GREMLIN Database
PF01809 - Putative membrane protein insertion efficiency factor
UniProt: O34601 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 71 (68)
Sequences: 20184 (11408)
Seq/√Len: 1383.4
META: 0.935

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_G50_T3.8371.00
5_F43_A2.5331.00
6_I35_I2.2881.00
42_G46_G2.1141.00
10_R35_I2.0361.00
13_Q32_Q1.9621.00
48_W52_K1.9131.00
26_F62_P1.8981.00
13_Q35_I1.7471.00
26_F61_H1.7331.00
35_I39_K1.7131.00
11_G15_F1.6221.00
27_Y32_Q1.5681.00
20_T23_T1.5381.00
52_K56_K1.4841.00
5_F38_I1.4131.00
58_H61_H1.3931.00
51_I55_L1.3881.00
38_I47_G1.3741.00
32_Q36_E1.3581.00
15_F18_P1.3451.00
27_Y65_V1.3141.00
41_H45_K1.3131.00
6_I39_K1.3111.00
38_I50_T1.3091.00
37_A68_V1.2741.00
49_L69_P1.2401.00
10_R14_K1.2121.00
38_I43_A1.1921.00
36_E40_T1.1801.00
9_I34_G1.1091.00
32_Q35_I1.1051.00
10_R13_Q1.0681.00
25_R61_H1.0421.00
15_F19_L1.0201.00
55_L58_H1.0181.00
26_F56_K1.0161.00
3_T7_A0.9761.00
16_I20_T0.9751.00
34_G38_I0.9671.00
7_A11_G0.9441.00
34_G47_G0.9351.00
2_K43_A0.9281.00
47_G51_I0.9261.00
6_I10_R0.9101.00
52_K58_H0.9091.00
41_H68_V0.9061.00
36_E39_K0.8851.00
38_I46_G0.8801.00
9_I13_Q0.8601.00
46_G50_T0.8581.00
36_E68_V0.8581.00
61_H64_G0.8521.00
41_H69_P0.8181.00
4_L8_L0.8071.00
44_L47_G0.7851.00
2_K39_K0.7641.00
41_H49_L0.7531.00
4_L7_A0.7481.00
52_K55_L0.7371.00
17_S32_Q0.7341.00
56_K61_H0.7251.00
25_R62_P0.7131.00
45_K49_L0.7021.00
44_L48_W0.6951.00
49_L52_K0.6931.00
11_G14_K0.6851.00
37_A49_L0.6681.00
36_E67_P0.6641.00
19_L23_T0.6571.00
8_L11_G0.6531.00
2_K38_I0.6461.00
12_Y16_I0.6211.00
47_G55_L0.6121.00
7_A10_R0.6081.00
25_R58_H0.6061.00
14_K19_L0.6041.00
16_I19_L0.6031.00
48_W51_I0.6031.00
5_F47_G0.6011.00
9_I12_Y0.5931.00
6_I38_I0.5891.00
50_T54_I0.5811.00
17_S22_P0.5811.00
42_G50_T0.5761.00
13_Q31_S0.5751.00
2_K6_I0.5651.00
48_W55_L0.5541.00
49_L68_V0.5531.00
8_L43_A0.5481.00
25_R63_G0.5391.00
17_S29_T0.5341.00
9_I35_I0.5341.00
9_I38_I0.5331.00
47_G50_T0.5261.00
15_F20_T0.5201.00
23_T27_Y0.5151.00
40_T68_V0.5101.00
52_K61_H0.5081.00
34_G54_I0.5061.00
10_R39_K0.5021.00
60_F63_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fccA 5 0.8451 23.3 0.906 Contact Map
3mw9A 5 0.831 8.1 0.924 Contact Map
3k92A 5 0.831 6.9 0.926 Contact Map
1bgvA 5 0.831 6.3 0.928 Contact Map
3qpiA 1 0.4366 5.9 0.929 Contact Map
4at7B 1 0.8873 5.8 0.929 Contact Map
3iylA 11 0.6901 5.1 0.931 Contact Map
1jmuB 3 0.6901 4.7 0.932 Contact Map
1gtmA 5 0.831 4.4 0.933 Contact Map
2h9aA 1 0 4.2 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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