GREMLIN Database
PF03981 - Ubiquinol-cytochrome C chaperone
UniProt: A7INK9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 176 (169)
Sequences: 1994 (1462)
Seq/√Len: 112.4
META: 0.802

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_A175_P4.2261.00
71_Q75_D3.5131.00
50_L152_V3.4311.00
108_G132_N3.0931.00
166_V171_V2.8021.00
100_K104_E2.5991.00
122_D150_A2.5391.00
133_I148_L2.5161.00
62_G164_Y2.4861.00
52_T77_F2.4661.00
91_G94_T2.4531.00
122_D153_R2.3951.00
57_H114_D2.3511.00
99_M102_I2.2891.00
51_H151_Y2.2531.00
60_K114_D2.2231.00
163_P166_V2.1771.00
19_Y80_D2.1311.00
57_H156_A2.1121.00
94_T98_K2.0361.00
22_I55_V2.0041.00
42_E102_I1.9651.00
156_A160_H1.9461.00
45_F49_V1.9161.00
129_V152_V1.9001.00
53_V110_A1.8391.00
98_K101_K1.8141.00
22_I52_T1.8011.00
12_R16_E1.7171.00
55_V73_I1.6951.00
60_K110_A1.6831.00
108_G131_R1.6781.00
37_V47_M1.6711.00
53_V114_D1.6491.00
113_Y128_A1.6421.00
126_I146_A1.6091.00
116_A124_A1.6011.00
22_I73_I1.5931.00
46_E109_R1.4621.00
54_L156_A1.4441.00
31_F47_M1.4411.00
40_T43_G1.4411.00
20_G24_A1.3951.00
71_Q74_F1.3871.00
126_I149_A1.3601.00
96_P99_M1.3471.00
25_Q28_R1.3471.00
53_V57_H1.3181.00
16_E76_A1.3171.00
77_F80_D1.3111.00
94_T97_K1.3091.00
155_A158_K1.2990.99
112_A132_N1.2730.99
15_I69_M1.2610.99
129_V148_L1.2460.99
75_D78_A1.2380.99
63_D66_E1.2380.99
77_F81_M1.2250.99
31_F151_Y1.2140.99
56_C106_F1.1960.99
120_P153_R1.1770.99
90_I98_K1.1690.99
25_Q31_F1.1590.99
109_R113_Y1.1460.99
46_E135_S1.1350.99
86_R92_D1.1320.99
15_I76_A1.1310.99
78_A106_F1.0890.98
42_E105_A1.0790.98
30_D35_F1.0770.98
108_G112_A1.0710.98
80_D84_A1.0640.98
61_G160_H1.0620.98
36_G144_E1.0430.98
58_R62_G1.0370.97
15_I22_I1.0360.97
32_Y47_M1.0350.97
154_A158_K1.0340.97
25_Q51_H1.0260.97
115_A119_E1.0220.97
56_C107_Y1.0150.97
81_M102_I1.0140.97
111_A115_A1.0020.97
42_E135_S0.9970.97
52_T78_A0.9960.97
129_V133_I0.9900.97
81_M84_A0.9850.96
54_L159_L0.9770.96
157_A161_A0.9630.96
48_V84_A0.9490.96
46_E102_I0.9430.95
151_Y155_A0.9390.95
119_E124_A0.9320.95
164_Y168_A0.9320.95
74_F107_Y0.9320.95
110_A114_D0.9250.95
103_G107_Y0.9230.95
51_H155_A0.9210.95
19_Y77_F0.9120.95
23_V27_R0.9090.94
31_F37_V0.9070.94
126_I145_A0.8970.94
18_L55_V0.8970.94
71_Q78_A0.8880.94
66_E69_M0.8840.94
41_L88_I0.8830.94
117_L156_A0.8750.93
140_E144_E0.8730.93
30_D33_T0.8680.93
16_E20_G0.8650.93
61_G156_A0.8590.93
39_D44_R0.8580.93
64_T67_R0.8550.92
25_Q74_F0.8380.92
39_D86_R0.8230.91
77_F96_P0.8230.91
90_I96_P0.8220.91
21_A24_A0.8160.91
56_C73_I0.8140.91
11_S14_T0.8080.90
117_L153_R0.8060.90
165_E169_R0.8030.90
54_L58_R0.8010.90
166_V169_R0.7980.90
25_Q151_Y0.7980.90
150_A153_R0.7910.89
114_D118_A0.7820.89
37_V43_G0.7670.88
27_R44_R0.7600.87
142_S145_A0.7570.87
105_A109_R0.7520.87
130_S145_A0.7510.87
145_A149_A0.7460.86
162_T166_V0.7400.86
46_E81_M0.7390.86
44_R92_D0.7370.86
70_S78_A0.7370.86
42_E98_K0.7340.85
57_H118_A0.7320.85
115_A120_P0.7190.84
52_T56_C0.7150.84
98_K102_I0.7110.84
113_Y129_V0.7100.83
50_L129_V0.7090.83
90_I94_T0.7070.83
27_R39_D0.7070.83
78_A132_N0.7060.83
74_F106_F0.7060.83
35_F134_L0.7030.83
78_A99_M0.7030.83
18_L69_M0.7030.83
154_A157_A0.7020.83
72_D75_D0.7000.83
78_A100_K0.6930.82
18_L172_L0.6880.81
79_A83_A0.6860.81
139_A144_E0.6860.81
62_G163_P0.6780.81
26_S29_P0.6740.80
30_D34_D0.6730.80
48_V80_D0.6720.80
106_F110_A0.6710.80
19_Y23_V0.6710.80
62_G66_E0.6710.80
71_Q107_Y0.6630.79
82_D93_L0.6600.79
65_P68_S0.6570.78
62_G65_P0.6560.78
42_E94_T0.6510.78
27_R32_Y0.6470.77
162_T172_L0.6470.77
47_M134_L0.6440.77
10_M13_A0.6370.76
88_I102_I0.6310.76
59_L66_E0.6300.76
150_A154_A0.6280.75
55_V59_L0.6280.75
78_A102_I0.6260.75
56_C110_A0.6220.75
34_D147_A0.6200.74
15_I20_G0.6190.74
48_V81_M0.6150.74
126_I152_V0.6140.74
4_S9_A0.6120.73
13_A17_R0.6080.73
153_R156_A0.6030.72
113_Y125_L0.6020.72
113_Y116_A0.6010.72
14_T69_M0.6010.72
125_L153_R0.5980.72
45_F81_M0.5980.72
39_D89_G0.5960.71
44_R86_R0.5950.71
44_R109_R0.5950.71
19_Y82_D0.5860.70
59_L70_S0.5850.70
39_D43_G0.5850.70
99_M103_G0.5820.70
45_F102_I0.5800.69
65_P165_E0.5790.69
74_F77_F0.5780.69
89_G92_D0.5770.69
128_A132_N0.5750.69
88_I104_E0.5720.68
116_A128_A0.5710.68
116_A153_R0.5710.68
46_E108_G0.5710.68
31_F51_H0.5710.68
162_T173_E0.5700.68
121_D153_R0.5620.67
125_L152_V0.5580.66
48_V83_A0.5550.66
55_V172_L0.5550.66
47_M133_I0.5540.66
130_S137_G0.5540.66
56_C74_F0.5540.66
78_A103_G0.5530.66
27_R92_D0.5520.66
45_F105_A0.5520.66
27_R87_E0.5500.65
55_V126_I0.5440.65
80_D133_I0.5430.64
144_E147_A0.5420.64
41_L45_F0.5380.64
100_K103_G0.5370.64
25_Q29_P0.5360.63
39_D92_D0.5360.63
90_I93_L0.5340.63
158_K173_E0.5330.63
108_G128_A0.5300.63
168_A171_V0.5300.63
53_V60_K0.5280.62
115_A124_A0.5270.62
36_G134_L0.5270.62
116_A152_V0.5260.62
46_E132_N0.5200.61
97_K110_A0.5190.61
41_L84_A0.5190.61
44_R87_E0.5190.61
51_H107_Y0.5180.61
82_D105_A0.5170.61
38_P56_C0.5160.60
41_L102_I0.5140.60
35_F147_A0.5130.60
150_A169_R0.5110.60
126_I130_S0.5100.60
158_K161_A0.5090.59
87_E92_D0.5080.59
153_R157_A0.5070.59
17_R21_A0.5060.59
11_S15_I0.5030.59
80_D83_A0.5020.58
70_S98_K0.5020.58
88_I91_G0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dlyA 1 0.5852 8.1 0.953 Contact Map
2ekfA 1 0.25 7.1 0.954 Contact Map
1nktA 3 0.3523 6.8 0.954 Contact Map
1s69A 1 0.5795 6.7 0.954 Contact Map
4xdiA 1 0.5909 6.6 0.955 Contact Map
2kscA 1 0.5795 6.2 0.955 Contact Map
3aq9A 1 0.5398 6.2 0.955 Contact Map
2ig3A 2 0.5568 5.2 0.957 Contact Map
4ackA 1 0.358 4.3 0.959 Contact Map
4nk2A 2 0.6705 4.2 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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