GREMLIN Database
PF01595 - UPF0053 inner membrane protein YfjD
UniProt: P37908 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 410 (404)
Sequences: 24275 (16314)
Seq/√Len: 811.7
META: 0.844

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
377_E383_T3.6901.00
207_G232_Y3.1531.00
210_I233_R3.1201.00
124_A128_I3.1181.00
233_R238_D3.0871.00
384_R391_D2.9351.00
336_N339_S2.9041.00
205_I306_L2.9011.00
233_R264_L2.8721.00
213_D216_S2.8491.00
342_I407_V2.8391.00
262_T265_R2.8001.00
273_V282_Q2.7531.00
135_W139_A2.6221.00
94_F140_I2.5931.00
384_R393_D2.5561.00
277_T285_K2.5521.00
212_D216_S2.5351.00
195_V282_Q2.5121.00
391_D408_F2.4981.00
205_I303_I2.4971.00
386_R391_D2.4911.00
111_Y114_K2.4801.00
393_D408_F2.4731.00
341_I395_L2.4311.00
231_L267_A2.4201.00
247_E268_D2.3281.00
371_I405_V2.3261.00
207_G236_L2.3181.00
42_R124_A2.2571.00
210_I240_I2.2451.00
396_D404_Q2.2111.00
11_S65_N2.1991.00
341_I404_Q2.1971.00
118_P122_L2.1641.00
395_L406_K2.0651.00
351_I355_F2.0551.00
198_I279_L2.0231.00
295_L303_I1.9951.00
45_K124_A1.9931.00
210_I264_L1.9861.00
275_E304_Q1.9751.00
339_S406_K1.9541.00
42_R121_F1.9391.00
242_M270_I1.9281.00
370_V387_I1.9271.00
346_A351_I1.9011.00
208_I217_I1.8921.00
335_Q339_S1.8791.00
219_R223_H1.8511.00
33_A44_E1.8511.00
52_R131_M1.8071.00
28_R113_E1.8031.00
233_R240_I1.8001.00
13_Y122_L1.7731.00
29_L43_V1.7621.00
227_G244_R1.7541.00
203_S302_D1.7531.00
396_D403_K1.7201.00
206_I220_Q1.7171.00
293_V306_L1.6951.00
208_I231_L1.6781.00
352_N357_W1.6671.00
37_N117_Y1.6621.00
334_P340_V1.6501.00
284_V287_Q1.6461.00
14_F60_G1.6451.00
42_R120_S1.6431.00
211_N233_R1.6131.00
339_S408_F1.6051.00
198_I307_V1.5951.00
122_L125_P1.5831.00
212_D217_I1.5721.00
206_I229_I1.5691.00
209_D212_D1.5671.00
32_M117_Y1.5641.00
114_K118_P1.5621.00
183_M187_V1.5621.00
282_Q307_V1.5541.00
295_L306_L1.5481.00
364_A373_E1.5291.00
351_I407_V1.5211.00
332_V346_A1.5161.00
398_Q403_K1.5061.00
131_M135_W1.4991.00
334_P337_D1.4951.00
285_K289_N1.4881.00
335_Q338_G1.4791.00
139_A143_M1.4691.00
169_V184_L1.4611.00
277_T282_Q1.4551.00
11_S61_N1.4541.00
310_E314_E1.4501.00
346_A367_V1.4451.00
206_I226_H1.4371.00
341_I406_K1.4341.00
32_M37_N1.4331.00
371_I392_I1.4271.00
17_S119_S1.4271.00
393_D406_K1.4241.00
44_E48_R1.4191.00
235_S238_D1.4171.00
279_L312_I1.4171.00
43_V120_S1.4151.00
195_V296_V1.4141.00
49_K52_R1.4041.00
143_M147_M1.4041.00
332_V354_A1.4031.00
3_I71_L1.3981.00
367_V405_V1.3841.00
242_M293_V1.3831.00
46_L120_S1.3721.00
128_I131_M1.3701.00
68_A92_L1.3681.00
270_I295_L1.3651.00
39_S117_Y1.3571.00
351_I367_V1.3561.00
139_A142_R1.3541.00
119_S122_L1.3461.00
16_G115_V1.3431.00
212_D220_Q1.3361.00
232_Y239_A1.3311.00
193_M197_D1.3301.00
30_R44_E1.3261.00
206_I224_S1.3141.00
16_G108_A1.3121.00
216_S219_R1.3101.00
261_E265_R1.3081.00
30_R34_K1.3061.00
322_T325_S1.3041.00
33_A41_K1.2891.00
239_A295_L1.2891.00
86_A90_G1.2881.00
173_R181_Q1.2871.00
31_H35_Q1.2861.00
371_I385_V1.2781.00
202_R302_D1.2731.00
41_K45_K1.2621.00
10_I64_V1.2611.00
390_Y407_V1.2601.00
221_L229_I1.2601.00
335_Q406_K1.2571.00
342_I367_V1.2571.00
374_A387_I1.2561.00
335_Q341_I1.2441.00
43_V116_A1.2431.00
277_T281_T1.2391.00
348_V352_N1.2351.00
145_M150_I1.2341.00
19_T22_M1.2301.00
72_G92_L1.2291.00
45_K49_K1.2271.00
14_F126_L1.2261.00
271_Y289_N1.2261.00
187_V316_I1.2191.00
204_E345_T1.2191.00
195_V273_V1.2121.00
395_L404_Q1.1981.00
202_R237_D1.1971.00
338_G409_P1.1951.00
392_I405_V1.1851.00
352_N359_L1.1831.00
342_I351_I1.1821.00
218_L222_S1.1791.00
13_Y119_S1.1761.00
352_N358_H1.1721.00
368_N372_L1.1711.00
205_I236_L1.1691.00
66_I69_S1.1611.00
224_S229_I1.1591.00
166_R185_L1.1551.00
172_S176_I1.1481.00
195_V307_V1.1441.00
221_L245_V1.1411.00
273_V296_V1.1391.00
298_N304_Q1.1361.00
333_T341_I1.1241.00
103_L144_L1.1191.00
274_P277_T1.1191.00
271_Y294_G1.1101.00
286_F294_G1.1051.00
372_L378_I1.0941.00
61_N65_N1.0911.00
136_L139_A1.0891.00
371_I375_L1.0871.00
196_D275_E1.0861.00
39_S43_V1.0861.00
215_K219_R1.0811.00
374_A385_V1.0811.00
237_D302_D1.0811.00
56_L127_Q1.0791.00
372_L402_I1.0751.00
39_S121_F1.0721.00
183_M316_I1.0721.00
6_I10_I1.0641.00
52_R135_W1.0591.00
11_S15_S1.0571.00
210_I267_A1.0551.00
208_I229_I1.0521.00
331_E343_D1.0521.00
271_Y285_K1.0511.00
125_P128_I1.0481.00
57_V123_L1.0361.00
7_M64_V1.0291.00
313_L317_V1.0221.00
56_L126_L1.0211.00
402_I405_V1.0141.00
371_I394_I1.0121.00
293_V308_T1.0111.00
37_N40_A1.0101.00
84_G88_A1.0081.00
251_L266_A1.0071.00
240_I267_A1.0041.00
332_V342_I1.0001.00
121_F125_P0.9921.00
40_A117_Y0.9871.00
46_L53_L0.9851.00
42_R45_K0.9811.00
18_E105_K0.9721.00
381_A396_D0.9681.00
8_V95_V0.9641.00
370_V374_A0.9621.00
334_P338_G0.9601.00
181_Q185_L0.9581.00
56_L134_V0.9501.00
263_M267_A0.9471.00
390_Y409_P0.9461.00
292_K309_V0.9421.00
82_D86_A0.9411.00
38_R41_K0.9401.00
39_S42_R0.9371.00
4_L68_A0.9361.00
392_I407_V0.9351.00
127_Q131_M0.9351.00
387_I392_I0.9341.00
219_R253_S0.9321.00
170_H185_L0.9231.00
207_G303_I0.9221.00
29_L44_E0.9221.00
237_D303_I0.9221.00
65_N96_V0.9201.00
214_W261_E0.9201.00
321_T327_T0.9161.00
190_L280_S0.9161.00
211_N264_L0.9151.00
234_D238_D0.9151.00
2_I6_I0.9131.00
378_I397_V0.9121.00
51_D142_R0.9081.00
298_N302_D0.9081.00
115_V119_S0.9071.00
16_G20_G0.9071.00
347_N350_E0.9051.00
348_V364_A0.9031.00
132_P136_L0.9011.00
344_G368_N0.9011.00
45_K48_R0.8891.00
243_L266_A0.8881.00
4_L75_V0.8881.00
162_K192_K0.8881.00
39_S120_S0.8881.00
101_E105_K0.8821.00
219_R222_S0.8811.00
343_D404_Q0.8801.00
228_R292_K0.8751.00
143_M146_R0.8731.00
36_G40_A0.8711.00
264_L267_A0.8691.00
138_N142_R0.8651.00
118_P121_F0.8651.00
385_V392_I0.8641.00
70_A73_T0.8631.00
81_G84_G0.8611.00
3_I7_M0.8591.00
73_T77_M0.8581.00
389_E409_P0.8551.00
50_P53_L0.8521.00
375_L379_P0.8501.00
208_I220_Q0.8491.00
29_L47_L0.8471.00
100_A104_P0.8461.00
381_A397_V0.8431.00
24_L112_P0.8421.00
370_V392_I0.8421.00
7_M67_L0.8381.00
58_L61_N0.8381.00
52_R138_N0.8361.00
62_N89_T0.8301.00
33_A37_N0.8301.00
386_R389_E0.8291.00
282_Q286_F0.8281.00
343_D346_A0.8271.00
230_V295_L0.8191.00
162_K166_R0.8181.00
30_R33_A0.8181.00
70_A74_I0.8151.00
194_T197_D0.8131.00
61_N64_V0.8061.00
19_T108_A0.8041.00
366_T369_G0.7981.00
235_S303_I0.7971.00
198_I312_I0.7961.00
375_L385_V0.7941.00
28_R31_H0.7941.00
243_L248_A0.7931.00
166_R189_D0.7911.00
221_L248_A0.7891.00
8_V100_A0.7881.00
76_G80_Y0.7881.00
208_I212_D0.7871.00
162_K188_L0.7871.00
24_L29_L0.7851.00
332_V340_V0.7851.00
26_R48_R0.7831.00
394_I397_V0.7821.00
355_F390_Y0.7781.00
364_A370_V0.7781.00
261_E266_A0.7781.00
217_I263_M0.7751.00
220_Q224_S0.7701.00
310_E320_F0.7701.00
190_L283_L0.7691.00
214_W217_I0.7651.00
251_L254_E0.7571.00
232_Y235_S0.7561.00
244_R268_D0.7561.00
16_G119_S0.7531.00
232_Y236_L0.7521.00
136_L140_I0.7511.00
273_V294_G0.7481.00
66_I70_A0.7481.00
294_G307_V0.7481.00
69_S73_T0.7411.00
90_G94_F0.7411.00
286_F291_K0.7351.00
285_K288_R0.7341.00
204_E401_M0.7341.00
24_L43_V0.7341.00
196_D365_R0.7341.00
209_D238_D0.7291.00
236_L303_I0.7261.00
397_V403_K0.7251.00
209_D234_D0.7251.00
220_Q223_H0.7241.00
207_G239_A0.7231.00
240_I264_L0.7231.00
28_R32_M0.7231.00
145_M149_G0.7201.00
146_R151_K0.7181.00
230_V239_A0.7151.00
17_S123_L0.7141.00
317_V320_F0.7131.00
193_M315_E0.7121.00
52_R127_Q0.7121.00
215_K259_T0.7111.00
24_L113_E0.7101.00
32_M36_G0.7091.00
397_V402_I0.7091.00
252_M255_K0.7071.00
160_L168_I0.7071.00
114_K117_Y0.7061.00
60_G64_V0.7021.00
272_F297_V0.6991.00
334_P354_A0.6981.00
70_A89_T0.6971.00
380_V383_T0.6971.00
124_A127_Q0.6951.00
340_V355_F0.6941.00
76_G88_A0.6931.00
4_L92_L0.6921.00
58_L62_N0.6881.00
85_V89_T0.6881.00
232_Y238_D0.6851.00
368_N401_M0.6831.00
217_I261_E0.6801.00
46_L127_Q0.6791.00
41_K44_E0.6791.00
209_D232_Y0.6771.00
9_V12_A0.6761.00
320_F323_S0.6741.00
342_I346_A0.6741.00
38_R121_F0.6731.00
43_V47_L0.6721.00
397_V400_N0.6721.00
272_F295_L0.6711.00
387_I390_Y0.6701.00
202_R205_I0.6681.00
32_M35_Q0.6681.00
15_S61_N0.6671.00
12_A16_G0.6671.00
342_I354_A0.6671.00
331_E346_A0.6671.00
214_W218_L0.6651.00
107_I150_I0.6651.00
217_I221_L0.6651.00
197_D365_R0.6651.00
37_N41_K0.6651.00
8_V96_V0.6641.00
222_S250_R0.6641.00
51_D55_S0.6631.00
62_N93_T0.6631.00
320_F325_S0.6611.00
271_Y291_K0.6611.00
210_I217_I0.6601.00
227_G246_R0.6591.00
66_I73_T0.6591.00
24_L32_M0.6561.00
21_M116_A0.6561.00
202_R304_Q0.6551.00
292_K313_L0.6541.00
61_N96_V0.6541.00
29_L40_A0.6541.00
88_A92_L0.6531.00
227_G322_T0.6521.00
333_T404_Q0.6501.00
126_L130_M0.6471.00
59_I62_N0.6461.00
310_E325_S0.6461.00
173_R176_I0.6441.00
24_L28_R0.6421.00
315_E319_D0.6411.00
375_L383_T0.6411.00
65_N68_A0.6401.00
310_E315_E0.6391.00
251_L255_K0.6381.00
215_K260_K0.6381.00
74_I77_M0.6381.00
171_E175_Q0.6361.00
165_L172_S0.6361.00
228_R293_V0.6361.00
47_L50_P0.6351.00
58_L96_V0.6351.00
352_N355_F0.6341.00
5_I9_V0.6321.00
176_I181_Q0.6311.00
131_M134_V0.6301.00
112_P116_A0.6291.00
209_D233_R0.6291.00
15_S19_T0.6291.00
132_P135_W0.6291.00
102_V106_T0.6281.00
121_F124_A0.6271.00
283_L312_I0.6251.00
134_V138_N0.6231.00
24_L47_L0.6231.00
228_R323_S0.6211.00
162_K191_E0.6211.00
51_D106_T0.6211.00
247_E324_M0.6201.00
194_T278_P0.6191.00
274_P299_E0.6181.00
191_E280_S0.6171.00
62_N105_K0.6171.00
59_I133_L0.6171.00
21_M53_L0.6161.00
350_E354_A0.6161.00
102_V137_L0.6151.00
107_I111_Y0.6151.00
83_A87_I0.6141.00
160_L165_L0.6141.00
169_V181_Q0.6141.00
299_E369_G0.6141.00
13_Y17_S0.6131.00
196_D304_Q0.6121.00
43_V117_Y0.6121.00
245_V249_W0.6111.00
299_E302_D0.6101.00
244_R247_E0.6091.00
125_P129_L0.6061.00
75_V78_R0.6051.00
49_K138_N0.6051.00
352_N362_D0.6031.00
377_E380_V0.6031.00
338_G408_F0.6021.00
202_R300_Y0.6021.00
61_N102_V0.6011.00
242_M267_A0.6011.00
231_L241_S0.6011.00
239_A303_I0.6001.00
290_K321_T0.6001.00
403_K406_K0.5981.00
208_I263_M0.5971.00
331_E345_T0.5961.00
359_L364_A0.5941.00
284_V288_R0.5931.00
77_M81_G0.5931.00
140_I143_M0.5931.00
183_M186_S0.5921.00
330_E333_T0.5911.00
66_I89_T0.5891.00
24_L33_A0.5891.00
278_P281_T0.5891.00
216_S220_Q0.5881.00
334_P409_P0.5871.00
210_I213_D0.5871.00
368_N402_I0.5861.00
20_G115_V0.5831.00
11_S96_V0.5821.00
217_I248_A0.5811.00
72_G88_A0.5811.00
346_A350_E0.5811.00
128_I132_P0.5811.00
53_L56_L0.5811.00
8_V12_A0.5811.00
69_S92_L0.5801.00
274_P300_Y0.5791.00
357_W390_Y0.5781.00
32_M113_E0.5781.00
283_L317_V0.5781.00
362_D373_E0.5771.00
336_N340_V0.5751.00
190_L312_I0.5731.00
7_M68_A0.5711.00
108_A115_V0.5711.00
194_T276_G0.5711.00
351_I357_W0.5691.00
15_S65_N0.5691.00
57_V61_N0.5671.00
282_Q294_G0.5661.00
230_V242_M0.5661.00
38_R42_R0.5661.00
186_S316_I0.5661.00
17_S20_G0.5651.00
62_N66_I0.5631.00
340_V409_P0.5621.00
203_S300_Y0.5621.00
228_R244_R0.5611.00
314_E319_D0.5611.00
352_N361_E0.5601.00
10_I14_F0.5601.00
239_A270_I0.5601.00
12_A100_A0.5591.00
379_P383_T0.5571.00
15_S57_V0.5561.00
311_D319_D0.5551.00
130_M134_V0.5551.00
21_M119_S0.5541.00
19_T54_I0.5541.00
184_L188_L0.5531.00
83_A86_A0.5531.00
2_I5_I0.5521.00
183_M190_L0.5501.00
213_D217_I0.5481.00
354_A357_W0.5481.00
314_E325_S0.5481.00
223_H326_P0.5471.00
167_T171_E0.5451.00
217_I229_I0.5441.00
129_L132_P0.5441.00
66_I96_V0.5441.00
215_K218_L0.5441.00
93_T97_L0.5431.00
84_G87_I0.5421.00
310_E322_T0.5421.00
30_R48_R0.5421.00
217_I262_T0.5411.00
72_G76_G0.5401.00
8_V68_A0.5401.00
256_K260_K0.5391.00
242_M295_L0.5391.00
70_A85_V0.5391.00
383_T402_I0.5381.00
29_L33_A0.5371.00
375_L397_V0.5371.00
349_R353_K0.5371.00
69_S93_T0.5361.00
239_A272_F0.5361.00
93_T105_K0.5331.00
329_A333_T0.5331.00
53_L127_Q0.5321.00
334_P339_S0.5321.00
251_L256_K0.5321.00
348_V367_V0.5311.00
335_Q396_D0.5301.00
146_R149_G0.5301.00
20_G116_A0.5291.00
199_M304_Q0.5291.00
342_I355_F0.5281.00
51_D138_N0.5271.00
78_R81_G0.5261.00
8_V11_S0.5251.00
273_V277_T0.5251.00
347_N365_R0.5231.00
66_I92_L0.5181.00
231_L263_M0.5131.00
11_S58_L0.5131.00
256_K261_E0.5131.00
168_I188_L0.5121.00
27_Y31_H0.5121.00
228_R310_E0.5121.00
63_L67_L0.5111.00
182_D186_S0.5111.00
39_S118_P0.5101.00
220_Q229_I0.5101.00
133_L137_L0.5101.00
202_R236_L0.5091.00
340_V354_A0.5091.00
351_I405_V0.5071.00
193_M349_R0.5071.00
33_A40_A0.5071.00
58_L65_N0.5031.00
3_I6_I0.5031.00
76_G84_G0.5021.00
372_L397_V0.5021.00
374_A388_G0.5011.00
100_A105_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hg0A 2 0.5659 100 0.471 Contact Map
3lhhA 1 0.3049 99.9 0.749 Contact Map
3ocoA 2 0.3293 99.9 0.764 Contact Map
3oi8A 2 0.3756 99.9 0.766 Contact Map
3ocmA 5 0.3634 99.9 0.768 Contact Map
4iysA 2 0.3463 99.9 0.779 Contact Map
3kxrA 3 0.3878 99.9 0.779 Contact Map
2v8qE 1 0.5512 99.9 0.779 Contact Map
3lv9A 2 0.3171 99.9 0.781 Contact Map
3dedA 2 0.2073 99.9 0.79 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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