GREMLIN Database
PF12502 - (20-220) Uncharacterized protein
UniProt: A0JVG1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 201 (175)
Sequences: 2099 (1314)
Seq/√Len: 99.3
META: 0.477

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_L168_I4.5691.00
145_G165_F4.4551.00
134_I147_L3.9311.00
70_L145_G3.4361.00
52_E55_T2.9831.00
95_V100_G2.9251.00
136_V165_F2.6791.00
36_A183_L2.6441.00
68_S151_A2.5651.00
147_L161_L2.5511.00
70_L165_F2.4961.00
82_G137_D2.3441.00
75_F144_R2.2991.00
88_R104_E2.2931.00
173_G177_M2.2161.00
36_A74_A2.1891.00
92_G113_L2.1731.00
52_E57_R2.1231.00
15_K24_E2.0531.00
106_P111_T1.9721.00
136_V145_G1.9341.00
112_E132_R1.9271.00
105_I114_V1.9261.00
22_V171_V1.9231.00
38_L171_V1.9171.00
63_M164_L1.9071.00
133_F146_V1.8041.00
143_L168_I1.7761.00
67_G150_E1.7581.00
74_A183_L1.6961.00
150_E154_D1.6751.00
34_L61_V1.6701.00
109_F162_E1.6331.00
108_V166_R1.6321.00
84_W135_G1.5941.00
89_E104_E1.5441.00
116_K128_Y1.5231.00
120_G126_G1.5161.00
93_Q97_S1.5101.00
90_Q180_R1.5021.00
73_Q146_V1.4891.00
50_E60_A1.4171.00
103_E114_V1.3941.00
50_E62_T1.3850.99
25_I38_L1.3660.99
20_F167_Q1.3550.99
16_A24_E1.3280.99
70_L147_L1.3140.99
92_G96_G1.2840.99
143_L165_F1.2770.99
155_R162_E1.2730.99
71_Q133_F1.2700.99
177_M183_L1.2690.99
46_Q64_D1.2510.99
95_V115_A1.2420.99
37_L72_L1.2370.99
101_Q116_K1.2250.99
85_D111_T1.2080.99
98_Q142_F1.2060.99
42_R45_L1.2040.99
115_A131_A1.2030.99
93_Q96_G1.1820.98
189_K193_P1.1770.98
65_L160_N1.1660.98
58_V98_Q1.1500.98
96_G101_Q1.1500.98
69_S148_G1.1250.98
108_V162_E1.1170.98
136_V166_R1.1130.98
107_G112_E1.1130.98
28_T38_L1.1090.97
42_R167_Q1.0800.97
96_G102_V1.0790.97
115_A133_F1.0760.97
22_V25_I1.0600.97
45_L63_M1.0590.97
20_F26_D1.0580.97
79_R140_R1.0440.96
64_D69_S1.0430.96
158_A162_E1.0260.96
21_D139_P1.0200.96
119_A127_G1.0150.96
82_G85_D1.0150.96
120_G124_G1.0090.96
87_I180_R1.0000.95
31_Y38_L0.9980.95
104_E111_T0.9960.95
47_L61_V0.9810.95
134_I165_F0.9810.95
148_G176_P0.9800.95
119_A129_R0.9780.95
71_Q131_A0.9610.94
50_E71_Q0.9560.94
147_L165_F0.9530.94
81_E137_D0.9520.94
85_D88_R0.9500.94
85_D104_E0.9460.94
179_P182_L0.9360.93
34_L49_L0.9350.93
186_R189_K0.9320.93
163_S167_Q0.9210.93
159_A163_S0.9200.93
104_E113_L0.9100.92
119_A124_G0.9070.92
162_E166_R0.8900.92
143_L170_V0.8830.91
142_F146_V0.8820.91
39_I168_I0.8620.90
78_P82_G0.8570.90
71_Q115_A0.8530.90
72_L143_L0.8480.90
50_E69_S0.8480.90
147_L158_A0.8480.90
177_M184_Q0.8390.89
42_R160_N0.8320.89
133_F144_R0.8270.88
92_G104_E0.8210.88
154_D157_A0.8180.88
86_E89_E0.8110.87
78_P83_L0.8100.87
139_P166_R0.8100.87
15_K23_S0.8010.87
17_T20_F0.7880.86
94_S98_Q0.7880.86
62_T72_L0.7870.86
78_P140_R0.7820.85
178_P183_L0.7790.85
89_E93_Q0.7740.85
155_R159_A0.7690.84
150_E153_L0.7630.84
95_V133_F0.7560.83
168_I181_D0.7550.83
18_G21_D0.7550.83
20_F25_I0.7550.83
25_I29_D0.7540.83
131_A148_G0.7510.83
37_L170_V0.7470.83
49_L120_G0.7470.83
53_E56_Q0.7430.82
62_T71_Q0.7370.82
36_A177_M0.7370.82
85_D89_E0.7350.82
27_G31_Y0.7350.82
93_Q153_L0.7270.81
109_F136_V0.7250.81
45_L65_L0.7140.80
31_Y169_V0.7120.80
56_Q129_R0.7080.79
93_Q101_Q0.7070.79
105_I155_R0.7050.79
94_S97_S0.7040.79
88_R111_T0.7020.79
118_P128_Y0.6980.78
30_G41_P0.6970.78
60_A71_Q0.6960.78
51_I58_V0.6940.78
73_Q95_V0.6900.77
26_D29_D0.6900.77
49_L62_T0.6880.77
114_V130_V0.6870.77
100_G118_P0.6850.77
147_L162_E0.6810.76
50_E59_V0.6810.76
15_K20_F0.6800.76
62_T69_S0.6780.76
134_I145_G0.6710.75
45_L50_E0.6680.75
31_Y40_A0.6660.75
62_T148_G0.6650.75
94_S146_V0.6570.74
49_L53_E0.6550.74
103_E128_Y0.6500.73
36_A178_P0.6480.73
17_T166_R0.6380.72
87_I142_F0.6380.72
22_V38_L0.6360.71
117_L153_L0.6320.71
172_R176_P0.6310.71
98_Q118_P0.6300.71
52_E146_V0.6270.70
145_G185_L0.6260.70
39_I64_D0.6260.70
176_P182_L0.6200.70
31_Y78_P0.6200.70
26_D38_L0.6160.69
17_T24_E0.6140.69
148_G180_R0.6130.69
190_D193_P0.6120.69
49_L81_E0.6060.68
80_T140_R0.6060.68
116_K127_G0.6030.67
76_A140_R0.6020.67
46_Q187_L0.6010.67
61_V74_A0.5990.67
92_G102_V0.5940.66
58_V144_R0.5940.66
137_D142_F0.5900.66
150_E183_L0.5900.66
46_Q51_I0.5890.66
139_P143_L0.5880.65
128_Y131_A0.5830.65
52_E73_Q0.5820.65
89_E92_G0.5820.65
135_G142_F0.5810.65
136_V179_P0.5790.64
71_Q75_F0.5680.63
142_F148_G0.5660.63
83_L142_F0.5650.62
154_D159_A0.5640.62
65_L68_S0.5620.62
36_A184_Q0.5600.62
48_R64_D0.5580.61
53_E58_V0.5580.61
124_G127_G0.5580.61
102_V111_T0.5540.61
133_F137_D0.5540.61
60_A176_P0.5530.61
140_R172_R0.5530.61
146_V176_P0.5520.61
83_L137_D0.5510.61
78_P136_V0.5500.60
95_V146_V0.5490.60
175_S178_P0.5490.60
105_I111_T0.5440.60
116_K130_V0.5440.60
78_P179_P0.5420.59
71_Q152_A0.5410.59
28_T31_Y0.5390.59
50_E58_V0.5390.59
46_Q67_G0.5380.59
43_E190_D0.5370.59
185_L189_K0.5350.58
156_D159_A0.5320.58
54_A59_V0.5290.57
160_N168_I0.5290.57
150_E157_A0.5270.57
47_L50_E0.5270.57
109_F168_I0.5270.57
49_L187_L0.5270.57
57_R64_D0.5250.57
71_Q146_V0.5230.57
27_G30_G0.5220.56
166_R174_E0.5210.56
70_L86_E0.5180.56
58_V87_I0.5170.56
25_I40_A0.5170.56
57_R61_V0.5150.55
49_L160_N0.5130.55
84_W137_D0.5120.55
103_E187_L0.5120.55
187_L190_D0.5070.54
16_A23_S0.5050.54
60_A74_A0.5040.54
93_Q155_R0.5040.54
100_G142_F0.5030.54
45_L168_I0.5030.54
99_G139_P0.5020.54
75_F147_L0.5010.53
29_D38_L0.5010.53
36_A192_A0.5010.53
32_V58_V0.5000.53
60_A179_P0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nlaA 2 0.1393 5.5 0.967 Contact Map
1irqA 2 0.0995 3.7 0.969 Contact Map
1jrmA 1 0.5124 3.6 0.97 Contact Map
3qoqA 3 0.1095 3.3 0.97 Contact Map
1bazA 4 0.1244 3.2 0.971 Contact Map
3dbhI 1 0.4279 2.7 0.972 Contact Map
2ay0A 2 0.1144 2.4 0.972 Contact Map
3lydA 2 0.7264 2.1 0.973 Contact Map
1ysqA 1 0.5473 1.9 0.974 Contact Map
3r2cJ 1 0.2388 1.9 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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