GREMLIN Database
PF08663 - (113-180) Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain
UniProt: L0I8M6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 68 (60)
Sequences: 1397 (1012)
Seq/√Len: 130.7
META: 0.862

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_K35_L3.0611.00
19_L48_V2.9391.00
20_V48_V2.3761.00
15_E47_R2.2631.00
23_K48_V2.2241.00
23_K45_V2.0021.00
3_V6_R1.9011.00
23_K41_Y1.8081.00
12_D55_V1.8051.00
23_K27_E1.7281.00
20_V24_A1.6041.00
31_A34_E1.5811.00
3_V25_L1.5571.00
25_L29_E1.4691.00
16_Y52_R1.4441.00
30_K34_E1.3811.00
27_E41_Y1.3281.00
12_D54_E1.3091.00
16_Y48_V1.3071.00
35_L41_Y1.3061.00
6_R21_S1.2721.00
17_Y21_S1.2401.00
5_S9_Y1.2341.00
17_Y20_V1.1920.99
21_S25_L1.1870.99
37_T42_Q1.1770.99
17_Y24_A1.1080.99
6_R14_Q1.0920.99
27_E45_V1.0890.99
14_Q18_A1.0350.98
27_E35_L1.0300.98
4_L26_L1.0250.98
19_L47_R1.0190.98
7_S14_Q0.9920.98
24_A28_S0.9690.98
30_K38_N0.9390.97
9_Y13_I0.9370.97
50_E53_A0.8980.96
13_I17_Y0.8840.96
38_N42_Q0.8500.95
16_Y21_S0.8330.94
6_R20_V0.8290.94
46_G49_D0.8270.94
12_D58_S0.8190.94
1_D4_L0.8120.93
20_V41_Y0.8030.93
46_G50_E0.7750.92
33_R37_T0.7740.92
18_A22_K0.7450.90
16_Y20_V0.7420.90
13_I16_Y0.7370.90
36_E49_D0.7310.89
47_R50_E0.7280.89
2_S5_S0.7110.88
31_A38_N0.6990.87
41_Y45_V0.6970.87
5_S58_S0.6870.86
49_D54_E0.6850.86
34_E38_N0.6840.86
48_V52_R0.6820.86
3_V55_V0.6710.85
21_S56_D0.6680.84
19_L23_K0.6630.84
50_E54_E0.6580.84
32_E36_E0.6580.84
7_S59_V0.6520.83
5_S20_V0.6500.83
51_L55_V0.6410.82
12_D51_L0.6350.81
21_S24_A0.6330.81
2_S59_V0.6080.78
21_S29_E0.5940.77
9_Y16_Y0.5840.76
15_E19_L0.5800.75
1_D47_R0.5770.75
26_L43_E0.5740.74
21_S52_R0.5590.73
37_T60_S0.5550.72
55_V58_S0.5540.72
10_E41_Y0.5530.72
12_D21_S0.5500.71
31_A42_Q0.5470.71
10_E28_S0.5220.67
34_E42_Q0.5120.66
3_V48_V0.5120.66
3_V23_K0.5110.66
47_R51_L0.5080.65
20_V52_R0.5060.65
24_A38_N0.5040.65
6_R24_A0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j9oB 7 0.2794 23.1 0.839 Contact Map
3s9gA 2 0.9706 21.1 0.843 Contact Map
1rq0A 3 0.7206 10.8 0.862 Contact Map
3ojaB 1 0.8676 9.4 0.865 Contact Map
1gk4A 2 0.8088 9.4 0.866 Contact Map
3q3eA 1 1 7.4 0.872 Contact Map
2f23A 1 0.9853 6.4 0.875 Contact Map
2pnvA 5 0.5735 6.2 0.876 Contact Map
2ve7C 1 0.8382 6 0.877 Contact Map
1x8yA 2 0.6765 5.9 0.878 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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