GREMLIN Database
PF05230 - (30-209) Probable diguanylate cyclase AdrA
UniProt: P0AAP1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 180 (175)
Sequences: 1915 (1440)
Seq/√Len: 108.8
META: 0.729

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_R53_H4.5541.00
58_I71_Y4.0051.00
13_R17_A3.3521.00
68_R72_N3.2141.00
84_V98_L3.1451.00
47_W83_W3.1171.00
24_F49_F3.0311.00
129_L134_I2.9531.00
78_V124_S2.8891.00
33_S141_A2.6581.00
105_L117_G2.4411.00
77_A105_L2.4071.00
82_M128_T2.3871.00
29_S144_E2.3741.00
28_A41_W2.3731.00
80_A101_M2.3541.00
132_T135_T2.2541.00
17_A53_H2.1731.00
69_E72_N2.1301.00
56_W60_S2.0601.00
10_R14_L2.0571.00
85_G89_V2.0431.00
57_Q61_R1.9801.00
31_L36_P1.9651.00
140_S145_W1.8641.00
170_L174_K1.8471.00
46_G50_V1.8331.00
78_V120_L1.8311.00
87_M93_P1.7571.00
55_A72_N1.7521.00
102_C114_F1.7251.00
104_N155_Y1.6921.00
51_W55_A1.6671.00
112_R116_A1.6531.00
120_L124_S1.6421.00
124_S128_T1.6201.00
47_W79_L1.5751.00
141_A144_E1.5371.00
59_A72_N1.5301.00
33_S144_E1.5091.00
50_V54_L1.4891.00
106_M114_F1.4771.00
89_V125_C1.4701.00
176_R179_V1.4631.00
27_I87_M1.4511.00
91_V140_S1.4381.00
98_L121_M1.4301.00
74_K120_L1.4131.00
92_L149_L1.4071.00
103_L160_G1.4041.00
62_A68_R1.3981.00
20_L23_M1.3801.00
46_G54_L1.3551.00
90_N93_P1.3301.00
84_V94_S1.3230.99
169_K172_E1.2890.99
9_A59_A1.2700.99
64_D67_S1.2460.99
24_F45_V1.2370.99
33_S36_P1.2130.99
12_V15_P1.2080.99
128_T132_T1.2060.99
59_A68_R1.1820.99
109_G113_L1.1790.99
153_V156_P1.1770.99
58_I72_N1.1730.99
113_L117_G1.1600.99
92_L95_T1.1530.99
172_E176_R1.1160.98
75_T79_L1.1010.98
68_R71_Y1.0960.98
10_R56_W1.0670.98
88_G137_S1.0410.97
84_V121_M1.0350.97
42_L46_G1.0290.97
12_V96_A1.0280.97
36_P40_W1.0260.97
85_G129_L1.0210.97
111_P115_V1.0180.97
15_P158_L1.0050.97
173_H176_R1.0020.96
140_S144_E0.9800.96
139_N143_L0.9690.96
91_V142_P0.9620.96
12_V171_A0.9530.95
85_G128_T0.9470.95
166_T170_L0.9440.95
103_L107_G0.9410.95
85_G125_C0.9310.95
19_G51_W0.9270.95
86_V128_T0.9190.94
24_F48_A0.9070.94
162_V166_T0.9020.94
37_P42_L0.9000.94
139_N142_P0.8950.93
157_L161_W0.8910.93
142_P146_W0.8830.93
67_S71_Y0.8820.93
92_L140_S0.8720.93
24_F95_T0.8680.92
93_P140_S0.8670.92
95_T153_V0.8640.92
18_V22_G0.8620.92
62_A71_Y0.8550.92
119_V123_V0.8330.91
25_L29_S0.8270.90
94_S97_M0.8200.90
60_S63_V0.8140.90
130_E133_G0.8120.90
126_L130_E0.8110.90
38_G42_L0.8100.90
37_P40_W0.8060.89
13_R56_W0.8020.89
154_I167_A0.8000.89
162_V170_L0.7980.89
143_L146_W0.7970.89
79_L82_M0.7950.89
96_A148_S0.7850.88
82_M86_V0.7740.87
66_L70_I0.7700.87
17_A35_P0.7690.87
51_W90_N0.7600.86
129_L132_T0.7570.86
107_G124_S0.7410.85
26_P108_A0.7360.85
175_R178_Q0.7340.84
30_T87_M0.7330.84
129_L135_T0.7290.84
81_G125_C0.7210.83
8_F108_A0.7210.83
90_N140_S0.7180.83
48_A155_Y0.7180.83
45_V49_F0.7150.83
87_M90_N0.7140.83
78_V125_C0.7130.83
71_Y75_T0.7130.83
85_G88_G0.7130.83
75_T127_V0.7120.83
59_A69_E0.7110.83
150_P156_P0.7090.82
15_P159_F0.7080.82
118_L121_M0.7080.82
168_T171_A0.7030.82
129_L133_G0.6980.81
55_A69_E0.6950.81
9_A15_P0.6940.81
78_V139_N0.6930.81
30_T33_S0.6920.81
91_V146_W0.6910.81
51_W163_S0.6880.80
63_V127_V0.6850.80
93_P148_S0.6810.80
164_Y170_L0.6780.79
58_I61_R0.6770.79
15_P18_V0.6750.79
160_G167_A0.6740.79
49_F53_H0.6740.79
83_W97_M0.6740.79
102_C121_M0.6700.79
6_L65_P0.6690.79
70_I113_L0.6690.79
55_A155_Y0.6690.79
32_V111_P0.6650.78
123_V127_V0.6650.78
22_G94_S0.6640.78
131_L135_T0.6570.77
92_L145_W0.6560.77
81_G155_Y0.6530.77
110_G155_Y0.6520.77
107_G163_S0.6500.77
21_A48_A0.6480.76
140_S148_S0.6420.76
167_A178_Q0.6410.76
171_A175_R0.6370.75
107_G160_G0.6340.75
156_P173_H0.6320.75
88_G132_T0.6320.75
57_Q63_V0.6310.74
30_T90_N0.6300.74
102_C117_G0.6270.74
78_V123_V0.6260.74
138_F142_P0.6250.74
101_M121_M0.6220.73
166_T173_H0.6200.73
142_P145_W0.6120.72
40_W86_V0.6120.72
108_A113_L0.6100.72
68_R169_K0.6100.72
20_L80_A0.6090.72
53_H164_Y0.6080.72
126_L131_L0.6080.72
166_T174_K0.6020.71
12_V104_N0.6010.71
51_W76_D0.6000.71
48_A51_W0.5990.71
45_V50_V0.5990.71
57_Q60_S0.5940.70
18_V158_L0.5940.70
8_F12_V0.5910.70
96_A152_I0.5860.69
96_A153_V0.5850.69
39_W42_L0.5840.69
53_H69_E0.5830.68
32_V136_V0.5780.68
21_A25_L0.5780.68
118_L155_Y0.5750.67
99_M156_P0.5730.67
100_I156_P0.5720.67
85_G122_V0.5710.67
15_P166_T0.5710.67
42_L61_R0.5690.67
65_P77_A0.5690.67
99_M106_M0.5670.66
109_G166_T0.5620.66
55_A150_P0.5590.65
131_L179_V0.5590.65
110_G117_G0.5580.65
92_L106_M0.5550.65
121_M144_E0.5530.64
90_N145_W0.5520.64
105_L114_F0.5510.64
8_F11_R0.5500.64
91_V139_N0.5500.64
23_M101_M0.5490.64
44_L83_W0.5490.64
127_V130_E0.5480.64
154_I179_V0.5480.64
20_L92_L0.5470.64
37_P122_V0.5440.63
71_Y74_K0.5380.62
111_P161_W0.5380.62
96_A140_S0.5380.62
166_T169_K0.5380.62
63_V134_I0.5370.62
162_V175_R0.5310.61
168_T172_E0.5300.61
34_H63_V0.5300.61
86_V132_T0.5280.61
77_A120_L0.5270.61
34_H137_S0.5270.61
40_W137_S0.5220.60
62_A65_P0.5210.60
5_G86_V0.5190.60
39_W120_L0.5190.60
149_L152_I0.5180.59
174_K178_Q0.5180.59
146_W162_V0.5160.59
161_W165_Q0.5150.59
60_S169_K0.5150.59
81_G120_L0.5130.59
20_L101_M0.5120.59
173_H177_L0.5120.59
60_S127_V0.5110.58
112_R115_V0.5090.58
169_K173_H0.5080.58
175_R179_V0.5080.58
121_M125_C0.5070.58
7_R12_V0.5060.58
12_V73_L0.5050.58
17_A24_F0.5000.57
115_V118_L0.5000.57
80_A97_M0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pgrA 1 0.9056 15.8 0.933 Contact Map
3l1lA 2 0.3667 9 0.94 Contact Map
2micA 2 0.2278 8.9 0.94 Contact Map
4m5bA 1 0.7556 5.8 0.945 Contact Map
2l8sA 1 0.2556 5.2 0.946 Contact Map
2m7gA 1 0.2389 5.2 0.946 Contact Map
3j01B 1 0.3778 4.1 0.949 Contact Map
4mt1A 3 0.4056 3.9 0.949 Contact Map
4mndA 2 0.8944 3.7 0.95 Contact Map
2rddB 1 0.2056 3.6 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.007 seconds.