GREMLIN Database
PF14112 - Uncharacterized protein
UniProt: B2TKH6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 129 (124)
Sequences: 795 (643)
Seq/√Len: 57.7
META: 0.448

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_F42_N6.6731.00
54_E73_S3.3891.00
8_S124_C3.3071.00
78_I101_Y3.0191.00
98_V119_I2.8161.00
26_I50_I2.5561.00
29_T33_D2.4211.00
32_G35_I2.2821.00
9_L82_F2.2821.00
87_N90_L2.2811.00
20_F96_S2.2071.00
56_D72_F2.0861.00
121_F124_C1.9091.00
43_F105_Y1.8981.00
6_I126_S1.8951.00
16_D19_K1.8431.00
82_F125_V1.7960.99
105_Y121_F1.7850.99
20_F24_M1.7110.99
40_K50_I1.6480.99
3_K104_H1.5820.98
54_E74_S1.5620.98
24_M55_I1.5320.98
49_D52_F1.5040.98
64_D67_E1.4900.98
8_S121_F1.4780.98
36_L40_K1.4650.97
26_I47_H1.4640.97
40_K47_H1.4320.97
69_L82_F1.4290.97
42_N68_L1.4010.97
85_K125_V1.3970.97
11_L94_Y1.3870.96
8_S43_F1.3750.96
8_S105_Y1.3500.96
86_Y94_Y1.3340.96
7_V99_L1.2710.94
66_Q80_P1.2550.94
81_K84_E1.2540.94
78_I82_F1.2230.93
7_V101_Y1.2160.93
8_S103_F1.2000.92
29_T34_S1.1970.92
37_S40_K1.1940.92
15_T19_K1.1930.92
12_G39_F1.1760.92
71_G75_D1.1550.91
91_N94_Y1.1400.90
72_F99_L1.1330.90
12_G20_F1.1330.90
74_S127_Y1.1300.90
94_Y120_D1.1120.89
86_Y91_N1.1010.89
12_G95_N1.0980.88
73_S101_Y1.0930.88
75_D78_I1.0890.88
47_H51_D1.0610.87
105_Y108_I1.0170.84
81_K85_K1.0150.84
43_F103_F1.0140.84
47_H50_I1.0110.84
12_G16_D1.0060.84
16_D57_W0.9870.82
86_Y90_L0.9670.81
30_D33_D0.9440.80
35_I69_L0.9430.79
5_N8_S0.9370.79
79_I83_N0.9370.79
107_G114_Y0.9290.78
60_E80_P0.9270.78
5_N102_D0.9030.76
40_K48_Y0.9000.76
9_L75_D0.8990.76
122_I125_V0.8950.76
16_D85_K0.8930.76
28_Y49_D0.8800.75
12_G119_I0.8700.74
57_W96_S0.8640.73
17_A21_E0.8550.72
114_Y117_N0.8360.71
29_T32_G0.8360.71
11_L40_K0.8350.71
108_I111_H0.8320.70
77_D125_V0.8320.70
58_I97_I0.8320.70
57_W95_N0.8210.69
100_L103_F0.8210.69
53_S100_L0.8140.69
54_E99_L0.8100.68
21_E79_I0.8080.68
5_N9_L0.8060.68
68_L71_G0.7960.67
11_L122_I0.7920.67
16_D20_F0.7890.66
69_L97_I0.7880.66
66_Q83_N0.7670.64
6_I104_H0.7580.63
45_I105_Y0.7580.63
42_N117_N0.7560.63
9_L78_I0.7530.63
14_F20_F0.7520.62
37_S95_N0.7370.61
9_L99_L0.7320.60
31_D51_D0.7310.60
106_D112_I0.7280.60
48_Y69_L0.7210.59
11_L21_E0.7170.59
14_F57_W0.7140.58
14_F119_I0.7060.58
74_S101_Y0.7000.57
28_Y33_D0.6890.56
28_Y73_S0.6830.55
24_M80_P0.6800.55
90_L94_Y0.6770.54
111_H118_E0.6750.54
107_G110_N0.6730.54
27_K127_Y0.6630.53
28_Y31_D0.6630.53
7_V78_I0.6610.53
31_D39_F0.6600.53
48_Y72_F0.6550.52
39_F67_E0.6540.52
7_V21_E0.6460.51
36_L68_L0.6430.51
22_E108_I0.6390.50
5_N84_E0.6390.50
9_L125_V0.6360.50
19_K65_F0.6340.50
54_E78_I0.6330.50
38_Q92_K0.6270.49
50_I53_S0.6230.49
12_G19_K0.6200.48
77_D89_K0.6130.47
12_G98_V0.6120.47
78_I125_V0.6110.47
19_K46_Q0.6110.47
43_F121_F0.6070.47
36_L47_H0.5990.46
9_L56_D0.5980.46
65_F87_N0.5920.45
25_E34_S0.5890.45
54_E127_Y0.5860.44
44_R112_I0.5840.44
36_L50_I0.5820.44
108_I121_F0.5760.43
4_E18_K0.5760.43
28_Y51_D0.5750.43
83_N94_Y0.5730.43
76_Y122_I0.5730.43
68_L97_I0.5680.43
12_G58_I0.5550.41
66_Q120_D0.5510.41
17_A25_E0.5510.41
45_I103_F0.5510.41
25_E60_E0.5490.41
34_S46_Q0.5480.40
61_G84_E0.5470.40
54_E57_W0.5450.40
15_T67_E0.5420.40
62_L87_N0.5420.40
77_D81_K0.5370.39
42_N114_Y0.5370.39
9_L101_Y0.5350.39
111_H116_G0.5300.39
54_E101_Y0.5280.38
18_K21_E0.5280.38
31_D34_S0.5270.38
34_S67_E0.5260.38
46_Q124_C0.5220.38
47_H72_F0.5190.37
18_K25_E0.5190.37
58_I72_F0.5170.37
107_G111_H0.5170.37
20_F95_N0.5150.37
54_E75_D0.5140.37
83_N86_Y0.5140.37
54_E72_F0.5120.37
78_I86_Y0.5100.36
3_K6_I0.5090.36
29_T35_I0.5070.36
109_C112_I0.5060.36
17_A31_D0.5050.36
17_A57_W0.5050.36
63_K67_E0.5030.36
20_F57_W0.5030.36
17_A24_M0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1na6A 2 0.9535 21.2 0.917 Contact Map
4y66A 1 0.3566 7.7 0.932 Contact Map
1el6A 3 0.6744 7.5 0.932 Contact Map
1j2mA 1 0.5736 5.8 0.936 Contact Map
2fkiA 1 0.3566 4.5 0.939 Contact Map
4fo0A 2 0.3411 3 0.944 Contact Map
2a1vA 1 0.4264 2.9 0.945 Contact Map
2cp0A 1 0.3333 2.9 0.945 Contact Map
1gccA 1 0.3333 2.3 0.947 Contact Map
4u6uA 1 0.4186 2 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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