00
166_G170_L0.8731.00
201_T242_T0.8721.00
102_V106_V0.8701.00
29_F33_S0.8681.00
55_V175_L0.8631.00
99_V103_V0.8621.00
189_R193_E0.8591.00
171_V174_G0.8551.00
25_V29_F0.8531.00
30_T47_W0.8491.00
34_L47_W0.8491.00
233_M237_L0.8481.00
224_M279_P0.8461.00
152_P156_F0.8441.00
176_L232_R0.8401.00
244_M248_L0.8341.00
276_I279_P0.8311.00
53_M61_A0.8251.00
187_N191_L0.8241.00
297_I300_S0.8241.00
22_L64_M0.8231.00
166_G171_V0.8221.00
197_T201_T0.8221.00
181_Y184_R0.8211.00
98_I102_V0.8161.00
37_S44_A0.8121.00
137_L160_V0.8101.00
217_T220_I0.8091.00
69_A94_T0.8091.00
31_L82_L0.8051.00
144_V156_F0.8031.00
108_L112_L0.8021.00
209_M246_V0.7991.00
135_P167_A0.7991.00
216_F220_I0.7981.00
112_L126_R0.7971.00
27_F30_T0.7941.00
194_S198_L0.7921.00
158_I263_Y0.7901.00
80_S97_N0.7881.00
253_D256_L0.7861.00
277_L281_N0.7851.00
295_K298_S0.7851.00
30_T34_L0.7841.00
192_F195_L0.7841.00
139_G159_W0.7841.00
174_G178_K0.7791.00
203_T206_W0.7761.00
86_T90_N0.7731.00
108_L130_G0.7721.00
291_R294_R0.7711.00
153_L157_L0.7671.00
165_I273_F0.7661.00
22_L52_I0.7651.00
183_L186_R0.7651.00
67_G70_L0.7630.99
62_G102_V0.7620.99
93_W147_T0.7600.99
20_V24_L0.7600.99
239_F282_I0.7580.99
40_G45_P0.7570.99
101_A104_G0.7560.99
232_R284_T0.7520.99
24_L28_I0.7510.99
65_W105_A0.7500.99
296_H299_E0.7480.99
76_N93_W0.7480.99
85_S89_L0.7470.99
203_T207_L0.7470.99
295_K299_E0.7460.99
96_I146_L0.7420.99
217_T221_V0.7410.99
108_L111_L0.7390.99
38_Q50_T0.7380.99
162_S166_G0.7370.99
231_P284_T0.7360.99
225_W230_L0.7360.99
96_I99_V0.7360.99
283_M286_V0.7350.99
137_L156_F0.7340.99
49_P52_I0.7330.99
100_E136_P0.7280.99
58_Y175_L0.7280.99
140_G144_V0.7230.99
281_N284_T0.7230.99
140_G143_V0.7230.99
28_I32_F0.7210.99
38_Q41_T0.7180.99
104_G167_A0.7160.99
288_Y291_R0.7130.99
50_T100_E0.7110.99
42_Q85_S0.7110.99
26_S30_T0.7080.99
82_L85_S0.7050.99
236_F239_F0.7030.99
37_S42_Q0.7010.99
53_M68_I0.7000.99
161_L165_I0.6990.99
164_S274_L0.6990.99
26_S49_P0.6980.99
296_H301_E0.6970.99
96_I143_V0.6960.99
142_L145_L0.6950.99
103_V135_P0.6940.99
139_G142_L0.6890.99
296_H300_S0.6870.99
30_T49_P0.6830.99
237_L241_T0.6810.99
137_L141_V0.6800.99
73_S77_I0.6790.99
227_A287_M0.6780.99
187_N190_L0.6750.99
261_R265_M0.6750.99
173_L176_L0.6730.99
285_M289_A0.6710.99
89_L92_T0.6710.99
263_Y266_S0.6700.99
128_A278_L0.6660.99
270_W274_L0.6660.99
19_L23_G0.6650.99
127_L175_L0.6620.99
292_A295_K0.6600.99
135_P139_G0.6590.99
88_S91_M0.6570.98
136_P160_V0.6560.98
165_I169_A0.6550.98
48_F51_S0.6550.98
232_R236_F0.6530.98
293_E296_H0.6520.98
75_G79_A0.6490.98
201_T205_S0.6480.98
34_L37_S0.6470.98
103_V107_L0.6450.98
113_P123_D0.6450.98
169_A239_F0.6430.98
59_R175_L0.6400.98
58_Y108_L0.6350.98
91_M95_T0.6350.98
234_E284_T0.6340.98
236_F284_T0.6330.98
44_A97_N0.6290.98
62_G65_W0.6280.98
72_C76_N0.6280.98
218_F268_M0.6280.98
231_P235_A0.6270.98
44_A159_W0.6250.98
117_P123_D0.6240.98
180_H183_L0.6190.98
115_Y123_D0.6190.98
86_T89_L0.6170.98
37_S40_G0.6170.98
132_A136_P0.6170.98
80_S90_N0.6130.98
100_E135_P0.6120.98
50_T54_M0.6110.98
149_G152_P0.6040.97
163_E166_G0.6020.97
107_L111_L0.6020.97
299_E302_T0.6010.97
93_W96_I0.6000.97
193_E208_S0.5990.97
108_L126_R0.5980.97
166_G169_A0.5970.97
286_V289_A0.5960.97
140_G156_F0.5950.97
214_W217_T0.5950.97
57_F71_S0.5910.97
123_D127_L0.5900.97
23_G74_L0.5900.97
141_V152_P0.5880.97
51_S167_A0.5880.97
191_L195_L0.5860.97
188_P191_L0.5820.97
148_P155_A0.5810.97
110_K113_P0.5810.97
124_W127_L0.5800.97
97_N101_A0.5790.97
128_A168_L0.5780.97
257_L272_P0.5760.97
89_L93_W0.5760.97
173_L237_L0.5750.97
121_L128_A0.5750.97
149_G153_L0.5740.97
64_M68_I0.5740.97
213_P217_T0.5740.97
26_S163_E0.5730.96
195_L199_A0.5720.96
99_V102_V0.5690.96
129_L133_I0.5690.96
51_S172_P0.5680.96
47_W159_W0.5660.96
46_L159_W0.5660.96
206_W210_L0.5650.96
205_S249_M0.5640.96
266_S270_W0.5630.96
194_S197_T0.5630.96
84_F90_N0.5610.96
227_A280_A0.5610.96
95_T99_V0.5600.96
33_S49_P0.5590.96
29_F32_F0.5580.96
178_K181_Y0.5560.96
198_L201_T0.5560.96
220_I272_P0.5560.96
42_Q49_P0.5550.96
19_L70_L0.5540.96
93_W159_W0.5530.96
140_G159_W0.5530.96
56_A68_I0.5510.96
298_S302_T0.5490.96
210_L249_M0.5490.96
22_L68_I0.5480.95
231_P288_Y0.5480.95
276_I280_A0.5480.95
45_P269_P0.5410.95
272_P276_I0.5390.95
138_L141_V0.5380.95
224_M283_M0.5370.95
183_L292_A0.5370.95
62_G105_A0.5370.95
278_L282_I0.5370.95
39_F42_Q0.5360.95
76_N80_S0.5330.95
165_I270_W0.5330.95
112_L123_D0.5320.95
176_L233_M0.5300.95
134_V137_L0.5290.95
288_Y292_A0.5290.95
66_P70_L0.5280.94
33_S47_W0.5280.94
121_L286_V0.5270.94
114_W127_L0.5270.94
98_I101_A0.5260.94
163_E167_A0.5210.94
125_L129_L0.5210.94
186_R189_R0.5200.94
235_A238_I0.5190.94
51_S170_L0.5170.94
48_F163_E0.5160.94
113_P122_A0.5160.94
109_R113_P0.5140.94
44_A162_S0.5140.94
80_S143_V0.5130.94
93_W100_E0.5130.94
60_H63_R0.5130.94
232_R285_M0.5110.93
48_F225_W0.5100.93
19_L71_S0.5090.93
262_T265_M0.5060.93
106_V109_R0.5060.93
60_H68_I0.5040.93
274_L279_P0.5030.93
80_S93_W0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ksfA 1 0.3376 62.8 0.928 Contact Map
3effK 4 0.3666 21.8 0.945 Contact Map
4huqS 1 0.3569 8.6 0.954 Contact Map
3vouA 4 0.3891 8.5 0.954 Contact Map
2wswA 3 0.4212 6.7 0.956 Contact Map
3ne5A 3 0.5434 6.5 0.957 Contact Map
2k1eA 3 0.328 6.3 0.957 Contact Map
2l2lB 1 0.1061 6 0.957 Contact Map
1lnqA 6 0.2605 5.9 0.957 Contact Map
3wdfA 1 0.1608 5.6 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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