GREMLIN Database
PF16277 - Uncharacterized protein
UniProt: B2IUZ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 72 (59)
Sequences: 3681 (2449)
Seq/√Len: 318.8
META: 0.91

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_E56_Q4.0071.00
3_L28_E2.6761.00
53_N56_Q2.2881.00
12_D20_R2.1901.00
30_Y36_E2.1841.00
9_L18_L2.1771.00
41_D45_K2.0461.00
12_D19_H2.0061.00
6_V25_T1.9531.00
19_H22_Q1.8451.00
4_L28_E1.7451.00
36_E51_T1.7401.00
8_A58_M1.7271.00
35_F54_A1.6801.00
16_S50_E1.6641.00
8_A23_V1.6481.00
2_K5_D1.3931.00
30_Y49_I1.3271.00
24_G39_F1.3111.00
13_L56_Q1.3001.00
8_A60_L1.2931.00
25_T40_S1.2861.00
46_A49_I1.2861.00
52_L56_Q1.1941.00
22_Q47_Y1.1811.00
10_T20_R1.1781.00
31_E34_V1.1391.00
5_D59_T1.1201.00
10_T58_M1.0521.00
37_V57_L1.0421.00
33_G54_A0.9161.00
24_G37_V0.8951.00
18_L48_A0.8141.00
9_L39_F0.7991.00
6_V40_S0.7801.00
34_V51_T0.7660.99
26_I35_F0.7600.99
36_E50_E0.7510.99
41_D47_Y0.7480.99
40_S47_Y0.7420.99
4_L27_V0.7330.99
13_L52_L0.7270.99
4_L30_Y0.7230.99
34_V53_N0.7190.99
13_L18_L0.7150.99
23_V60_L0.7140.99
30_Y51_T0.7130.99
11_E15_E0.7080.99
29_A32_P0.7030.99
27_V38_E0.7010.99
26_I44_G0.6990.99
8_A30_Y0.6990.99
40_S46_A0.6960.99
25_T48_A0.6950.99
40_S48_A0.6900.99
29_A33_G0.6840.99
26_I29_A0.6830.99
13_L16_S0.6780.99
3_L29_A0.6610.98
34_V54_A0.6550.98
11_E55_S0.6520.98
30_Y34_V0.6310.98
23_V47_Y0.6130.98
7_V57_L0.5980.97
27_V46_A0.5840.97
4_L25_T0.5780.97
16_S51_T0.5720.96
42_L47_Y0.5720.96
3_L27_V0.5700.96
16_S48_A0.5650.96
22_Q60_L0.5570.96
32_P54_A0.5520.95
10_T13_L0.5450.95
18_L39_F0.5450.95
5_D35_F0.5400.95
23_V58_M0.5330.95
54_A57_L0.5290.94
6_V60_L0.5250.94
46_A52_L0.5220.94
44_G48_A0.5160.94
7_V37_V0.5130.93
38_E49_I0.5120.93
23_V42_L0.5120.93
17_G31_E0.5100.93
26_I30_Y0.5060.93
28_E36_E0.5040.93
8_A22_Q0.5020.93
40_S49_I0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y35A 1 0.6944 65.2 0.826 Contact Map
1w36D 1 0.2778 58.9 0.833 Contact Map
4tseA 2 0.875 34.1 0.856 Contact Map
4l0jA 2 0.9306 33.2 0.857 Contact Map
3e1sA 1 0.9028 27.8 0.863 Contact Map
3pieA 1 0.8472 23.6 0.867 Contact Map
4fibA 1 0.8194 20 0.872 Contact Map
4xi6A 2 0.75 19 0.873 Contact Map
1dj7B 1 0.7639 17.1 0.875 Contact Map
2ldmA 1 0.8611 14.1 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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