GREMLIN Database
PF04279 - Probable intracellular septation protein A
UniProt: P0A710 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 177 (175)
Sequences: 4665 (2909)
Seq/√Len: 219.9
META: 0.915

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_D143_Q4.1441.00
83_A131_G3.7981.00
102_Q113_Q3.4451.00
86_A128_I3.3661.00
142_P145_I3.0841.00
71_D75_K2.9591.00
41_W45_R2.8671.00
114_P118_K2.5961.00
75_K143_Q2.5261.00
141_L145_I2.4081.00
39_Y43_R2.2671.00
23_Y66_L2.1441.00
90_L124_A2.1141.00
12_V28_A2.0341.00
38_I42_V1.9061.00
136_Y141_L1.8961.00
63_G67_F1.8931.00
112_P115_V1.8811.00
30_I59_V1.8431.00
29_L58_V1.8351.00
37_L47_V1.8311.00
130_C154_L1.8201.00
112_P172_H1.7881.00
21_D24_A1.7251.00
135_I139_F1.6911.00
102_Q106_G1.6591.00
91_V96_M1.6431.00
16_F24_A1.6151.00
137_I141_L1.6011.00
128_I132_L1.5991.00
163_L166_G1.5921.00
83_A87_G1.4971.00
33_T55_F1.4861.00
10_L151_V1.4471.00
51_A55_F1.4281.00
125_V129_L1.4181.00
145_I148_N1.4161.00
91_V95_V1.4161.00
117_S121_L1.4141.00
89_L120_N1.4121.00
34_A59_V1.4071.00
48_E51_A1.4061.00
41_W47_V1.3951.00
16_F28_A1.3731.00
22_I74_I1.3701.00
24_A27_A1.3541.00
34_A55_F1.3481.00
93_Q117_S1.3461.00
93_Q120_N1.3451.00
37_L55_F1.3331.00
38_I41_W1.3241.00
83_A128_I1.3141.00
161_F165_S1.3061.00
17_Y143_Q1.2871.00
42_V45_R1.2781.00
75_K138_A1.2651.00
23_Y69_H1.2281.00
155_T158_T1.2181.00
49_K53_I1.1721.00
148_N151_V1.1711.00
88_A91_V1.1631.00
20_Y24_A1.1591.00
135_I138_A1.1251.00
152_F156_A1.1191.00
26_T74_I1.1161.00
18_K148_N1.1121.00
15_A19_I1.0981.00
118_K168_Y1.0921.00
26_T65_T1.0921.00
89_L101_I1.0861.00
14_F18_K1.0851.00
27_A31_V1.0841.00
87_G91_V1.0761.00
71_D74_I1.0641.00
85_F127_F1.0621.00
26_T62_G1.0611.00
110_T174_P1.0601.00
64_L68_F1.0541.00
30_I63_G1.0511.00
121_L125_V1.0511.00
129_L133_A1.0481.00
7_F10_L1.0461.00
163_L167_I1.0391.00
132_L136_Y1.0361.00
149_F154_L1.0321.00
41_W44_F1.0241.00
99_P120_N1.0211.00
86_A124_A1.0201.00
60_V63_G1.0181.00
136_Y140_W1.0181.00
99_P102_Q0.9991.00
82_Y154_L0.9941.00
89_L100_L0.9911.00
52_L56_V0.9891.00
40_S44_F0.9891.00
17_Y147_V0.9841.00
90_L125_V0.9811.00
115_V168_Y0.9801.00
91_V124_A0.9671.00
53_I57_L0.9661.00
40_S51_A0.9431.00
153_G156_A0.9421.00
112_P118_K0.9351.00
115_V118_K0.9351.00
83_A135_I0.9341.00
100_L103_R0.9331.00
64_L67_F0.9311.00
137_I145_I0.9280.99
65_T74_I0.9260.99
144_N148_N0.9260.99
126_F157_L0.9130.99
90_L121_L0.9060.99
166_G170_Y0.8980.99
72_E76_W0.8920.99
47_V52_L0.8830.99
40_S47_V0.8830.99
126_F161_F0.8780.99
131_G135_I0.8710.99
79_T132_L0.8690.99
16_F20_Y0.8690.99
148_N152_F0.8680.99
12_V16_F0.8660.99
92_S100_L0.8630.99
29_L33_T0.8620.99
113_Q117_S0.8570.99
30_I62_G0.8540.99
105_L109_L0.8530.99
167_I170_Y0.8510.99
122_A165_S0.8490.99
11_V15_A0.8430.99
133_A157_L0.8240.99
149_F153_G0.8130.99
137_I149_F0.8050.99
30_I34_A0.8000.99
61_F64_L0.7980.98
5_L8_L0.7960.98
12_V32_A0.7930.98
24_A28_A0.7930.98
159_L163_L0.7900.98
109_L169_I0.7890.98
98_K103_R0.7890.98
30_I33_T0.7830.98
76_W139_F0.7810.98
39_Y42_V0.7760.98
57_L81_I0.7720.98
33_T40_S0.7670.98
50_M53_I0.7600.98
159_L162_T0.7600.98
86_A90_L0.7590.98
105_L108_E0.7540.98
110_T176_E0.7500.98
28_A31_V0.7500.98
151_V155_T0.7490.98
81_I85_F0.7450.98
122_A161_F0.7430.98
37_L52_L0.7420.98
91_V100_L0.7410.98
167_I171_R0.7370.97
94_W97_K0.7370.97
99_P117_S0.7350.97
164_L167_I0.7340.97
162_T166_G0.7330.97
15_A18_K0.7200.97
6_D48_E0.7160.97
84_L88_A0.7130.97
84_L87_G0.7120.97
88_A100_L0.7090.97
10_L14_F0.7060.97
78_V138_A0.7060.97
115_V172_H0.7050.97
168_Y172_H0.7040.97
29_L32_A0.6920.96
89_L124_A0.6910.96
90_L95_V0.6900.96
2_K48_E0.6880.96
82_Y130_C0.6840.96
171_R174_P0.6830.96
103_R107_K0.6790.96
17_Y144_N0.6680.95
34_A38_I0.6650.95
96_M99_P0.6630.95
92_S99_P0.6610.95
118_K121_L0.6610.95
72_E139_F0.6600.95
31_V34_A0.6590.95
130_C157_L0.6570.95
133_A137_I0.6550.95
112_P174_P0.6540.95
81_I84_L0.6530.95
30_I66_L0.6520.95
61_F80_V0.6500.95
72_E138_A0.6470.95
96_M103_R0.6440.95
35_I39_Y0.6420.94
82_Y158_T0.6320.94
71_D144_N0.6240.94
5_L39_Y0.6230.93
64_L73_F0.6220.93
52_L55_F0.6220.93
53_I84_L0.6210.93
122_A168_Y0.6190.93
8_L32_A0.6170.93
3_Q8_L0.6110.93
22_I143_Q0.6080.93
90_L93_Q0.6060.93
170_Y173_M0.6060.93
79_T134_N0.6030.92
56_V60_V0.6020.92
68_F73_F0.6010.92
5_L43_R0.6000.92
82_Y155_T0.6000.92
169_I173_M0.5970.92
32_A36_V0.5970.92
137_I140_W0.5950.92
29_L74_I0.5930.92
93_Q121_L0.5860.91
166_G173_M0.5860.91
22_I25_A0.5810.91
119_L165_S0.5800.91
89_L92_S0.5790.91
92_S96_M0.5790.91
41_W52_L0.5790.91
82_Y85_F0.5770.91
121_L124_A0.5760.91
162_T169_I0.5730.90
153_G157_L0.5720.90
143_Q147_V0.5710.90
111_L119_L0.5660.90
49_K104_M0.5620.89
22_I71_D0.5590.89
111_L115_V0.5590.89
133_A149_F0.5580.89
54_T58_V0.5560.89
151_V154_L0.5430.88
37_L51_A0.5430.88
10_L17_Y0.5410.88
3_Q7_F0.5400.88
158_T162_T0.5370.87
4_F8_L0.5370.87
97_K113_Q0.5350.87
61_F81_I0.5350.87
76_W138_A0.5340.87
166_G169_I0.5300.87
33_T37_L0.5300.87
168_Y171_R0.5300.87
54_T81_I0.5260.86
61_F84_L0.5260.86
21_D25_A0.5240.86
30_I58_V0.5210.86
28_A32_A0.5190.85
156_A163_L0.5180.85
35_I38_I0.5160.85
99_P103_R0.5150.85
23_Y27_A0.5140.85
101_I119_L0.5130.85
76_W135_I0.5120.85
23_Y26_T0.5090.84
18_K21_D0.5070.84
123_W162_T0.5020.84
100_L104_M0.5020.84
90_L94_W0.5000.83
38_I45_R0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.9096 12.7 0.948 Contact Map
4pgrA 1 0.7345 4.4 0.958 Contact Map
1hgvA 8 0.2599 4.4 0.958 Contact Map
3m73A 3 0.7062 3.9 0.959 Contact Map
4pypA 1 0.9209 3.2 0.961 Contact Map
4zw9A 1 0.9605 2.3 0.964 Contact Map
1pjnA 1 0.0452 2.1 0.964 Contact Map
3wdoA 1 0.9435 1.9 0.965 Contact Map
4pd6A 3 0.5932 1.7 0.966 Contact Map
4lz6A 1 0.9209 1.7 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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