GREMLIN Database
PF14088 - Putative uncharacterized protein
UniProt: E8MXR4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 288 (282)
Sequences: 985 (850)
Seq/√Len: 50.6
META: 0.911

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_D62_K7.5971.00
217_D238_R4.6761.00
151_E260_Q3.7651.00
8_N12_L3.1821.00
52_L80_S3.1671.00
8_N14_D2.9451.00
192_V199_R2.8101.00
9_L22_L2.6481.00
152_F266_L2.6211.00
82_P105_L2.6151.00
222_H284_H2.5271.00
203_Y244_A2.5181.00
90_V105_L2.4931.00
262_N265_A2.4451.00
91_H126_A2.4261.00
9_L12_L2.3431.00
10_D14_D2.3221.00
9_L14_D2.2791.00
111_V121_L2.2501.00
222_H225_Q2.2181.00
79_T82_P2.1881.00
201_E246_R2.1851.00
64_I89_A2.1741.00
29_A69_N2.1231.00
220_L223_K2.0981.00
227_E231_G2.0711.00
104_Y131_E1.9811.00
53_E80_S1.9650.99
155_G267_Q1.9640.99
217_D240_D1.9580.99
146_H149_R1.9430.99
20_L46_V1.9320.99
8_N13_S1.9060.99
229_S284_H1.9030.99
278_E282_K1.8750.99
114_D117_P1.8540.99
239_L246_R1.8500.99
223_K227_E1.8140.99
8_N15_P1.8120.99
205_D243_R1.8110.99
184_K187_L1.8090.99
31_D83_R1.7820.99
203_Y246_R1.7390.99
149_R175_D1.7150.99
17_G26_E1.7110.99
81_Q107_Q1.7030.99
12_L15_P1.6770.98
159_K267_Q1.6560.98
191_Y274_M1.6520.98
232_A273_A1.6470.98
239_L244_A1.6460.98
39_E45_L1.6390.98
176_H192_V1.5990.98
79_T105_L1.5990.98
3_R6_A1.5960.98
22_L26_E1.5950.98
213_K238_R1.5820.98
9_L13_S1.5820.98
90_V126_A1.5690.97
78_I106_L1.5250.97
56_D62_K1.5170.97
170_I178_I1.4780.96
111_V123_T1.4720.96
159_K268_D1.4680.96
187_L215_Y1.4580.96
27_A70_H1.4560.96
213_K245_A1.4470.96
17_G22_L1.4470.96
96_T101_T1.4400.96
229_S283_P1.4380.96
237_Q246_R1.4370.96
268_D272_D1.4110.95
225_Q229_S1.3830.95
200_V277_L1.3770.95
150_M154_D1.3700.94
2_T5_L1.3620.94
20_L25_A1.3240.93
9_L15_P1.3220.93
197_H250_L1.3210.93
44_N73_K1.3120.93
190_A201_E1.3060.93
149_R174_K1.2960.93
220_L224_E1.2940.93
34_V37_L1.2880.92
6_A36_I1.2770.92
201_E239_L1.2740.92
204_I215_Y1.2720.92
10_D13_S1.2710.92
273_A276_R1.2680.92
155_G264_D1.2680.92
19_R22_L1.2470.91
272_D276_R1.2420.91
182_A189_W1.2330.91
87_E91_H1.2270.90
234_L249_Y1.2170.90
237_Q248_A1.2140.90
28_A33_A1.2120.90
97_L133_R1.2110.90
230_F280_A1.2030.90
142_L150_M1.2000.89
271_I275_V1.1910.89
230_F234_L1.1900.89
55_T79_T1.1810.89
170_I179_S1.1760.88
6_A25_A1.1700.88
22_L25_A1.1650.88
109_E123_T1.1650.88
259_N262_N1.1650.88
69_N131_E1.1530.87
180_T191_Y1.1520.87
239_L242_K1.1500.87
230_F277_L1.1400.87
90_V103_F1.1380.87
20_L23_V1.1350.87
277_L281_L1.1310.86
262_N266_L1.1270.86
31_D70_H1.1260.86
33_A47_V1.1040.85
165_T275_V1.0960.85
149_R194_L1.0930.84
40_D44_N1.0900.84
230_F249_Y1.0870.84
260_Q263_W1.0810.84
34_V47_V1.0750.83
199_R248_A1.0750.83
146_H174_K1.0740.83
206_T243_R1.0730.83
198_A206_T1.0710.83
18_L25_A1.0600.83
53_E56_D1.0580.82
203_Y239_L1.0540.82
70_H126_A1.0530.82
84_P87_E1.0530.82
163_K268_D1.0500.82
19_R24_E1.0460.82
202_L219_L1.0440.82
21_S25_A1.0420.82
44_N74_T1.0300.81
67_M75_A1.0260.80
27_A37_L1.0250.80
218_A221_Q1.0230.80
146_H194_L1.0200.80
25_A36_I1.0160.80
235_E248_A1.0120.80
153_W156_L0.9920.78
69_N104_Y0.9820.77
179_S190_A0.9810.77
163_K272_D0.9710.77
198_A266_L0.9690.77
254_H266_L0.9610.76
182_A202_L0.9570.76
107_Q123_T0.9570.76
232_A276_R0.9520.75
202_L277_L0.9450.75
32_F37_L0.9450.75
113_I116_S0.9410.74
98_P135_I0.9400.74
32_F83_R0.9380.74
251_I269_A0.9340.74
179_S188_T0.9330.74
47_V70_H0.9300.74
234_L277_L0.9210.73
180_T274_M0.9170.72
21_S41_A0.9100.72
47_V62_K0.9080.72
18_L21_S0.9030.71
220_L238_R0.9020.71
26_E30_G0.8970.71
205_D244_A0.8950.71
68_S89_A0.8920.70
207_A212_N0.8830.70
73_K100_D0.8820.69
201_E242_K0.8760.69
198_A202_L0.8720.69
149_R173_G0.8660.68
217_D220_L0.8610.68
159_K271_I0.8580.67
26_E29_A0.8550.67
232_A249_Y0.8540.67
74_T102_S0.8430.66
143_A146_H0.8420.66
239_L245_A0.8410.66
17_G25_A0.8370.65
111_V149_R0.8350.65
13_S18_L0.8340.65
227_E233_P0.8270.64
82_P127_G0.8260.64
213_K217_D0.8130.63
256_G259_N0.8130.63
114_D252_R0.8110.63
237_Q250_L0.8050.62
110_A121_L0.7980.62
249_Y273_A0.7970.62
109_E121_L0.7960.62
253_G257_L0.7920.61
146_H175_D0.7890.61
152_F267_Q0.7890.61
230_F276_R0.7880.61
148_L263_W0.7880.61
191_Y270_M0.7860.61
214_H218_A0.7850.60
157_L161_R0.7830.60
213_K241_E0.7830.60
242_K246_R0.7810.60
199_R237_Q0.7800.60
270_M274_M0.7760.60
69_N129_S0.7730.59
83_R126_A0.7730.59
194_L199_R0.7700.59
17_G20_L0.7690.59
2_T6_A0.7690.59
43_G151_E0.7690.59
37_L98_P0.7680.59
19_R25_A0.7670.59
273_A280_A0.7660.59
68_S97_L0.7650.58
112_R118_P0.7640.58
156_L160_A0.7620.58
58_D64_I0.7620.58
18_L46_V0.7590.58
238_R245_A0.7530.57
147_I150_M0.7500.57
203_Y206_T0.7480.57
113_I119_A0.7480.57
79_T187_L0.7450.56
198_A203_Y0.7440.56
16_T106_L0.7440.56
34_V41_A0.7390.56
72_A204_I0.7380.56
145_R149_R0.7370.56
266_L270_M0.7360.56
106_L121_L0.7360.56
21_S39_E0.7360.56
108_V120_P0.7340.55
154_D158_K0.7320.55
182_A187_L0.7300.55
155_G158_K0.7270.55
68_S88_K0.7260.54
219_L236_W0.7250.54
20_L24_E0.7250.54
4_W7_E0.7220.54
201_E248_A0.7210.54
91_H129_S0.7190.54
176_H188_T0.7180.54
32_F65_T0.7180.54
116_S119_A0.7180.54
159_K163_K0.7160.53
54_R83_R0.7090.53
184_K215_Y0.7080.53
17_G24_E0.7070.53
39_E46_V0.7040.52
47_V75_A0.7010.52
148_L151_E0.7010.52
229_S279_N0.7010.52
50_N57_H0.6980.52
157_L169_N0.6970.52
264_D268_D0.6970.52
55_T124_V0.6940.51
155_G263_W0.6940.51
221_Q261_E0.6920.51
6_A38_T0.6910.51
31_D55_T0.6890.51
24_E27_A0.6870.50
200_V270_M0.6870.50
201_E237_Q0.6820.50
170_I181_G0.6800.50
152_F180_T0.6790.50
87_E129_S0.6780.50
51_Q77_W0.6760.49
179_S243_R0.6750.49
140_K230_F0.6730.49
115_N221_Q0.6720.49
23_V26_E0.6710.49
202_L285_L0.6710.49
82_P90_V0.6700.49
156_L270_M0.6680.49
198_A201_E0.6660.48
267_Q270_M0.6650.48
152_F262_N0.6640.48
112_R207_A0.6630.48
160_A191_Y0.6630.48
160_A167_F0.6620.48
148_L258_P0.6600.48
54_R112_R0.6570.47
254_H262_N0.6560.47
204_I212_N0.6530.47
50_N59_H0.6520.47
251_I265_A0.6510.47
38_T47_V0.6500.47
186_G207_A0.6500.47
15_P55_T0.6490.47
172_P259_N0.6490.47
167_F274_M0.6470.46
156_L167_F0.6440.46
153_W172_P0.6430.46
34_V70_H0.6420.46
216_F220_L0.6420.46
88_K91_H0.6420.46
55_T133_R0.6410.46
131_E269_A0.6400.46
187_L202_L0.6400.46
114_D120_P0.6380.45
234_L281_L0.6370.45
153_W270_M0.6360.45
149_R193_V0.6350.45
213_K240_D0.6340.45
247_I281_L0.6340.45
16_T25_A0.6310.45
92_W101_T0.6270.44
86_H116_S0.6240.44
231_G276_R0.6220.44
102_S118_P0.6220.44
34_V45_L0.6170.43
63_L90_V0.6140.43
39_E43_G0.6140.43
166_L275_V0.6140.43
57_H61_G0.6120.43
276_R279_N0.6120.43
148_L260_Q0.6110.43
176_H179_S0.6100.43
35_D49_E0.6090.42
10_D15_P0.6080.42
167_F191_Y0.6080.42
47_V133_R0.6070.42
17_G23_V0.6040.42
38_T90_V0.6030.42
268_D271_I0.6030.42
263_W270_M0.6020.42
109_E113_I0.6020.42
160_A169_N0.6000.42
60_L77_W0.5970.41
7_E10_D0.5960.41
60_L93_L0.5940.41
154_D157_L0.5940.41
229_S280_A0.5930.41
49_E66_Y0.5930.41
64_I79_T0.5920.41
31_D34_V0.5910.41
75_A103_F0.5900.41
46_V110_A0.5890.40
18_L24_E0.5890.40
48_I51_Q0.5890.40
64_I93_L0.5870.40
111_V114_D0.5870.40
32_F108_V0.5830.40
11_L14_D0.5800.40
226_I236_W0.5790.39
86_H94_N0.5790.39
65_T86_H0.5770.39
84_P127_G0.5760.39
56_D59_H0.5740.39
152_F265_A0.5730.39
91_H105_L0.5730.39
187_L285_L0.5720.39
97_L103_F0.5640.38
253_G256_G0.5640.38
77_W113_I0.5630.38
239_L248_A0.5630.38
276_R282_K0.5620.38
51_Q59_H0.5600.38
64_I68_S0.5590.38
139_R224_E0.5580.37
265_A282_K0.5560.37
29_A70_H0.5550.37
63_L75_A0.5550.37
198_A262_N0.5530.37
63_L73_K0.5530.37
69_N75_A0.5520.37
223_K226_I0.5500.37
29_A97_L0.5500.37
229_S249_Y0.5480.36
198_A259_N0.5450.36
108_V137_E0.5430.36
202_L247_I0.5420.36
57_H65_T0.5420.36
142_L174_K0.5410.36
231_G249_Y0.5410.36
263_W267_Q0.5400.36
34_V110_A0.5400.36
182_A219_L0.5390.36
109_E120_P0.5380.36
50_N116_S0.5370.35
192_V201_E0.5370.35
150_M174_K0.5370.35
225_Q250_L0.5360.35
112_R276_R0.5350.35
59_H66_Y0.5340.35
16_T228_A0.5330.35
142_L147_I0.5310.35
55_T125_I0.5290.35
34_V39_E0.5290.35
201_E245_A0.5290.35
189_W274_M0.5250.34
38_T62_K0.5250.34
49_E57_H0.5240.34
47_V96_T0.5240.34
232_A277_L0.5220.34
32_F63_L0.5220.34
191_Y200_V0.5210.34
164_S258_P0.5210.34
206_T244_A0.5190.34
76_I256_G0.5190.34
269_A273_A0.5180.34
264_D280_A0.5180.34
42_D137_E0.5180.34
56_D162_Q0.5160.33
204_I208_D0.5150.33
201_E205_D0.5140.33
115_N228_A0.5120.33
214_H221_Q0.5120.33
69_N122_F0.5110.33
20_L38_T0.5090.33
158_K161_R0.5080.33
176_H185_S0.5080.33
71_D224_E0.5070.33
28_A34_V0.5050.32
204_I207_A0.5050.32
87_E109_E0.5050.32
160_A271_I0.5040.32
170_I180_T0.5030.32
281_L285_L0.5030.32
141_E224_E0.5020.32
76_I232_A0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vldA 2 0.3438 99.3 0.866 Contact Map
4hs5A 1 0.2917 17.4 0.972 Contact Map
4jpdA 5 0.3646 15.7 0.972 Contact Map
4da2A 1 0.4062 13.2 0.973 Contact Map
2w7vA 2 0.1736 13 0.973 Contact Map
3sscA 1 0.5104 9.6 0.975 Contact Map
3se7A 4 0.2569 9.3 0.975 Contact Map
1ew4A 1 0.3611 8.5 0.975 Contact Map
3h2tA 2 0.1771 8.1 0.976 Contact Map
3v2cY 1 0.316 7.7 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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