GREMLIN Database
PF11303 - Uncharacterized protein
UniProt: C1CZL3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 143 (136)
Sequences: 1883 (1346)
Seq/√Len: 115.4
META: 0.853

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_I118_L3.9721.00
40_C60_A3.3501.00
42_V89_L3.1411.00
96_D109_K3.0511.00
70_E73_Q2.7201.00
49_N92_Y2.5731.00
17_R21_L2.5101.00
71_A75_A2.4401.00
81_A89_L2.3391.00
80_L119_K2.2711.00
38_Q47_L2.1171.00
108_L117_R2.0511.00
52_A88_L1.9991.00
15_D32_A1.9931.00
34_N48_Y1.9921.00
64_T90_S1.9771.00
26_T92_Y1.9701.00
128_G131_A1.9341.00
71_A74_V1.8901.00
95_L100_A1.8231.00
13_A32_A1.7521.00
122_L126_E1.7031.00
106_A125_Y1.6911.00
77_L89_L1.6901.00
28_P49_N1.6841.00
75_A78_K1.6811.00
131_A134_R1.6791.00
103_A121_F1.6251.00
34_N51_Y1.6081.00
11_Y105_G1.5801.00
69_L73_Q1.5241.00
73_Q76_Q1.5231.00
48_Y51_Y1.5111.00
73_Q113_A1.5101.00
11_Y14_G1.5051.00
47_L52_A1.5031.00
87_T122_L1.4901.00
8_T106_A1.4851.00
46_P93_E1.4611.00
44_D78_K1.4301.00
63_I81_A1.4131.00
25_E29_A1.4001.00
55_S60_A1.3901.00
40_C55_S1.3551.00
52_A90_S1.3491.00
26_T96_D1.3111.00
119_K123_D1.2961.00
55_S88_L1.2790.99
103_A125_Y1.2450.99
19_G34_N1.2290.99
130_T134_R1.2070.99
52_A64_T1.1760.99
64_T95_L1.1620.99
29_A107_Q1.1490.99
18_S35_P1.1290.99
66_R69_L1.1280.99
34_N50_E1.1060.98
97_T111_D1.1030.98
75_A79_A1.0930.98
9_F25_E1.0780.98
62_W90_S1.0770.98
86_Y127_Q1.0730.98
38_Q88_L1.0600.98
101_I108_L1.0490.98
84_R126_E1.0440.98
137_P140_G1.0440.98
16_H57_E1.0410.98
9_F29_A1.0330.98
21_L32_A1.0250.97
102_S107_Q1.0090.97
127_Q131_A1.0080.97
64_T102_S1.0010.97
76_Q113_A1.0000.97
46_P91_P0.9990.97
40_C138_C0.9890.97
38_Q51_Y0.9810.97
38_Q55_S0.9770.97
78_K82_Q0.9470.96
29_A102_S0.9320.96
74_V78_K0.9200.95
52_A62_W0.9050.95
39_N140_G0.9040.95
13_A105_G0.8950.94
86_Y135_G0.8800.94
95_L102_S0.8640.93
42_V78_K0.8610.93
37_W58_H0.8580.93
66_R96_D0.8460.93
63_I101_I0.8420.92
66_R70_E0.8320.92
133_E136_A0.8310.92
54_H58_H0.8220.91
38_Q48_Y0.8120.91
76_Q79_A0.8050.91
97_T100_A0.8010.90
67_P98_P0.7980.90
20_S49_N0.7920.90
100_A109_K0.7800.89
17_R32_A0.7760.89
23_Y50_E0.7750.89
67_P91_P0.7750.89
87_T126_E0.7750.89
99_V113_A0.7730.89
6_A108_L0.7630.88
27_P92_Y0.7580.88
103_A130_T0.7410.87
63_I122_L0.7410.87
63_I99_V0.7350.86
67_P93_E0.7350.86
20_S50_E0.7330.86
13_A30_G0.7310.86
42_V81_A0.7240.85
12_S25_E0.7220.85
115_D119_K0.7170.85
76_Q80_L0.7160.85
12_S24_N0.7040.84
89_L101_I0.6980.83
74_V95_L0.6980.83
99_V112_K0.6800.82
97_T109_K0.6770.81
128_G134_R0.6770.81
129_A134_R0.6710.81
95_L109_K0.6680.80
13_A16_H0.6610.80
92_Y95_L0.6580.79
7_Q10_K0.6560.79
11_Y25_E0.6560.79
117_R120_A0.6500.79
70_E114_D0.6440.78
26_T109_K0.6420.78
45_Q91_P0.6400.78
40_C62_W0.6380.77
41_G100_A0.6350.77
96_D100_A0.6300.76
76_Q112_K0.6290.76
63_I113_A0.6270.76
55_S86_Y0.6260.76
26_T49_N0.6250.76
35_P116_A0.6240.76
61_V101_I0.6210.75
123_D129_A0.6110.74
30_G105_G0.6100.74
62_W95_L0.6070.74
66_R98_P0.6050.74
66_R93_E0.6050.74
37_W43_Y0.6030.73
97_T112_K0.5990.73
134_R140_G0.5980.73
68_D98_P0.5930.72
12_S15_D0.5920.72
74_V89_L0.5920.72
106_A122_L0.5880.71
47_L51_Y0.5880.71
125_Y128_G0.5860.71
14_G32_A0.5850.71
28_P53_V0.5750.70
63_I80_L0.5720.69
54_H57_E0.5690.69
25_E32_A0.5680.69
132_P135_G0.5670.69
40_C90_S0.5670.69
41_G80_L0.5630.68
37_W51_Y0.5630.68
84_R87_T0.5590.68
77_L118_L0.5590.68
10_K13_A0.5570.67
108_L112_K0.5570.67
110_V117_R0.5540.67
101_I110_V0.5530.67
72_A75_A0.5500.66
56_L127_Q0.5480.66
51_Y55_S0.5480.66
26_T95_L0.5460.66
33_H58_H0.5460.66
65_Y92_Y0.5460.66
46_P49_N0.5450.66
87_T101_I0.5450.66
85_T126_E0.5440.66
81_A87_T0.5430.65
34_N110_V0.5430.65
69_L74_V0.5380.65
6_A106_A0.5370.65
56_L88_L0.5350.64
21_L50_E0.5330.64
42_V87_T0.5320.64
38_Q50_E0.5280.63
106_A131_A0.5260.63
16_H58_H0.5240.63
67_P92_Y0.5230.63
39_N52_A0.5220.62
67_P71_A0.5190.62
36_V116_A0.5180.62
134_R137_P0.5180.62
100_A107_Q0.5180.62
79_A116_A0.5170.62
28_P31_G0.5160.62
16_H33_H0.5100.61
33_H57_E0.5090.60
106_A126_E0.5080.60
127_Q139_S0.5070.60
41_G88_L0.5040.60
62_W107_Q0.5030.60
38_Q52_A0.5010.59
17_R35_P0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g78A 1 0.3846 7.5 0.954 Contact Map
3g23A 2 0.5245 7.2 0.954 Contact Map
4tkxL 1 0.5874 6.6 0.955 Contact Map
4eysA 3 0.5105 6.1 0.956 Contact Map
3r2cJ 1 0.2727 5.8 0.956 Contact Map
1lwbA 1 0.3007 5.7 0.956 Contact Map
1cvrA 1 0.5524 5.5 0.956 Contact Map
1rv3A 3 0.951 4.9 0.957 Contact Map
3eoqA 2 0.9441 4.8 0.958 Contact Map
3us6A 1 0.4406 4.6 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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