GREMLIN Database
PF14060 - Uncharacterized protein
UniProt: G2PQZ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 166 (154)
Sequences: 1488 (1097)
Seq/√Len: 88.4
META:

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_K68_K4.4021.00
26_F87_S4.3041.00
110_V130_V4.2541.00
155_D158_K3.3921.00
40_S98_E3.0071.00
122_H153_D2.9151.00
85_K131_T2.8641.00
112_F126_L2.5791.00
116_E121_D2.4811.00
17_G20_Q2.4241.00
42_F70_L2.4001.00
74_T146_V2.3971.00
42_F45_L2.2511.00
72_V148_L2.2281.00
33_T74_T2.1601.00
66_S158_K2.1121.00
70_L150_L2.1121.00
99_E102_R2.0161.00
154_I158_K2.0081.00
60_F64_A1.9561.00
15_L18_F1.8531.00
86_S90_S1.8351.00
66_S154_I1.8131.00
130_V146_V1.7911.00
101_M128_M1.7911.00
58_Q62_D1.7791.00
31_D77_N1.7731.00
104_K109_N1.7221.00
101_M112_F1.7001.00
125_E151_T1.6791.00
115_K125_E1.6781.00
35_V103_V1.6691.00
27_E102_R1.6021.00
25_K87_S1.5641.00
125_E149_S1.5631.00
32_V80_I1.5381.00
40_S116_E1.4240.99
103_V146_V1.3830.99
124_S153_D1.3010.99
84_M145_T1.2550.98
42_F48_I1.2280.98
5_I11_A1.2070.98
13_V18_F1.2000.98
132_G144_E1.1900.98
13_V17_G1.1900.98
14_P18_F1.1870.98
99_E111_K1.1700.97
113_Y127_L1.1620.97
117_G124_S1.1270.97
8_V11_A1.1230.97
10_M16_A1.1060.96
38_N128_M1.1060.96
10_M14_P1.0930.96
54_D162_L1.0820.96
70_L148_L1.0790.96
7_I13_V1.0770.96
36_V102_R1.0760.96
71_K115_K1.0700.96
35_V148_L1.0580.95
4_Y10_M1.0490.95
29_L83_D1.0240.94
4_Y16_A1.0160.94
3_K9_V1.0140.94
37_V68_K1.0130.94
60_F63_I1.0110.94
72_V147_I1.0050.94
118_K122_H1.0030.94
121_D157_N0.9950.93
155_D160_G0.9850.93
49_D52_V0.9810.93
45_L49_D0.9720.93
54_D57_A0.9640.92
5_I94_S0.9630.92
88_V129_F0.9580.92
9_V12_L0.9570.92
83_D87_S0.9560.92
76_E143_F0.9510.92
62_D158_K0.9500.92
74_T88_V0.9490.92
22_L159_I0.9460.92
42_F60_F0.9440.92
26_F83_D0.9370.91
67_L75_T0.9310.91
47_K157_N0.9290.91
31_D34_S0.9260.91
81_G84_M0.9230.91
62_D65_S0.9230.91
13_V19_S0.9200.90
39_K43_N0.9190.90
32_V163_T0.9180.90
108_A132_G0.9140.90
3_K18_F0.9090.90
9_V14_P0.9060.90
38_N67_L0.9030.90
86_S89_D0.9010.90
123_V126_L0.9000.89
7_I14_P0.8950.89
85_K89_D0.8940.89
112_F128_M0.8830.89
23_F159_I0.8810.88
158_K161_S0.8770.88
90_S94_S0.8770.88
59_D161_S0.8710.88
88_V102_R0.8700.88
125_E129_F0.8670.88
36_V73_F0.8450.86
36_V71_K0.8440.86
31_D104_K0.8330.85
96_K115_K0.8300.85
11_A16_A0.8200.85
50_V70_L0.8150.84
156_L160_G0.8120.84
29_L104_K0.8010.83
96_K113_Y0.7950.83
71_K149_S0.7880.82
5_I25_K0.7830.82
92_L95_S0.7820.82
71_K99_E0.7740.81
76_E81_G0.7680.81
54_D117_G0.7660.80
131_T143_F0.7610.80
45_L60_F0.7590.80
129_F145_T0.7580.80
26_F73_F0.7560.79
43_N66_S0.7410.78
22_L84_M0.7370.78
47_K116_E0.7350.78
100_L163_T0.7340.77
149_S155_D0.7240.76
40_S43_N0.7240.76
128_M148_L0.7230.76
153_D157_N0.7220.76
67_L124_S0.7220.76
2_K7_I0.7080.75
40_S64_A0.7030.74
83_D89_D0.7030.74
22_L87_S0.7020.74
75_T126_L0.7010.74
113_Y123_V0.7000.74
131_T145_T0.6950.74
43_N70_L0.6950.74
44_L106_K0.6910.73
11_A97_M0.6850.72
98_E116_E0.6820.72
10_M13_V0.6810.72
9_V16_A0.6750.71
66_S155_D0.6740.71
72_V112_F0.6740.71
33_T130_V0.6650.70
30_D115_K0.6610.70
23_F132_G0.6560.69
67_L142_K0.6550.69
115_K124_S0.6510.69
4_Y11_A0.6510.69
67_L160_G0.6450.68
26_F80_I0.6450.68
31_D106_K0.6410.67
22_L88_V0.6340.67
59_D158_K0.6310.66
4_Y53_D0.6290.66
71_K151_T0.6280.66
1_M20_Q0.6270.66
63_I154_I0.6260.66
66_S153_D0.6260.66
37_V67_L0.6250.65
11_A19_S0.6200.65
78_K96_K0.6100.64
127_L162_L0.6050.63
153_D156_L0.6030.63
64_A161_S0.6030.63
104_K118_K0.6020.63
118_K121_D0.5990.62
31_D145_T0.5960.62
47_K63_I0.5960.62
95_S125_E0.5920.61
46_A69_S0.5890.61
40_S44_L0.5890.61
94_S111_K0.5860.61
4_Y12_L0.5800.60
77_N81_G0.5800.60
99_E113_Y0.5790.60
1_M4_Y0.5760.59
7_I16_A0.5740.59
74_T148_L0.5700.58
159_I162_L0.5690.58
58_Q148_L0.5660.58
10_M165_K0.5650.58
23_F147_I0.5610.57
41_M112_F0.5600.57
15_L114_I0.5590.57
53_D143_F0.5580.57
76_E108_A0.5570.57
36_V97_M0.5560.57
22_L56_E0.5540.56
94_S159_I0.5520.56
99_E125_E0.5510.56
23_F71_K0.5500.56
105_D150_L0.5490.56
48_I160_G0.5470.55
53_D58_Q0.5460.55
29_L32_V0.5460.55
1_M7_I0.5440.55
63_I108_A0.5420.55
145_T162_L0.5370.54
99_E103_V0.5350.54
8_V12_L0.5350.54
14_P19_S0.5340.54
22_L34_S0.5340.54
84_M113_Y0.5340.54
156_L163_T0.5280.53
129_F147_I0.5280.53
71_K159_I0.5280.53
114_I123_V0.5270.53
28_D113_Y0.5230.52
8_V15_L0.5220.52
38_N98_E0.5200.52
45_L107_D0.5170.51
128_M151_T0.5160.51
5_I78_K0.5130.51
111_K132_G0.5130.51
88_V127_L0.5120.51
86_S93_K0.5120.51
127_L130_V0.5110.50
45_L106_K0.5100.50
125_E132_G0.5090.50
34_S104_K0.5070.50
32_V129_F0.5050.50
74_T102_R0.5050.50
77_N80_I0.5030.49
94_S113_Y0.5000.49
33_T103_V0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k3bA 1 0.6627 15.5 0.932 Contact Map
3zbiC 1 0.1687 12.1 0.935 Contact Map
4fybB 1 0.6024 9.1 0.938 Contact Map
2jnaA 2 0.5542 8.6 0.939 Contact Map
1jx7A 5 0.6446 7.9 0.94 Contact Map
2d1pB 1 0.6506 6.5 0.943 Contact Map
2q3lA 2 0.253 6.2 0.943 Contact Map
2r2qA 1 0.2349 5.6 0.944 Contact Map
4nv5A 1 0.7229 4.9 0.946 Contact Map
4mxgA 1 0.6747 4.5 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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