GREMLIN Database
PF14276 - Uncharacterized protein
UniProt: D5XAK5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 126 (125)
Sequences: 2115 (1921)
Seq/√Len: 171.8
META: 0.826

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_N50_Q3.6811.00
87_R103_E3.6571.00
91_Y102_A3.2161.00
59_K89_K2.8811.00
48_W95_R2.7931.00
96_E99_E2.7311.00
58_L85_M2.7271.00
84_S103_E2.3371.00
66_S82_N2.1941.00
77_E113_H2.1901.00
43_L100_L2.1391.00
87_R106_E2.1281.00
42_H54_G2.1131.00
15_V19_T2.0221.00
81_I107_L2.0101.00
39_M58_L1.9931.00
46_R97_K1.9811.00
38_V54_G1.9741.00
99_E102_A1.9471.00
37_Q108_K1.8521.00
56_S89_K1.8171.00
92_M100_L1.7651.00
40_E108_K1.7411.00
48_W51_A1.7231.00
19_T23_N1.6731.00
35_H61_S1.6361.00
80_S83_M1.6131.00
83_M106_E1.5621.00
52_E93_D1.5291.00
40_E105_G1.5281.00
54_G57_K1.5231.00
52_E56_S1.4831.00
42_H47_N1.4341.00
17_F21_T1.4161.00
22_Y120_L1.3631.00
89_K93_D1.3481.00
16_G20_F1.3481.00
31_D61_S1.2911.00
50_Q54_G1.2521.00
33_M37_Q1.2501.00
21_T72_F1.2481.00
42_H50_Q1.2291.00
3_T7_T1.2061.00
32_L81_I1.1861.00
36_I107_L1.1561.00
116_E123_K1.1541.00
40_E44_R1.1301.00
62_W82_N1.1251.00
34_A37_Q1.1091.00
20_F24_Y1.1091.00
21_T68_N1.0490.99
22_Y25_I1.0240.99
62_W85_M1.0240.99
81_I111_L1.0100.99
28_T65_T1.0070.99
35_H57_K0.9680.99
35_H38_V0.9630.99
35_H54_G0.9560.99
49_Q52_E0.9470.99
14_L18_S0.9450.99
20_F23_N0.9440.99
5_V9_V0.9380.99
91_Y103_E0.9370.99
112_K116_E0.9250.99
44_R101_L0.9230.99
31_D35_H0.9120.99
67_S123_K0.9100.99
39_M54_G0.9050.98
105_G108_K0.9040.98
78_L82_N0.9010.98
2_K5_V0.8970.98
15_V18_S0.8900.98
88_L100_L0.8830.98
66_S123_K0.8760.98
85_M107_L0.8740.98
41_K44_R0.8730.98
88_L104_L0.8720.98
84_S106_E0.8680.98
69_W75_H0.8540.98
71_V75_H0.8470.98
26_N115_P0.8430.98
40_E101_L0.8390.98
90_N94_T0.8320.97
69_W73_I0.8270.97
24_Y72_F0.8260.97
75_H79_D0.8250.97
52_E95_R0.8220.97
69_W72_F0.8120.97
51_A92_M0.8070.97
25_I79_D0.8030.97
29_T111_L0.7990.97
103_E106_E0.7960.97
28_T69_W0.7890.96
50_Q53_Q0.7890.96
38_V41_K0.7850.96
5_V8_L0.7800.96
57_K60_S0.7800.96
65_T68_N0.7790.96
91_Y96_E0.7760.96
77_E117_K0.7760.96
122_L126_L0.7740.96
41_K45_A0.7690.96
26_N119_A0.7650.96
36_I58_L0.7500.95
40_E104_L0.7480.95
21_T118_E0.7470.95
23_N27_N0.7460.95
43_L48_W0.7430.95
26_N30_D0.7340.95
33_M108_K0.7340.95
86_A109_L0.7240.94
16_G23_N0.7200.94
60_S63_D0.7150.94
65_T69_W0.7140.94
53_Q57_K0.7130.94
94_T101_L0.6860.92
34_A38_V0.6850.92
90_N93_D0.6820.92
66_S78_L0.6800.92
58_L81_I0.6760.92
81_I110_L0.6680.91
69_W79_D0.6650.91
30_D34_A0.6580.91
34_A41_K0.6530.90
90_N105_G0.6470.90
83_M110_L0.6440.90
70_A78_L0.6440.90
25_I73_I0.6420.90
33_M112_K0.6410.90
84_S88_L0.6400.90
55_F92_M0.6300.89
32_L111_L0.6300.89
36_I104_L0.6270.89
59_K63_D0.6260.89
19_T22_Y0.6260.89
24_Y28_T0.6230.88
94_T98_P0.6190.88
70_A113_H0.6170.88
79_D113_H0.6170.88
116_E119_A0.6170.88
18_S22_Y0.6050.87
71_V126_L0.6050.87
11_F15_V0.6050.87
58_L108_K0.6040.87
42_H45_A0.6020.87
16_G19_T0.6020.87
74_D80_S0.6000.86
9_V12_A0.6000.86
111_L118_E0.5980.86
55_F107_L0.5950.86
89_K105_G0.5930.86
45_A49_Q0.5910.86
18_S69_W0.5860.85
104_L108_K0.5740.84
87_R102_A0.5640.83
38_V49_Q0.5600.82
80_S110_L0.5580.82
49_Q53_Q0.5510.81
71_V79_D0.5510.81
100_L104_L0.5480.81
97_K101_L0.5450.81
7_T10_V0.5450.81
49_Q108_K0.5360.80
33_M111_L0.5360.80
31_D57_K0.5350.79
25_I69_W0.5320.79
25_I115_P0.5320.79
4_F8_L0.5320.79
18_S21_T0.5310.79
55_F82_N0.5310.79
86_A90_N0.5280.79
75_H124_N0.5280.79
29_T115_P0.5260.78
36_I108_K0.5250.78
109_L112_K0.5240.78
52_E89_K0.5240.78
43_L46_R0.5210.78
39_M51_A0.5210.78
45_A57_K0.5200.78
20_F27_N0.5190.77
39_M100_L0.5140.77
19_T61_S0.5110.76
24_Y68_N0.5090.76
6_A12_A0.5080.76
16_G52_E0.5060.76
91_Y98_P0.5050.76
11_F33_M0.5030.75
84_S107_L0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jkvA 2 0.8095 47 0.853 Contact Map
4cgkA 3 0.6349 38.6 0.86 Contact Map
4yvqC 1 0.7222 37.4 0.861 Contact Map
3u8pA 1 0.9603 21.9 0.877 Contact Map
4cq4A 4 0.6508 21.6 0.877 Contact Map
4yvoA 1 0.7143 21.3 0.877 Contact Map
4or2A 2 0.7937 18 0.882 Contact Map
3n71A 1 0.9444 16.6 0.883 Contact Map
4rknA 4 0.7381 16 0.884 Contact Map
4qinA 2 0.9841 14 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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