GREMLIN Database
PF08495 - (28-371) Uncharacterized protein
UniProt: D0LZC1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 344 (320)
Sequences: 6230 (5190)
Seq/√Len: 290.1
META: 0.697

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_R187_E5.5101.00
191_A199_R4.8541.00
179_R186_Y4.3141.00
237_D240_T3.9751.00
195_D241_G3.6751.00
185_L245_Y3.0691.00
177_V180_A3.0691.00
29_A140_G2.8481.00
237_D242_A2.8301.00
176_G254_R2.7731.00
187_E190_D2.7401.00
31_I151_V2.6701.00
73_G76_A2.5441.00
218_A258_M2.4821.00
186_Y242_A2.4811.00
33_C126_A2.4721.00
250_P253_S2.3131.00
191_A195_D2.3091.00
32_G138_C2.2511.00
3_V53_V2.2171.00
177_V249_V2.1861.00
315_R318_E2.1411.00
179_R251_E2.0231.00
38_V48_A2.0221.00
78_G82_A2.0061.00
230_V258_M1.9861.00
185_L249_V1.9441.00
63_T139_S1.9051.00
303_V338_G1.8461.00
5_A21_L1.8221.00
92_A160_V1.7941.00
20_L23_D1.7791.00
52_V334_A1.7621.00
184_T244_M1.7461.00
5_A51_V1.7441.00
174_E254_R1.7211.00
75_H113_S1.7181.00
196_V199_R1.7091.00
19_Q23_D1.7011.00
35_S38_V1.6941.00
270_A274_L1.6821.00
139_S142_R1.6751.00
22_R141_N1.6521.00
56_F59_A1.6411.00
40_A43_E1.6351.00
184_T242_A1.6331.00
139_S149_A1.6331.00
301_V334_A1.6251.00
134_R145_S1.6201.00
29_A63_T1.6181.00
188_L193_A1.6121.00
128_D132_F1.6051.00
181_D186_Y1.6001.00
22_R140_G1.5991.00
67_L142_R1.5931.00
79_A113_S1.5921.00
175_R188_L1.5911.00
65_A144_Q1.5911.00
79_A83_R1.5851.00
235_A244_M1.5821.00
3_V25_Y1.5571.00
64_A150_C1.5441.00
177_V255_A1.5331.00
15_P19_Q1.5171.00
161_G281_K1.5041.00
94_L153_F1.5001.00
207_G211_T1.4961.00
144_Q147_L1.4901.00
21_L51_V1.4701.00
70_D146_G1.4651.00
208_L212_G1.4631.00
40_A50_S1.4591.00
169_D259_R1.4571.00
191_A196_V1.4561.00
270_A322_A1.4551.00
274_L326_S1.4511.00
20_L24_V1.4491.00
270_A325_R1.4481.00
192_P195_D1.4441.00
184_T237_D1.4191.00
237_D244_M1.4161.00
188_L255_A1.4091.00
170_R228_V1.4051.00
231_R247_G1.3981.00
29_A61_L1.3981.00
76_A80_S1.3901.00
175_R189_D1.3851.00
58_R156_D1.3651.00
125_L342_I1.3621.00
93_L150_C1.3571.00
185_L188_L1.3421.00
195_D198_K1.3391.00
4_L94_L1.3301.00
175_R200_Y1.3261.00
198_K238_A1.3261.00
302_A323_A1.3251.00
192_P241_G1.3161.00
106_A109_E1.3061.00
234_I246_A1.3061.00
170_R256_Q1.3051.00
124_G338_G1.3011.00
217_L255_A1.2991.00
189_D196_V1.2981.00
169_D264_R1.2961.00
93_L152_G1.2751.00
178_T187_E1.2721.00
137_V149_A1.2671.00
197_Y216_P1.2611.00
127_G339_Y1.2601.00
7_G14_H1.2581.00
12_V16_K1.2571.00
3_V28_S1.2531.00
193_A243_L1.2531.00
76_A79_A1.2321.00
94_L303_V1.2321.00
50_S334_A1.2221.00
174_E256_Q1.2211.00
184_T240_T1.2211.00
89_G156_D1.2191.00
16_K19_Q1.2051.00
232_P307_G1.2051.00
97_A125_L1.1981.00
110_G114_V1.1851.00
80_S83_R1.1841.00
52_V299_L1.1681.00
180_A250_P1.1601.00
274_L283_E1.1591.00
300_A331_A1.1511.00
197_Y243_L1.1471.00
270_A326_S1.1461.00
108_V121_V1.1401.00
65_A147_L1.1381.00
208_L211_T1.1261.00
263_R267_S1.1161.00
31_I149_A1.1151.00
176_G252_G1.1011.00
78_G110_G1.0981.00
271_D274_L1.0891.00
63_T151_V1.0841.00
161_G284_R1.0801.00
209_P212_G1.0761.00
124_G336_F1.0721.00
61_L151_V1.0701.00
126_A137_V1.0641.00
188_L196_V1.0621.00
10_E47_Q1.0611.00
180_A251_E1.0571.00
300_A327_L1.0571.00
317_E321_K1.0521.00
94_L301_V1.0501.00
175_R196_V1.0411.00
322_A325_R1.0401.00
272_A281_K1.0371.00
271_D280_A1.0361.00
4_L31_I1.0331.00
95_V150_C1.0281.00
79_A114_V1.0231.00
45_H48_A1.0181.00
67_L146_G1.0171.00
177_V188_L1.0091.00
198_K203_E1.0051.00
212_G243_L0.9961.00
33_C96_F0.9901.00
75_H78_G0.9851.00
168_W260_T0.9821.00
169_D261_D0.9801.00
273_S326_S0.9801.00
223_D226_A0.9701.00
186_Y240_T0.9651.00
265_L312_L0.9641.00
305_G341_E0.9631.00
67_L147_L0.9621.00
97_A107_L0.9611.00
130_T306_L0.9561.00
196_V200_Y0.9541.00
59_A153_F0.9531.00
16_K20_L0.9531.00
105_D248_A0.9521.00
68_V146_G0.9461.00
94_L122_A0.9431.00
99_G125_L0.9421.00
309_R313_G0.9421.00
280_A283_E0.9421.00
60_K154_Y0.9321.00
180_A249_V0.9311.00
269_A273_S0.9291.00
187_E192_P0.9251.00
233_L245_Y0.9211.00
104_G125_L0.9211.00
92_A120_V0.9201.00
33_C336_F0.9161.00
128_D339_Y0.9151.00
136_W145_S0.9111.00
302_A333_C0.9051.00
68_V71_V0.9031.00
91_R154_Y0.9021.00
324_R333_C0.8971.00
122_A162_C0.8941.00
180_A253_S0.8941.00
18_F138_C0.8921.00
268_S272_A0.8851.00
274_L282_L0.8851.00
8_S11_M0.8821.00
267_S271_D0.8791.00
328_P331_A0.8771.00
8_S38_V0.8751.00
26_P29_A0.8731.00
75_H79_A0.8691.00
173_P189_D0.8631.00
187_E193_A0.8631.00
17_V49_L0.8611.00
67_L144_Q0.8581.00
74_S78_G0.8581.00
111_I150_C0.8521.00
65_A139_S0.8521.00
316_A337_Y0.8501.00
195_D199_R0.8501.00
166_T230_V0.8491.00
306_L310_M0.8471.00
91_R156_D0.8461.00
304_S337_Y0.8431.00
299_L332_V0.8381.00
204_R207_G0.8371.00
38_V47_Q0.8361.00
280_A284_R0.8331.00
46_D309_R0.8321.00
61_L153_F0.8311.00
69_R146_G0.8291.00
266_L270_A0.8281.00
92_A153_F0.8281.00
163_G281_K0.8231.00
300_A333_C0.8231.00
173_P257_L0.8181.00
65_A149_A0.8181.00
128_D133_E0.8171.00
103_D248_A0.8171.00
97_A148_V0.8161.00
108_V342_I0.8161.00
155_G159_V0.8131.00
66_A80_S0.8101.00
132_F135_T0.8101.00
5_A18_F0.8091.00
110_G113_S0.8091.00
77_A80_S0.8071.00
194_A236_A0.8071.00
218_A228_V0.8060.99
266_L318_E0.8040.99
165_Q268_S0.8010.99
163_G272_A0.7980.99
90_L93_L0.7960.99
304_S308_R0.7950.99
125_L340_G0.7950.99
111_I121_V0.7940.99
37_G127_G0.7880.99
62_R154_Y0.7880.99
93_L119_V0.7870.99
336_F339_Y0.7850.99
165_Q271_D0.7850.99
59_A155_G0.7830.99
232_P246_A0.7800.99
305_G308_R0.7780.99
66_A84_K0.7750.99
56_F61_L0.7710.99
7_G17_V0.7700.99
90_L152_G0.7680.99
41_G324_R0.7660.99
19_Q22_R0.7660.99
40_A45_H0.7650.99
194_A198_K0.7640.99
37_G309_R0.7630.99
43_E317_E0.7630.99
304_S319_E0.7540.99
18_F143_L0.7510.99
163_G280_A0.7510.99
161_G285_A0.7500.99
66_A148_V0.7500.99
197_Y233_L0.7490.99
267_S270_A0.7490.99
318_E321_K0.7480.99
4_L54_A0.7450.99
261_D264_R0.7430.99
93_L121_V0.7380.99
155_G158_L0.7360.99
124_G305_G0.7350.99
7_G138_C0.7340.99
266_L269_A0.7300.99
95_V107_L0.7290.99
266_L322_A0.7280.99
89_G92_A0.7270.99
180_A186_Y0.7270.99
183_H244_M0.7200.99
3_V51_V0.7200.99
12_V15_P0.7180.99
178_T189_D0.7160.99
103_D106_A0.7140.99
25_Y28_S0.7100.99
91_R152_G0.7080.99
181_D184_T0.7040.99
7_G11_M0.7020.99
63_T66_A0.7020.99
77_A81_V0.7010.99
197_Y260_T0.7000.99
174_E220_W0.7000.99
232_P339_Y0.7000.99
221_P253_S0.7000.99
9_P129_D0.6990.99
282_L326_S0.6990.99
215_Y255_A0.6980.99
75_H110_G0.6970.99
34_S128_D0.6950.99
49_L52_V0.6940.99
207_G210_A0.6930.98
213_M216_P0.6890.98
28_S53_V0.6890.98
14_H138_C0.6880.98
203_E206_A0.6860.98
34_S135_T0.6850.98
100_L339_Y0.6830.98
171_F259_R0.6820.98
304_S336_F0.6800.98
99_G135_T0.6770.98
64_A84_K0.6770.98
14_H143_L0.6770.98
320_L324_R0.6760.98
3_V21_L0.6720.98
324_R328_P0.6680.98
158_L162_C0.6660.98
58_R61_L0.6640.98
231_R308_R0.6610.98
4_L301_V0.6600.98
38_V50_S0.6600.98
17_V51_V0.6590.98
56_F155_G0.6570.98
109_E112_H0.6540.98
98_E101_R0.6540.98
181_D251_E0.6530.98
139_S144_Q0.6520.98
176_G189_D0.6460.98
7_G34_S0.6450.98
219_L231_R0.6440.98
216_P221_P0.6410.97
173_P200_Y0.6400.97
327_L333_C0.6400.97
128_D135_T0.6380.97
107_L148_V0.6380.97
81_V85_L0.6380.97
22_R27_H0.6370.97
309_R337_Y0.6360.97
100_L135_T0.6350.97
17_V20_L0.6350.97
321_K324_R0.6350.97
6_F9_P0.6320.97
96_F303_V0.6320.97
14_H18_F0.6310.97
5_A49_L0.6310.97
127_G306_L0.6310.97
96_F153_F0.6300.97
177_V248_A0.6280.97
183_H247_G0.6270.97
129_D132_F0.6250.97
228_V256_Q0.6240.97
338_G342_I0.6220.97
86_A89_G0.6190.97
168_W319_E0.6190.97
31_I139_S0.6190.97
38_V127_G0.6170.97
92_A162_C0.6160.97
36_A306_L0.6150.97
122_A303_V0.6140.97
66_A81_V0.6100.97
319_E322_A0.6070.97
99_G127_G0.6050.96
299_L334_A0.6040.96
54_A299_L0.6030.96
312_L319_E0.6030.96
274_L280_A0.6020.96
216_P222_A0.6020.96
202_G205_L0.6020.96
178_T192_P0.6010.96
81_V84_K0.6000.96
124_G335_G0.6000.96
82_A110_G0.6000.96
308_R319_E0.5990.96
34_S38_V0.5970.96
335_G341_E0.5950.96
182_G248_A0.5930.96
245_Y249_V0.5930.96
78_G81_V0.5930.96
73_G80_S0.5930.96
216_P223_D0.5920.96
198_K241_G0.5890.96
322_A326_S0.5860.96
29_A139_S0.5840.96
79_A82_A0.5790.95
57_E60_K0.5790.95
233_L243_L0.5790.95
315_R319_E0.5770.95
112_H121_V0.5770.95
217_L220_W0.5760.95
104_G183_H0.5750.95
31_I63_T0.5740.95
98_E146_G0.5740.95
42_A324_R0.5730.95
194_A243_L0.5720.95
327_L331_A0.5720.95
35_S127_G0.5690.95
205_L208_L0.5690.95
4_L52_V0.5680.95
33_C36_A0.5680.95
79_A110_G0.5660.95
73_G77_A0.5660.95
168_W216_P0.5650.95
215_Y220_W0.5630.95
36_A127_G0.5630.95
5_A32_G0.5620.95
128_D131_R0.5610.95
93_L115_V0.5590.95
106_A110_G0.5570.94
106_A182_G0.5560.94
229_S232_P0.5520.94
82_A85_L0.5520.94
82_A114_V0.5510.94
326_S331_A0.5510.94
230_V306_L0.5500.94
11_M49_L0.5500.94
196_V257_L0.5490.94
15_P18_F0.5490.94
15_P143_L0.5460.94
88_P92_A0.5410.94
39_I304_S0.5400.93
306_L339_Y0.5380.93
99_G339_Y0.5360.93
307_G310_M0.5350.93
112_H116_G0.5350.93
311_A314_E0.5350.93
326_S330_G0.5340.93
92_A122_A0.5340.93
167_G231_R0.5330.93
92_A95_V0.5330.93
221_P226_A0.5320.93
178_T196_V0.5320.93
126_A135_T0.5300.93
216_P219_L0.5290.93
18_F21_L0.5290.93
75_H106_A0.5290.93
296_T330_G0.5280.93
29_A151_V0.5280.93
246_A307_G0.5280.93
273_S282_L0.5260.93
188_L241_G0.5260.93
101_R146_G0.5240.92
83_R87_G0.5240.92
273_S322_A0.5230.92
213_M307_G0.5210.92
49_L54_A0.5200.92
64_A85_L0.5160.92
193_A196_V0.5160.92
282_L296_T0.5160.92
119_V152_G0.5160.92
265_L268_S0.5150.92
249_V255_A0.5130.92
300_A304_S0.5130.92
90_L154_Y0.5120.92
98_E135_T0.5110.92
177_V253_S0.5110.92
167_G260_T0.5100.91
115_V152_G0.5090.91
105_D247_G0.5090.91
308_R341_E0.5080.91
214_L217_L0.5080.91
83_R195_D0.5070.91
35_S339_Y0.5070.91
262_A312_L0.5060.91
164_S226_A0.5060.91
83_R114_V0.5050.91
9_P12_V0.5050.91
10_E129_D0.5030.91
111_I114_V0.5020.91
46_D313_G0.5020.91
168_W311_A0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3istA 2 0.2936 12.1 0.964 Contact Map
4jvoA 2 0.2558 11.2 0.965 Contact Map
3h7cX 1 0.1599 10.1 0.965 Contact Map
1zuwA 2 0.2936 8.1 0.967 Contact Map
1zbrA 2 0.1599 6.6 0.968 Contact Map
4injA 2 0.25 6.6 0.968 Contact Map
1xknA 1 0.1715 6 0.969 Contact Map
4e5sA 2 0.25 4.9 0.97 Contact Map
3rkcA 2 0.2703 4.8 0.97 Contact Map
1zl0A 1 0.2413 4.5 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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