GREMLIN Database
PF05648 - Peroxisomal membrane protein 11B
UniProt: O96011 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 259 (222)
Sequences: 1294 (952)
Seq/√Len: 63.9
META: 0.16

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_R243_S4.9961.00
55_G59_L4.5731.00
79_D140_Y4.1801.00
149_E204_H3.6091.00
209_L245_L3.1871.00
30_H233_G2.9961.00
93_R130_S2.9771.00
148_Q196_L2.6581.00
92_N133_M2.3751.00
61_L101_N2.3391.00
23_Y239_G2.3291.00
127_Y131_L2.2561.00
2_D6_R2.2281.00
105_A111_A2.2211.00
95_L126_Y2.2121.00
19_R217_D2.2041.00
7_F247_I2.1311.00
213_R217_D2.0671.00
43_K47_Q2.0191.00
64_S101_N1.9931.00
57_K100_D1.9831.00
231_G234_I1.9111.00
20_A240_L1.8931.00
158_K162_G1.8861.00
69_E73_R1.8861.00
140_Y144_L1.8581.00
103_L120_A1.8511.00
58_L104_W1.8001.00
145_L200_V1.7701.00
152_A197_L1.7561.00
6_R10_Q1.7160.99
20_A24_A1.6970.99
97_F101_N1.6740.99
88_V133_M1.6730.99
104_W108_S1.6250.99
216_C242_S1.6190.99
98_A101_N1.5970.99
21_A52_L1.5910.99
236_G239_G1.5730.99
217_D242_S1.5710.99
82_L86_I1.5660.99
217_D221_P1.5030.98
57_K103_L1.4800.98
66_D221_P1.4790.98
158_K161_G1.4720.98
142_I204_H1.4640.98
220_I224_K1.4410.98
242_S245_L1.4240.98
4_W8_S1.4200.98
92_N130_S1.4050.98
128_L222_L1.3850.97
134_N242_S1.3770.97
64_S98_A1.3760.97
101_N104_W1.3730.97
40_E43_K1.3700.97
18_C52_L1.3590.97
23_Y57_K1.3560.97
209_L242_S1.3480.97
57_K63_N1.3420.97
117_E199_R1.3360.97
138_D214_N1.3310.97
92_N129_F1.3130.96
57_K108_S1.3120.96
128_L227_L1.3040.96
131_L225_L1.2960.96
99_C119_W1.2960.96
62_G242_S1.2890.96
16_R26_S1.2730.96
99_C122_R1.2650.96
45_I237_L1.2580.95
209_L248_L1.2490.95
48_L110_L1.2370.95
57_K239_G1.2230.95
79_D82_L1.2150.94
121_Q125_R1.2110.94
19_R221_P1.2090.94
26_S49_E1.2080.94
190_L196_L1.2000.94
232_P236_G1.1920.94
138_D207_L1.1880.94
67_A97_F1.1860.94
210_D214_N1.1800.94
248_L255_L1.1620.93
130_S133_M1.1530.93
234_I238_C1.1440.92
61_L108_S1.1160.92
237_L241_V1.1150.91
196_L199_R1.1130.91
100_D213_R1.1030.91
89_S93_R1.1020.91
28_L37_A1.0910.91
20_A247_I1.0890.91
149_E152_A1.0800.90
19_R225_L1.0660.90
82_L144_L1.0640.89
236_G240_L1.0600.89
100_D224_K1.0580.89
28_L45_I1.0460.89
142_I211_V1.0420.88
11_S14_R1.0410.88
101_N128_L1.0290.88
159_G162_G1.0260.88
40_E65_A1.0250.88
19_R242_S1.0250.88
60_R96_Y1.0170.87
15_E104_W1.0120.87
154_S157_L1.0110.87
154_S197_L1.0060.87
25_C45_I1.0050.87
100_D239_G1.0040.87
109_G115_D0.9980.86
22_Q57_K0.9970.86
24_A27_L0.9970.86
79_D83_R0.9930.86
92_N230_C0.9910.86
74_A86_I0.9860.86
63_N97_F0.9820.85
240_L243_S0.9810.85
64_S100_D0.9720.85
40_E44_Q0.9690.85
51_H55_G0.9670.84
122_R125_R0.9590.84
45_I73_R0.9510.83
189_K196_L0.9470.83
240_L244_I0.9450.83
109_G112_P0.9380.83
16_R246_S0.9380.83
10_Q13_A0.9350.82
96_Y236_G0.9330.82
137_R141_E0.9320.82
209_L249_T0.9320.82
14_R100_D0.9310.82
120_A124_F0.9310.82
223_D228_W0.9260.82
123_S130_S0.9230.82
157_L161_G0.9220.81
47_Q109_G0.9220.81
141_E203_G0.9200.81
145_L149_E0.9140.81
78_S153_C0.9130.81
131_L221_P0.9110.81
54_L62_G0.9100.81
147_E150_S0.9030.80
124_F224_K0.8940.79
221_P224_K0.8830.79
25_C215_A0.8740.78
120_A123_S0.8650.77
47_Q51_H0.8600.77
197_L201_L0.8590.77
68_L208_L0.8540.76
40_E112_P0.8530.76
135_L214_N0.8530.76
115_D118_K0.8400.75
73_R215_A0.8390.75
117_E139_A0.8390.75
128_L225_L0.8370.75
51_H58_L0.8370.75
45_I48_L0.8300.74
97_F100_D0.8280.74
96_Y214_N0.8170.73
25_C28_L0.8150.73
53_S119_W0.8150.73
39_P43_K0.8140.73
51_H64_S0.8130.73
27_L31_A0.8100.72
209_L213_R0.8060.72
241_V245_L0.8060.72
128_L221_P0.8050.72
20_A23_Y0.8030.72
17_L21_A0.8020.72
148_Q151_S0.8020.72
131_L134_N0.7980.71
198_A202_R0.7960.71
46_R49_E0.7950.71
20_A246_S0.7940.71
153_C244_I0.7920.71
100_D108_S0.7910.71
71_A94_A0.7890.70
68_L91_L0.7890.70
90_H97_F0.7840.70
71_A90_H0.7820.70
32_L109_G0.7820.70
57_K62_G0.7800.69
67_A93_R0.7790.69
240_L245_L0.7790.69
188_L196_L0.7710.69
54_L108_S0.7710.69
91_L136_S0.7650.68
149_E153_C0.7640.68
49_E57_K0.7630.68
159_G188_L0.7620.68
100_D227_L0.7590.67
104_W238_C0.7540.67
207_L219_F0.7490.66
131_L214_N0.7470.66
150_S155_R0.7420.66
18_C58_L0.7420.66
96_Y133_M0.7400.65
156_R188_L0.7380.65
7_F18_C0.7350.65
146_M149_E0.7330.65
90_H93_R0.7320.65
43_K215_A0.7290.64
143_R147_E0.7290.64
223_D229_R0.7270.64
160_S188_L0.7270.64
189_K201_L0.7240.64
64_S68_L0.7240.64
67_A90_H0.7240.64
209_L216_C0.7230.64
12_Q16_R0.7200.63
62_G217_D0.7170.63
67_A94_A0.7170.63
103_L107_K0.7110.62
51_H59_L0.7060.62
149_E200_V0.7050.62
221_P225_L0.7030.61
235_V239_G0.7020.61
113_R116_Q0.6980.61
104_W243_S0.6980.61
145_L207_L0.6940.60
15_E26_S0.6910.60
126_Y129_F0.6880.60
54_L107_K0.6880.60
46_R50_S0.6870.60
100_D103_L0.6720.58
162_G196_L0.6710.58
61_L68_L0.6700.58
190_L199_R0.6670.57
102_V212_V0.6660.57
155_R190_L0.6650.57
152_A155_R0.6620.57
68_L110_L0.6530.56
54_L216_C0.6520.56
133_M202_R0.6510.56
55_G58_L0.6480.55
155_R196_L0.6460.55
157_L190_L0.6440.55
107_K116_Q0.6380.54
154_S196_L0.6370.54
92_N95_L0.6370.54
155_R189_K0.6360.54
162_G189_K0.6320.53
96_Y99_C0.6310.53
20_A29_G0.6300.53
245_L249_T0.6300.53
97_F104_W0.6290.53
189_K199_R0.6280.53
73_R76_H0.6270.53
130_S134_N0.6270.53
8_S17_L0.6270.53
95_L112_P0.6260.53
216_C238_C0.6210.52
15_E20_A0.6210.52
82_L141_E0.6200.52
27_L237_L0.6190.52
7_F17_L0.6180.52
119_W141_E0.6130.51
46_R222_L0.6130.51
199_R212_V0.6110.51
106_G243_S0.6070.50
124_F213_R0.6060.50
9_A66_D0.6030.50
199_R206_P0.6010.50
93_R127_Y0.6000.50
55_G102_V0.5990.50
208_L212_V0.5970.49
96_Y220_I0.5910.49
221_P239_G0.5910.49
148_Q203_G0.5870.48
7_F16_R0.5850.48
250_L256_R0.5820.48
210_D213_R0.5810.47
14_R23_Y0.5800.47
218_L242_S0.5790.47
145_L188_L0.5770.47
9_A12_Q0.5750.47
7_F20_A0.5720.46
114_V208_L0.5710.46
141_E216_C0.5700.46
135_L139_A0.5690.46
122_R126_Y0.5670.46
85_C142_I0.5660.46
156_R189_K0.5660.46
38_S65_A0.5630.45
51_H62_G0.5590.45
14_R63_N0.5580.45
52_L97_F0.5570.45
146_M208_L0.5560.45
139_A150_S0.5550.44
10_Q14_R0.5540.44
8_S12_Q0.5540.44
58_L89_S0.5540.44
5_V24_A0.5500.44
94_A138_D0.5470.44
57_K124_F0.5440.43
87_T92_N0.5440.43
135_L215_A0.5430.43
85_C150_S0.5420.43
68_L72_K0.5420.43
87_T109_G0.5420.43
96_Y101_N0.5420.43
146_M214_N0.5410.43
129_F215_A0.5390.43
127_Y221_P0.5370.42
243_S247_I0.5350.42
136_S143_R0.5340.42
150_S154_S0.5280.41
156_R162_G0.5280.41
202_R248_L0.5260.41
157_L160_S0.5240.41
18_C59_L0.5240.41
83_R189_K0.5210.41
149_E197_L0.5200.41
5_V10_Q0.5170.40
93_R238_C0.5150.40
7_F254_W0.5140.40
2_D240_L0.5110.40
57_K64_S0.5090.39
105_A108_S0.5090.39
189_K197_L0.5090.39
16_R22_Q0.5080.39
13_A16_R0.5060.39
115_D129_F0.5050.39
219_F238_C0.5050.39
12_Q26_S0.5040.39
135_L196_L0.5040.39
26_S217_D0.5030.39
161_G188_L0.5020.39
127_Y230_C0.5020.39
35_H241_V0.5010.38
106_G116_Q0.5000.38
149_E154_S0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sz7A 2 0.5212 40.4 0.951 Contact Map
2lxlA 1 0.5328 18.7 0.958 Contact Map
1wr1B 1 0.2124 9 0.964 Contact Map
4txrA 1 0.556 5.5 0.967 Contact Map
2a9hA 4 0.278 5.4 0.967 Contact Map
4jrbA 1 0.7027 5.2 0.968 Contact Map
2msvA 1 0.2857 4.8 0.968 Contact Map
4opcA 1 0.2934 4.7 0.968 Contact Map
2kmfA 1 0.2432 4.4 0.969 Contact Map
3bpoA 1 0.2201 4 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0087 seconds.