GREMLIN Database
PF09357 - (55-273) Uncharacterized protein
UniProt: G8X4D5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 219 (216)
Sequences: 1602 (1252)
Seq/√Len: 85.2
META: 0.656

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_N208_K4.3011.00
143_G160_V4.1151.00
199_D205_N3.8421.00
154_A207_L3.7761.00
200_Q215_M3.7741.00
160_V203_F3.3991.00
152_L172_A2.9721.00
143_G147_A2.8321.00
194_R218_T2.6481.00
152_L175_F2.5561.00
172_A186_Y2.5561.00
142_T162_N2.5511.00
1_D5_N2.5201.00
151_L155_L2.5181.00
174_Y178_I2.5011.00
188_R191_L2.4911.00
201_T205_N2.4711.00
200_Q216_E2.4611.00
27_K118_K2.4001.00
53_N101_K2.1831.00
166_S171_V2.1081.00
7_K99_D2.0371.00
56_F102_V2.0271.00
36_K119_L2.0201.00
157_T214_R1.9571.00
168_L187_H1.9521.00
23_I39_L1.9371.00
146_V189_A1.9141.00
144_S147_A1.8851.00
47_K51_D1.8581.00
27_K35_L1.8491.00
155_L161_F1.8481.00
142_T164_G1.8211.00
43_L112_Q1.8201.00
24_E27_K1.7951.00
211_L215_M1.7631.00
15_I107_A1.7231.00
161_F174_Y1.7121.00
200_Q212_V1.6991.00
118_K121_M1.6851.00
139_Q166_S1.6351.00
198_S202_K1.6081.00
23_I115_L1.6051.00
2_F7_K1.6011.00
35_L39_L1.5821.00
176_E182_D1.5601.00
161_F171_V1.5471.00
3_F74_R1.5391.00
183_L186_Y1.5231.00
149_I189_A1.5221.00
60_Y102_V1.5161.00
139_Q161_F1.5030.99
155_L203_F1.4610.99
13_K110_L1.4490.99
61_R109_D1.4400.99
193_I215_M1.4350.99
149_I183_L1.4200.99
188_R192_E1.4170.99
193_I202_K1.4140.99
7_K94_F1.3900.99
158_E207_L1.3820.99
74_R96_T1.3650.99
213_K217_N1.3540.99
3_F7_K1.3240.99
208_K212_V1.3210.99
74_R91_D1.3090.99
176_E183_L1.2860.98
173_E176_E1.2750.98
194_R215_M1.2730.98
2_F94_F1.2720.98
191_L194_R1.2570.98
148_L183_L1.2130.98
153_Y190_F1.2120.98
67_L70_K1.1920.97
153_Y187_H1.1720.97
20_I114_Y1.1590.97
71_Y98_H1.1570.97
214_R218_T1.1460.97
6_I10_F1.1410.97
150_E196_R1.1390.97
185_Q191_L1.1340.96
190_F218_T1.1270.96
209_E213_K1.1230.96
149_I186_Y1.1040.96
94_F99_D1.1020.96
36_K123_E1.0980.96
34_I44_D1.0920.96
49_Y101_K1.0870.95
143_G203_F1.0800.95
152_L186_Y1.0700.95
176_E184_G1.0520.95
201_T211_L1.0500.95
28_P38_Y1.0460.94
12_S106_M1.0440.94
152_L171_V1.0380.94
140_T180_N1.0270.94
50_F57_Y1.0260.94
13_K17_Y1.0160.94
66_Y71_Y1.0080.93
147_A160_V1.0020.93
42_E45_K0.9980.93
11_T103_A0.9970.93
27_K39_L0.9950.93
139_Q171_V0.9940.93
154_A204_L0.9940.93
151_L154_A0.9840.92
189_A193_I0.9830.92
149_I193_I0.9820.92
197_K200_Q0.9750.92
12_S15_I0.9660.92
32_E122_M0.9660.92
171_V179_F0.9610.91
140_T162_N0.9570.91
158_E210_K0.9530.91
24_E118_K0.9400.91
33_R37_K0.9400.91
190_F215_M0.9350.90
12_S110_L0.9290.90
185_Q188_R0.9230.90
210_K213_K0.9200.90
47_K57_Y0.9170.89
84_D101_K0.9120.89
129_E132_Q0.9100.89
204_L208_K0.9090.89
16_Y20_I0.9050.89
156_H214_R0.8820.88
102_V106_M0.8770.87
172_A187_H0.8760.87
11_T18_N0.8750.87
89_E95_S0.8690.87
169_K187_H0.8600.86
204_L207_L0.8550.86
156_H159_G0.8510.86
89_E100_F0.8460.85
145_K183_L0.8430.85
3_F91_D0.8380.85
167_D187_H0.8370.85
96_T99_D0.8330.84
1_D6_I0.8320.84
174_Y179_F0.8290.84
39_L115_L0.8160.83
57_Y105_I0.8160.83
73_T76_K0.8160.83
146_V193_I0.8130.83
148_L175_F0.8040.82
146_V188_R0.8040.82
100_F104_K0.7990.82
158_E161_F0.7990.82
175_F178_I0.7890.81
143_G158_E0.7800.80
26_K38_Y0.7790.80
47_K112_Q0.7780.80
205_N212_V0.7720.80
108_H111_I0.7670.79
175_F183_L0.7630.79
69_H73_T0.7630.79
91_D96_T0.7590.78
56_F71_Y0.7580.78
49_Y53_N0.7580.78
23_I111_I0.7570.78
71_Y96_T0.7570.78
171_V174_Y0.7450.77
186_Y189_A0.7370.76
19_A111_I0.7360.76
127_P133_G0.7350.76
3_F96_T0.7330.76
10_F185_Q0.7310.76
140_T165_A0.7290.76
118_K122_M0.7270.75
24_E114_Y0.7250.75
203_F207_L0.7200.75
153_Y168_L0.7190.75
4_K65_N0.7180.74
50_F61_R0.7140.74
108_H114_Y0.7070.73
24_E115_L0.7030.73
145_K154_A0.7000.73
66_Y108_H0.6990.73
190_F214_R0.6980.72
12_S103_A0.6900.72
89_E112_Q0.6890.71
32_E116_E0.6860.71
212_V215_M0.6860.71
141_W160_V0.6860.71
114_Y118_K0.6830.71
141_W148_L0.6820.71
148_L152_L0.6810.71
187_H191_L0.6800.70
31_G34_I0.6780.70
19_A102_V0.6780.70
172_A176_E0.6740.70
152_L168_L0.6730.70
169_K173_E0.6690.69
2_F99_D0.6670.69
168_L192_E0.6650.69
66_Y70_K0.6650.69
194_R200_Q0.6610.68
7_K28_P0.6560.68
142_T163_N0.6540.67
143_G159_G0.6530.67
40_N121_M0.6530.67
118_K185_Q0.6520.67
206_S210_K0.6490.67
7_K95_S0.6480.67
157_T210_K0.6480.67
158_E206_S0.6470.67
190_F194_R0.6440.66
25_T92_H0.6420.66
139_Q174_Y0.6420.66
28_P61_R0.6390.66
185_Q199_D0.6360.65
42_E46_L0.6350.65
20_I111_I0.6330.65
140_T163_N0.6310.65
191_L195_M0.6310.65
161_F179_F0.6310.65
53_N200_Q0.6300.65
149_I181_I0.6290.64
20_I24_E0.6290.64
95_S99_D0.6280.64
145_K181_I0.6270.64
27_K102_V0.6270.64
46_L108_H0.6260.64
119_L161_F0.6240.64
56_F98_H0.6240.64
56_F97_S0.6220.64
162_N180_N0.6220.64
171_V175_F0.6200.63
194_R211_L0.6200.63
125_R136_K0.6160.63
42_E61_R0.6160.63
188_R193_I0.6150.63
32_E35_L0.6120.62
7_K114_Y0.6080.62
184_G194_R0.6070.62
73_T80_K0.6060.62
149_I172_A0.6060.62
135_P138_K0.6050.61
46_L112_Q0.6040.61
187_H199_D0.6040.61
120_L123_E0.6030.61
12_S105_I0.6000.61
192_E202_K0.6000.61
19_A108_H0.5960.60
102_V105_I0.5930.60
148_L204_L0.5890.59
135_P139_Q0.5860.59
192_E197_K0.5860.59
143_G155_L0.5860.59
36_K93_S0.5840.59
195_M198_S0.5840.59
199_D202_K0.5820.59
192_E203_F0.5800.58
183_L189_A0.5800.58
21_F89_E0.5780.58
52_N104_K0.5780.58
140_T174_Y0.5760.58
194_R214_R0.5730.57
21_F25_T0.5690.57
3_F99_D0.5680.57
109_D113_V0.5680.57
138_K180_N0.5670.57
11_T39_L0.5660.56
104_K119_L0.5650.56
86_F89_E0.5630.56
161_F178_I0.5630.56
23_I119_L0.5620.56
173_E182_D0.5610.56
131_S177_N0.5600.56
83_L101_K0.5600.56
138_K170_D0.5590.55
117_D121_M0.5580.55
149_I203_F0.5580.55
77_F98_H0.5570.55
87_Y103_A0.5570.55
149_I153_Y0.5570.55
168_L190_F0.5570.55
38_Y46_L0.5560.55
5_N40_N0.5560.55
47_K114_Y0.5560.55
22_K31_G0.5520.55
55_D71_Y0.5500.54
154_A160_V0.5490.54
137_V177_N0.5490.54
199_D206_S0.5460.54
25_T52_N0.5460.54
179_F182_D0.5400.53
73_T81_L0.5400.53
191_L218_T0.5390.53
55_D102_V0.5380.53
152_L188_R0.5380.53
168_L185_Q0.5380.53
67_L71_Y0.5380.53
57_Y60_Y0.5370.53
131_S134_N0.5360.52
141_W145_K0.5350.52
16_Y110_L0.5340.52
160_V171_V0.5310.52
54_L109_D0.5310.52
33_R115_L0.5280.51
121_M125_R0.5270.51
161_F164_G0.5230.51
200_Q211_L0.5210.50
194_R199_D0.5200.50
149_I171_V0.5170.50
65_N127_P0.5150.50
22_K101_K0.5150.50
149_I157_T0.5140.49
165_A195_M0.5140.49
25_T62_T0.5130.49
23_I27_K0.5120.49
145_K167_D0.5120.49
86_F90_V0.5120.49
111_I115_L0.5110.49
55_D109_D0.5080.49
127_P134_N0.5080.49
41_N119_L0.5080.49
176_E186_Y0.5080.49
35_L122_M0.5060.48
181_I207_L0.5060.48
70_K90_V0.5030.48
102_V109_D0.5020.48
3_F94_F0.5010.48
144_S189_A0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2g1pA 1 0.3653 16.7 0.958 Contact Map
4ujpE 1 0.5205 13.4 0.96 Contact Map
2dpmA 1 0.3653 10.4 0.962 Contact Map
3wtsC 1 0.3699 9.3 0.963 Contact Map
2o03A 2 0.3014 8.6 0.963 Contact Map
2cobA 1 0.3196 8.3 0.963 Contact Map
3zeyX 1 0.516 7.8 0.964 Contact Map
1yf3A 1 0.3744 7.7 0.964 Contact Map
2vj4A 1 0.3562 7.2 0.964 Contact Map
3mwmA 2 0.2785 6.3 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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