GREMLIN Database
PF15580 - Uncharacterized protein
UniProt: H3SK11 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 97 (93)
Sequences: 1967 (1723)
Seq/√Len: 178.7
META: 0.909

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_W90_K3.8861.00
77_G85_I3.3731.00
75_G85_I2.5921.00
78_G81_N2.5721.00
38_E72_T2.2301.00
46_L93_A2.0761.00
51_Y66_C1.9711.00
62_D81_N1.9261.00
6_W94_S1.8661.00
67_F74_K1.8221.00
53_K67_F1.7621.00
81_N84_E1.7511.00
23_Y40_S1.7141.00
69_E74_K1.6161.00
36_S76_Y1.6021.00
12_L80_N1.5941.00
38_E76_Y1.5811.00
14_N45_N1.5701.00
37_V85_I1.4791.00
7_L86_L1.4771.00
40_S72_T1.4701.00
26_R38_E1.4271.00
16_D20_E1.4051.00
64_I84_E1.3971.00
87_E91_N1.3891.00
3_I87_E1.3841.00
27_I37_V1.3811.00
3_I83_R1.3551.00
38_E74_K1.3331.00
58_R84_E1.3331.00
58_R81_N1.3121.00
66_C75_G1.2901.00
48_E71_N1.2741.00
21_H32_N1.2731.00
58_R62_D1.2711.00
53_K65_H1.2531.00
28_A36_S1.2171.00
55_I65_H1.2141.00
10_W14_N1.1871.00
9_N80_N1.1551.00
2_D83_R1.1541.00
47_E71_N1.1391.00
42_N71_N1.1221.00
90_K93_A1.1051.00
56_I64_I1.1011.00
78_G84_E1.0030.99
17_N20_E1.0030.99
73_F89_F0.9990.99
56_I84_E0.9970.99
54_T66_C0.9920.99
83_R87_E0.9890.99
66_C88_I0.9840.99
21_H31_D0.9760.99
10_W39_I0.9640.99
11_F15_C0.9480.99
30_L36_S0.9480.99
59_S81_N0.9310.99
3_I6_W0.9170.99
25_L39_I0.9070.99
5_I9_N0.9050.99
67_F76_Y0.8970.99
65_H76_Y0.8850.98
49_K92_W0.8830.98
25_L35_W0.8780.98
66_C92_W0.8740.98
5_I8_E0.8680.98
41_L44_T0.8670.98
3_I86_L0.8650.98
5_I83_R0.8600.98
51_Y92_W0.8490.98
37_V86_L0.8370.98
15_C19_W0.8270.98
90_K94_S0.8060.97
8_E83_R0.7810.97
10_W25_L0.7720.96
77_G81_N0.7710.96
39_I89_F0.7710.96
22_S43_E0.7710.96
64_I88_I0.7660.96
42_N47_E0.7650.96
3_I90_K0.7580.96
51_Y88_I0.7450.96
16_D19_W0.7240.95
54_T92_W0.7220.95
37_V73_F0.7120.94
58_R78_G0.7070.94
36_S74_K0.7050.94
61_N79_P0.6970.94
2_D5_I0.6960.94
30_L76_Y0.6890.93
11_F30_L0.6800.93
8_E82_L0.6780.93
51_Y54_T0.6770.93
11_F19_W0.6650.92
88_I92_W0.6630.92
44_T48_E0.6590.92
4_L83_R0.6550.91
18_D43_E0.6520.91
9_N13_Q0.6510.91
58_R64_I0.6510.91
23_Y42_N0.6490.91
46_L51_Y0.6470.91
15_C20_E0.6450.91
46_L49_K0.6430.91
61_N65_H0.6380.90
59_S62_D0.6360.90
32_N76_Y0.6300.90
89_F93_A0.6240.89
11_F79_P0.6230.89
14_N39_I0.6200.89
30_L33_P0.6160.89
35_W82_L0.6010.88
26_R72_T0.5980.87
68_V92_W0.5910.87
66_C73_F0.5880.86
64_I85_I0.5880.86
57_E65_H0.5830.86
88_I91_N0.5750.85
21_H24_G0.5740.85
14_N43_E0.5720.85
55_I67_F0.5580.83
37_V82_L0.5560.83
18_D22_S0.5540.83
43_E46_L0.5490.82
14_N37_V0.5470.82
18_D21_H0.5340.81
64_I81_N0.5330.81
44_T89_F0.5290.80
51_Y68_V0.5280.80
23_Y29_T0.5190.79
8_E81_N0.5180.79
24_G40_S0.5180.79
81_N86_L0.5170.79
60_N81_N0.5170.79
25_L28_A0.5150.78
8_E35_W0.5090.77
55_I60_N0.5080.77
2_D9_N0.5050.77
62_D84_E0.5030.77
35_W78_G0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m0jB 1 0.2784 24.9 0.919 Contact Map
4hecA 2 0.7732 7 0.937 Contact Map
1x9mA 1 0.5361 6.4 0.938 Contact Map
2xykA 1 0.3402 5.3 0.94 Contact Map
1gaiA 1 0.8454 5.1 0.94 Contact Map
2gw6A 2 0.4021 4.8 0.941 Contact Map
1sy9B 1 0.1959 4.5 0.942 Contact Map
1dw9A 6 0.5052 3.8 0.944 Contact Map
2plcA 1 0.8866 3.7 0.944 Contact Map
3vyxA 1 0.8041 3.4 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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