GREMLIN Database
PF10552 - (135-245) Toxin-antitoxin system, toxin component, Bro family
UniProt: I7IW01 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 111 (99)
Sequences: 917 (733)
Seq/√Len: 73.6
META: 0.59

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_D13_K6.5601.00
69_I75_L3.2711.00
63_F75_L3.0921.00
5_V9_V2.6271.00
79_D82_R2.4951.00
9_V12_I2.3491.00
76_S79_D2.1661.00
30_R60_E2.1171.00
34_S56_F1.9451.00
60_E72_Y1.8401.00
29_A84_L1.7941.00
29_A88_T1.7661.00
27_R31_D1.7301.00
52_R56_F1.6741.00
25_K80_F1.6661.00
62_D66_S1.6451.00
26_L87_I1.5290.99
20_S23_R1.5240.99
92_P100_I1.4110.99
20_S74_D1.3920.98
30_R63_F1.3840.98
33_K37_V1.3270.98
97_Q101_Q1.3000.98
95_P98_Q1.2770.97
33_K36_E1.2590.97
60_E64_K1.2530.97
30_R59_L1.2280.97
60_E63_F1.2240.96
63_F83_A1.2170.96
70_S74_D1.2130.96
10_D14_N1.2130.96
99_D102_Q1.1730.95
91_Y97_Q1.1720.95
6_E13_K1.1580.95
22_Q77_K1.1490.95
80_F84_L1.1420.95
26_L60_E1.1420.95
62_D90_W1.1400.95
40_G43_S1.1300.94
54_K99_D1.1070.94
58_Q65_D1.0870.93
64_K71_R1.0820.93
40_G46_Y1.0650.93
59_L87_I1.0560.92
28_K65_D1.0220.91
27_R60_E1.0170.91
24_F73_E1.0120.90
64_K72_Y0.9900.90
61_H65_D0.9790.89
43_S46_Y0.9740.89
21_N74_D0.9560.88
22_Q80_F0.9540.88
9_V13_K0.9500.87
85_N89_N0.9420.87
62_D86_F0.9370.87
17_E20_S0.9350.87
19_D22_Q0.9180.86
31_D34_S0.9180.86
26_L83_A0.9160.86
31_D35_V0.9100.85
17_E74_D0.9080.85
94_Y98_Q0.9020.85
23_R71_R0.8970.84
37_V92_P0.8960.84
8_D11_F0.8930.84
40_G45_F0.8700.82
86_F95_P0.8560.81
98_Q102_Q0.8550.81
6_E10_D0.8530.81
97_Q102_Q0.8470.81
62_D65_D0.8400.80
64_K70_S0.8380.80
33_K87_I0.8340.80
67_F82_R0.8330.80
58_Q90_W0.8250.79
31_D56_F0.8170.78
17_E23_R0.8150.78
18_I26_L0.8130.78
35_V38_C0.8090.78
29_A87_I0.7920.76
26_L75_L0.7870.76
75_L83_A0.7850.75
33_K91_Y0.7830.75
71_R74_D0.7810.75
23_R74_D0.7600.73
81_D84_L0.7590.73
24_F28_K0.7480.72
67_F83_A0.7480.72
84_L88_T0.7470.72
30_R34_S0.7440.71
75_L87_I0.7370.71
29_A32_R0.7230.69
34_S90_W0.7200.69
58_Q62_D0.7060.67
16_S19_D0.7030.67
94_Y97_Q0.6980.67
48_D52_R0.6970.66
29_A89_N0.6870.65
86_F90_W0.6830.65
53_R57_R0.6810.65
31_D73_E0.6690.63
33_K101_Q0.6630.63
39_G43_S0.6610.62
51_K54_K0.6600.62
27_R64_K0.6480.61
54_K83_A0.6380.60
26_L80_F0.6370.60
24_F71_R0.6270.58
25_K84_L0.6250.58
93_S96_L0.6240.58
67_F72_Y0.6180.57
85_N88_T0.6160.57
63_F69_I0.6160.57
14_N78_K0.6150.57
66_S86_F0.6130.57
15_T76_S0.6070.56
39_G46_Y0.6040.56
27_R56_F0.6040.56
98_Q101_Q0.6040.56
60_E71_R0.6020.55
22_Q76_S0.6000.55
21_N68_V0.5930.54
94_Y102_Q0.5930.54
72_Y96_L0.5870.53
18_I23_R0.5820.53
33_K88_T0.5810.53
18_I87_I0.5790.52
23_R73_E0.5780.52
11_F15_T0.5750.52
38_C46_Y0.5670.51
38_C43_S0.5660.51
81_D85_N0.5650.51
15_T77_K0.5650.51
58_Q93_S0.5500.49
45_F51_K0.5500.49
17_E77_K0.5450.48
94_Y99_D0.5330.47
4_N8_D0.5290.46
82_R86_F0.5270.46
30_R75_L0.5250.46
19_D23_R0.5170.45
36_E88_T0.5120.44
42_K47_K0.5100.44
55_V92_P0.5100.44
82_R85_N0.5060.43
7_K10_D0.5050.43
35_V56_F0.5030.43
38_C41_K0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4icgC 1 0.4775 13.8 0.912 Contact Map
4cemA 1 0.3153 11.8 0.914 Contact Map
2g8lA 2 0.9279 11.2 0.916 Contact Map
2wq1A 3 0.2883 10.8 0.916 Contact Map
4gouA 1 0.964 10.6 0.916 Contact Map
4y66B 1 0.7838 10.1 0.917 Contact Map
2ffjA 2 0.8468 9.2 0.918 Contact Map
3mtuE 2 0.3604 8.7 0.919 Contact Map
3w92A 3 0.2793 8.5 0.92 Contact Map
3pt1A 1 0.9009 8.4 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0048 seconds.