GREMLIN Database
PF11292 - Uncharacterized protein
UniProt: D5UMZ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 144 (143)
Sequences: 1381 (990)
Seq/√Len: 82.8
META: 0.792

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_K112_L3.9211.00
133_H136_R3.7521.00
60_G67_W3.7231.00
91_A96_Q3.4961.00
65_E72_H3.2011.00
74_P77_V2.9481.00
2_F58_S2.6451.00
73_L78_I2.5621.00
68_A129_V2.4991.00
91_A95_R2.4741.00
85_P88_A2.4581.00
79_S117_L2.2861.00
92_A96_Q2.1401.00
101_A126_Y2.1341.00
73_L117_L2.0951.00
27_N31_R1.9591.00
79_S118_D1.9471.00
57_A104_Y1.8881.00
81_A138_L1.8871.00
84_V112_L1.8491.00
109_I130_S1.8301.00
79_S116_V1.7051.00
2_F60_G1.6871.00
93_L105_H1.6841.00
82_A114_A1.6571.00
59_V129_V1.5981.00
59_V66_L1.5841.00
81_A116_V1.5811.00
57_A68_A1.5581.00
80_R116_V1.5451.00
119_D122_D1.5280.99
68_A104_Y1.5230.99
14_F18_V1.4910.99
12_W20_A1.4890.99
92_A97_L1.4750.99
66_L129_V1.4590.99
7_V11_W1.4570.99
112_L131_T1.4020.99
92_A114_A1.3640.99
83_A131_T1.3640.99
71_A122_D1.3610.99
74_P117_L1.3550.99
67_W72_H1.3540.99
89_K93_L1.2960.98
61_V137_L1.2850.98
8_P11_W1.2560.98
82_A116_V1.2410.98
83_A138_L1.1940.97
84_V97_L1.1910.97
97_L112_L1.1720.97
87_E90_S1.1710.97
62_R65_E1.1670.97
73_L77_V1.1580.97
136_R139_A1.1570.97
77_V117_L1.1480.96
119_D123_P1.1480.96
135_E139_A1.1420.96
33_A36_M1.1330.96
64_G75_L1.0920.95
26_I30_A1.0810.95
75_L141_I1.0620.94
46_L50_I1.0340.94
61_V140_C1.0210.93
134_P140_C0.9960.92
86_A89_K0.9950.92
59_V115_V0.9920.92
10_Y13_L0.9910.92
115_V138_L0.9880.92
81_A113_V0.9850.92
75_L78_I0.9730.91
57_A106_R0.9670.91
12_W45_L0.9640.91
89_K105_H0.9470.90
81_A142_P0.9400.90
136_R140_C0.9300.89
86_A111_T0.9280.89
117_L124_T0.9230.89
18_V21_L0.9190.89
9_W13_L0.9180.89
28_L31_R0.9160.89
32_G56_R0.8880.87
41_P134_P0.8830.87
71_A119_D0.8800.87
59_V137_L0.8770.86
17_G20_A0.8760.86
21_L25_E0.8730.86
47_A51_L0.8730.86
85_P135_E0.8620.86
38_A42_V0.8580.85
138_L142_P0.8550.85
112_L128_L0.8450.84
77_V118_D0.8370.84
27_N36_M0.8350.84
24_Y28_L0.8340.84
139_A142_P0.8310.83
1_Y133_H0.8200.83
101_A128_L0.8160.82
62_R67_W0.8150.82
5_L132_R0.8050.81
131_T134_P0.7970.81
86_A110_K0.7950.81
71_A102_F0.7950.81
32_G37_Y0.7830.80
62_R75_L0.7750.79
65_E75_L0.7700.78
12_W15_A0.7630.78
21_L24_Y0.7620.78
98_D126_Y0.7610.78
23_C27_N0.7570.77
113_V138_L0.7540.77
84_V92_A0.7500.77
85_P89_K0.7470.76
25_E40_F0.7430.76
115_V129_V0.7330.75
7_V20_A0.7330.75
119_D124_T0.7320.75
129_V137_L0.7290.75
93_L112_L0.7280.74
39_L43_V0.7200.74
7_V14_F0.7170.73
68_A98_D0.7060.72
21_L45_L0.7040.72
66_L115_V0.7030.72
103_V125_P0.7020.72
35_W39_L0.7000.72
11_W15_A0.6980.71
19_A68_A0.6960.71
25_E29_A0.6960.71
88_A96_Q0.6930.71
90_S95_R0.6840.70
20_A44_F0.6830.70
55_S108_W0.6810.69
117_L120_P0.6770.69
48_A56_R0.6760.69
11_W84_V0.6670.68
78_I117_L0.6610.67
29_A32_G0.6580.67
23_C39_L0.6530.66
71_A124_T0.6510.66
97_L103_V0.6490.66
82_A92_A0.6470.65
55_S132_R0.6470.65
10_Y108_W0.6410.65
85_P97_L0.6410.65
98_D125_P0.6390.65
83_A113_V0.6330.64
38_A66_L0.6330.64
97_L108_W0.6320.64
9_W108_W0.6270.63
50_I54_M0.6250.63
88_A91_A0.6230.63
64_G76_D0.6230.63
60_G70_N0.6180.62
78_I81_A0.6130.61
80_R96_Q0.6100.61
49_A52_W0.6100.61
23_C40_F0.6090.61
56_R69_G0.6020.60
13_L17_G0.6020.60
67_W78_I0.5980.59
15_A18_V0.5940.59
68_A77_V0.5930.59
37_Y40_F0.5920.59
32_G35_W0.5920.59
96_Q114_A0.5910.59
33_A37_Y0.5890.58
73_L118_D0.5850.58
13_L16_A0.5850.58
137_L141_I0.5840.58
83_A135_E0.5810.57
98_D103_V0.5760.57
53_S107_G0.5660.55
81_A143_A0.5650.55
75_L113_V0.5650.55
7_V109_I0.5640.55
60_G136_R0.5610.55
45_L75_L0.5580.54
100_A123_P0.5570.54
114_A129_V0.5570.54
49_A53_S0.5570.54
66_L88_A0.5570.54
17_G45_L0.5570.54
97_L107_G0.5550.54
71_A123_P0.5550.54
84_V89_K0.5530.54
134_P139_A0.5500.53
7_V57_A0.5490.53
79_S107_G0.5480.53
26_I29_A0.5480.53
10_Y130_S0.5480.53
32_G41_P0.5450.53
14_F20_A0.5410.52
93_L110_K0.5410.52
36_M40_F0.5400.52
41_P44_F0.5350.51
67_W70_N0.5350.51
42_V54_M0.5310.51
101_A125_P0.5310.51
83_A120_P0.5290.50
59_V68_A0.5270.50
57_A115_V0.5260.50
97_L126_Y0.5230.50
14_F21_L0.5220.50
61_V115_V0.5200.49
135_E142_P0.5160.49
15_A47_A0.5140.48
1_Y134_P0.5120.48
12_W19_A0.5110.48
94_G127_W0.5090.48
105_H112_L0.5070.48
40_F44_F0.5050.47
17_G21_L0.5010.47
37_Y44_F0.5000.47
69_G105_H0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d4eA 4 0.4861 17.2 0.94 Contact Map
3frnA 1 0.5556 9.7 0.946 Contact Map
4i3vA 4 0.3125 9.2 0.947 Contact Map
4knaA 2 0.2847 8.7 0.947 Contact Map
3k2wA 5 0.3472 5.3 0.952 Contact Map
3rh9A 2 0.3681 5.2 0.952 Contact Map
4c7rA 3 0.6597 5.2 0.952 Contact Map
4o6rA 4 0.2986 5.1 0.953 Contact Map
3wflA 1 0.5833 4.8 0.953 Contact Map
2j6lA 5 0.4583 4.6 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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