GREMLIN Database
PF11812 - Phosphate ABC transporter membrane protein 2, PhoT family
UniProt: I3YD59 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 418 (416)
Sequences: 1442 (894)
Seq/√Len: 43.8
META: 0.748

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_R166_G5.3251.00
155_R159_D3.7181.00
46_Q176_K3.6201.00
138_I157_V3.5751.00
53_P129_E3.4411.00
55_T58_A3.3031.00
273_L364_T3.1381.00
209_L276_A3.0921.00
48_T142_V3.0851.00
10_A14_R3.0331.00
206_T369_V2.9721.00
116_R123_L2.9711.00
86_R102_Y2.9521.00
31_V35_A2.9281.00
51_R131_W2.9001.00
14_R18_I2.8931.00
138_I165_V2.8761.00
147_D150_A2.7201.00
62_D67_R2.6331.00
56_L128_Q2.6241.00
97_E160_E2.6221.00
137_D156_R2.6131.00
405_F409_M2.5551.00
11_R14_R2.5331.00
38_V42_Y2.5141.00
223_L318_F2.4981.00
152_Q155_R2.4901.00
305_A308_G2.4631.00
12_E15_F2.4061.00
142_V165_V2.4011.00
213_L280_T2.3771.00
51_R129_E2.3441.00
131_W175_E2.3011.00
167_Q171_Q2.2911.00
50_I134_A2.2591.00
36_D40_K2.2391.00
228_F317_Q2.2081.00
84_A88_Q2.2011.00
17_L20_A2.1951.00
286_I339_H2.1941.00
21_I25_L2.1921.00
94_D97_E2.1691.00
108_G193_L2.1161.00
11_R18_I2.1150.99
24_G28_A2.1120.99
30_V34_F2.1060.99
72_I77_Y2.0980.99
234_W237_L2.0960.99
49_Y177_R2.0940.99
116_R120_D2.0910.99
283_T336_G2.0050.99
197_A200_L1.9800.99
117_V124_I1.9610.99
147_D151_A1.9510.99
133_L193_L1.9480.99
43_T46_Q1.9380.99
291_S329_M1.9150.99
20_A24_G1.9080.99
208_T212_A1.8940.99
35_A39_S1.8880.99
17_L21_I1.8870.99
56_L116_R1.8850.99
214_S280_T1.8640.99
296_K339_H1.8570.99
181_I185_H1.8450.99
286_I290_S1.8360.99
267_V274_V1.8040.98
18_I21_I1.7980.98
53_P173_R1.7830.98
100_R158_T1.7750.98
337_M403_M1.7620.98
197_A201_M1.7600.98
160_E164_W1.7360.98
302_I324_L1.7070.98
52_L84_A1.6980.98
123_L126_T1.6740.97
182_F196_I1.6470.97
38_V394_M1.6470.97
82_R102_Y1.6430.97
25_L29_F1.6420.97
313_P316_T1.6390.97
282_M339_H1.6030.97
166_G169_E1.5980.96
402_L405_F1.5960.96
49_Y175_E1.5920.96
92_V101_L1.5900.96
166_G170_Q1.5870.96
54_V80_L1.5810.96
55_T127_S1.5600.96
217_I280_T1.5490.96
56_L130_I1.5300.95
88_Q173_R1.5240.95
21_I24_G1.5130.95
335_L339_H1.5010.95
213_L217_I1.4950.95
213_L277_M1.4850.95
48_T134_A1.4830.95
307_L316_T1.4640.94
68_D71_S1.4600.94
155_R162_I1.4580.94
208_T363_F1.4310.94
63_P67_R1.4240.93
178_F183_F1.4220.93
134_A138_I1.4060.93
34_F329_M1.4030.93
41_G387_E1.3920.93
140_M145_N1.3910.93
384_G409_M1.3830.92
165_V174_I1.3680.92
81_I132_V1.3570.92
120_D123_L1.3570.92
35_A38_V1.3550.91
293_A339_H1.3450.91
220_G280_T1.3440.91
232_N235_T1.3400.91
139_D143_K1.3330.91
141_L165_V1.3250.91
81_I105_L1.3230.90
273_L363_F1.3050.90
283_T339_H1.3030.90
62_D65_G1.2960.90
26_G262_I1.2900.89
27_L31_V1.2840.89
211_L333_T1.2820.89
115_E119_E1.2780.89
9_Y13_R1.2730.89
23_V26_G1.2690.89
14_R17_L1.2680.89
104_I138_I1.2680.89
42_Y46_Q1.2540.88
324_L418_W1.2480.88
66_T71_S1.2450.88
61_I124_I1.2410.87
4_S34_F1.2380.87
112_L133_L1.2300.87
82_R86_R1.2220.87
152_Q159_D1.2030.86
339_H394_M1.2020.86
63_P66_T1.1960.85
48_T176_K1.1960.85
39_S42_Y1.1810.85
146_I151_A1.1790.85
136_D384_G1.1650.84
41_G394_M1.1590.84
399_F403_M1.1590.84
197_A359_V1.1560.83
78_S110_P1.1560.83
117_V123_L1.1490.83
6_K10_A1.1470.83
209_L363_F1.1440.83
54_V132_V1.1390.82
56_L123_L1.1350.82
303_R321_V1.1350.82
61_I71_S1.1340.82
56_L61_I1.1340.82
72_I75_A1.1290.82
266_G416_R1.1040.80
162_I166_G1.1030.80
415_E418_W1.1010.80
128_Q131_W1.0970.80
261_F277_M1.0960.80
141_L162_I1.0890.79
136_D156_R1.0860.79
207_L329_M1.0850.79
204_F208_T1.0800.79
23_V30_V1.0730.78
383_R389_T1.0690.78
205_Y363_F1.0680.78
16_R20_A1.0680.78
73_A118_M1.0660.78
182_F388_R1.0660.78
53_P157_V1.0660.78
116_R128_Q1.0620.78
206_T210_A1.0580.77
326_M339_H1.0540.77
28_A32_L1.0540.77
402_L406_V1.0430.76
278_V288_I1.0430.76
53_P127_S1.0430.76
42_Y394_M1.0410.76
138_I142_V1.0400.76
49_Y133_L1.0390.76
257_G278_V1.0360.76
159_D162_I1.0320.76
5_L9_Y1.0310.76
339_H344_T1.0290.75
115_E118_M1.0280.75
104_I157_V1.0250.75
128_Q132_V1.0220.75
410_L417_R1.0210.75
277_M280_T1.0190.75
158_T161_A1.0180.75
153_G159_D1.0170.75
394_M398_A1.0080.74
207_L210_A1.0070.74
116_R130_I1.0060.74
144_G155_R1.0050.74
291_S337_M1.0040.74
294_A298_V1.0030.74
210_A337_M1.0010.73
13_R16_R0.9970.73
49_Y131_W0.9920.73
65_G71_S0.9820.72
406_V409_M0.9810.72
239_E292_R0.9790.72
372_V392_A0.9780.72
122_S126_T0.9730.71
142_V176_K0.9720.71
210_A369_V0.9710.71
373_Q377_W0.9690.71
83_D93_T0.9670.71
37_I394_M0.9600.70
205_Y364_T0.9580.70
146_I157_V0.9580.70
353_I359_V0.9570.70
186_G357_V0.9550.70
314_L318_F0.9500.69
6_K20_A0.9420.69
148_R151_A0.9390.69
57_T60_V0.9360.68
131_W177_R0.9360.68
146_I155_R0.9330.68
111_Q115_E0.9290.68
151_A155_R0.9290.68
189_R380_S0.9290.68
6_K26_G0.9270.68
89_F101_L0.9200.67
314_L317_Q0.9180.67
374_I395_V0.9140.66
262_I277_M0.9110.66
81_I109_A0.9110.66
104_I165_V0.9090.66
58_A125_G0.9070.66
148_R155_R0.9040.66
63_P117_V0.9030.65
271_T414_F0.9000.65
186_G358_D0.9000.65
390_S393_I0.9000.65
79_K86_R0.8990.65
64_A68_D0.8980.65
56_L132_V0.8970.65
6_K402_L0.8970.65
384_G388_R0.8960.65
43_T387_E0.8930.65
29_F318_F0.8920.65
13_R163_G0.8900.64
26_G30_V0.8890.64
151_A154_D0.8810.64
315_Q328_G0.8740.63
398_A417_R0.8730.63
253_F339_H0.8710.63
353_I384_G0.8680.62
41_G45_F0.8660.62
329_M333_T0.8640.62
7_R126_T0.8630.62
376_L379_D0.8620.62
324_L416_R0.8610.62
205_Y280_T0.8540.61
30_V262_I0.8540.61
200_L217_I0.8530.61
398_A402_L0.8510.61
386_V390_S0.8510.61
148_R169_E0.8470.60
355_F385_F0.8470.60
19_G23_V0.8470.60
71_S74_G0.8460.60
83_D87_Q0.8460.60
361_S365_D0.8450.60
253_F265_F0.8400.60
322_L329_M0.8390.60
313_P317_Q0.8370.60
211_L215_F0.8300.59
156_R379_D0.8290.59
190_E353_I0.8260.59
25_L30_V0.8250.58
357_V376_L0.8240.58
309_V316_T0.8230.58
56_L60_V0.8230.58
105_L220_G0.8200.58
378_A381_P0.8190.58
353_I372_V0.8190.58
280_T314_L0.8170.58
219_V384_G0.8160.58
89_F92_V0.8140.57
26_G201_M0.8140.57
2_N5_L0.8120.57
29_F316_T0.8110.57
26_G197_A0.8110.57
60_V79_K0.8080.57
58_A67_R0.8020.56
384_G387_E0.8010.56
2_N6_K0.8000.56
92_V98_L0.7990.56
287_I335_L0.7980.56
374_I413_K0.7970.56
62_D117_V0.7920.55
21_I35_A0.7880.55
213_L276_A0.7870.55
47_Q252_V0.7840.55
226_E296_K0.7800.54
26_G280_T0.7780.54
51_R175_E0.7780.54
372_V376_L0.7770.54
271_T329_M0.7760.54
113_L209_L0.7760.54
196_I253_F0.7720.53
48_T174_I0.7720.53
346_P351_G0.7690.53
23_V27_L0.7690.53
330_L339_H0.7690.53
143_K179_N0.7670.53
97_E100_R0.7670.53
206_T217_I0.7670.53
106_S192_E0.7650.53
252_V405_F0.7630.53
215_F412_R0.7630.53
204_F399_F0.7620.52
52_L132_V0.7610.52
371_P377_W0.7590.52
277_M364_T0.7590.52
227_E303_R0.7530.52
197_A204_F0.7520.51
354_A367_A0.7510.51
211_L414_F0.7490.51
5_L295_L0.7470.51
413_K417_R0.7460.51
24_G27_L0.7460.51
170_Q173_R0.7450.51
4_S7_R0.7450.51
142_V174_I0.7440.51
22_A344_T0.7440.51
2_N297_S0.7440.51
196_I200_L0.7430.51
339_H361_S0.7430.51
385_F395_V0.7390.50
366_S384_G0.7390.50
317_Q321_V0.7380.50
379_D382_E0.7370.50
291_S295_L0.7360.50
28_A31_V0.7350.50
253_F316_T0.7310.49
305_A316_T0.7270.49
141_L148_R0.7250.49
95_R186_G0.7250.49
368_T375_F0.7230.49
339_H393_I0.7230.49
92_V164_W0.7210.49
209_L260_V0.7210.49
78_S82_R0.7200.48
37_I316_T0.7200.48
52_L85_L0.7180.48
88_Q171_Q0.7180.48
50_I122_S0.7180.48
189_R198_G0.7130.48
147_D155_R0.7130.48
283_T341_L0.7110.48
135_D156_R0.7100.47
253_F286_I0.7100.47
2_N313_P0.7100.47
407_A411_R0.7090.47
252_V267_V0.7070.47
190_E384_G0.7060.47
67_R77_Y0.7060.47
200_L204_F0.7040.47
59_S221_A0.7030.47
120_D126_T0.7020.47
62_D66_T0.7020.47
34_F38_V0.7010.47
27_L316_T0.7000.47
326_M402_L0.6960.46
152_Q335_L0.6940.46
201_M205_Y0.6940.46
354_A390_S0.6930.46
95_R98_L0.6920.46
209_L272_P0.6880.45
131_W134_A0.6880.45
82_R98_L0.6880.45
36_D42_Y0.6870.45
112_L174_I0.6850.45
205_Y359_V0.6850.45
199_A370_L0.6840.45
380_S383_R0.6830.45
51_R173_R0.6810.45
251_I326_M0.6790.45
197_A210_A0.6790.45
23_V365_D0.6780.44
354_A365_D0.6780.44
26_G29_F0.6780.44
167_Q173_R0.6750.44
63_P124_I0.6730.44
306_A316_T0.6710.44
117_V128_Q0.6710.44
117_V125_G0.6700.44
120_D128_Q0.6700.44
376_L389_T0.6700.44
7_R24_G0.6700.44
116_R122_S0.6690.44
91_E101_L0.6670.43
355_F377_W0.6670.43
32_L201_M0.6660.43
219_V322_L0.6650.43
96_S214_S0.6630.43
201_M204_F0.6620.43
46_Q49_Y0.6610.43
258_L384_G0.6600.43
30_V56_L0.6580.43
329_M414_F0.6560.42
196_I353_I0.6560.42
131_W173_R0.6550.42
258_L366_S0.6550.42
394_M401_F0.6550.42
46_Q180_T0.6540.42
79_K129_E0.6530.42
71_S76_N0.6530.42
148_R163_G0.6520.42
65_G68_D0.6500.42
209_L220_G0.6490.42
36_D262_I0.6490.42
283_T408_V0.6470.42
20_A23_V0.6470.42
43_T176_K0.6460.41
29_F32_L0.6450.41
46_Q151_A0.6440.41
161_A192_E0.6420.41
341_L399_F0.6410.41
372_V390_S0.6410.41
353_I381_P0.6410.41
288_I353_I0.6400.41
356_I372_V0.6400.41
90_P187_T0.6390.41
50_I132_V0.6380.41
379_D383_R0.6380.41
161_A179_N0.6360.40
210_A280_T0.6360.40
121_P262_I0.6330.40
190_E193_L0.6330.40
137_D265_F0.6330.40
44_A101_L0.6330.40
73_A174_I0.6330.40
198_G359_V0.6320.40
6_K14_R0.6310.40
86_R98_L0.6310.40
370_L392_A0.6300.40
98_L102_Y0.6300.40
16_R53_P0.6280.40
183_F394_M0.6230.39
355_F372_V0.6220.39
21_I58_A0.6220.39
67_R117_V0.6220.39
55_T128_Q0.6220.39
146_I150_A0.6210.39
20_A110_P0.6180.39
317_Q322_L0.6170.39
211_L314_L0.6160.39
100_R160_E0.6160.39
297_S309_V0.6150.39
83_D86_R0.6150.39
69_M72_I0.6150.39
101_L164_W0.6150.39
352_M355_F0.6140.38
79_K102_Y0.6130.38
73_A114_Q0.6110.38
230_P339_H0.6110.38
360_P372_V0.6100.38
94_D99_R0.6090.38
95_R349_M0.6080.38
322_L405_F0.6080.38
25_L28_A0.6070.38
116_R119_E0.6060.38
63_P71_S0.6060.38
148_R152_Q0.6060.38
233_R313_P0.6050.38
115_E158_T0.6040.38
140_M144_G0.6030.37
31_V34_F0.6020.37
134_A176_K0.6010.37
10_A18_I0.6010.37
177_R219_V0.6000.37
77_Y124_I0.6000.37
34_F280_T0.5990.37
188_S269_R0.5990.37
214_S296_K0.5980.37
218_G417_R0.5980.37
185_H196_I0.5980.37
17_L55_T0.5970.37
173_R417_R0.5970.37
63_P68_D0.5970.37
166_G212_A0.5960.37
344_T373_Q0.5960.37
113_L141_L0.5950.37
381_P384_G0.5940.37
206_T291_S0.5940.37
325_A338_A0.5910.36
93_T101_L0.5890.36
200_L205_Y0.5880.36
181_I388_R0.5880.36
44_A391_A0.5880.36
98_L349_M0.5860.36
4_S61_I0.5860.36
375_F379_D0.5860.36
370_L395_V0.5850.36
20_A142_V0.5850.36
2_N222_A0.5850.36
64_A67_R0.5840.36
185_H197_A0.5830.36
113_L132_V0.5830.36
87_Q167_Q0.5820.36
3_A237_L0.5820.36
280_T313_P0.5820.36
90_P101_L0.5820.36
307_L313_P0.5810.36
252_V260_V0.5810.36
148_R162_I0.5800.35
62_D252_V0.5780.35
244_N351_G0.5760.35
211_L235_T0.5730.35
141_L155_R0.5720.35
380_S384_G0.5710.35
31_V118_M0.5700.35
261_F271_T0.5690.34
13_R17_L0.5660.34
186_G196_I0.5660.34
129_E133_L0.5650.34
295_L303_R0.5630.34
103_S161_A0.5630.34
51_R55_T0.5620.34
6_K13_R0.5620.34
353_I358_D0.5620.34
31_V61_I0.5610.34
112_L116_R0.5610.34
373_Q378_A0.5590.34
181_I193_L0.5580.34
61_I64_A0.5580.34
201_M362_G0.5580.34
91_E94_D0.5560.33
136_D140_M0.5550.33
366_S394_M0.5550.33
344_T377_W0.5540.33
265_F379_D0.5530.33
92_V95_R0.5530.33
144_G414_F0.5510.33
3_A65_G0.5510.33
206_T277_M0.5490.33
318_F409_M0.5490.33
90_P97_E0.5490.33
255_L376_L0.5480.33
282_M338_A0.5480.33
76_N79_K0.5480.33
154_D182_F0.5470.33
3_A335_L0.5470.33
90_P93_T0.5460.32
17_L27_L0.5460.32
354_A372_V0.5460.32
99_R136_D0.5440.32
135_D220_G0.5440.32
206_T262_I0.5440.32
215_F333_T0.5440.32
291_S322_L0.5430.32
23_V201_M0.5420.32
215_F326_M0.5420.32
3_A344_T0.5410.32
82_R88_Q0.5410.32
214_S220_G0.5410.32
203_S341_L0.5410.32
4_S280_T0.5380.32
103_S193_L0.5370.32
300_P328_G0.5360.32
255_L384_G0.5350.32
58_A128_Q0.5330.31
368_T373_Q0.5320.31
186_G329_M0.5320.31
81_I85_L0.5310.31
240_V324_L0.5300.31
7_R55_T0.5300.31
64_A71_S0.5290.31
235_T284_L0.5290.31
189_R382_E0.5280.31
367_A372_V0.5280.31
38_V41_G0.5280.31
6_K58_A0.5280.31
210_A277_M0.5270.31
223_L362_G0.5260.31
290_S368_T0.5250.31
180_T208_T0.5250.31
23_V314_L0.5250.31
6_K21_I0.5250.31
196_I349_M0.5240.31
119_E163_G0.5230.31
10_A13_R0.5220.31
291_S376_L0.5210.30
169_E176_K0.5200.30
13_R28_A0.5200.30
104_I161_A0.5200.30
47_Q388_R0.5190.30
204_F207_L0.5190.30
75_A79_K0.5180.30
107_V138_I0.5180.30
378_A382_E0.5160.30
78_S104_I0.5160.30
11_R235_T0.5150.30
206_T363_F0.5140.30
25_L240_V0.5140.30
82_R89_F0.5130.30
248_V272_P0.5120.30
247_A415_E0.5120.30
12_E217_I0.5120.30
240_V271_T0.5110.30
211_L337_M0.5110.30
243_N269_R0.5110.30
25_L171_Q0.5100.30
56_L117_V0.5100.30
387_E394_M0.5060.29
124_I295_L0.5050.29
187_T376_L0.5040.29
25_L31_V0.5030.29
337_M399_F0.5020.29
56_L80_L0.5020.29
334_I340_A0.5010.29
136_D265_F0.5010.29
259_A298_V0.5010.29
13_R21_I0.5010.29
90_P189_R0.5010.29
28_A153_G0.5010.29
182_F391_A0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d31C 2 0.5694 99.9 0.853 Contact Map
3tuiA 2 0.5048 99.9 0.853 Contact Map
2onkC 2 0.5455 99.9 0.854 Contact Map
4ymuD 2 0.5144 99.9 0.855 Contact Map
3rlfF 1 0.9067 99.9 0.86 Contact Map
4tquM 1 0.6268 99.8 0.867 Contact Map
4tquN 1 0.6411 99.8 0.869 Contact Map
3rlfG 1 0.622 99.8 0.879 Contact Map
2m8rA 1 0.0933 23.5 0.98 Contact Map
2yevB 1 0.1292 18.2 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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