GREMLIN Database
PF14081 - Uncharacterized protein
UniProt: A4YVY8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 147 (143)
Sequences: 1229 (1027)
Seq/√Len: 85.9
META: 0.845

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_T59_F5.0351.00
37_C114_E3.7131.00
101_L115_C3.5251.00
10_K17_F2.9861.00
42_H66_L2.7431.00
62_L118_L2.7041.00
31_T55_A2.5911.00
20_H31_T2.5221.00
65_E70_R2.3721.00
16_W63_Y2.3181.00
60_W63_Y2.3101.00
133_A137_F2.2701.00
19_I34_T2.2481.00
21_V32_Y2.1841.00
6_R10_K2.1671.00
119_I129_W2.0141.00
45_L118_L1.9851.00
34_T104_S1.8961.00
46_I101_L1.8601.00
18_A56_L1.8461.00
122_D126_C1.7921.00
8_V106_W1.7841.00
9_A13_E1.7301.00
11_I107_F1.7251.00
79_S86_P1.7081.00
18_A60_W1.6961.00
103_W106_W1.6821.00
122_D133_A1.6201.00
89_L118_L1.6041.00
18_A31_T1.5281.00
24_D27_G1.5071.00
30_F96_H1.5041.00
105_R113_F1.5041.00
126_C132_V1.4810.99
4_E106_W1.4530.99
44_E115_C1.3540.99
82_F87_A1.3420.99
33_T36_F1.3400.99
36_F63_Y1.3120.99
7_F17_F1.3100.99
38_L107_F1.3020.99
88_M129_W1.2930.98
77_P86_P1.2790.98
96_H100_H1.2710.98
10_K14_H1.2550.98
73_P76_A1.2540.98
37_C41_D1.2340.98
78_S89_L1.2170.98
20_H52_M1.2040.98
20_H56_L1.2010.98
10_K19_I1.1980.98
40_F67_D1.1820.97
16_W60_W1.1800.97
135_A138_R1.1700.97
20_H55_A1.1660.97
72_I76_A1.1500.97
90_L145_T1.1480.97
77_P88_M1.1310.96
47_V58_T1.1210.96
7_F34_T1.1000.96
18_A63_Y1.0980.96
7_F10_K1.0680.95
102_G105_R1.0610.95
85_A121_T1.0470.95
89_L113_F1.0360.94
97_Y102_G1.0340.94
45_L116_L1.0200.94
36_F45_L1.0190.94
8_V12_R0.9860.93
120_Y133_A0.9820.92
72_I89_L0.9810.92
127_F130_S0.9650.92
7_F19_I0.9620.92
50_L54_I0.9610.92
62_L81_I0.9580.92
24_D29_S0.9570.91
86_P125_G0.9510.91
75_G90_L0.9500.91
69_G72_I0.9430.91
23_A29_S0.9370.91
61_H64_R0.9280.90
34_T103_W0.9130.89
36_F42_H0.9060.89
52_M55_A0.8990.89
74_V91_P0.8890.88
122_D134_S0.8830.88
56_L60_W0.8810.88
82_F85_A0.8630.87
6_R17_F0.8620.87
88_M127_F0.8570.86
74_V90_L0.8510.86
5_Q9_A0.8490.86
14_H60_W0.8470.86
62_L65_E0.8450.85
90_L119_I0.8280.84
30_F99_D0.8260.84
93_S96_H0.8220.84
44_E104_S0.8190.84
45_L62_L0.8020.82
88_M92_V0.7940.82
37_C87_A0.7870.81
50_L55_A0.7760.80
7_F103_W0.7710.80
36_F62_L0.7650.79
82_F121_T0.7610.79
97_Y101_L0.7590.79
48_F120_Y0.7530.78
30_F100_H0.7470.78
50_L121_T0.7430.77
92_V101_L0.7410.77
57_D61_H0.7220.75
46_I92_V0.7190.75
37_C107_F0.7150.74
58_T99_D0.7120.74
40_F63_Y0.7110.74
6_R12_R0.7110.74
90_L143_D0.7090.74
29_S114_E0.7080.74
124_D134_S0.7080.74
67_D94_R0.7060.74
96_H99_D0.7040.73
98_A105_R0.7010.73
37_C108_Y0.6930.72
136_Q140_A0.6870.72
92_V144_L0.6850.71
126_C130_S0.6770.70
104_S108_Y0.6750.70
50_L120_Y0.6750.70
32_Y97_Y0.6710.70
46_I115_C0.6700.70
55_A85_A0.6680.69
133_A138_R0.6680.69
91_P114_E0.6680.69
91_P116_L0.6630.69
15_G67_D0.6580.68
97_Y113_F0.6570.68
54_I85_A0.6560.68
100_H144_L0.6540.68
54_I58_T0.6510.67
105_R111_D0.6500.67
36_F40_F0.6490.67
39_K67_D0.6440.67
100_H119_I0.6420.66
102_G106_W0.6410.66
119_I128_P0.6410.66
37_C42_H0.6390.66
4_E32_Y0.6390.66
48_F142_P0.6370.66
4_E24_D0.6370.66
32_Y52_M0.6310.65
85_A125_G0.6300.65
119_I143_D0.6280.65
8_V107_F0.6260.64
66_L69_G0.6250.64
78_S81_I0.6250.64
17_F34_T0.6240.64
61_H65_E0.6200.64
123_R126_C0.6200.64
104_S113_F0.6150.63
122_D132_V0.6140.63
47_V50_L0.6120.63
67_D87_A0.6120.63
94_R112_R0.6050.62
50_L123_R0.6020.61
33_T60_W0.5970.61
93_S125_G0.5950.61
98_A112_R0.5940.60
117_Q125_G0.5920.60
81_I100_H0.5910.60
77_P121_T0.5900.60
4_E8_V0.5900.60
29_S136_Q0.5830.59
44_E92_V0.5810.59
49_S60_W0.5810.59
46_I100_H0.5730.58
41_D51_P0.5720.58
7_F107_F0.5710.57
40_F66_L0.5710.57
58_T61_H0.5700.57
97_Y100_H0.5680.57
20_H51_P0.5680.57
48_F100_H0.5660.57
38_L41_D0.5650.57
30_F60_W0.5610.56
85_A123_R0.5590.56
11_I108_Y0.5590.56
76_A91_P0.5570.56
16_W56_L0.5520.55
11_I39_K0.5520.55
64_R68_A0.5470.54
106_W134_S0.5460.54
58_T63_Y0.5460.54
93_S145_T0.5430.54
31_T52_M0.5430.54
19_I125_G0.5420.54
47_V62_L0.5380.53
47_V63_Y0.5290.52
84_N134_S0.5260.51
7_F104_S0.5260.51
42_H46_I0.5230.51
79_S82_F0.5190.50
104_S115_C0.5180.50
75_G91_P0.5150.50
83_M86_P0.5150.50
95_R100_H0.5140.50
16_W36_F0.5110.49
54_I57_D0.5070.49
17_F49_S0.5070.49
32_Y103_W0.5060.49
45_L63_Y0.5030.48
36_F115_C0.5030.48
4_E7_F0.5020.48
102_G113_F0.5020.48
123_R134_S0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hcnA 2 0.9864 14.7 0.942 Contact Map
1lbqA 2 0.9796 13.3 0.944 Contact Map
3b2yA 1 0.7823 10.3 0.946 Contact Map
2plnA 2 0.6599 9.5 0.947 Contact Map
2boaA 1 0.9524 9.3 0.947 Contact Map
3fo3A 4 0.4218 9 0.948 Contact Map
3jwhA 1 0.2993 8.8 0.948 Contact Map
3l2fA 6 0.5034 8.2 0.949 Contact Map
3jpzA 2 0.517 8 0.949 Contact Map
2ls5A 1 0.5646 7.1 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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