GREMLIN Database
PF03802 - Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
UniProt: P0A6G5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 169 (166)
Sequences: 1059 (910)
Seq/√Len: 70.6
META: 0.845

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_Q152_T3.6241.00
31_P96_L3.5011.00
142_Q146_V3.1111.00
40_P162_M3.0601.00
60_L100_T2.9921.00
45_D50_R2.9241.00
161_R164_A2.8651.00
35_F56_G2.7891.00
100_T115_I2.5791.00
28_H88_S2.4491.00
81_S84_E2.3571.00
7_I11_L2.3001.00
134_P143_S2.2731.00
143_S146_V2.1871.00
56_G113_W2.1081.00
161_R165_L2.1051.00
34_S86_M2.0771.00
46_S49_T2.0221.00
52_I166_L2.0011.00
59_A107_H1.9641.00
57_V85_G1.9391.00
145_A148_A1.8531.00
38_V113_W1.8501.00
21_Q32_L1.8371.00
37_V52_I1.7431.00
39_A49_T1.7311.00
5_V10_L1.7311.00
61_R74_Q1.7271.00
9_E80_A1.7191.00
33_V100_T1.6480.99
37_V49_T1.6430.99
60_L115_I1.6300.99
139_L161_R1.6160.99
45_D83_P1.6120.99
33_V89_I1.6050.99
7_I15_D1.5920.99
12_V16_E1.5820.99
41_G44_K1.5810.99
21_Q118_L1.5310.99
20_R75_A1.5210.99
24_W88_S1.4920.99
10_L13_S1.4670.99
138_L161_R1.4450.99
42_P155_L1.4270.98
37_V53_F1.3960.98
64_A99_A1.3950.98
61_R87_L1.3870.98
38_V111_R1.3810.98
53_F56_G1.3350.98
91_A96_L1.3190.97
154_Q157_D1.3020.97
36_T84_E1.2990.97
32_L36_T1.2970.97
8_P12_V1.2810.97
119_T123_E1.2770.97
13_S36_T1.2620.97
37_V166_L1.2500.96
30_V90_A1.2450.96
102_E106_S1.2250.96
94_R98_L1.2080.96
127_R135_R1.1510.94
155_L159_L1.1470.94
25_L32_L1.1390.94
39_A53_F1.1310.94
107_H169_V1.1270.94
92_P95_D1.1160.93
13_S79_S1.1050.93
16_E79_S1.0980.93
118_L124_I1.0840.92
89_I96_L1.0770.92
18_Q22_H1.0720.92
44_K111_R1.0610.92
136_R141_E1.0590.91
107_H110_G1.0470.91
112_L165_L1.0460.91
125_L130_Y1.0420.91
23_V27_R1.0310.90
119_T122_G1.0100.89
103_L113_W1.0030.89
35_F113_W0.9980.89
50_R83_P0.9930.89
19_A131_S0.9830.88
69_W99_A0.9800.88
112_L138_L0.9770.88
28_H73_E0.9680.87
35_F115_I0.9630.87
146_V150_G0.9510.86
36_T81_S0.9500.86
39_A162_M0.9490.86
43_I159_L0.9310.85
148_A151_K0.9300.85
49_T159_L0.9240.85
41_G111_R0.9140.84
49_T53_F0.9110.84
45_D78_V0.9080.84
33_V115_I0.9050.84
147_C153_H0.9020.83
21_Q25_L0.9000.83
11_L15_D0.9000.83
84_E118_L0.8950.83
71_I89_I0.8900.83
33_V105_H0.8850.82
33_V60_L0.8740.81
64_A89_I0.8680.81
100_T117_V0.8670.81
15_D111_R0.8570.80
13_S17_R0.8520.80
139_L158_L0.8520.80
137_C140_C0.8470.79
58_T62_A0.8460.79
25_L118_L0.8360.78
35_F53_F0.8250.77
78_V83_P0.8210.77
28_H31_P0.8200.77
73_E88_S0.8180.77
35_F87_L0.8110.76
30_V88_S0.8020.75
91_A95_D0.7990.75
137_C147_C0.7960.75
146_V152_T0.7830.74
12_V15_D0.7810.74
38_V41_G0.7780.73
39_A81_S0.7760.73
158_L162_M0.7740.73
69_W89_I0.7720.73
34_S84_E0.7690.72
35_F60_L0.7680.72
140_C147_C0.7590.71
114_D149_R0.7550.71
99_A102_E0.7530.71
151_K155_L0.7520.71
57_V61_R0.7510.71
95_D98_L0.7500.70
101_I132_L0.7500.70
136_R164_A0.7480.70
24_W86_M0.7470.70
20_R86_M0.7450.70
57_V76_A0.7450.70
106_S110_G0.7410.70
45_D49_T0.7390.69
19_A22_H0.7330.69
43_I81_S0.7310.68
32_L88_S0.7290.68
138_L144_A0.7280.68
42_P49_T0.7200.67
18_Q124_I0.7180.67
111_R149_R0.7140.67
24_W73_E0.7140.67
160_N164_A0.7120.66
38_V56_G0.7070.66
40_P158_L0.7030.65
38_V44_K0.7010.65
56_G85_G0.6960.65
30_V72_Q0.6920.64
11_L17_R0.6920.64
52_I109_L0.6840.63
11_L14_R0.6830.63
124_I130_Y0.6740.62
111_R116_D0.6700.62
59_A169_V0.6660.61
165_L168_D0.6640.61
71_I90_A0.6640.61
101_I127_R0.6600.61
80_A98_L0.6590.60
27_R73_E0.6570.60
31_P89_I0.6570.60
138_L158_L0.6550.60
109_L169_V0.6540.60
56_G81_S0.6540.60
101_I133_P0.6480.59
64_A96_L0.6460.59
13_S84_E0.6430.59
64_A69_W0.6410.58
14_R17_R0.6410.58
49_T83_P0.6400.58
36_T79_S0.6350.58
140_C153_H0.6340.58
25_L31_P0.6330.57
9_E88_S0.6250.56
137_C153_H0.6180.56
32_L118_L0.6150.55
111_R114_D0.6150.55
101_I130_Y0.6150.55
159_L163_E0.6150.55
42_P159_L0.6130.55
46_S145_A0.6120.55
63_L102_E0.6100.55
97_K104_E0.6100.55
131_S161_R0.6070.54
33_V57_V0.5960.53
20_R23_V0.5940.53
7_I10_L0.5930.53
5_V9_E0.5920.52
36_T113_W0.5910.52
13_S81_S0.5900.52
67_Q95_D0.5880.52
57_V87_L0.5870.52
21_Q84_E0.5850.52
156_T160_N0.5840.51
149_R152_T0.5820.51
105_H136_R0.5750.50
93_A125_L0.5700.50
11_L44_K0.5700.50
92_P168_D0.5690.50
33_V96_L0.5680.50
108_P168_D0.5650.49
66_K128_R0.5630.49
31_P91_A0.5610.49
55_H169_V0.5600.49
63_L103_L0.5590.48
54_N102_E0.5580.48
107_H165_L0.5540.48
21_Q36_T0.5530.48
141_E144_A0.5510.47
121_E141_E0.5460.47
29_P122_G0.5450.47
44_K149_R0.5450.47
95_D99_A0.5430.47
163_E167_N0.5420.46
26_K117_V0.5410.46
22_H26_K0.5400.46
10_L151_K0.5390.46
18_Q150_G0.5360.46
76_A85_G0.5350.46
53_F57_V0.5300.45
39_A46_S0.5290.45
96_L117_V0.5280.45
68_G122_G0.5280.45
88_S122_G0.5270.45
143_S160_N0.5240.44
155_L167_N0.5240.44
127_R145_A0.5220.44
47_E54_N0.5210.44
138_L148_A0.5210.44
98_L102_E0.5170.43
11_L111_R0.5160.43
10_L37_V0.5140.43
79_S86_M0.5140.43
79_S84_E0.5120.43
166_L169_V0.5120.43
10_L81_S0.5110.43
54_N65_A0.5110.43
59_A63_L0.5050.42
123_E129_D0.5030.42
40_P138_L0.5030.42
144_A148_A0.5020.42
21_Q34_S0.5010.41
17_R84_E0.5000.41
93_A119_T0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hc7A 2 0.6805 35.1 0.937 Contact Map
2pt7G 2 0.4615 16 0.946 Contact Map
3j65n 1 0.9941 14.5 0.947 Contact Map
3j21k 1 0.929 13.8 0.948 Contact Map
1nj1A 2 0.6627 11.6 0.95 Contact Map
4macA 2 0.2308 11.5 0.95 Contact Map
1zt2A 3 0.8343 10.6 0.951 Contact Map
4ncxA 2 0.6923 10.5 0.951 Contact Map
3j3bq 1 0.9112 10.5 0.951 Contact Map
4cwbA 1 0.7929 9.5 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0072 seconds.