GREMLIN Database
PF02654 - Adenosylcobinamide-GDP ribazoletransferase
UniProt: P36561 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 244 (239)
Sequences: 8384 (6740)
Seq/√Len: 436.0
META: 0.84

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_R100_E4.5041.00
86_C114_A3.8391.00
98_M220_T3.6371.00
151_A233_I3.3711.00
46_S70_L3.1041.00
217_L228_T2.9731.00
83_A115_L2.8961.00
49_V69_V2.8721.00
143_A240_F2.6821.00
82_L118_V2.6621.00
118_V238_L2.6041.00
60_P123_I2.5111.00
147_S233_I2.3711.00
91_S101_I2.3671.00
67_V123_I2.3281.00
209_A239_V2.3081.00
64_L120_L2.2821.00
76_G113_L2.2491.00
154_L232_A2.1481.00
64_L121_A2.1421.00
107_L112_G2.1381.00
68_L117_F2.1341.00
10_I35_F2.0541.00
93_R97_R2.0441.00
205_V243_A2.0141.00
7_L41_L1.9981.00
4_W16_P1.9871.00
213_L217_L1.9511.00
64_L123_I1.9401.00
103_R162_R1.8001.00
158_H214_G1.7771.00
58_G128_E1.7351.00
85_T228_T1.7331.00
71_V117_F1.7241.00
94_S97_R1.6951.00
3_F7_L1.6881.00
122_K237_E1.6671.00
83_A111_G1.6541.00
61_L125_V1.6111.00
178_Q181_V1.5901.00
50_F66_S1.5811.00
125_V242_L1.5561.00
182_T186_A1.5351.00
42_L73_M1.5231.00
88_G102_M1.4901.00
64_L124_L1.4821.00
214_G218_K1.4811.00
96_D100_E1.4601.00
120_L123_I1.4491.00
24_D27_H1.4401.00
122_K234_E1.4401.00
206_T236_G1.4381.00
215_Q218_K1.4361.00
95_R98_M1.4301.00
116_I119_V1.4271.00
175_D178_Q1.4251.00
155_M229_L1.4171.00
213_L232_A1.4111.00
95_R99_L1.4061.00
50_F130_A1.3971.00
71_V79_L1.3951.00
165_G170_F1.3881.00
116_I120_L1.3801.00
89_V98_M1.3691.00
60_P127_S1.3291.00
46_S66_S1.3211.00
162_R165_G1.3131.00
49_V53_L1.3061.00
79_L115_L1.3041.00
8_S15_V1.3001.00
1_K27_H1.2921.00
85_T89_V1.2911.00
118_V122_K1.2871.00
90_F110_H1.2841.00
89_V221_L1.2821.00
2_L30_R1.2781.00
11_T42_L1.2781.00
212_I216_L1.2641.00
45_I69_V1.2591.00
83_A107_L1.2511.00
47_G137_L1.2491.00
224_Q229_L1.2221.00
130_A133_G1.2201.00
7_L38_I1.2181.00
174_I178_Q1.1941.00
53_L57_C1.1931.00
60_P124_L1.1891.00
154_L214_G1.1831.00
107_L111_G1.1761.00
202_A240_F1.1741.00
159_R218_K1.1621.00
177_R181_V1.1581.00
62_A66_S1.1441.00
79_L234_E1.1431.00
91_S98_M1.1411.00
224_Q228_T1.1321.00
206_T240_F1.1311.00
47_G51_M1.1221.00
113_L119_V1.1221.00
42_L74_T1.1161.00
71_V76_G1.1081.00
4_W15_V1.1061.00
150_T236_G1.0951.00
83_A109_T1.0841.00
32_I155_M1.0821.00
209_A235_L1.0771.00
158_H218_K1.0751.00
21_Q24_D1.0671.00
82_L86_C1.0641.00
167_G171_I1.0531.00
109_T113_L1.0471.00
166_L170_F1.0421.00
174_I177_R1.0291.00
61_L124_L1.0231.00
42_L46_S1.0221.00
121_A238_L1.0141.00
215_Q219_R1.0101.00
173_K176_G1.0091.00
70_L144_C1.0051.00
118_V234_E1.0031.00
143_A241_L0.9981.00
3_F34_T0.9931.00
173_K178_Q0.9921.00
122_K238_L0.9841.00
71_V113_L0.9841.00
162_R225_T0.9801.00
89_V217_L0.9791.00
146_V240_F0.9731.00
150_T210_I0.9721.00
4_W8_S0.9641.00
125_V238_L0.9581.00
173_K177_R0.9561.00
85_T217_L0.9541.00
98_M221_L0.9541.00
95_R222_G0.9531.00
99_L162_R0.9421.00
40_L145_A0.9371.00
53_L62_A0.9351.00
232_A236_G0.9331.00
175_D179_T0.9281.00
63_A67_V0.9201.00
175_D181_V0.9201.00
161_A225_T0.9191.00
166_L171_I0.9131.00
82_L114_A0.9101.00
216_L220_T0.9091.00
63_A127_S0.9021.00
173_K181_V0.9011.00
82_L235_L0.9001.00
5_A8_S0.8931.00
99_L225_T0.8911.00
93_R101_I0.8911.00
94_S100_E0.8901.00
141_A145_A0.8891.00
47_G141_A0.8871.00
164_E168_N0.8861.00
51_M55_A0.8781.00
65_F121_A0.8781.00
112_G115_L0.8771.00
123_I127_S0.8741.00
67_V119_V0.8721.00
196_G199_G0.8691.00
63_A123_I0.8691.00
177_R180_C0.8691.00
160_Y168_N0.8541.00
112_G116_I0.8521.00
124_L128_E0.8511.00
91_S94_S0.8491.00
12_R75_G0.8471.00
2_L27_H0.8461.00
93_R98_M0.8411.00
210_I214_G0.8401.00
167_G170_F0.8401.00
158_H224_Q0.8361.00
13_L45_I0.8321.00
71_V119_V0.8311.00
144_C237_E0.8281.00
42_L144_C0.8241.00
75_G92_A0.8191.00
1_K4_W0.8161.00
141_A144_C0.8151.00
157_R214_G0.8101.00
211_F215_Q0.8081.00
176_G180_C0.8071.00
221_L228_T0.8061.00
98_M110_H0.8021.00
50_F54_Q0.7981.00
10_I38_I0.7971.00
100_E106_R0.7871.00
12_R72_L0.7831.00
149_G183_L0.7801.00
186_A189_F0.7741.00
53_L56_W0.7701.00
40_L141_A0.7701.00
43_G47_G0.7661.00
172_G175_D0.7641.00
174_I181_V0.7621.00
154_L158_H0.7591.00
166_L169_V0.7561.00
46_S50_F0.7531.00
172_G177_R0.7531.00
57_C61_L0.7501.00
84_D226_G0.7461.00
174_I180_C0.7451.00
206_T210_I0.7441.00
59_A63_A0.7371.00
176_G179_T0.7361.00
173_K179_T0.7331.00
172_G176_G0.7301.00
38_I41_L0.7241.00
42_L70_L0.7201.00
61_L242_L0.7191.00
89_V228_T0.7141.00
148_R233_I0.7141.00
8_S17_R0.7121.00
140_L144_C0.7101.00
79_L122_K0.7101.00
9_F77_F0.7031.00
88_G92_A0.7021.00
160_Y167_G0.7001.00
66_S70_L0.6961.00
125_V128_E0.6941.00
106_R109_T0.6921.00
83_A112_G0.6891.00
174_I179_T0.6851.00
160_Y164_E0.6851.00
50_F134_E0.6851.00
185_L189_F0.6821.00
168_N171_I0.6781.00
130_A134_E0.6761.00
126_L140_L0.6741.00
79_L119_V0.6741.00
224_Q232_A0.6741.00
10_I151_A0.6741.00
76_G110_H0.6711.00
26_E30_R0.6681.00
63_A126_L0.6681.00
216_L219_R0.6631.00
236_G240_F0.6621.00
198_H202_A0.6621.00
49_V65_F0.6581.00
2_L33_I0.6581.00
144_C234_E0.6571.00
183_L187_A0.6571.00
153_L157_R0.6561.00
80_D84_D0.6561.00
165_G169_V0.6561.00
45_I73_M0.6551.00
153_L210_I0.6540.99
84_D227_D0.6500.99
54_Q62_A0.6480.99
161_A223_G0.6420.99
189_F192_V0.6410.99
144_C147_S0.6400.99
31_G35_F0.6330.99
4_W7_L0.6330.99
75_G110_H0.6310.99
5_A31_G0.6290.99
5_A24_D0.6260.99
70_L237_E0.6250.99
13_L73_M0.6220.99
44_A48_L0.6210.99
146_V206_T0.6210.99
105_S110_H0.6210.99
50_F62_A0.6200.99
142_A240_F0.6170.99
8_S16_P0.6170.99
70_L143_A0.6170.99
218_K222_G0.6160.99
233_I236_G0.6140.99
125_V241_L0.6130.99
3_F41_L0.6110.99
107_L115_L0.6070.99
6_M38_I0.6060.99
6_M35_F0.6050.99
121_A124_L0.6040.99
202_A206_T0.6040.99
57_C62_A0.6030.99
158_H229_L0.6020.99
217_L221_L0.6010.99
172_G180_C0.6000.99
43_G145_A0.5960.99
90_F98_M0.5900.99
213_L228_T0.5890.99
154_L224_Q0.5880.99
76_G90_F0.5840.99
182_T185_L0.5830.99
79_L113_L0.5830.99
229_L232_A0.5810.99
58_G61_L0.5810.99
50_F135_S0.5770.99
146_V203_M0.5710.99
5_A27_H0.5710.99
160_Y163_E0.5660.99
90_F93_R0.5650.99
226_G230_G0.5650.99
176_G181_V0.5630.98
2_L34_T0.5630.98
199_G202_A0.5620.98
60_P128_E0.5610.98
94_S98_M0.5600.98
139_S143_A0.5600.98
172_G178_Q0.5600.98
12_R92_A0.5590.98
86_C231_A0.5590.98
68_L72_L0.5590.98
43_G144_C0.5580.98
164_E169_V0.5570.98
5_A28_Y0.5570.98
48_L51_M0.5560.98
162_R167_G0.5560.98
99_L102_M0.5540.98
7_L15_V0.5540.98
6_M31_G0.5540.98
147_S237_E0.5530.98
147_S150_T0.5510.98
52_V56_W0.5500.98
66_S126_L0.5500.98
210_I236_G0.5490.98
121_A242_L0.5470.98
149_G153_L0.5470.98
9_F28_Y0.5470.98
8_S12_R0.5450.98
85_T90_F0.5400.98
102_M225_T0.5370.98
155_M158_H0.5360.98
209_A213_L0.5350.98
82_L231_A0.5340.98
85_T221_L0.5320.98
68_L121_A0.5310.98
163_E168_N0.5310.98
47_G144_C0.5300.98
40_L44_A0.5280.98
88_G98_M0.5280.98
188_I192_V0.5270.98
101_I110_H0.5250.98
46_S69_V0.5230.98
34_T37_L0.5220.98
87_D104_D0.5210.98
9_F166_L0.5210.98
213_L235_L0.5200.97
10_I31_G0.5170.97
5_A22_G0.5160.97
205_V239_V0.5160.97
69_V73_M0.5140.97
39_G43_G0.5130.97
104_D109_T0.5120.97
154_L229_L0.5100.97
212_I215_Q0.5100.97
48_L52_V0.5100.97
201_A204_V0.5090.97
84_D87_D0.5090.97
1_K21_Q0.5080.97
17_R20_S0.5060.97
239_V243_A0.5040.97
75_G93_R0.5030.97
217_L224_Q0.5030.97
227_D230_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qncA 2 0.3156 2.9 0.963 Contact Map
3j45G 1 0.2459 2.7 0.964 Contact Map
4nefA 4 0.291 1.8 0.967 Contact Map
2jttC 1 0.127 1.7 0.968 Contact Map
4w252 1 0.2295 1.5 0.969 Contact Map
4xk8J 1 0.1598 1.3 0.97 Contact Map
4rngA 2 0.291 1.1 0.971 Contact Map
3mp7B 1 0.2213 1.1 0.971 Contact Map
2ww9B 1 0.2213 1 0.972 Contact Map
2y69E 1 0.209 1 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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