GREMLIN Database
PF16079 - Uncharacterized protein
UniProt: C0CV72 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 89 (79)
Sequences: 1090 (900)
Seq/√Len: 101.3
META: 0.85

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_G37_C3.3931.00
19_G33_I3.1491.00
17_L38_G2.4691.00
18_I40_A2.2891.00
79_Q83_Q2.2431.00
22_C28_V2.1991.00
16_Y78_N2.1551.00
42_A68_I2.1481.00
37_C74_A2.0241.00
38_G68_I1.9301.00
59_D62_N1.9271.00
15_C19_G1.8311.00
22_C36_T1.8111.00
21_G38_G1.7551.00
15_C37_C1.6911.00
72_L76_G1.5791.00
16_Y20_M1.5611.00
75_T79_Q1.4821.00
13_V44_L1.4571.00
67_G70_S1.4191.00
42_A45_G1.4001.00
25_S35_V1.3841.00
27_K32_V1.3821.00
67_G72_L1.3310.99
45_G63_A1.2880.99
14_I68_I1.2830.99
24_A29_K1.2700.99
79_Q82_K1.2410.99
25_S29_K1.2400.99
20_M33_I1.2280.99
27_K31_E1.2170.99
81_V85_G1.2120.99
77_V80_M1.1610.98
78_N82_K1.1420.98
42_A64_V1.1370.98
46_V60_V1.0900.97
20_M24_A1.0800.97
53_P57_A1.0620.97
26_S31_E1.0620.97
17_L68_I1.0020.96
54_G58_S0.9930.95
48_G52_M0.9510.94
66_I70_S0.9500.94
12_T73_A0.9490.94
58_S62_N0.9430.94
71_G75_T0.9370.94
81_V84_L0.9290.93
36_T39_V0.9170.93
25_S28_V0.9020.92
19_G25_S0.8950.92
24_A35_V0.8940.92
28_V36_T0.8820.92
78_N83_Q0.8760.91
21_G24_A0.8750.91
11_I70_S0.8330.89
38_G72_L0.8320.89
78_N81_V0.8100.88
27_K30_D0.8050.87
66_I69_V0.7990.87
62_N65_A0.7890.86
11_I45_G0.7520.84
72_L77_V0.7360.82
22_C37_C0.7350.82
14_I65_A0.7270.82
20_M81_V0.7260.81
48_G51_T0.7180.81
24_A81_V0.7140.80
22_C25_S0.7120.80
26_S39_V0.7070.80
43_A56_P0.6980.79
14_I64_V0.6980.79
67_G75_T0.6960.79
72_L75_T0.6960.79
33_I37_C0.6950.79
12_T55_F0.6910.78
45_G48_G0.6780.77
39_V85_G0.6640.75
80_M84_L0.6610.75
19_G30_D0.6580.75
32_V84_L0.6500.74
43_A58_S0.6390.73
22_C29_K0.6300.72
31_E83_Q0.6270.71
47_V51_T0.6230.71
15_C70_S0.6220.71
11_I14_I0.6120.69
28_V31_E0.6040.68
60_V64_V0.6000.68
35_V39_V0.5960.67
71_G76_G0.5960.67
8_V12_T0.5950.67
38_G65_A0.5930.67
26_S35_V0.5890.66
65_A70_S0.5870.66
14_I44_L0.5840.66
49_M53_P0.5800.65
7_G10_A0.5760.65
55_F65_A0.5690.64
55_F59_D0.5690.64
13_V69_V0.5610.63
12_T81_V0.5590.62
7_G13_V0.5560.62
43_A85_G0.5490.61
16_Y30_D0.5470.61
22_C27_K0.5460.61
42_A46_V0.5420.60
73_A76_G0.5410.60
52_M56_P0.5340.59
10_A62_N0.5260.58
22_C35_V0.5250.58
32_V36_T0.5230.57
48_G61_V0.5210.57
51_T54_G0.5210.57
11_I15_C0.5180.57
7_G12_T0.5160.56
49_M52_M0.5160.56
65_A69_V0.5090.55
9_A12_T0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w41A 1 0.3708 17.3 0.892 Contact Map
3b9wA 3 0.9101 17 0.892 Contact Map
2b2hA 3 0.8989 16.3 0.893 Contact Map
3j21Z 1 0.3596 15.8 0.893 Contact Map
4czbA 2 0.9326 15 0.895 Contact Map
3o85A 1 0.5281 15 0.895 Contact Map
3cpqA 2 0.3596 13 0.897 Contact Map
3on1A 1 0.3708 12.3 0.898 Contact Map
4cz8A 2 1 11.3 0.9 Contact Map
3hd6A 3 0.9326 10.9 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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