GREMLIN Database
PF10003 - Uncharacterized protein
UniProt: B6JCJ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 151 (147)
Sequences: 3132 (2225)
Seq/√Len: 183.5
META:

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_E94_T3.8411.00
61_V65_R2.4541.00
7_L129_F2.3051.00
118_S123_R2.1811.00
25_L55_I2.1181.00
74_L79_L2.0741.00
57_W61_V2.0651.00
43_P46_G2.0151.00
80_R92_E2.0101.00
72_L138_F1.9781.00
37_V45_F1.9231.00
69_F84_V1.8681.00
70_E83_R1.8621.00
101_R118_S1.8191.00
82_R92_E1.7981.00
82_R90_A1.7621.00
79_L97_P1.7501.00
35_L39_M1.7351.00
4_T71_Q1.7041.00
56_Y60_R1.6691.00
114_G125_A1.6591.00
29_S48_F1.6571.00
81_L124_V1.6331.00
19_I23_S1.6181.00
103_D118_S1.5971.00
4_T73_V1.5871.00
18_F22_M1.5851.00
22_M56_Y1.5801.00
131_S134_E1.5581.00
11_R66_A1.5431.00
100_V117_L1.5071.00
54_L58_A1.4941.00
95_F100_V1.4891.00
84_V90_A1.4841.00
96_N99_W1.4781.00
18_F63_Y1.4591.00
26_V52_V1.4501.00
21_L25_L1.4471.00
138_F142_L1.4291.00
115_I139_A1.4241.00
125_A128_K1.4171.00
80_R94_T1.3961.00
81_L117_L1.3611.00
6_E71_Q1.3481.00
76_P97_P1.3401.00
103_D123_R1.3201.00
73_V80_R1.3111.00
83_R91_M1.2981.00
14_S17_G1.2931.00
13_L17_G1.2871.00
65_R68_A1.2761.00
116_Y123_R1.2741.00
99_W120_R1.2671.00
33_G45_F1.2641.00
83_R93_W1.2551.00
139_A143_R1.2351.00
15_R60_R1.2241.00
21_L24_V1.2171.00
71_Q82_R1.2051.00
137_S141_A1.2031.00
112_V132_P1.1951.00
50_L54_L1.1871.00
13_L18_F1.1781.00
36_F44_V1.1611.00
6_E69_F1.1531.00
14_S63_Y1.1451.00
20_I24_V1.1391.00
29_S52_V1.1371.00
72_L81_L1.1321.00
75_T78_E1.1231.00
46_G49_V1.1121.00
140_K144_L1.0951.00
104_V115_I1.0791.00
32_S48_F1.0751.00
85_S91_M1.0721.00
62_N66_A1.0661.00
96_N120_R1.0571.00
37_V48_F1.0491.00
62_N65_R1.0291.00
48_F51_D1.0271.00
85_S89_H1.0251.00
54_L57_W1.0160.99
57_W60_R1.0160.99
93_W124_V1.0090.99
20_I23_S1.0040.99
141_A145_A0.9840.99
135_K139_A0.9600.99
30_F52_V0.9400.99
85_S90_A0.9330.99
79_L117_L0.9300.99
37_V42_W0.9240.99
26_V30_F0.9190.99
71_Q84_V0.9130.99
35_L49_V0.9040.99
33_G48_F0.8980.99
25_L32_S0.8930.99
136_A144_L0.8930.99
73_V82_R0.8930.99
35_L38_R0.8920.99
116_Y125_A0.8900.99
65_R86_H0.8890.99
102_L139_A0.8890.99
105_E123_R0.8850.99
104_V113_E0.8840.99
133_N136_A0.8770.98
125_A135_K0.8730.98
22_M59_F0.8640.98
33_G37_V0.8630.98
115_I134_E0.8620.98
49_V53_V0.8610.98
63_Y66_A0.8590.98
144_L147_Q0.8540.98
102_L142_L0.8530.98
15_R19_I0.8500.98
34_I38_R0.8490.98
144_L148_D0.8440.98
105_E114_G0.8420.98
40_G43_P0.8410.98
16_T20_I0.8350.98
11_R15_R0.8320.98
141_A144_L0.8300.98
99_W119_A0.8230.98
58_A61_V0.8200.98
23_S26_V0.8070.97
32_S37_V0.7980.97
130_L134_E0.7950.97
115_I127_G0.7940.97
24_V28_A0.7940.97
99_W121_A0.7690.97
23_S27_A0.7650.96
11_R63_Y0.7640.96
93_W122_Q0.7640.96
109_E136_A0.7580.96
22_M52_V0.7550.96
72_L126_V0.7520.96
5_A141_A0.7510.96
55_I58_A0.7470.96
22_M26_V0.7440.96
134_E137_S0.7420.96
59_F62_N0.7370.96
107_H111_G0.7360.96
75_T97_P0.7280.95
56_Y63_Y0.7220.95
60_R63_Y0.7160.95
36_F41_A0.7140.95
15_R63_Y0.7110.95
21_L55_I0.7060.94
15_R18_F0.7040.94
115_I138_F0.7020.94
25_L52_V0.7010.94
17_G22_M0.6960.94
45_F48_F0.6900.94
53_V57_W0.6810.93
138_F149_A0.6800.93
74_L97_P0.6750.93
25_L28_A0.6750.93
5_A138_F0.6700.93
95_F124_V0.6690.93
59_F63_Y0.6660.93
36_F40_G0.6630.92
107_H113_E0.6610.92
102_L143_R0.6600.92
47_F51_D0.6600.92
74_L146_L0.6590.92
7_L127_G0.6550.92
8_T69_F0.6520.92
5_A8_T0.6490.92
83_R128_K0.6490.92
41_A44_V0.6480.92
68_A85_S0.6470.91
106_E136_A0.6450.91
145_A149_A0.6440.91
81_L126_V0.6430.91
107_H132_P0.6340.91
95_F119_A0.6300.90
68_A128_K0.6220.90
44_V51_D0.6220.90
40_G44_V0.6210.90
36_F43_P0.6200.90
33_G46_G0.6130.89
137_S140_K0.6060.89
16_T23_S0.6010.88
34_I40_G0.6000.88
79_L100_V0.6000.88
5_A11_R0.5930.88
83_R86_H0.5900.87
43_P49_V0.5890.87
85_S88_G0.5890.87
76_P149_A0.5840.87
18_F55_I0.5780.86
22_M29_S0.5770.86
31_I35_L0.5750.86
22_M60_R0.5750.86
83_R129_F0.5650.85
18_F59_F0.5650.85
114_G128_K0.5640.85
6_E38_R0.5620.85
34_I45_F0.5590.84
106_E113_E0.5560.84
34_I37_V0.5550.84
52_V56_Y0.5450.83
96_N119_A0.5430.83
78_E96_N0.5410.82
131_S136_A0.5390.82
18_F56_Y0.5390.82
67_R88_G0.5390.82
111_G132_P0.5380.82
40_G51_D0.5360.82
11_R18_F0.5340.82
113_E135_K0.5320.81
115_I118_S0.5300.81
108_H111_G0.5300.81
14_S19_I0.5250.80
44_V100_V0.5120.79
74_L149_A0.5100.79
127_G138_F0.5090.78
100_V127_G0.5090.78
10_H62_N0.5060.78
31_I87_R0.5010.77
27_A31_I0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uzxA 1 0.1656 24.3 0.926 Contact Map
3edyA 1 0.4503 14.7 0.933 Contact Map
4wd8A 3 0.8278 8.7 0.94 Contact Map
3d9sA 3 0.4437 6 0.944 Contact Map
2b6oA 6 0.4172 5.5 0.945 Contact Map
4rdqA 5 0.9735 4.6 0.947 Contact Map
2a26A 4 0.1589 4.6 0.947 Contact Map
4ldeA 1 0.5033 4.5 0.947 Contact Map
2l2lA 1 0.1457 4.5 0.947 Contact Map
4hhuA 1 0.7086 4.5 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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