GREMLIN Database
PF14462 - (1-93) Uncharacterized protein
UniProt: C7R645 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 93 (78)
Sequences: 715 (580)
Seq/√Len: 65.7
META: 0.724

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_I67_L3.7141.00
18_D77_T2.9901.00
24_V29_I2.8321.00
31_G59_I2.7111.00
26_S33_E2.6771.00
15_F24_V2.3671.00
32_R61_L2.1391.00
27_P68_S2.0551.00
28_S64_K1.8651.00
35_L61_L1.8331.00
24_V37_M1.7471.00
17_V34_I1.7291.00
14_R21_N1.7150.99
57_K63_E1.7090.99
18_D40_K1.6200.99
32_R62_D1.5940.99
66_D71_G1.5850.99
48_L77_T1.5800.99
28_S66_D1.5560.99
16_R74_R1.4090.98
40_K77_T1.3560.97
33_E64_K1.3030.97
34_I38_A1.2780.96
14_R23_T1.2690.96
32_R36_I1.2530.96
30_T33_E1.2390.95
27_P66_D1.1980.94
78_L81_E1.1820.94
59_I65_I1.1740.94
79_E82_C1.1350.93
22_F38_A1.1060.92
17_V20_N1.1050.92
34_I48_L1.0990.91
26_S29_I1.0910.91
30_T62_D1.0580.90
50_L69_Q1.0360.89
16_R19_K1.0270.88
30_T64_K1.0120.88
70_P73_E1.0090.88
12_Q23_T0.9890.86
57_K69_Q0.9820.86
50_L65_I0.9600.85
36_I41_T0.9560.85
31_G75_F0.9480.84
12_Q25_D0.9470.84
43_V61_L0.9410.84
49_I76_R0.9260.83
8_N13_W0.9130.82
58_E61_L0.8890.80
78_L82_C0.8790.79
15_F34_I0.8710.79
28_S68_S0.8460.77
35_L77_T0.8230.75
31_G62_D0.8210.74
35_L40_K0.8010.73
38_A77_T0.7910.72
49_I56_P0.7840.71
64_K72_I0.7730.70
18_D75_F0.7710.70
27_P70_P0.7700.70
33_E36_I0.7460.67
56_P78_L0.7330.66
47_L80_R0.7230.65
29_I37_M0.7220.65
51_S79_E0.7140.64
31_G34_I0.7120.64
78_L84_E0.7090.63
36_I39_G0.7090.63
68_S71_G0.7060.63
17_V48_L0.7020.62
56_P76_R0.7000.62
34_I75_F0.6960.62
9_N27_P0.6900.61
18_D34_I0.6870.61
57_K60_S0.6860.61
81_E84_E0.6850.61
10_G13_W0.6830.60
51_S78_L0.6750.59
15_F37_M0.6680.59
65_I75_F0.6670.58
22_F33_E0.6620.58
19_K74_R0.6570.57
20_N25_D0.6510.57
46_Y77_T0.6360.55
8_N25_D0.6340.55
65_I70_P0.6270.54
47_L58_E0.6270.54
13_W18_D0.6230.53
52_G69_Q0.6220.53
52_G55_Q0.6130.52
66_D70_P0.6050.51
17_V22_F0.6040.51
17_V30_T0.6040.51
27_P54_G0.6010.51
47_L55_Q0.5920.50
60_S63_E0.5750.48
66_D69_Q0.5730.48
58_E80_R0.5700.47
29_I77_T0.5700.47
16_R21_N0.5690.47
68_S74_R0.5680.47
12_Q59_I0.5610.46
11_S36_I0.5610.46
10_G21_N0.5580.46
31_G48_L0.5560.46
12_Q74_R0.5510.45
46_Y84_E0.5430.44
46_Y52_G0.5400.44
55_Q74_R0.5290.42
78_L83_R0.5260.42
11_S65_I0.5180.41
44_E80_R0.5120.40
17_V21_N0.5080.40
56_P60_S0.5020.39
49_I58_E0.5020.39
46_Y85_G0.5010.39
22_F39_G0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cu3A 2 0.6022 17.5 0.895 Contact Map
1tygB 1 0.6129 13.5 0.901 Contact Map
1rqbA 2 0.0215 12.1 0.903 Contact Map
2lekA 1 0.6989 10.3 0.906 Contact Map
1f0zA 1 0.6237 9.5 0.907 Contact Map
1z4hA 1 0.7097 6.8 0.913 Contact Map
3wfpA 2 0.2903 5.2 0.917 Contact Map
2d5uA 1 0.8495 4.3 0.921 Contact Map
2k5pA 1 0.7097 3.9 0.923 Contact Map
4hdoA 1 0.9247 3.7 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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