GREMLIN Database
PF11335 - (177-322) Galanin
UniProt: E4TUT2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 146 (142)
Sequences: 920 (749)
Seq/√Len: 62.8
META: 0.895

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_L95_I5.7241.00
49_V64_G5.4851.00
25_D57_E4.2231.00
67_Q71_R3.5721.00
53_D80_K3.2551.00
9_E101_S3.1681.00
18_T65_E2.9431.00
47_P67_Q2.9211.00
68_V71_R2.6741.00
53_D83_T2.6551.00
59_H83_T2.5641.00
59_H86_R2.2891.00
14_K72_Y2.2391.00
12_F72_Y1.8991.00
80_K84_E1.8961.00
20_T69_E1.8741.00
16_F73_I1.8711.00
48_I57_E1.8521.00
75_S78_L1.8401.00
20_T64_G1.7891.00
24_P86_R1.7871.00
49_V70_A1.7370.99
111_N114_E1.7270.99
46_P65_E1.7250.99
108_E112_L1.7030.99
7_F103_F1.7020.99
22_I62_V1.6600.99
52_E76_T1.6050.99
51_L79_M1.4940.98
51_L62_V1.4900.98
59_H87_E1.4640.98
128_E132_S1.4230.98
24_P94_A1.3710.97
119_R125_E1.3580.97
139_G143_D1.3410.97
52_E71_R1.3310.97
94_A107_T1.3230.96
91_H108_E1.2990.96
73_I97_F1.2860.96
78_L82_L1.2600.95
69_E97_F1.2560.95
25_D32_G1.2530.95
51_L71_R1.1950.94
12_F16_F1.1510.92
11_D100_N1.1400.92
25_D28_E1.1360.92
85_F89_R1.1210.91
135_D139_G1.1090.91
49_V67_Q1.0940.90
48_I61_V1.0910.90
28_E48_I1.0540.89
123_N126_V1.0470.88
28_E61_V1.0440.88
28_E32_G1.0430.88
69_E73_I1.0420.88
10_A102_I1.0350.88
20_T97_F1.0260.87
88_K143_D1.0250.87
25_D61_V1.0230.87
52_E75_S1.0170.87
70_A79_M1.0110.86
38_L41_L0.9930.85
64_G70_A0.9880.85
85_F140_I0.9830.85
51_L54_P0.9800.85
58_K117_I0.9610.84
11_D101_S0.9580.83
51_L67_Q0.9260.81
27_L36_K0.9140.80
18_T25_D0.9070.80
22_I97_F0.9070.80
37_K41_L0.9050.80
84_E88_K0.8980.79
4_R134_L0.8850.78
55_E83_T0.8820.78
57_E61_V0.8790.78
12_F73_I0.8780.78
134_L138_I0.8740.77
120_T131_Y0.8690.77
12_F75_S0.8680.77
109_H127_L0.8670.77
100_N125_E0.8620.76
7_F24_P0.8510.75
60_F82_L0.8490.75
28_E57_E0.8360.74
78_L146_L0.8330.74
85_F95_I0.8240.73
23_L61_V0.8220.73
89_R136_L0.8190.72
141_V146_L0.8170.72
53_D133_M0.8100.72
53_D64_G0.8100.72
19_N65_E0.8050.71
86_R91_H0.8030.71
110_K129_E0.8030.71
90_K128_E0.7910.70
23_L45_R0.7900.70
16_F99_N0.7900.70
11_D14_K0.7810.69
27_L61_V0.7780.69
52_E107_T0.7770.68
54_P57_E0.7770.68
20_T65_E0.7730.68
72_Y146_L0.7730.68
82_L101_S0.7710.68
37_K40_S0.7710.68
66_D140_I0.7650.67
27_L48_I0.7640.67
55_E87_E0.7590.67
20_T71_R0.7560.66
75_S79_M0.7500.66
50_K57_E0.7490.66
21_F103_F0.7470.65
60_F74_L0.7370.64
14_K69_E0.7360.64
2_I11_D0.7330.64
32_G61_V0.7260.63
138_I142_D0.7240.63
100_N128_E0.7240.63
83_T86_R0.7070.61
17_K66_D0.6980.60
72_Y141_V0.6950.60
17_K106_I0.6910.59
61_V67_Q0.6900.59
130_Y137_V0.6840.59
4_R107_T0.6830.59
24_P48_I0.6790.58
16_F100_N0.6780.58
16_F97_F0.6750.58
114_E117_I0.6720.57
31_L119_R0.6720.57
95_I102_I0.6690.57
13_N114_E0.6680.57
6_I112_L0.6660.57
14_K52_E0.6620.56
51_L68_V0.6600.56
32_G74_L0.6570.56
133_M137_V0.6510.55
52_E72_Y0.6500.55
108_E121_N0.6490.55
49_V81_R0.6450.54
19_N46_P0.6430.54
6_I71_R0.6400.54
43_F119_R0.6350.53
122_L127_L0.6260.52
22_I55_E0.6250.52
128_E135_D0.6250.52
19_N98_V0.6220.52
27_L31_L0.6170.51
48_I86_R0.6140.51
1_T5_G0.6110.50
124_M128_E0.6090.50
66_D131_Y0.6080.50
71_R79_M0.6070.50
71_R77_S0.6040.50
6_I115_P0.5980.49
84_E87_E0.5960.49
10_A21_F0.5940.48
52_E79_M0.5930.48
58_K142_D0.5920.48
22_I95_I0.5900.48
37_K93_V0.5880.48
58_K110_K0.5880.48
60_F97_F0.5860.47
130_Y133_M0.5820.47
88_K129_E0.5750.46
6_I108_E0.5730.46
9_E60_F0.5720.46
52_E74_L0.5720.46
56_F62_V0.5690.45
64_G135_D0.5680.45
85_F136_L0.5680.45
4_R111_N0.5670.45
10_A146_L0.5660.45
13_N66_D0.5620.45
78_L115_P0.5590.44
98_V103_F0.5580.44
94_A105_A0.5580.44
7_F96_S0.5580.44
13_N98_V0.5550.44
49_V52_E0.5550.44
51_L74_L0.5550.44
3_F62_V0.5540.44
53_D145_N0.5530.44
60_F66_D0.5530.44
55_E80_K0.5520.44
24_P59_H0.5470.43
117_I120_T0.5430.43
99_N104_V0.5430.43
60_F115_P0.5360.42
32_G36_K0.5350.42
12_F121_N0.5300.41
13_N141_V0.5270.41
104_V135_D0.5260.41
29_R61_V0.5240.40
127_L140_I0.5220.40
42_N45_R0.5180.40
54_P141_V0.5150.39
59_H82_L0.5140.39
6_I113_F0.5120.39
15_Q64_G0.5120.39
63_Y101_S0.5110.39
18_T64_G0.5100.39
17_K69_E0.5090.39
129_E132_S0.5090.39
18_T69_E0.5050.38
4_R9_E0.5040.38
7_F105_A0.5040.38
118_F142_D0.5030.38
77_S145_N0.5020.38
55_E92_P0.5010.38
13_N100_N0.5010.38
64_G118_F0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kioB 1 0.5753 3.8 0.95 Contact Map
4bxtA 3 0.1849 3.7 0.95 Contact Map
2xheB 1 0.3082 3.1 0.952 Contact Map
1tg7A 1 0.589 3 0.953 Contact Map
1skvA 2 0.1986 2.8 0.953 Contact Map
3claA 3 0.6781 2.8 0.953 Contact Map
3v3kB 1 0.3904 2.6 0.954 Contact Map
3sb1A 2 0.363 2.5 0.954 Contact Map
3ksvA 2 0.7534 2.4 0.955 Contact Map
4kp2A 2 0.3082 2.4 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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