GREMLIN Database
PAAD - Probable aromatic acid decarboxylase
UniProt: Q9Y8K8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 201 (182)
Sequences: 1844 (1207)
Seq/√Len: 89.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_E155_R3.1621.00
144_A154_A3.0611.00
107_L150_A3.0361.00
148_E152_K2.9151.00
153_L158_V2.8561.00
16_R43_E2.7251.00
32_R179_N2.6211.00
144_A151_L2.5631.00
144_A155_R2.4451.00
20_G119_L2.3721.00
32_R35_Q2.3221.00
47_I85_P2.2941.00
183_G196_Y2.2271.00
187_D198_R2.2261.00
108_A114_I2.1951.00
100_I136_V2.1581.00
21_I30_G2.0261.00
22_S119_L1.9781.00
45_H76_Y1.9611.00
147_L151_L1.9551.00
98_I185_A1.8791.00
104_I137_I1.8781.00
51_S81_I1.8601.00
76_Y84_S1.8421.00
33_T98_I1.7311.00
142_L164_S1.6781.00
130_N154_A1.6721.00
127_I158_V1.6431.00
49_S119_L1.6411.00
174_I177_M1.5731.00
151_L155_R1.5691.00
97_M126_F1.5691.00
175_D179_N1.5191.00
102_C107_L1.5151.00
144_A156_L1.5091.00
93_T192_K1.5081.00
148_E151_L1.4931.00
100_I185_A1.4680.99
94_S126_F1.4670.99
184_K196_Y1.4550.99
109_E114_I1.4460.99
136_V185_A1.4290.99
107_L153_L1.4290.99
153_L160_I1.4030.99
19_I34_V1.4030.99
130_N159_Y1.3990.99
61_G170_L1.3910.99
134_V189_L1.3660.99
27_T56_A1.3620.99
17_I189_L1.3580.99
78_Q117_N1.3460.99
159_Y188_L1.3440.99
50_K79_S1.3240.99
172_K176_D1.3200.99
96_G189_L1.3170.99
30_G100_I1.3040.99
113_G149_N1.3040.99
124_L146_E1.2930.99
108_A149_N1.2140.98
105_K114_I1.2010.98
108_A112_N1.1910.98
33_T100_I1.1870.98
161_M181_I1.1780.98
99_I110_I1.1760.98
50_K78_Q1.1760.98
56_A60_L1.1760.98
45_H90_F1.1740.98
33_T182_V1.1660.97
15_K95_K1.1560.97
145_I149_N1.1540.97
98_I189_L1.1400.97
115_G124_L1.1360.97
109_E116_S1.1300.97
18_I126_F1.1220.97
104_I149_N1.1190.97
136_V181_I1.1110.97
105_K120_S1.1060.96
167_F178_I1.1050.96
29_Y165_P1.0960.96
29_Y163_A1.0920.96
127_I156_L1.0910.96
18_I94_S1.0800.96
110_I123_A1.0770.96
113_G145_I1.0740.96
137_I161_M1.0740.96
93_T190_G1.0720.96
183_G193_H1.0640.96
40_L191_I1.0570.95
145_I156_L1.0530.95
19_I100_I1.0470.95
153_L156_L1.0380.95
132_R188_L1.0320.95
19_I44_I1.0290.95
34_V44_I1.0250.95
136_V163_A1.0160.94
97_M122_T1.0130.94
104_I108_A1.0100.94
33_T185_A0.9880.93
28_I178_I0.9780.93
36_F195_I0.9750.93
127_I143_G0.9730.93
50_K53_E0.9710.93
140_T161_M0.9680.93
18_I85_P0.9650.93
105_K109_E0.9590.92
76_Y80_Q0.9540.92
36_F39_E0.9530.92
154_A158_V0.9470.92
16_R95_K0.9400.92
109_E120_S0.9270.91
166_A180_F0.9240.91
82_E86_S0.9200.91
53_E69_K0.9090.90
31_I56_A0.9040.90
97_M123_A0.9020.90
140_T181_I0.8950.90
32_R175_D0.8910.89
21_I52_A0.8870.89
144_A158_V0.8840.89
116_S120_S0.8810.89
154_A160_I0.8810.89
132_R190_G0.8800.89
104_I146_E0.8780.89
126_F133_L0.8780.89
161_M184_K0.8670.88
57_Q63_N0.8670.88
90_F94_S0.8580.87
171_P176_D0.8570.87
161_M185_A0.8480.87
99_I123_A0.8470.87
107_L149_N0.8470.87
163_A181_I0.8450.87
34_V46_I0.8430.87
136_V161_M0.8420.86
58_K82_E0.8370.86
143_G149_N0.8360.86
55_V105_K0.8340.86
54_K81_I0.8320.86
88_S128_R0.8310.86
152_K156_L0.8290.86
134_V188_L0.8260.85
29_Y181_I0.8250.85
48_I52_A0.8200.85
86_S118_L0.8190.85
38_N73_S0.8180.85
54_K58_K0.8080.84
105_K124_L0.8060.84
46_I72_S0.8040.84
102_C135_L0.7950.83
42_Y95_K0.7930.83
88_S129_T0.7930.83
42_Y191_I0.7920.83
20_G97_M0.7870.82
111_A152_K0.7860.82
147_L153_L0.7830.82
88_S125_N0.7710.81
161_M188_L0.7700.81
21_I27_T0.7700.81
31_I60_L0.7700.81
54_K57_Q0.7690.81
110_I135_L0.7640.81
25_S51_S0.7640.81
149_N153_L0.7580.80
67_E70_K0.7520.80
117_N120_S0.7510.79
97_M133_L0.7510.79
115_G120_S0.7500.79
135_L153_L0.7400.78
152_K155_R0.7380.78
112_N149_N0.7360.78
180_F196_Y0.7330.78
32_R182_V0.7300.78
50_K54_K0.7280.77
122_T126_F0.7280.77
125_N128_R0.7270.77
137_I164_S0.7230.77
93_T131_K0.7120.76
48_I68_L0.7110.76
90_F93_T0.7100.76
99_I135_L0.7070.75
36_F179_N0.7060.75
74_Y84_S0.7040.75
46_I75_I0.6960.74
137_I142_L0.6930.74
17_I42_Y0.6870.73
43_E90_F0.6850.73
184_K188_L0.6800.72
48_I75_I0.6780.72
114_I117_N0.6780.72
43_E74_Y0.6770.72
126_F131_K0.6760.72
125_N129_T0.6750.72
109_E117_N0.6740.72
66_N69_K0.6730.72
144_A153_L0.6720.71
36_F182_V0.6670.71
69_K75_I0.6660.71
163_A180_F0.6650.71
18_I97_M0.6510.69
72_S75_I0.6470.69
15_K41_G0.6460.69
48_I56_A0.6460.69
173_N176_D0.6410.68
54_K82_E0.6410.68
29_Y178_I0.6390.68
98_I134_V0.6370.67
36_F193_H0.6340.67
165_P177_M0.6290.66
18_I47_I0.6270.66
109_E146_E0.6180.65
31_I35_Q0.6150.65
113_G143_G0.6150.65
111_A153_L0.6140.65
137_I147_L0.6130.64
79_S82_E0.6120.64
108_A111_A0.6110.64
27_T30_G0.6010.63
102_C150_A0.6000.63
53_E78_Q0.5950.62
16_R93_T0.5950.62
21_I48_I0.5930.62
62_I68_L0.5930.62
29_Y167_F0.5870.61
105_K115_G0.5860.61
179_N182_V0.5840.61
123_A133_L0.5840.61
17_I96_G0.5780.60
33_T186_L0.5780.60
27_T52_A0.5760.60
96_G131_K0.5760.60
32_R178_I0.5750.60
81_I86_S0.5730.59
165_P184_K0.5730.59
128_R146_E0.5700.59
176_D179_N0.5680.59
22_S103_S0.5660.58
16_R45_H0.5600.58
108_A113_G0.5570.57
90_F96_G0.5520.56
193_H198_R0.5510.56
55_V163_A0.5500.56
124_L143_G0.5500.56
47_I82_E0.5460.56
35_Q62_I0.5440.55
115_G143_G0.5410.55
130_N188_L0.5400.55
164_S181_I0.5390.55
135_L160_I0.5270.53
79_S172_K0.5260.53
18_I122_T0.5250.53
52_A58_K0.5240.53
104_I124_L0.5230.53
45_H74_Y0.5210.52
166_A177_M0.5210.52
102_C106_T0.5210.52
169_I196_Y0.5190.52
48_I51_S0.5170.52
93_T198_R0.5150.51
151_L154_A0.5130.51
86_S94_S0.5110.51
43_E95_K0.5100.51
140_T162_P0.5100.51
99_I106_T0.5100.51
187_D196_Y0.5070.50
16_R90_F0.5050.50
103_S164_S0.5050.50
38_N105_K0.5030.50
171_P174_I0.5030.50
60_L68_L0.5020.50
63_N67_E0.5010.50
29_Y111_A0.5010.50
34_V41_G0.5010.50
31_I62_I0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rhfA 6 0.9303 100 0.348 Contact Map
4zavA 6 0.9403 100 0.349 Contact Map
2ejbA 6 0.8557 100 0.36 Contact Map
1sbzA 6 0.9154 100 0.362 Contact Map
3lqkA 5 0.9254 100 0.499 Contact Map
3mcuA 5 0.8756 100 0.527 Contact Map
1g63A 6 0.7662 100 0.54 Contact Map
1qzuA 3 0.7164 100 0.543 Contact Map
1p3y1 6 0.8159 100 0.56 Contact Map
3wisA 4 0.8109 100 0.568 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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